ES2481517A2 - Método para el diagnóstico de la enfermedad de parkinson en estadios tempranos - Google Patents
Método para el diagnóstico de la enfermedad de parkinson en estadios tempranos Download PDFInfo
- Publication number
- ES2481517A2 ES2481517A2 ES201300104A ES201300104A ES2481517A2 ES 2481517 A2 ES2481517 A2 ES 2481517A2 ES 201300104 A ES201300104 A ES 201300104A ES 201300104 A ES201300104 A ES 201300104A ES 2481517 A2 ES2481517 A2 ES 2481517A2
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- ES
- Spain
- Prior art keywords
- parkinson
- disease
- diagnosis
- early stages
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Método para el diagnóstico de la enfermedad de Parkinson en estadios tempranos. La presente invención se relaciona con un método in vitro para el diagnóstico de la enfermedad de Parkinson que comprende la cuantificación en sangre, suero o plasma de los niveles de nitro-α-sinucleína nitrosilada en los residuos Tyr125 y/o Tyr136. Asimismo, también se relaciona con un método para evaluar la eficacia de la terapia administrada a un individuo que padece la enfermedad de Parkinson y con el uso de anticuerpos específicos de los residuos Tyr125 y/o Tyrl36 y/o Tyr39 nitrosilados de la nitro-α-sinucleína o de inhibidores de la oxido nítrico sintasa en la elaboración de una composición farmacéutica para el tratamiento de la enfermedad de Parkinson.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201300104A ES2481517B1 (es) | 2013-01-29 | 2013-01-29 | Método para el diagnóstico de la enfermedad de parkinson en estadios tempranos |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201300104A ES2481517B1 (es) | 2013-01-29 | 2013-01-29 | Método para el diagnóstico de la enfermedad de parkinson en estadios tempranos |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ES2481517A2 true ES2481517A2 (es) | 2014-07-30 |
| ES2481517R1 ES2481517R1 (es) | 2014-08-21 |
| ES2481517B1 ES2481517B1 (es) | 2015-06-01 |
Family
ID=51220971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201300104A Expired - Fee Related ES2481517B1 (es) | 2013-01-29 | 2013-01-29 | Método para el diagnóstico de la enfermedad de parkinson en estadios tempranos |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2481517B1 (es) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023077122A1 (en) * | 2021-11-01 | 2023-05-04 | Nitrase Therapeutics, Inc. | Methods of diagnosing a synucleinopathy |
| WO2023156983A1 (en) * | 2022-02-21 | 2023-08-24 | Universidade Nova De Lisboa | Compounds and compositions for neurodegenerative diseases |
| US12071649B1 (en) | 2017-12-03 | 2024-08-27 | Nitrase Therapeutics, Inc. | Identification of modulators of nitration and therapeutic uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0203446D0 (en) * | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
-
2013
- 2013-01-29 ES ES201300104A patent/ES2481517B1/es not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12071649B1 (en) | 2017-12-03 | 2024-08-27 | Nitrase Therapeutics, Inc. | Identification of modulators of nitration and therapeutic uses thereof |
| WO2023077122A1 (en) * | 2021-11-01 | 2023-05-04 | Nitrase Therapeutics, Inc. | Methods of diagnosing a synucleinopathy |
| WO2023156983A1 (en) * | 2022-02-21 | 2023-08-24 | Universidade Nova De Lisboa | Compounds and compositions for neurodegenerative diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2481517B1 (es) | 2015-06-01 |
| ES2481517R1 (es) | 2014-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 2481517 Country of ref document: ES Kind code of ref document: B1 Effective date: 20150601 |
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| FD2A | Announcement of lapse in spain |
Effective date: 20210915 |