ES2494915T3 - P53 natural como biomarcador para el tratamiento con inhibidores de mTOR en combinación con un agente citotóxico - Google Patents

P53 natural como biomarcador para el tratamiento con inhibidores de mTOR en combinación con un agente citotóxico Download PDF

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Publication number
ES2494915T3
ES2494915T3 ES09173161.2T ES09173161T ES2494915T3 ES 2494915 T3 ES2494915 T3 ES 2494915T3 ES 09173161 T ES09173161 T ES 09173161T ES 2494915 T3 ES2494915 T3 ES 2494915T3
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Prior art keywords
biomarker
natural
treatment
combination
cytotoxic agent
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Expired - Lifetime
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ES09173161.2T
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English (en)
Inventor
Iwan Beuvink
Anne Boulay
Heidi Lane
Terence O'reilly
George Thomas
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Novartis AG
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Novartis Forschungsstiftung
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Novartis AG
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Novartis Forschungsstiftung
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Uso de la determinación de la presencia del gen p53, TP53, natural, en oposición a la ausencia, la deficiencia o la supresión del gen de p53, TP53, o la presencia de un gen de p53, TP53, mutado en la muestra biológica; como un biomarcador para determinar la sensibilidad de una enfermedad proliferativa al tratamiento con un inhibidor de mTOR en combinación con un agente citotóxico.

Description

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Claims (1)

  1. imagen1
ES09173161.2T 2004-02-23 2005-02-22 P53 natural como biomarcador para el tratamiento con inhibidores de mTOR en combinación con un agente citotóxico Expired - Lifetime ES2494915T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54685604P 2004-02-23 2004-02-23
US546856P 2004-02-23

Publications (1)

Publication Number Publication Date
ES2494915T3 true ES2494915T3 (es) 2014-09-16

Family

ID=34886278

Family Applications (1)

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ES09173161.2T Expired - Lifetime ES2494915T3 (es) 2004-02-23 2005-02-22 P53 natural como biomarcador para el tratamiento con inhibidores de mTOR en combinación con un agente citotóxico

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Country Link
US (1) US7749698B2 (es)
EP (2) EP1721007A2 (es)
JP (1) JP5005355B2 (es)
KR (2) KR101382077B1 (es)
CN (1) CN1957092B (es)
AU (1) AU2005215910B2 (es)
BR (1) BRPI0507958A (es)
CA (1) CA2555542A1 (es)
ES (1) ES2494915T3 (es)
MX (1) MXPA06009550A (es)
RU (2) RU2429297C2 (es)
WO (1) WO2005080593A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006224B2 (en) * 2005-11-21 2015-04-14 Novartis Ag Neuroendocrine tumor treatment
EP1996193A2 (en) 2006-03-13 2008-12-03 OSI Pharmaceuticals, Inc. Combined treatment with an egfr kinase inhibitor and an agent that sensitizes tumor cells to the effects of egfr kinase inhibitors
EP2591775A1 (en) * 2006-04-05 2013-05-15 Novartis AG Combinations comprising mtor inhibitors for treating cancer
WO2008022256A2 (en) * 2006-08-16 2008-02-21 Blagosklonny Mikhail V Methods and compositions for preventing or treating age-related diseases
BRPI0907637A8 (pt) 2008-01-25 2018-01-02 P53 Inc biomarcadores p53
WO2012052758A1 (en) 2010-10-22 2012-04-26 Astrazeneca Ab Response biomarkers for iap antagonists in human cancers
GB2488028A (en) * 2011-02-09 2012-08-15 Astrazeneca Ab mTOR mutants as biomarkers for mTOR inhibitor treatment
EP2711017B1 (en) * 2011-05-19 2016-08-03 Toray Industries, Inc. Immunity inducing agent
RU2509808C1 (ru) * 2012-10-30 2014-03-20 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) СПОСОБ ОПРЕДЕЛЕНИЯ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК НЕМЕЛКОКЛЕТОЧНОГО РАКА ЛЕГКИХ К ДЕЙСТВИЮ ПРЕПАРАТОВ, РЕАКТИВИРУЮЩИХ БЕЛОК р53
JP6055430B2 (ja) * 2013-03-29 2016-12-27 三ツ星ベルト株式会社 伝動用ベルト
RU2558860C1 (ru) * 2014-03-28 2015-08-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт онкологии" Сибирского отделения Российской академии медицинских наук (ФГБУ "НИИ онкологии" СО РАМН) Способ прогнозирования лимфогенного метастазирования при трипл негативной инвазивной карциноме неспецифического типа молочной железы
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
BR112023001575A2 (pt) * 2020-07-30 2023-04-04 Diadem S P A Método in vitro ou ex vivo para diagnóstico ou prognóstico de doença neurodegenerativa e uso de um kit diagnóstico para implementação do mesmo
CN117942400A (zh) * 2022-10-31 2024-04-30 四川大学 Beclin 1抑制剂在制备治疗p53野生型癌症的药物中的用途
CN117942399A (zh) * 2022-10-31 2024-04-30 四川大学 USP5抑制剂在制备治疗p53野生型癌症的药物中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6A (en) * 1836-08-10 Thomas Blanchard Machine for forming end pieces of plank blocks for ships
DK0863984T3 (da) * 1995-11-30 2006-08-28 Univ Texas Fremgangsmåder og præparater til behandling af cancer
AU735896B2 (en) 1998-02-18 2001-07-19 Theryte Limited Treating cancer
LT3351246T (lt) 2001-02-19 2019-07-10 Novartis Pharma Ag Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui

Also Published As

Publication number Publication date
EP2228452B1 (en) 2014-07-16
KR101382077B1 (ko) 2014-04-10
JP2007522812A (ja) 2007-08-16
CN1957092A (zh) 2007-05-02
US7749698B2 (en) 2010-07-06
US20080194613A1 (en) 2008-08-14
AU2005215910B2 (en) 2008-05-01
RU2385944C2 (ru) 2010-04-10
KR20120084333A (ko) 2012-07-27
RU2429297C2 (ru) 2011-09-20
CN1957092B (zh) 2013-04-03
MXPA06009550A (es) 2007-03-01
EP2228452A1 (en) 2010-09-15
WO2005080593A2 (en) 2005-09-01
JP5005355B2 (ja) 2012-08-22
KR20070022665A (ko) 2007-02-27
AU2005215910A1 (en) 2005-09-01
BRPI0507958A (pt) 2007-07-17
WO2005080593A3 (en) 2005-11-24
RU2006133828A (ru) 2008-03-27
WO2005080593A8 (en) 2006-10-19
RU2008116567A (ru) 2009-11-10
EP1721007A2 (en) 2006-11-15
CA2555542A1 (en) 2005-09-01

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