DK1399139T3 - Compositions based on branched chain amino acids for the improvement of the ventricular myocardial function in patients suffering from diabetes - Google Patents

Compositions based on branched chain amino acids for the improvement of the ventricular myocardial function in patients suffering from diabetes Download PDF

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Publication number
DK1399139T3
DK1399139T3 DK02735773.0T DK02735773T DK1399139T3 DK 1399139 T3 DK1399139 T3 DK 1399139T3 DK 02735773 T DK02735773 T DK 02735773T DK 1399139 T3 DK1399139 T3 DK 1399139T3
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Prior art keywords
amino acids
branched chain
lysine
threonine
sum
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Application number
DK02735773.0T
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Danish (da)
English (en)
Inventor
Franco Conti
Francesco Saverio Dioguardi
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Determinants Of Metabolism Res Lab S R L
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Publication of DK1399139T3 publication Critical patent/DK1399139T3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK02735773.0T 2001-06-15 2002-06-10 Compositions based on branched chain amino acids for the improvement of the ventricular myocardial function in patients suffering from diabetes DK1399139T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001TO000580A ITTO20010580A1 (it) 2001-06-15 2001-06-15 Composizioni a base di aminoacidi per il miglioramento della funzioneventricolare miocardica in pazienti affetti da diabete.
PCT/IB2002/002149 WO2002102360A2 (en) 2001-06-15 2002-06-10 Compositions based on branched chain amino acids for improving the myocardial ventricular function in patients suffering from diabetes

Publications (1)

Publication Number Publication Date
DK1399139T3 true DK1399139T3 (en) 2015-01-12

Family

ID=11458964

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02735773.0T DK1399139T3 (en) 2001-06-15 2002-06-10 Compositions based on branched chain amino acids for the improvement of the ventricular myocardial function in patients suffering from diabetes

Country Status (12)

Country Link
US (2) US20040157903A1 (enExample)
EP (1) EP1399139B1 (enExample)
JP (1) JP4364632B2 (enExample)
KR (1) KR100894365B1 (enExample)
AU (1) AU2002309122A1 (enExample)
CA (1) CA2448745C (enExample)
CY (1) CY1115918T1 (enExample)
DK (1) DK1399139T3 (enExample)
ES (1) ES2527527T3 (enExample)
IT (1) ITTO20010580A1 (enExample)
PT (1) PT1399139E (enExample)
WO (1) WO2002102360A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITTO20030789A1 (it) 2003-10-07 2005-04-08 Professional Dietetics Srl Composizione a base di amino acidi per il trattamento
EP1537865A1 (de) * 2003-12-03 2005-06-08 Franz-Peter Dr. Liebel Verwendung von schwefelhaltigen Verbindungen und proteolytischen Enzymen zur Prophylaxe und Therapie des UDP-Glucuronosyl-transferase 1-defizitären Diabetes mellitus Typ II
EP1537864A1 (de) * 2003-12-03 2005-06-08 Franz-Peter Dr. Liebel Verwendung von Aminosäuren und schwefeltragenden Verbindungen zur Prophylaxe und Therapie des UDP-Glucuronosyltransferase1-defizitären Diabetes mellitus Typ II
US20080032915A1 (en) * 2004-02-12 2008-02-07 Campina Nederland Holding B.V. Cysteine Rich Peptides for Improving Thiol Homeostasis
JP2008056566A (ja) * 2004-12-28 2008-03-13 Toudai Tlo Ltd 低酸素応答促進剤
JP2009536016A (ja) * 2006-01-20 2009-10-08 インエル ビョルク, アミノ酸を含む食品組成物
US8633192B2 (en) 2006-12-15 2014-01-21 Tima Foundation Compositions and uses thereof
EP2117596B1 (en) * 2006-12-15 2018-01-03 TIMA Foundation Antioxidant composition and its use in diabetes
US8795973B2 (en) * 2010-11-29 2014-08-05 University of Leceister Methods for identifying inhibitors of mannan-binding lectin associated serine protease (MASP) proteins and uses thereof
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
IT201700087359A1 (it) * 2017-07-28 2019-01-28 Professional Dietetics Spa Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale
MA49906A (fr) 2017-08-14 2020-06-24 Axcella Health Inc Acides aminés à chaîne ramifiée pour le traitement d'une maladie du foie
EP3810123A1 (en) 2018-06-20 2021-04-28 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053589A (en) * 1975-11-24 1977-10-11 Control Drug Inc. Method of treating nutritional deficiency during cardiac cachexia, diabetes, hypoglycemia, gastroenterology, lipid, cell glycogen and keratin-related skin conditions and alcoholism
JPS60255722A (ja) 1984-05-30 1985-12-17 Otsuka Pharmaceut Factory Inc 糖尿病用アミノ酸輸液
US5032608A (en) * 1986-09-10 1991-07-16 Dudrick Stanley J Method and substrate composition for treating atherosclerosis
US5132113A (en) * 1990-10-26 1992-07-21 Maurizio Luca Nutritional composition containing essential amino acids
AU655780B2 (en) * 1990-10-30 1995-01-12 Clintec Nutrition Company A method and composition for the protection of a metabolic recovery of ischemic cardiac tissue
US5276018A (en) * 1992-07-17 1994-01-04 Brigham And Women's Hospital Composition comprising amino acids and methods for decreasing muscle breakdown
LU88369A1 (fr) * 1993-07-12 1994-04-01 Michel Urso Prof Medecin Et Ch Acides aminés à chaînes ramifiées
IT1289754B1 (it) 1996-12-16 1998-10-16 Professional Dietetics Srl Composizioni a base di aminoacidi
IT1320783B1 (it) * 2000-07-04 2003-12-10 Professional Dietetics Srl Composizioni a base di aminoacidi, atte al miglioramento delleprestazioni muscolari.
IT1320782B1 (it) * 2000-07-04 2003-12-10 Professional Dietetics Srl Composizioni a base di aminoacidi, atte al trattamentodell'insufficienza cardiaca.

Also Published As

Publication number Publication date
CY1115918T1 (el) 2017-01-25
WO2002102360A2 (en) 2002-12-27
PT1399139E (pt) 2015-01-14
EP1399139B1 (en) 2014-10-15
US8653136B2 (en) 2014-02-18
WO2002102360A3 (en) 2003-05-30
CA2448745A1 (en) 2002-12-27
US20080194665A1 (en) 2008-08-14
KR100894365B1 (ko) 2009-04-22
ES2527527T3 (es) 2015-01-26
KR20040008217A (ko) 2004-01-28
CA2448745C (en) 2012-09-04
JP4364632B2 (ja) 2009-11-18
EP1399139A2 (en) 2004-03-24
JP2004534073A (ja) 2004-11-11
ITTO20010580A1 (it) 2002-12-15
US20040157903A1 (en) 2004-08-12
AU2002309122A1 (en) 2003-01-02

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