ES2494915T3 - P53 natural como biomarcador para el tratamiento con inhibidores de mTOR en combinación con un agente citotóxico - Google Patents

P53 natural como biomarcador para el tratamiento con inhibidores de mTOR en combinación con un agente citotóxico Download PDF

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Publication number
ES2494915T3
ES2494915T3 ES09173161.2T ES09173161T ES2494915T3 ES 2494915 T3 ES2494915 T3 ES 2494915T3 ES 09173161 T ES09173161 T ES 09173161T ES 2494915 T3 ES2494915 T3 ES 2494915T3
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biomarker
natural
treatment
combination
cytotoxic agent
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Iwan Beuvink
Anne Boulay
Heidi Lane
Terence O'reilly
George Thomas
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Novartis AG
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Novartis Forschungsstiftung
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Novartis AG
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Novartis Forschungsstiftung
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Uso de la determinación de la presencia del gen p53, TP53, natural, en oposición a la ausencia, la deficiencia o la supresión del gen de p53, TP53, o la presencia de un gen de p53, TP53, mutado en la muestra biológica; como un biomarcador para determinar la sensibilidad de una enfermedad proliferativa al tratamiento con un inhibidor de mTOR en combinación con un agente citotóxico.

Description

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Claims (1)

  1. imagen1
ES09173161.2T 2004-02-23 2005-02-22 P53 natural como biomarcador para el tratamiento con inhibidores de mTOR en combinación con un agente citotóxico Active ES2494915T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54685604P 2004-02-23 2004-02-23
US546856P 2004-02-23

Publications (1)

Publication Number Publication Date
ES2494915T3 true ES2494915T3 (es) 2014-09-16

Family

ID=34886278

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Application Number Title Priority Date Filing Date
ES09173161.2T Active ES2494915T3 (es) 2004-02-23 2005-02-22 P53 natural como biomarcador para el tratamiento con inhibidores de mTOR en combinación con un agente citotóxico

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US (1) US7749698B2 (es)
EP (2) EP1721007A2 (es)
JP (1) JP5005355B2 (es)
KR (2) KR101382077B1 (es)
CN (1) CN1957092B (es)
AU (1) AU2005215910B2 (es)
BR (1) BRPI0507958A (es)
CA (1) CA2555542A1 (es)
ES (1) ES2494915T3 (es)
MX (1) MXPA06009550A (es)
RU (2) RU2385944C2 (es)
WO (1) WO2005080593A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006224B2 (en) 2005-11-21 2015-04-14 Novartis Ag Neuroendocrine tumor treatment
EP1996193A2 (en) 2006-03-13 2008-12-03 OSI Pharmaceuticals, Inc. Combined treatment with an egfr kinase inhibitor and an agent that sensitizes tumor cells to the effects of egfr kinase inhibitors
EP2004163B1 (en) * 2006-04-05 2014-09-17 Novartis Pharma AG Combination of everolimus and vinorelbine
RU2010104916A (ru) * 2006-08-16 2011-08-20 Михаил В. Благосклонный (US) Способ профилактики и лечения возрастных заболеваний
BRPI0907637A8 (pt) 2008-01-25 2018-01-02 P53 Inc biomarcadores p53
WO2012052758A1 (en) 2010-10-22 2012-04-26 Astrazeneca Ab Response biomarkers for iap antagonists in human cancers
GB2488028A (en) * 2011-02-09 2012-08-15 Astrazeneca Ab mTOR mutants as biomarkers for mTOR inhibitor treatment
CA2836568C (en) * 2011-05-19 2020-07-21 Toray Industries, Inc. Immunity induction agent
RU2509808C1 (ru) * 2012-10-30 2014-03-20 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) СПОСОБ ОПРЕДЕЛЕНИЯ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК НЕМЕЛКОКЛЕТОЧНОГО РАКА ЛЕГКИХ К ДЕЙСТВИЮ ПРЕПАРАТОВ, РЕАКТИВИРУЮЩИХ БЕЛОК р53
JP6055430B2 (ja) 2013-03-29 2016-12-27 三ツ星ベルト株式会社 伝動用ベルト
RU2558860C1 (ru) * 2014-03-28 2015-08-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт онкологии" Сибирского отделения Российской академии медицинских наук (ФГБУ "НИИ онкологии" СО РАМН) Способ прогнозирования лимфогенного метастазирования при трипл негативной инвазивной карциноме неспецифического типа молочной железы
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042828A2 (en) * 1998-02-18 1999-08-26 Theryte Limited Treating cancer
EP2762140B1 (en) * 2001-02-19 2017-03-22 Novartis AG Treatment of solid brain tumours with a rapamycin derivative

Also Published As

Publication number Publication date
EP2228452B1 (en) 2014-07-16
RU2385944C2 (ru) 2010-04-10
US20080194613A1 (en) 2008-08-14
EP1721007A2 (en) 2006-11-15
JP5005355B2 (ja) 2012-08-22
AU2005215910A1 (en) 2005-09-01
AU2005215910B2 (en) 2008-05-01
KR101382077B1 (ko) 2014-04-10
WO2005080593A2 (en) 2005-09-01
BRPI0507958A (pt) 2007-07-17
KR20070022665A (ko) 2007-02-27
EP2228452A1 (en) 2010-09-15
CN1957092A (zh) 2007-05-02
JP2007522812A (ja) 2007-08-16
WO2005080593A3 (en) 2005-11-24
US7749698B2 (en) 2010-07-06
MXPA06009550A (es) 2007-03-01
RU2006133828A (ru) 2008-03-27
RU2008116567A (ru) 2009-11-10
WO2005080593A8 (en) 2006-10-19
CN1957092B (zh) 2013-04-03
KR20120084333A (ko) 2012-07-27
RU2429297C2 (ru) 2011-09-20
CA2555542A1 (en) 2005-09-01

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