ES2469797T3 - Compuestos farmacéuticos - Google Patents
Compuestos farmacéuticos Download PDFInfo
- Publication number
- ES2469797T3 ES2469797T3 ES09731468.6T ES09731468T ES2469797T3 ES 2469797 T3 ES2469797 T3 ES 2469797T3 ES 09731468 T ES09731468 T ES 09731468T ES 2469797 T3 ES2469797 T3 ES 2469797T3
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- ES
- Spain
- Prior art keywords
- methyl
- isopropyl
- ylmethyl
- piperazin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 27
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- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 22
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- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 8
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- 238000013519 translation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
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- 239000000225 tumor suppressor protein Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
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- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
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- 210000002700 urine Anatomy 0.000 description 1
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- 229920002554 vinyl polymer Polymers 0.000 description 1
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- 235000012431 wafers Nutrition 0.000 description 1
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- 238000001262 western blot Methods 0.000 description 1
- 239000011995 wilkinson's catalyst Substances 0.000 description 1
- UTODFRQBVUVYOB-UHFFFAOYSA-P wilkinson's catalyst Chemical compound [Cl-].C1=CC=CC=C1P(C=1C=CC=CC=1)(C=1C=CC=CC=1)[Rh+](P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C=1C=CC=CC=1)P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 UTODFRQBVUVYOB-UHFFFAOYSA-P 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4425608P | 2008-04-11 | 2008-04-11 | |
| GB0806527 | 2008-04-11 | ||
| GBGB0806527.8A GB0806527D0 (en) | 2008-04-11 | 2008-04-11 | Pharmaceutical compounds |
| US44256 | 2008-04-11 | ||
| PCT/GB2009/050358 WO2009125230A1 (en) | 2008-04-11 | 2009-04-09 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2469797T3 true ES2469797T3 (es) | 2014-06-20 |
Family
ID=39433425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09731468.6T Active ES2469797T3 (es) | 2008-04-11 | 2009-04-09 | Compuestos farmacéuticos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8383619B2 (OSRAM) |
| EP (1) | EP2271618B1 (OSRAM) |
| JP (1) | JP5653903B2 (OSRAM) |
| CY (1) | CY1115256T1 (OSRAM) |
| DK (1) | DK2271618T3 (OSRAM) |
| ES (1) | ES2469797T3 (OSRAM) |
| GB (1) | GB0806527D0 (OSRAM) |
| HR (1) | HRP20140516T1 (OSRAM) |
| PL (1) | PL2271618T3 (OSRAM) |
| PT (1) | PT2271618E (OSRAM) |
| RS (1) | RS53389B (OSRAM) |
| SI (1) | SI2271618T1 (OSRAM) |
| TW (1) | TWI453201B (OSRAM) |
| WO (1) | WO2009125230A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2523565T3 (es) * | 2005-04-13 | 2014-11-27 | Astex Therapeutics Limited | Derivados de hidroxibenzamida y sus usos como inhibidores de la hsp90 |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| GB201009853D0 (en) * | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
| US9044474B2 (en) * | 2010-11-08 | 2015-06-02 | The Ohio State University | Compositions and methods for increasing drug efficacy in cancer |
| US10729692B2 (en) * | 2017-02-26 | 2020-08-04 | Institute For Cancer Research | Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death |
| AU2021211925A1 (en) * | 2020-01-20 | 2022-08-25 | Neophore Limited | Isoindoline derivatives which bind to an ATP binding site |
| US20230183197A1 (en) * | 2020-06-01 | 2023-06-15 | Neophore Limited | Inhibitors of mlh1 and/or pms2 for cancer treatment |
| GB202110373D0 (en) * | 2021-07-19 | 2021-09-01 | Neophore Ltd | Inhibitor compounds |
| GB202117224D0 (en) * | 2021-11-29 | 2022-01-12 | Neophore Ltd | Inhibitor compounds |
| GB202117225D0 (en) * | 2021-11-29 | 2022-01-12 | Neophore Ltd | Protac compounds |
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2009
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- 2009-04-09 RS RS20140346A patent/RS53389B/sr unknown
- 2009-04-09 JP JP2011503505A patent/JP5653903B2/ja not_active Expired - Fee Related
- 2009-04-10 TW TW098112063A patent/TWI453201B/zh not_active IP Right Cessation
-
2010
- 2010-10-12 US US12/902,658 patent/US8383619B2/en not_active Expired - Fee Related
-
2013
- 2013-01-30 US US13/753,904 patent/US8664218B2/en not_active Expired - Fee Related
-
2014
- 2014-07-07 CY CY20141100506T patent/CY1115256T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011516536A (ja) | 2011-05-26 |
| DK2271618T3 (da) | 2014-06-16 |
| JP5653903B2 (ja) | 2015-01-14 |
| EP2271618B1 (en) | 2014-05-21 |
| WO2009125230A1 (en) | 2009-10-15 |
| US8664218B2 (en) | 2014-03-04 |
| SI2271618T1 (sl) | 2014-07-31 |
| US8383619B2 (en) | 2013-02-26 |
| TW201002688A (en) | 2010-01-16 |
| TWI453201B (zh) | 2014-09-21 |
| RS53389B (sr) | 2014-10-31 |
| PT2271618E (pt) | 2014-07-28 |
| US20130210820A1 (en) | 2013-08-15 |
| PL2271618T3 (pl) | 2014-09-30 |
| CY1115256T1 (el) | 2017-01-04 |
| GB0806527D0 (en) | 2008-05-14 |
| EP2271618A1 (en) | 2011-01-12 |
| HRP20140516T1 (hr) | 2014-07-04 |
| US20110098290A1 (en) | 2011-04-28 |
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