ES2439943T3 - Método de reparación de desgarros de menisco - Google Patents
Método de reparación de desgarros de menisco Download PDFInfo
- Publication number
- ES2439943T3 ES2439943T3 ES06802853.9T ES06802853T ES2439943T3 ES 2439943 T3 ES2439943 T3 ES 2439943T3 ES 06802853 T ES06802853 T ES 06802853T ES 2439943 T3 ES2439943 T3 ES 2439943T3
- Authority
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- Spain
- Prior art keywords
- pair
- collagen
- sheets according
- tear
- weight
- Prior art date
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- 230000008439 repair process Effects 0.000 title claims abstract description 16
- 206010072970 Meniscus injury Diseases 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title description 6
- 239000012528 membrane Substances 0.000 claims abstract description 53
- 102000008186 Collagen Human genes 0.000 claims abstract description 35
- 108010035532 Collagen Proteins 0.000 claims abstract description 35
- 229920001436 collagen Polymers 0.000 claims abstract description 34
- 239000000463 material Substances 0.000 claims abstract description 25
- 102000012422 Collagen Type I Human genes 0.000 claims abstract description 15
- 108010022452 Collagen Type I Proteins 0.000 claims abstract description 15
- 230000004888 barrier function Effects 0.000 claims abstract description 11
- 230000010261 cell growth Effects 0.000 claims abstract description 5
- 230000021164 cell adhesion Effects 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims description 16
- 230000005499 meniscus Effects 0.000 claims description 11
- 241000283690 Bos taurus Species 0.000 claims description 6
- 239000003102 growth factor Substances 0.000 claims description 6
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims description 3
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims description 3
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims description 3
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims description 3
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims description 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 2
- 229920000045 Dermatan sulfate Polymers 0.000 claims description 2
- 102000011782 Keratins Human genes 0.000 claims description 2
- 108010076876 Keratins Proteins 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 210000001612 chondrocyte Anatomy 0.000 claims description 2
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims description 2
- 229940051593 dermatan sulfate Drugs 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
- 101800003838 Epidermal growth factor Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229940116977 epidermal growth factor Drugs 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 230000000921 morphogenic effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 210000002437 synoviocyte Anatomy 0.000 description 11
- 210000005222 synovial tissue Anatomy 0.000 description 8
- 230000035876 healing Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 210000001258 synovial membrane Anatomy 0.000 description 4
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 description 3
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 3
- 210000002808 connective tissue Anatomy 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 2
- 102100037852 Insulin-like growth factor I Human genes 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 229940096423 bovine collagen type i Drugs 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 241000283707 Capra Species 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 108010000685 platelet-derived growth factor AB Proteins 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/044—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/902—Method of implanting
- Y10S623/908—Bone
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71336005P | 2005-09-02 | 2005-09-02 | |
| US713360P | 2005-09-02 | ||
| PCT/US2006/034329 WO2007028078A2 (en) | 2005-09-02 | 2006-09-01 | Method of repairing meniscal tears |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2439943T3 true ES2439943T3 (es) | 2014-01-27 |
Family
ID=37809610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06802853.9T Active ES2439943T3 (es) | 2005-09-02 | 2006-09-01 | Método de reparación de desgarros de menisco |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8084428B2 (enExample) |
| EP (1) | EP1937293B1 (enExample) |
| JP (2) | JP5225844B2 (enExample) |
| CN (1) | CN101252948A (enExample) |
| AU (1) | AU2006287197B2 (enExample) |
| CA (1) | CA2621153C (enExample) |
| ES (1) | ES2439943T3 (enExample) |
| PL (1) | PL1937293T3 (enExample) |
| RU (1) | RU2421173C2 (enExample) |
| WO (1) | WO2007028078A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1948258B1 (en) * | 2005-10-24 | 2013-01-02 | Ed. Geistlich Söhne Ag Für Chemische Industrie | Method and device for synovial cell-charged collagen membrane or gel |
| WO2008131293A2 (en) | 2007-04-19 | 2008-10-30 | Collengin, Inc. | Oriented collagen-based materials, films and methods of making same |
| US10086079B2 (en) | 2008-08-11 | 2018-10-02 | Fibralign Corporation | Biocomposites and methods of making the same |
| US8513382B2 (en) | 2008-08-11 | 2013-08-20 | Fibralign Corporation | Biocomposites and methods of making the same |
| CN101756503A (zh) * | 2008-11-07 | 2010-06-30 | 南通芯迎设计服务有限公司 | 一种多功能桌子 |
| CA2749858C (en) * | 2009-01-16 | 2017-12-12 | Geistlich Pharma Ag | Method and membrane for skin regeneration |
| US10806833B1 (en) | 2009-05-11 | 2020-10-20 | Integra Lifesciences Corporation | Adherent resorbable matrix |
| US20110059178A1 (en) * | 2009-09-08 | 2011-03-10 | Musculoskeletal Transplant Foundation Inc. | Tissue Engineered Meniscus Repair Composition |
| WO2011031642A2 (en) * | 2009-09-08 | 2011-03-17 | Musculoskeletal Transplant Foundation Inc. | Tissue engineered meniscus repair composition |
| US10065046B2 (en) | 2010-07-15 | 2018-09-04 | Fibralign Corporation | Conductive biopolymer implant for enhancing tissue repair and regeneration using electromagnetic fields |
| US9724308B2 (en) | 2010-09-10 | 2017-08-08 | Fibralign Corporation | Biodegradable multilayer constructs |
| CN102229647B (zh) * | 2011-06-09 | 2013-02-20 | 北京大学第三医院 | 滑膜间充质干细胞亲和多肽修饰植入人体支架的方法 |
| US10238769B2 (en) | 2011-10-11 | 2019-03-26 | Fibralign Corporation | Graft for directed vascular and lymphatic regeneration and methods to guide endothelial cell assembly |
| CN102716515B (zh) * | 2012-07-02 | 2014-01-29 | 陕西博鸿生物科技有限公司 | 一种修复半月板撕裂的生物材料及其制备方法 |
| WO2014052912A1 (en) | 2012-09-28 | 2014-04-03 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| EP3054960B1 (en) | 2013-10-10 | 2022-12-21 | Fibralign Corporation | Method and device for lymphedema treatment |
| CN105903079A (zh) * | 2016-05-20 | 2016-08-31 | 中国人民解放军总医院 | 半月板基质来源的三维多孔海绵状支架、制备方法及应用 |
| US11857576B2 (en) * | 2017-12-07 | 2024-01-02 | Vericel Corporation | Compositions and methods for repairing cartilage defects |
| US12427228B2 (en) | 2018-10-05 | 2025-09-30 | Hiroshima University | Meniscus regeneration material |
| EP4103259A4 (en) | 2020-02-11 | 2024-02-28 | Embody, Inc. | Surgical cannula with removable pressure seal |
| AU2021220863B2 (en) | 2020-02-11 | 2023-12-14 | Embody, Inc. | Implant delivery device |
| EP4103069A4 (en) | 2020-02-11 | 2024-06-05 | Embody Inc. | SURGICAL ANCHORING DEVICE, DEVELOPMENT DEVICE AND METHOD OF USE |
| PL247461B1 (pl) | 2020-10-14 | 2025-07-07 | Kinga Ciemniewska-Gorzela | Kolagenowa kapa łąkotkowa i sposób wytwarzania kolagenowej kapy łąkotkowej |
| RU2761965C1 (ru) * | 2020-11-23 | 2021-12-14 | Александр Олегович Тутуров | Способ артроскопической рефиксации разрывов менисков при сочетанном повреждении связок коленного сустава |
| US11857170B2 (en) | 2022-03-04 | 2024-01-02 | Vericel Corporation | Methods and devices for repairing cartilage defects |
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| US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
| GB9400163D0 (en) * | 1994-01-06 | 1994-03-02 | Geistlich Soehne Ag | Membrane |
| US20030039695A1 (en) * | 2001-08-10 | 2003-02-27 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Collagen carrier of therapeutic genetic material, and method |
| US6352558B1 (en) * | 1996-02-22 | 2002-03-05 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method for promoting regeneration of surface cartilage in a damage joint |
| EP0896825B1 (en) * | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
| YU12201A (sh) | 1998-08-14 | 2005-06-10 | Verigen Transplantation Service International (Vtsi) Ag. | Metodi, instrumenti i materijali za transplantaciju ćelija hondrocita |
| US20040059416A1 (en) * | 1999-06-22 | 2004-03-25 | Murray Martha M. | Biologic replacement for fibrin clot |
| US6221109B1 (en) | 1999-09-15 | 2001-04-24 | Ed. Geistlich Söhne AG fur Chemische Industrie | Method of protecting spinal area |
| CZ301649B6 (cs) * | 2000-06-28 | 2010-05-12 | Ed. Geistlich Soehne Ag Fur Chemische Industrie Incorporated Under The Laws Of Switzerland | Trubice pro regeneraci nervu a zpusob jejich výroby |
| IT1318663B1 (it) | 2000-08-02 | 2003-08-27 | Mediolanum Farmaceutici Srl | Membrane di collagene a due facce di cui una organizzata a livellomacromolecolare. |
| EP1363685B1 (en) * | 2000-11-24 | 2007-08-08 | Universite Laval | Connective tissue substitutes, method of preparation and uses thereof |
| KR20040008125A (ko) * | 2001-01-30 | 2004-01-28 | 오르쏘젠 인크. | 활액 유도된 조직 또는 세포를 사용하여 관절 연골 내의결함 또는 병변을 치료 및 수복하기 위한 조성물 및 방법 |
| SK13892003A3 (sk) * | 2001-04-12 | 2004-07-07 | Verigen Transplantation Service International (Vtsi) Ag | Spôsob autológnej transplantácie |
| US6713085B2 (en) | 2001-04-27 | 2004-03-30 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method and membrane for mucosa regeneration |
| US6444222B1 (en) | 2001-05-08 | 2002-09-03 | Verigen Transplantation Services International Ag | Reinforced matrices |
| JP2003160506A (ja) * | 2001-08-10 | 2003-06-03 | Ed Geistlich Soehne Ag Fuer Chemische Industrie | 治療用遺伝物質のコラーゲン担体およびその方法 |
| CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| US8657881B2 (en) * | 2004-04-20 | 2014-02-25 | Depuy Mitek, Llc | Meniscal repair scaffold |
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| CN101252948A (zh) | 2008-08-27 |
| EP1937293B1 (en) | 2013-11-20 |
| JP2009506841A (ja) | 2009-02-19 |
| US20090186062A1 (en) | 2009-07-23 |
| WO2007028078A2 (en) | 2007-03-08 |
| AU2006287197A1 (en) | 2007-03-08 |
| CA2621153C (en) | 2016-10-18 |
| JP2012236112A (ja) | 2012-12-06 |
| CA2621153A1 (en) | 2007-03-08 |
| JP5225844B2 (ja) | 2013-07-03 |
| EP1937293A2 (en) | 2008-07-02 |
| EP1937293A4 (en) | 2011-07-20 |
| US8084428B2 (en) | 2011-12-27 |
| PL1937293T3 (pl) | 2014-03-31 |
| WO2007028078A3 (en) | 2007-09-13 |
| RU2008112185A (ru) | 2009-10-10 |
| AU2006287197B2 (en) | 2013-02-14 |
| RU2421173C2 (ru) | 2011-06-20 |
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