ES2426025T5 - Nuevo cristal estable de monoclorhidrato de 1-(2'-ciano-2'-desoxi- beta -D-arabinofuranosil)citosina - Google Patents

Nuevo cristal estable de monoclorhidrato de 1-(2'-ciano-2'-desoxi- beta -D-arabinofuranosil)citosina

Info

Publication number
ES2426025T5
ES2426025T5 ES10774734T ES10774734T ES2426025T5 ES 2426025 T5 ES2426025 T5 ES 2426025T5 ES 10774734 T ES10774734 T ES 10774734T ES 10774734 T ES10774734 T ES 10774734T ES 2426025 T5 ES2426025 T5 ES 2426025T5
Authority
ES
Spain
Prior art keywords
arabinofuranosyl
deoxy
cyano
beta
stable crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10774734T
Other languages
English (en)
Other versions
ES2426025T3 (es
Inventor
Shotaro Watanabe
Takahiro Hatakeyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delta Fly Pharma Inc
Original Assignee
Delta Fly Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43084859&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2426025(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Delta Fly Pharma Inc filed Critical Delta Fly Pharma Inc
Publication of ES2426025T3 publication Critical patent/ES2426025T3/es
Application granted granted Critical
Publication of ES2426025T5 publication Critical patent/ES2426025T5/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ES10774734T 2009-05-15 2010-05-14 Nuevo cristal estable de monoclorhidrato de 1-(2'-ciano-2'-desoxi- beta -D-arabinofuranosil)citosina Active ES2426025T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009118726 2009-05-15
JP2009118726 2009-05-15
PCT/JP2010/003261 WO2010131475A1 (ja) 2009-05-15 2010-05-14 １－（２'－シアノ－２'－デオキシ－β－Ｄ－アラビノフラノシル）シトシン・一塩酸塩の新規安定形結晶

Publications (2)

Publication Number Publication Date
ES2426025T3 ES2426025T3 (es) 2013-10-18
ES2426025T5 true ES2426025T5 (es) 2024-06-13

Family

ID=43084859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10774734T Active ES2426025T5 (es) 2009-05-15 2010-05-14 Nuevo cristal estable de monoclorhidrato de 1-(2'-ciano-2'-desoxi- beta -D-arabinofuranosil)citosina

Country Status (13)

Country Link
US (1) US8377905B2 (es)
EP (1) EP2431376B2 (es)
JP (2) JP5801715B2 (es)
KR (1) KR101414888B1 (es)
CN (1) CN102414216B (es)
DK (1) DK2431376T4 (es)
ES (1) ES2426025T5 (es)
FI (1) FI2431376T4 (es)
HR (1) HRP20131090T4 (es)
PL (1) PL2431376T3 (es)
PT (1) PT2431376E (es)
RU (1) RU2538593C2 (es)
WO (1) WO2010131475A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
WO2013146833A1 (ja) * 2012-03-28 2013-10-03 富士フイルム株式会社 １－（２－デオキシ－２－フルオロ－４－チオ－β－Ｄ－アラビノフラノシル）シトシンの塩

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2559917B2 (ja) 1990-06-15 1996-12-04 三共株式会社 ピリミジンヌクレオシド誘導体
CA2079413C (en) * 1991-09-30 2003-09-09 Masakatsu Kaneko Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation

Also Published As

Publication number Publication date
CN102414216B (zh) 2015-01-21
KR101414888B1 (ko) 2014-07-03
ES2426025T3 (es) 2013-10-18
HRP20131090T4 (hr) 2024-03-15
PT2431376E (pt) 2013-09-17
RU2011146144A (ru) 2013-06-20
JP5801715B2 (ja) 2015-10-28
HRP20131090T1 (hr) 2013-12-20
EP2431376B1 (en) 2013-08-14
US20120029182A1 (en) 2012-02-02
EP2431376B2 (en) 2024-02-07
CN102414216A (zh) 2012-04-11
US8377905B2 (en) 2013-02-19
JP2015157867A (ja) 2015-09-03
FI2431376T4 (fi) 2024-03-13
EP2431376A4 (en) 2012-08-01
WO2010131475A1 (ja) 2010-11-18
JPWO2010131475A1 (ja) 2012-11-01
JP6307045B2 (ja) 2018-04-04
DK2431376T3 (da) 2013-09-02
RU2538593C2 (ru) 2015-01-10
KR20120022940A (ko) 2012-03-12
PL2431376T3 (pl) 2014-01-31
DK2431376T4 (da) 2024-02-26
EP2431376A1 (en) 2012-03-21

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