ES2527527T3 - Composiciones basadas en aminoácidos de cadena ramificada para mejorar la función ventricular miocárdica en pacientes que padecen diabetes - Google Patents
Composiciones basadas en aminoácidos de cadena ramificada para mejorar la función ventricular miocárdica en pacientes que padecen diabetes Download PDFInfo
- Publication number
- ES2527527T3 ES2527527T3 ES02735773.0T ES02735773T ES2527527T3 ES 2527527 T3 ES2527527 T3 ES 2527527T3 ES 02735773 T ES02735773 T ES 02735773T ES 2527527 T3 ES2527527 T3 ES 2527527T3
- Authority
- ES
- Spain
- Prior art keywords
- diabetes
- chain amino
- patients suffering
- amino acid
- branched chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000005693 branched-chain amino acids Chemical class 0.000 title abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000002107 myocardial effect Effects 0.000 title 1
- 230000002861 ventricular Effects 0.000 title 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 2
- 239000004473 Threonine Substances 0.000 abstract 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 2
- 229930182817 methionine Natural products 0.000 abstract 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 2
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITTO20010580 | 2001-06-15 | ||
| IT2001TO000580A ITTO20010580A1 (it) | 2001-06-15 | 2001-06-15 | Composizioni a base di aminoacidi per il miglioramento della funzioneventricolare miocardica in pazienti affetti da diabete. |
| PCT/IB2002/002149 WO2002102360A2 (en) | 2001-06-15 | 2002-06-10 | Compositions based on branched chain amino acids for improving the myocardial ventricular function in patients suffering from diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2527527T3 true ES2527527T3 (es) | 2015-01-26 |
Family
ID=11458964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02735773.0T Expired - Lifetime ES2527527T3 (es) | 2001-06-15 | 2002-06-10 | Composiciones basadas en aminoácidos de cadena ramificada para mejorar la función ventricular miocárdica en pacientes que padecen diabetes |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20040157903A1 (enExample) |
| EP (1) | EP1399139B1 (enExample) |
| JP (1) | JP4364632B2 (enExample) |
| KR (1) | KR100894365B1 (enExample) |
| AU (1) | AU2002309122A1 (enExample) |
| CA (1) | CA2448745C (enExample) |
| CY (1) | CY1115918T1 (enExample) |
| DK (1) | DK1399139T3 (enExample) |
| ES (1) | ES2527527T3 (enExample) |
| IT (1) | ITTO20010580A1 (enExample) |
| PT (1) | PT1399139E (enExample) |
| WO (1) | WO2002102360A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITTO20030789A1 (it) | 2003-10-07 | 2005-04-08 | Professional Dietetics Srl | Composizione a base di amino acidi per il trattamento |
| EP1537865A1 (de) * | 2003-12-03 | 2005-06-08 | Franz-Peter Dr. Liebel | Verwendung von schwefelhaltigen Verbindungen und proteolytischen Enzymen zur Prophylaxe und Therapie des UDP-Glucuronosyl-transferase 1-defizitären Diabetes mellitus Typ II |
| EP1537864A1 (de) * | 2003-12-03 | 2005-06-08 | Franz-Peter Dr. Liebel | Verwendung von Aminosäuren und schwefeltragenden Verbindungen zur Prophylaxe und Therapie des UDP-Glucuronosyltransferase1-defizitären Diabetes mellitus Typ II |
| US20080032915A1 (en) * | 2004-02-12 | 2008-02-07 | Campina Nederland Holding B.V. | Cysteine Rich Peptides for Improving Thiol Homeostasis |
| JP2008056566A (ja) * | 2004-12-28 | 2008-03-13 | Toudai Tlo Ltd | 低酸素応答促進剤 |
| JP2009536016A (ja) * | 2006-01-20 | 2009-10-08 | インエル ビョルク， | アミノ酸を含む食品組成物 |
| US8633192B2 (en) | 2006-12-15 | 2014-01-21 | Tima Foundation | Compositions and uses thereof |
| EP2117596B1 (en) * | 2006-12-15 | 2018-01-03 | TIMA Foundation | Antioxidant composition and its use in diabetes |
| US8795973B2 (en) * | 2010-11-29 | 2014-08-05 | University of Leceister | Methods for identifying inhibitors of mannan-binding lectin associated serine protease (MASP) proteins and uses thereof |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| IT201700087359A1 (it) * | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
| MA49906A (fr) | 2017-08-14 | 2020-06-24 | Axcella Health Inc | Acides aminés à chaîne ramifiée pour le traitement d'une maladie du foie |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053589A (en) * | 1975-11-24 | 1977-10-11 | Control Drug Inc. | Method of treating nutritional deficiency during cardiac cachexia, diabetes, hypoglycemia, gastroenterology, lipid, cell glycogen and keratin-related skin conditions and alcoholism |
| JPS60255722A (ja) | 1984-05-30 | 1985-12-17 | Otsuka Pharmaceut Factory Inc | 糖尿病用アミノ酸輸液 |
| US5032608A (en) * | 1986-09-10 | 1991-07-16 | Dudrick Stanley J | Method and substrate composition for treating atherosclerosis |
| US5132113A (en) * | 1990-10-26 | 1992-07-21 | Maurizio Luca | Nutritional composition containing essential amino acids |
| AU655780B2 (en) * | 1990-10-30 | 1995-01-12 | Clintec Nutrition Company | A method and composition for the protection of a metabolic recovery of ischemic cardiac tissue |
| US5276018A (en) * | 1992-07-17 | 1994-01-04 | Brigham And Women's Hospital | Composition comprising amino acids and methods for decreasing muscle breakdown |
| LU88369A1 (fr) * | 1993-07-12 | 1994-04-01 | Michel Urso Prof Medecin Et Ch | Acides aminés à chaînes ramifiées |
| IT1289754B1 (it) | 1996-12-16 | 1998-10-16 | Professional Dietetics Srl | Composizioni a base di aminoacidi |
| IT1320783B1 (it) * | 2000-07-04 | 2003-12-10 | Professional Dietetics Srl | Composizioni a base di aminoacidi, atte al miglioramento delleprestazioni muscolari. |
| IT1320782B1 (it) * | 2000-07-04 | 2003-12-10 | Professional Dietetics Srl | Composizioni a base di aminoacidi, atte al trattamentodell'insufficienza cardiaca. |
-
2001
- 2001-06-15 IT IT2001TO000580A patent/ITTO20010580A1/it unknown
-
2002
- 2002-06-10 ES ES02735773.0T patent/ES2527527T3/es not_active Expired - Lifetime
- 2002-06-10 CA CA2448745A patent/CA2448745C/en not_active Expired - Fee Related
- 2002-06-10 US US10/480,774 patent/US20040157903A1/en not_active Abandoned
- 2002-06-10 KR KR1020037016184A patent/KR100894365B1/ko not_active Expired - Fee Related
- 2002-06-10 WO PCT/IB2002/002149 patent/WO2002102360A2/en not_active Ceased
- 2002-06-10 EP EP02735773.0A patent/EP1399139B1/en not_active Expired - Lifetime
- 2002-06-10 DK DK02735773.0T patent/DK1399139T3/en active
- 2002-06-10 AU AU2002309122A patent/AU2002309122A1/en not_active Abandoned
- 2002-06-10 JP JP2003504947A patent/JP4364632B2/ja not_active Expired - Fee Related
- 2002-06-10 PT PT2735773T patent/PT1399139E/pt unknown
-
2008
- 2008-04-17 US US12/104,722 patent/US8653136B2/en not_active Expired - Fee Related
-
2015
- 2015-01-12 CY CY20151100027T patent/CY1115918T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1115918T1 (el) | 2017-01-25 |
| WO2002102360A2 (en) | 2002-12-27 |
| PT1399139E (pt) | 2015-01-14 |
| EP1399139B1 (en) | 2014-10-15 |
| US8653136B2 (en) | 2014-02-18 |
| WO2002102360A3 (en) | 2003-05-30 |
| CA2448745A1 (en) | 2002-12-27 |
| US20080194665A1 (en) | 2008-08-14 |
| KR100894365B1 (ko) | 2009-04-22 |
| DK1399139T3 (en) | 2015-01-12 |
| KR20040008217A (ko) | 2004-01-28 |
| CA2448745C (en) | 2012-09-04 |
| JP4364632B2 (ja) | 2009-11-18 |
| EP1399139A2 (en) | 2004-03-24 |
| JP2004534073A (ja) | 2004-11-11 |
| ITTO20010580A1 (it) | 2002-12-15 |
| US20040157903A1 (en) | 2004-08-12 |
| AU2002309122A1 (en) | 2003-01-02 |
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