ES2425068T3 - Compuestos de pirido[2,3-d]pirimidin-7-ona como inhibidores de PI3K-alfa para el tratamiento del cáncer - Google Patents
Compuestos de pirido[2,3-d]pirimidin-7-ona como inhibidores de PI3K-alfa para el tratamiento del cáncer Download PDFInfo
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- ES2425068T3 ES2425068T3 ES08742864T ES08742864T ES2425068T3 ES 2425068 T3 ES2425068 T3 ES 2425068T3 ES 08742864 T ES08742864 T ES 08742864T ES 08742864 T ES08742864 T ES 08742864T ES 2425068 T3 ES2425068 T3 ES 2425068T3
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Optics & Photonics (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91116007P | 2007-04-11 | 2007-04-11 | |
| US911160P | 2007-04-11 | ||
| PCT/US2008/004807 WO2008127712A1 (en) | 2007-04-11 | 2008-04-11 | Pyrido [2, 3-d] pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2425068T3 true ES2425068T3 (es) | 2013-10-11 |
Family
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Family Applications (1)
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|---|---|---|---|
| ES08742864T Active ES2425068T3 (es) | 2007-04-11 | 2008-04-11 | Compuestos de pirido[2,3-d]pirimidin-7-ona como inhibidores de PI3K-alfa para el tratamiento del cáncer |
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|---|---|
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| JP (1) | JP2010523681A (enExample) |
| KR (1) | KR20090130104A (enExample) |
| CN (1) | CN101711249A (enExample) |
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| BR (1) | BRPI0810175A2 (enExample) |
| CA (1) | CA2683820A1 (enExample) |
| CO (1) | CO6241119A2 (enExample) |
| CR (1) | CR11098A (enExample) |
| DO (1) | DOP2009000242A (enExample) |
| EA (1) | EA018964B1 (enExample) |
| EC (1) | ECSP099722A (enExample) |
| ES (1) | ES2425068T3 (enExample) |
| IL (1) | IL201209A0 (enExample) |
| MA (1) | MA31336B1 (enExample) |
| MX (1) | MX2009010815A (enExample) |
| MY (1) | MY150747A (enExample) |
| NI (1) | NI200900183A (enExample) |
| NZ (1) | NZ579945A (enExample) |
| SV (1) | SV2009003389A (enExample) |
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| UA (1) | UA101315C2 (enExample) |
| WO (1) | WO2008127712A1 (enExample) |
| ZA (1) | ZA200906648B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1828186A1 (en) * | 2004-12-13 | 2007-09-05 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
| US8044062B2 (en) * | 2005-10-07 | 2011-10-25 | Exelixis, Inc. | Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha |
| ES2513165T3 (es) * | 2005-10-07 | 2014-10-24 | Exelixis, Inc. | Derivados de N-(3-amino-quinoxalin-2-il)-sulfonamida y su uso como inhibidores de la fosfatidilinositol-3-quinasa |
| JP2010500994A (ja) | 2006-08-16 | 2010-01-14 | エグゼリクシス， インコーポレイテッド | Ｐｉ３ｋおよびｍｅｋモジュレーターを使用する方法 |
| GEP20115306B (enExample) | 2006-09-15 | 2011-10-10 | Pfizer Prod Inc | |
| UA100979C2 (ru) | 2007-04-10 | 2013-02-25 | Экселиксис, Инк. | Применение пиридопиримидиноновых ингибиторов pi3k альфа для лечения рака |
| CA2683784A1 (en) * | 2007-04-11 | 2008-10-23 | Exelixis, Inc. | Pyrido[2,3-d]pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer |
| AR073524A1 (es) * | 2008-09-30 | 2010-11-10 | Exelixis Inc | Piridopirimidinonas inhibidores de pi3k a y m tor |
| NZ600954A (en) * | 2009-12-22 | 2013-11-29 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | |
| AR080151A1 (es) | 2010-02-09 | 2012-03-14 | Exelixis Inc | Metodos para tratar cancer usando inhibidores de piridopirimidinona de pi 3k y mtor en combinacion con inhibidores de autofagia |
| TWI642670B (zh) | 2010-09-14 | 2018-12-01 | 伊塞利克斯公司 | Ｐｉ３ｋ-德爾塔抑制劑以及其應用和生產方法 |
| WO2013056067A1 (en) * | 2011-10-13 | 2013-04-18 | Exelixis, Inc. | Compounds for use in the treatment of basal cell carcinoma |
| PE20141794A1 (es) | 2011-11-01 | 2014-12-17 | Exelixis Inc | N-(3-{[(3-{[2-cloro-5-(metoxi)fenil]amino}quinoxalin-2-il)amino]sulfonil}fenil)-2-metilalaninamida como inhibidor de fosfatidilinositol 3-quinasa para el tratamiento de neoplasias linfoproliferativas |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2937284A (en) * | 1958-05-01 | 1960-05-17 | Burroughs Wellcome Co | 2, 4-diamino-5, 6-dialkylpyrido (2, 3-d) pyrimidines and method |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| US7019002B2 (en) * | 2001-12-11 | 2006-03-28 | Pharmacia & Upjohn, S.P.A. | Pyridopyrimidinones derivatives as telomerase inhibitors |
| BRPI0510560A (pt) * | 2004-05-04 | 2007-11-20 | Warner Lambert Co | pirido[2,3-d] pirimidin-7-onas pirrolil substituìdas e seus derivados como agentes terapêuticos |
| US8044062B2 (en) * | 2005-10-07 | 2011-10-25 | Exelixis, Inc. | Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha |
| US8247408B2 (en) * | 2005-10-07 | 2012-08-21 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer |
| JP2010500994A (ja) * | 2006-08-16 | 2010-01-14 | エグゼリクシス， インコーポレイテッド | Ｐｉ３ｋおよびｍｅｋモジュレーターを使用する方法 |
| GEP20115306B (enExample) * | 2006-09-15 | 2011-10-10 | Pfizer Prod Inc |
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2008
- 2008-04-11 NZ NZ579945A patent/NZ579945A/en not_active IP Right Cessation
- 2008-04-11 US US12/595,233 patent/US20100209340A1/en not_active Abandoned
- 2008-04-11 ES ES08742864T patent/ES2425068T3/es active Active
- 2008-04-11 EP EP08742864.5A patent/EP2142544B8/en active Active
- 2008-04-11 MY MYPI20094194 patent/MY150747A/en unknown
- 2008-04-11 KR KR1020097023146A patent/KR20090130104A/ko not_active Ceased
- 2008-04-11 EA EA200970936A patent/EA018964B1/ru not_active IP Right Cessation
- 2008-04-11 AU AU2008239596A patent/AU2008239596B2/en not_active Ceased
- 2008-04-11 CN CN200880018758A patent/CN101711249A/zh active Pending
- 2008-04-11 JP JP2010503085A patent/JP2010523681A/ja active Pending
- 2008-04-11 WO PCT/US2008/004807 patent/WO2008127712A1/en not_active Ceased
- 2008-04-11 MX MX2009010815A patent/MX2009010815A/es active IP Right Grant
- 2008-04-11 UA UAA200911451A patent/UA101315C2/ru unknown
- 2008-04-11 BR BRPI0810175-2A2A patent/BRPI0810175A2/pt not_active IP Right Cessation
- 2008-04-11 CA CA002683820A patent/CA2683820A1/en not_active Abandoned
-
2009
- 2009-09-23 ZA ZA200906648A patent/ZA200906648B/xx unknown
- 2009-09-24 TN TNP2009000389A patent/TN2009000389A1/fr unknown
- 2009-09-29 IL IL201209A patent/IL201209A0/en unknown
- 2009-10-09 SV SV2009003389A patent/SV2009003389A/es not_active Application Discontinuation
- 2009-10-09 NI NI200900183A patent/NI200900183A/es unknown
- 2009-10-09 DO DO2009000242A patent/DOP2009000242A/es unknown
- 2009-10-30 MA MA32314A patent/MA31336B1/fr unknown
- 2009-11-09 CO CO09126919A patent/CO6241119A2/es not_active Application Discontinuation
- 2009-11-09 CR CR11098A patent/CR11098A/es unknown
- 2009-11-09 EC EC2009009722A patent/ECSP099722A/es unknown
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2013
- 2013-01-03 US US13/694,772 patent/US20130343988A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009010815A (es) | 2009-10-29 |
| HK1139941A1 (en) | 2010-09-30 |
| NZ579945A (en) | 2012-05-25 |
| CO6241119A2 (es) | 2011-01-20 |
| DOP2009000242A (es) | 2010-04-30 |
| US20100209340A1 (en) | 2010-08-19 |
| CR11098A (es) | 2010-01-27 |
| SV2009003389A (es) | 2010-04-27 |
| TN2009000389A1 (en) | 2010-12-31 |
| EP2142544B8 (en) | 2013-07-03 |
| US20130343988A1 (en) | 2013-12-26 |
| EP2142544A1 (en) | 2010-01-13 |
| CA2683820A1 (en) | 2008-10-23 |
| NI200900183A (es) | 2010-10-05 |
| AU2008239596B2 (en) | 2013-08-15 |
| EP2142544B1 (en) | 2013-05-22 |
| EA200970936A1 (ru) | 2010-02-26 |
| ECSP099722A (es) | 2009-12-28 |
| AU2008239596A1 (en) | 2008-10-23 |
| WO2008127712A1 (en) | 2008-10-23 |
| ZA200906648B (en) | 2010-04-28 |
| CN101711249A (zh) | 2010-05-19 |
| IL201209A0 (en) | 2010-05-31 |
| UA101315C2 (ru) | 2013-03-25 |
| MA31336B1 (fr) | 2010-04-01 |
| JP2010523681A (ja) | 2010-07-15 |
| MY150747A (en) | 2014-02-28 |
| BRPI0810175A2 (pt) | 2014-12-30 |
| EA018964B1 (ru) | 2013-12-30 |
| KR20090130104A (ko) | 2009-12-17 |
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