ES2422558T3 - Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado - Google Patents

Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado

Info

Publication number
ES2422558T3
ES2422558T3 ES05816233T ES05816233T ES2422558T3 ES 2422558 T3 ES2422558 T3 ES 2422558T3 ES 05816233 T ES05816233 T ES 05816233T ES 05816233 T ES05816233 T ES 05816233T ES 2422558 T3 ES2422558 T3 ES 2422558T3
Authority
ES
Spain
Prior art keywords
hyperpolarized
pyruvate
imaging method
imaging
cardiac imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES05816233T
Other languages
English (en)
Inventor
Mathilde Lerche
Rene Zandt
Klaes Golman
Mikkel Thaning
Jan-Henrik Ardenkjaer-Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Application granted granted Critical
Publication of ES2422558T3 publication Critical patent/ES2422558T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Signal Processing (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Uso de 13C_piruvalo hiperpolarizado para la fabricadón de un medio de obtención de imágenes por RM parasu uso en un método para evaluar la viabilidad de tejido miocárdico, en el que dicho método comprende: (8) adquirir imágenes de 13C-RM directas de 13C-plruvalo y sus metabolitos que contienen 13C alsnioa,lactato y bicarbonato, a partir de un sujeto al que se le administra previamente diCho medio deobtención de imágenes; y (b) opcionalmente, correlacionar la senal de 13e de un melabo1ilo con la senal de Ile de cualquier otrometa bolito detectado para obtener un contraste basado en la diferencia en la inlensidad de sel'lal dedos, preferiblemente tres, lo mils preferiblemente cuatro 13C-metabolilos.
ES05816233T 2004-11-19 2005-11-18 Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado Active ES2422558T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20045058 2004-11-19
PCT/NO2005/000434 WO2006054903A2 (en) 2004-11-19 2005-11-18 Method of cardiac imaging with the use of hyperpolarized 13 c-pyruvate

Publications (1)

Publication Number Publication Date
ES2422558T3 true ES2422558T3 (es) 2013-09-12

Family

ID=36182402

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05816233T Active ES2422558T3 (es) 2004-11-19 2005-11-18 Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado

Country Status (13)

Country Link
US (1) US8980224B2 (es)
EP (1) EP1824523B1 (es)
JP (1) JP5456256B2 (es)
KR (1) KR101249634B1 (es)
CN (1) CN101102799B (es)
AU (1) AU2005307194B2 (es)
BR (1) BRPI0518302A2 (es)
CA (1) CA2587795C (es)
ES (1) ES2422558T3 (es)
MX (1) MX2007006048A (es)
PL (1) PL1824523T3 (es)
RU (1) RU2391047C2 (es)
WO (1) WO2006054903A2 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2393750T3 (es) * 2005-12-16 2012-12-27 Ge Healthcare As Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas
US7202665B1 (en) * 2006-04-19 2007-04-10 Wisconsin Alumni Research Foundation Magnetic resonance spectroscopy of species with multiple peaks
US20080171893A1 (en) * 2006-07-11 2008-07-17 Spectra Gases, Inc. Isotopically labeled alpha-keto acids and esters
WO2008020765A2 (en) * 2006-08-18 2008-02-21 Ge Healthcare As Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
WO2008020764A1 (en) 2006-08-18 2008-02-21 Ge Healthcare As 13c-mr imaging or spectroscopy of cell death
CN101506179B (zh) 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物
CA2669556A1 (en) * 2006-11-21 2008-05-29 Ge Healthcare As Method for managing patients with cancers
WO2008086534A1 (en) 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US8483798B2 (en) * 2007-01-15 2013-07-09 General Electric Company System and method for metabolic MR imaging of a hyperpolarized agent
US8983570B2 (en) * 2007-03-27 2015-03-17 Cardiovascular Biotherapeutics, Inc. Therapeutic angiogenesis for treatment of the spine
US11224635B2 (en) 2007-03-27 2022-01-18 Venturis Thereuptics, Inc. Therapeutic angiogenesis for treatment of the spine and other tissues
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
KR20100023802A (ko) * 2007-05-17 2010-03-04 제너럴 일렉트릭 캄파니 과분극화 １３ｃ－피루베이트를 포함하는 영상화 매질을 사용하여 종양을 등급화하는 ｍｒ 방법
GB0713074D0 (en) * 2007-07-05 2007-08-15 Univ London A method of hyperpolarising a magnetic resonance agent
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
CN101796413B (zh) * 2007-09-07 2014-08-20 通用电气健康护理有限公司 测定pdh活性的方法和用于该方法中的成像介质
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
WO2009129265A1 (en) 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
DK2268321T3 (da) 2008-05-02 2013-12-02 Gen Electric Fremgangsmåde til bestemmelse af alanintransaminase (alt)-aktivitet ved 13c-mr-detektion under anvendelse af hyperpolariseret 13c-pyruvat
RU2543704C2 (ru) * 2009-04-02 2015-03-10 ДжиИ ХЕЛТКЕР ЛИМИТЕД Применение магнитно-резонансной визуализирующей среды, содержащей гиперполяризованный 13с-пируват, для обнаружения воспаления или инфекции
EP2476009A1 (en) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr detection using hyperpolarised 13c-fructose
EP2343568A1 (en) * 2009-12-30 2011-07-13 Koninklijke Philips Electronics N.V. Dynamic nuclear polarization apparatus with sample transport system
EP2539726B1 (en) * 2010-02-22 2020-05-13 Koninklijke Philips N.V. Rf antenna arrangement and method for multi nuclei mr image reconstruction involving parallel mri
US9452409B2 (en) 2011-04-22 2016-09-27 Vanderbilt University Para-hydrogen polarizer
US9381257B2 (en) * 2012-07-13 2016-07-05 Bracco Imaging S.P.A. Triarylmethyl radicals
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
KR101516634B1 (ko) * 2014-07-09 2015-05-06 연세대학교 산학협력단 13c-자기공명분광영상을 이용한 암 환자의 치료 예후를 예측하는 방법
RU2622983C1 (ru) * 2016-07-25 2017-06-21 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ интраоперационной визуализации ишемически-реперфузионного повреждения миокарда
US11500044B2 (en) * 2018-02-19 2022-11-15 Bruker France Sas Nuclear spin hyperpolarization in a porous matrix
US11350888B2 (en) * 2019-09-03 2022-06-07 Siemens Healthcare Gmbh Risk prediction for sudden cardiac death from image derived cardiac motion and structure features

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597548A (en) * 1990-07-18 1997-01-28 Board Of Regents, The University Of Texas System 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
ATE256293T1 (de) * 1997-01-08 2003-12-15 Amersham Health As Verfahren zur bilderzeugung mit magnetischer resonanz
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6958244B2 (en) * 2002-04-12 2005-10-25 Bruker Biospin Corp. Low-conductivity buffers for magnetic resonance measurements

Also Published As

Publication number Publication date
US20090162287A1 (en) 2009-06-25
AU2005307194B2 (en) 2011-02-10
EP1824523A2 (en) 2007-08-29
CN101102799B (zh) 2011-05-04
PL1824523T3 (pl) 2013-12-31
MX2007006048A (es) 2007-07-25
RU2007118383A (ru) 2008-12-27
WO2006054903A2 (en) 2006-05-26
RU2391047C2 (ru) 2010-06-10
EP1824523B1 (en) 2013-05-01
CA2587795C (en) 2015-01-20
CN101102799A (zh) 2008-01-09
AU2005307194A1 (en) 2006-05-26
KR101249634B1 (ko) 2013-04-01
WO2006054903A3 (en) 2007-03-15
KR20070089171A (ko) 2007-08-30
JP5456256B2 (ja) 2014-03-26
US8980224B2 (en) 2015-03-17
JP2008520335A (ja) 2008-06-19
CA2587795A1 (en) 2006-05-26
BRPI0518302A2 (pt) 2008-11-11

Similar Documents

Publication Publication Date Title
ES2422558T3 (es) Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado
ATE387144T1 (de) Datenerfassung , analyse und abbildung von ultraschall diagnostische herzbildern
DE60120360D1 (de) Dehnungsratenanalyse in diagnostischen ultraschallbildern
EP2068178A3 (en) A prism unit and a projection image display apparatus
ATE530921T1 (de) Echtzeit-traktographie
RU2012134327A (ru) Совмещение и навигация для эндоскопической хирургии на основе интеграции изображений
BRPI0604497A (pt) sincronização de dados de imagem de ultra-som com mapeamento elétrico
ATE456841T1 (de) Verfahren und computerprogramm zur räumlichen vereinigung von bildern
EP2019284A3 (en) Deactivatable measurement apparatus
WO2006121984A3 (en) Erythrocyte movement imaging and analysis
EP2077526A3 (en) Three-dimensional image reconstruction using doppler ultrasound
BRPI0512824A (pt) método para capturar uma seqüência de imagens por um dispositivo de geração de imagem e armazenar as imagens em um formato digital, e, dispositivo de geração de imagem para capturar uma seqüência de imagens
EP2254023A3 (en) Systems, apparatus and fast methods for aligning images to external markers in Near-to-Eye display systems
EP1976424A4 (en) EYE EXAMINATION METHOD BY OPTICAL COHERENCE TOMOGRAPHY
WO2012021862A3 (en) Detection of anatomical landmarks
MX2008015290A (es) Vista de lampara fluorescente de una estructura anatomica.
SI1769228T1 (sl) Termoakustični tomografski postopek in termoakustični tomograf
WO2011156810A3 (en) Second generation hand-held optical imager
WO2008067072A3 (en) Systems and methods for visualizing a cannula trajectory
EP2166375A3 (en) System and method of extracting plane features
EP1836956A3 (en) Activity-induced energy expenditure estimating instrument
EP2442277A3 (en) Diagnosis assisting apparatus, diagnosis assisting program, and diagnosis assisting method
EP2348388A3 (en) Image display device having imaging device
GB2548420A (en) Clock synchronization within wireless network
ATE375517T1 (de) Diagnosestellung von akuten myokardialen, ischämischen erkrankungen durch kombination von markern