ES2468965T3 - Moléculas bifuncionales para inhibir la entrada del HIV - Google Patents

Moléculas bifuncionales para inhibir la entrada del HIV Download PDF

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Publication number
ES2468965T3
ES2468965T3 ES09767375.0T ES09767375T ES2468965T3 ES 2468965 T3 ES2468965 T3 ES 2468965T3 ES 09767375 T ES09767375 T ES 09767375T ES 2468965 T3 ES2468965 T3 ES 2468965T3
Authority
ES
Spain
Prior art keywords
hiv
bifunctional molecule
tlt
bifunctional
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09767375.0T
Other languages
English (en)
Spanish (es)
Inventor
Shibo Jiang
Chungen Pan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Blood Center
Original Assignee
New York Blood Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Center filed Critical New York Blood Center
Application granted granted Critical
Publication of ES2468965T3 publication Critical patent/ES2468965T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ES09767375.0T 2008-05-28 2009-05-28 Moléculas bifuncionales para inhibir la entrada del HIV Active ES2468965T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5658008P 2008-05-28 2008-05-28
US56580P 2008-05-28
PCT/US2009/045504 WO2009155064A1 (en) 2008-05-28 2009-05-28 Bifunctional molecules for inhibiting hiv entry

Publications (1)

Publication Number Publication Date
ES2468965T3 true ES2468965T3 (es) 2014-06-17

Family

ID=41112467

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09767375.0T Active ES2468965T3 (es) 2008-05-28 2009-05-28 Moléculas bifuncionales para inhibir la entrada del HIV

Country Status (7)

Country Link
US (1) US8828931B2 (enExample)
EP (1) EP2291392B1 (enExample)
JP (1) JP2011521648A (enExample)
AU (1) AU2009260479A1 (enExample)
CA (1) CA2724900A1 (enExample)
ES (1) ES2468965T3 (enExample)
WO (1) WO2009155064A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009279616A1 (en) 2008-08-08 2010-02-11 New York Blood Center Small molecule inhibitors of retroviral assembly and maturation
CA2794632A1 (en) 2010-05-03 2011-11-10 New York Blood Center, Inc. Bifunctional molecules for inactivating hiv and blocking hiv entry
CA2991209C (en) * 2015-07-04 2023-02-07 Emory University Use of trem-1 inhibitors for treatment, elimination and eradication of hiv-1 infection
BR112019021787A2 (pt) * 2017-04-18 2020-05-05 Inst Pathogen Biology Cams lipopeptídeo para inibição potente do hiv, seu derivado, composição farmacêutica e uso do mesmo
WO2025006684A1 (en) * 2023-06-28 2025-01-02 Flagship Pioneering Innovations Vi, Llc Circular polyribonucleotides encoding antifusogenic polypeptides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444044A (en) 1992-03-26 1995-08-22 New York Blood Center Synthetic polypeptides as inhibitors of HIV-1
US7144991B2 (en) 1999-06-07 2006-12-05 Aletheon Pharmaceuticals, Inc. Streptavidin expressed gene fusions and methods of use thereof
US6605427B2 (en) * 2000-02-10 2003-08-12 Panacos Pharmaceuticals, Inc. Assay for detection of viral fusion inhibitors
US7556813B2 (en) * 2002-09-27 2009-07-07 Trimeris, Inc. Antiviral peptide-polymer conjugate comprising a polymer covalently attached to two or more synthetic HIV gp41 HR1 and/or HR2 peptides
EP1479774A1 (en) * 2003-05-20 2004-11-24 Academisch Medisch Centrum Viruses dependent on inducing agents for viral entry into a host cell
US20050113292A1 (en) * 2003-07-18 2005-05-26 Vanderbilt University Compositions of protein mimetics and methods of using same against HIV-1, SARS-coV and the like
WO2006105199A2 (en) * 2005-03-30 2006-10-05 Trimeris, Inc. Compositions and methods for synthesis of peptide and related conjugate
ATE537183T1 (de) * 2006-02-02 2011-12-15 Trimeris Inc Hiv-fusionshemmerpeptide mit verbesserten biologischen eigenschaften
AU2007286451A1 (en) * 2006-08-17 2008-02-21 F. Hoffmann-La Roche Ag A conjugate of an antibody against CCR5 and an antifusogenic peptide

Also Published As

Publication number Publication date
US8828931B2 (en) 2014-09-09
CA2724900A1 (en) 2009-12-23
WO2009155064A1 (en) 2009-12-23
EP2291392B1 (en) 2014-03-05
JP2011521648A (ja) 2011-07-28
AU2009260479A1 (en) 2009-12-23
US20090298774A1 (en) 2009-12-03
EP2291392A1 (en) 2011-03-09

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