ES2482290A1 - Inhibidores polares simétricos de colina cinasa con actividad antitumoral - Google Patents
Inhibidores polares simétricos de colina cinasa con actividad antitumoral Download PDFInfo
- Publication number
- ES2482290A1 ES2482290A1 ES201400466A ES201400466A ES2482290A1 ES 2482290 A1 ES2482290 A1 ES 2482290A1 ES 201400466 A ES201400466 A ES 201400466A ES 201400466 A ES201400466 A ES 201400466A ES 2482290 A1 ES2482290 A1 ES 2482290A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- machine
- legally binding
- google translate
- choline kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Pyridine Compounds (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
Abstract
Inhibidores polares simétricos de colina cinasa con actividad antitumoral. La presente invención se refiere a compuestos polares simétricos de bispiridinio, bisquinuclidinio y bisquinolinio con un linker derivado del 1,2-bis(p-toliloxi)etano inhibidores de colina cinasa, su síntesis y su uso como medicamento antitumoral.
Description
Claims (1)
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imagen1 imagen2 imagen3 imagen4 imagen5 imagen6
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201400466A ES2482290B1 (es) | 2014-06-05 | 2014-06-05 | Inhibidores polares simétricos de colina cinasa con actividad antitumoral |
PCT/ES2015/070437 WO2015185780A1 (es) | 2014-06-05 | 2015-06-03 | Inhibidores polares simétricos de colina cinasa con actividad antitumoral |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201400466A ES2482290B1 (es) | 2014-06-05 | 2014-06-05 | Inhibidores polares simétricos de colina cinasa con actividad antitumoral |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2482290A1 true ES2482290A1 (es) | 2014-08-01 |
ES2482290B1 ES2482290B1 (es) | 2015-05-19 |
Family
ID=51228241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201400466A Expired - Fee Related ES2482290B1 (es) | 2014-06-05 | 2014-06-05 | Inhibidores polares simétricos de colina cinasa con actividad antitumoral |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2482290B1 (es) |
WO (1) | WO2015185780A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3487857B1 (en) | 2016-07-25 | 2021-09-01 | Nerviano Medical Sciences S.r.l. | Purine and 3-deazapurine analogues as choline kinase inhibitors |
JP7178401B2 (ja) | 2017-07-11 | 2022-11-25 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | コリンキナーゼ阻害剤としてのピラゾロキナゾリン誘導体 |
CN116178258B (zh) * | 2023-03-15 | 2023-11-21 | 中国医学科学院北京协和医院 | N-甲基苯胺喹啉类化合物及其合成方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2237332A1 (es) * | 2004-01-14 | 2005-07-16 | Consejo Sup. Investig. Cientificas | Derivados de piridinio y quinolinio. |
-
2014
- 2014-06-05 ES ES201400466A patent/ES2482290B1/es not_active Expired - Fee Related
-
2015
- 2015-06-03 WO PCT/ES2015/070437 patent/WO2015185780A1/es active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2237332A1 (es) * | 2004-01-14 | 2005-07-16 | Consejo Sup. Investig. Cientificas | Derivados de piridinio y quinolinio. |
Non-Patent Citations (2)
Title |
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J Campos et al, Bioorganic & Medicinal Chemistry 2002, vol 10, págs 2215-2231. "Quantitative structure-activity relationships for a series of symmetrical bisquaternary anticancer compounds", todo el documento * |
J Campos et al, Il Farmaco 2003, vol 58, págs 221-229. "Anticancer bisquaternary heterocyclic compounds: a ras-ional design" * |
Also Published As
Publication number | Publication date |
---|---|
ES2482290B1 (es) | 2015-05-19 |
WO2015185780A1 (es) | 2015-12-10 |
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