ES2497574T3 - Hidróxido carbonato de magnesio directamente compresible - Google Patents

Hidróxido carbonato de magnesio directamente compresible Download PDF

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Publication number
ES2497574T3
ES2497574T3 ES11700067.9T ES11700067T ES2497574T3 ES 2497574 T3 ES2497574 T3 ES 2497574T3 ES 11700067 T ES11700067 T ES 11700067T ES 2497574 T3 ES2497574 T3 ES 2497574T3
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ES
Spain
Prior art keywords
magnesium carbonate
twenty
directly compressible
carbonate hydroxide
compressible magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11700067.9T
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English (en)
Inventor
Marianne Dohmen
Ralf Fiedler
Heike Mueller
Jens Klatyk
Hans-Kurt Peth
Guenter Moddelmog
Thorsten Wedel
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Merck Patent GmbH
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Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2497574T3 publication Critical patent/ES2497574T3/es
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F5/00—Compounds of magnesium
    • C01F5/24—Magnesium carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/11—Powder tap density
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/12—Surface area
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/21—Attrition-index or crushing strength of granulates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Geology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Medicinal Preparation (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Dental Preparations (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Hidróxido carbonato de magnesio directamente compresible (pesado conforme a los requisitos de PhEur, BP, USP y E 504) caracterizado por que presenta una superficie BET de al menos 44 hasta 70 m2/g, una densidad aparente de 0,40 hasta 0,60 g/mI y una densidad aparente compactada de 0,50 hasta 0,80 g/mI.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9
imagen10
E11700067
29-08-2014
(continuación)
Muestra
Fuerza de compresión [kN] Teórico Real Dureza de comprimido día 1 [N] Friabilidad [%]
C
5 5,9 103,8 0,01
10
10,1 189,3 0,01
20
19,2 361,2 0
30
32,1 491,6 0
D
5 5,4 88,1 0,11
10
10,5 194,7 0
20
20,4 415,9 0
30
30,4 492,2 0
E
5 5,5 61,0 0,66
10
11,7 124,5 0,07
20
21,2 238,0 0
30
30,7 419,1 0
F
5 ¡Debido a las propiedades de flujo deficientes no es posible
10
prensar!
20
30
G
5 5,2 15,1 6,92
10
10,1 39,9 1,20
20
20,4 120,2 0,22
30
31,0 269,9 0,11
H
5 5,0 24,2 3,70
10
10,5 59,1 0,34
20
20,8 158,6 0,08
30
31,0 290,5 0,04
Tabla 5:
Muestra
Fuerza de compresión [kN] Teórico Real Dureza de comprimido día 1 [N] Friabilidad [%]
A
5 10 20 30 5,4 10,6 21,3 31,0 52,0 124,6 321,5 457,0 0,92 0,14 0,06 0,01
B
5 10 20 30 4,6 9,9 20,6 29,8 37,6 88,3 272,9 397,1 1,11 0,05 0 0
12
E11700067
29-08-2014
(continuación)
Muestra
Fuerza de compresión [kN] Teórico Real Dureza de comprimido día 1 [N] Friabilidad [%]
C
5 5,9 103,8 0,01
10
10,1 189,3 0,01
20
19,2 361,2 0
30
32,1 491,6 0
D
5 5,4 88,1 0,11
10
10,5 194,7 0
20
20,4 415,9 0
30
30,4 492,2 0
E
5 5,5 61,0 0,66
10
11,7 124,5 0,07
20
21,2 238,0 0
30
30,7 419,1 0
F
5 ¡Debido a las propiedades de flujo deficientes no es posible
10
prensar!
20
30
I
5 5,4 39,4 0,47
10
10,5 92,0 0,07
20
20,3 207,4 0,01
30
29,8 329,5 0,08
K
5 4,8 58,9 0,16
10
10,4 139,5 0,09
20
20,7 268,3 0,06
30
28,3 329,3 0,08
L
5 4,7 56,5 0,18
10
9,2 121,5 0,11
20
20,4 267,5 0,08
30
30,4 350,8 0,05
5 Calidades comerciales utilizadas para los ensayos comparativos de artículos en polvo, así como hidróxido carbonatos de magnesio directamente compresibles, pesados:
F: Hidróxido carbonato de magnesio, pesado, puro, Ph EUR, BP, USP, E 504, Merck KGaA, Darmstadt [Alemania], Art. Nº. 1.05829, lote K38796529 (se trata de un artículo en polvo sin las propiedades de compresión directa prometidas)
10 G: Carbonato de magnesio directamente compresible pesado NutriMag MC, calidad farmacéutica, granulado, con pureza conforme a BP, USP, Ph.Eur, CALMAGS GmbH, Lüneburg [Alemania], lote: 308075060
13
imagen11

Claims (1)

  1. imagen1
    imagen2
ES11700067.9T 2010-02-03 2011-01-07 Hidróxido carbonato de magnesio directamente compresible Active ES2497574T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10001099 2010-02-03
EP10001099 2010-02-03
PCT/EP2011/000045 WO2011095269A2 (de) 2010-02-03 2011-01-07 Direkt verpressbares magnesiumhydroxidcarbonat

Publications (1)

Publication Number Publication Date
ES2497574T3 true ES2497574T3 (es) 2014-09-23

Family

ID=44355853

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11700067.9T Active ES2497574T3 (es) 2010-02-03 2011-01-07 Hidróxido carbonato de magnesio directamente compresible

Country Status (10)

Country Link
US (1) US20120301520A1 (es)
EP (1) EP2531178B1 (es)
JP (1) JP5926195B2 (es)
CA (1) CA2788740C (es)
DK (1) DK2531178T3 (es)
ES (1) ES2497574T3 (es)
HR (1) HRP20140757T1 (es)
PL (1) PL2531178T3 (es)
PT (1) PT2531178E (es)
WO (1) WO2011095269A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150273062A1 (en) * 2012-09-18 2015-10-01 Merck Patent Gmbh Magnesium hydroxide carbonate as carrier material in active ingredient-containing preparations
BR112015014739A2 (pt) * 2012-12-21 2017-07-11 Merck Patent Gmbh carbonato hidróxido de magnésio como excipiente em preparações farmacêuticas tendo liberação melhorada do ingrediente ativo
JP6194253B2 (ja) * 2014-01-20 2017-09-06 神島化学工業株式会社 水酸化マグネシウムの加圧粒状体、及びその製造方法
US20180265371A1 (en) * 2015-01-14 2018-09-20 Imerys Usa, Inc. A controlled process for precipitating polymorphs of calcium carbonate
BR112017015653B1 (pt) * 2015-02-02 2022-02-15 Merck Patent Gmbh Formulação em pó, seu uso e seu processo de preparação
CN109721083A (zh) * 2019-01-07 2019-05-07 河北科技大学 一种无水碳酸镁的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422176A (en) * 1973-05-05 1976-01-21 Beecham Group Ltd Pharmaceutical tablets
JPS6054915A (ja) * 1983-09-01 1985-03-29 Tokuyama Soda Co Ltd 球状塩基性炭酸マグネシウム及びその製造方法
DE69106226T2 (de) * 1990-06-04 1995-05-11 Tokuyama Corp Basisches Magnesiumkarbonat und Verfahren zu seiner Herstellung.
JPH04228420A (ja) * 1990-06-04 1992-08-18 Tokuyama Soda Co Ltd 塩基性炭酸マグネシウム及びその製造方法
JPH04369375A (ja) * 1991-06-17 1992-12-22 Matsushita Refrig Co Ltd 冷蔵庫
US5838571A (en) * 1996-01-29 1998-11-17 Alza Corporation Tablet press monitoring and controlling method and apparatus
JP3910495B2 (ja) * 2002-02-13 2007-04-25 日鉄鉱業株式会社 塩基性炭酸マグネシウム及びその製造方法、並びに該塩基性炭酸マグネシウムを含有する組成物又は構造体
CN101970008B (zh) * 2008-03-10 2013-10-30 拜耳消费者保健股份公司 含有抗酸剂和唾液刺激剂的可口的固体组合物

Also Published As

Publication number Publication date
PT2531178E (pt) 2014-09-12
CA2788740A1 (en) 2011-08-11
WO2011095269A3 (de) 2012-05-18
HRP20140757T1 (hr) 2014-10-24
DK2531178T3 (da) 2014-09-01
PL2531178T3 (pl) 2014-11-28
EP2531178B1 (de) 2014-06-04
CA2788740C (en) 2017-09-12
JP2013518833A (ja) 2013-05-23
WO2011095269A2 (de) 2011-08-11
EP2531178A2 (de) 2012-12-12
JP5926195B2 (ja) 2016-05-25
US20120301520A1 (en) 2012-11-29

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