ES2419304T3 - Dispositivo para prevenir alteraciones del ritmo circadiano - Google Patents
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- ES2419304T3 ES2419304T3 ES07855478T ES07855478T ES2419304T3 ES 2419304 T3 ES2419304 T3 ES 2419304T3 ES 07855478 T ES07855478 T ES 07855478T ES 07855478 T ES07855478 T ES 07855478T ES 2419304 T3 ES2419304 T3 ES 2419304T3
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
- A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
- A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychology (AREA)
- Social Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Developmental Disabilities (AREA)
- Pathology (AREA)
- Child & Adolescent Psychology (AREA)
- Radiology & Medical Imaging (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Radiation-Therapy Devices (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US833072 | 1986-02-26 | ||
| US11/833,072 US7748845B2 (en) | 2002-08-28 | 2007-08-02 | Method and device for preventing alterations in circadian rhythm |
| PCT/CA2007/002196 WO2009015457A1 (en) | 2007-08-02 | 2007-12-05 | Method and device for preventing alterations in circadian rhythm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2419304T3 true ES2419304T3 (es) | 2013-08-20 |
Family
ID=39170767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07855478T Active ES2419304T3 (es) | 2007-08-02 | 2007-12-05 | Dispositivo para prevenir alteraciones del ritmo circadiano |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7748845B2 (https=) |
| EP (1) | EP2175930B1 (https=) |
| JP (1) | JP5506677B2 (https=) |
| KR (1) | KR101511623B1 (https=) |
| AU (1) | AU2007357066B2 (https=) |
| CA (1) | CA2695453C (https=) |
| DK (1) | DK2175930T3 (https=) |
| ES (1) | ES2419304T3 (https=) |
| WO (1) | WO2009015457A1 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001085254A1 (en) * | 2000-05-10 | 2001-11-15 | Thomas Jefferson University | Photoreceptor system for melatonin regulation and phototherapy |
| US9681522B2 (en) | 2012-05-06 | 2017-06-13 | Lighting Science Group Corporation | Adaptive light system and associated methods |
| US8841864B2 (en) | 2011-12-05 | 2014-09-23 | Biological Illumination, Llc | Tunable LED lamp for producing biologically-adjusted light |
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| ES2400590B1 (es) * | 2011-03-31 | 2013-12-17 | Universidad De Murcia | Dispositivo de iluminación circadiano. |
| US8901850B2 (en) | 2012-05-06 | 2014-12-02 | Lighting Science Group Corporation | Adaptive anti-glare light system and associated methods |
| US8754832B2 (en) | 2011-05-15 | 2014-06-17 | Lighting Science Group Corporation | Lighting system for accenting regions of a layer and associated methods |
| US9173269B2 (en) | 2011-05-15 | 2015-10-27 | Lighting Science Group Corporation | Lighting system for accentuating regions of a layer and associated methods |
| US9778490B2 (en) | 2011-11-04 | 2017-10-03 | Spy Optic Inc. | Therapeutic eyewear |
| US9289574B2 (en) | 2011-12-05 | 2016-03-22 | Biological Illumination, Llc | Three-channel tuned LED lamp for producing biologically-adjusted light |
| US9913341B2 (en) | 2011-12-05 | 2018-03-06 | Biological Illumination, Llc | LED lamp for producing biologically-adjusted light including a cyan LED |
| US9220202B2 (en) | 2011-12-05 | 2015-12-29 | Biological Illumination, Llc | Lighting system to control the circadian rhythm of agricultural products and associated methods |
| US9402294B2 (en) | 2012-05-08 | 2016-07-26 | Lighting Science Group Corporation | Self-calibrating multi-directional security luminaire and associated methods |
| WO2014011581A2 (en) * | 2012-07-10 | 2014-01-16 | Photokinetics, Inc. | Optimization of light filters and illuminants and products derived therefrom |
| CN104969099A (zh) | 2012-09-26 | 2015-10-07 | 8797625加拿大有限公司 | 多层光干涉滤片 |
| US9174067B2 (en) | 2012-10-15 | 2015-11-03 | Biological Illumination, Llc | System for treating light treatable conditions and associated methods |
| US20140257439A1 (en) * | 2013-03-06 | 2014-09-11 | Verilux, Inc. | Adjustable therapeutic lights |
| US20140268731A1 (en) | 2013-03-15 | 2014-09-18 | Lighting Science Group Corpporation | Low bay lighting system and associated methods |
| JP6391669B2 (ja) | 2013-04-04 | 2018-09-19 | サーケイディアン・ザークライト・インコーポレーテッド | 概日神経内分泌機能を保護するための照明システム |
| US9750918B2 (en) * | 2013-04-11 | 2017-09-05 | Circadian Zirclight Inc. | Methods and devices for improving sleep performance in subject exposed to light at night |
| WO2015005908A1 (en) * | 2013-07-09 | 2015-01-15 | Brandes Bonnie | Therapeutic signal generator |
| US9410664B2 (en) | 2013-08-29 | 2016-08-09 | Soraa, Inc. | Circadian friendly LED light source |
| US10627650B2 (en) | 2013-09-10 | 2020-04-21 | Mitsui Chemicals, Inc. | Optical material and use thereof |
| US9857503B2 (en) | 2013-09-10 | 2018-01-02 | Mitsui Chemicals, Inc. | Optical material and use thereof |
| US10234608B2 (en) | 2013-11-15 | 2019-03-19 | University Of Utah Research Foundation | Nanoparticle light filtering method and apparatus |
| WO2015073933A1 (en) | 2013-11-15 | 2015-05-21 | University Of Utah Research Foundation | Nanoparticle light filtering method and apparatus |
| WO2015123690A1 (en) * | 2014-02-17 | 2015-08-20 | Koifman Dan | Device and method for selective wavelength filtration and selective wavelength transmission for therapeutic effect |
| US10100987B1 (en) | 2014-09-24 | 2018-10-16 | Ario, Inc. | Lamp with directional, independently variable light sources |
| LT6170B (lt) | 2014-10-27 | 2015-06-25 | Uab "Metapro Holding" | Paros širdies ritmo autonominės nervų sistemos balanso analizės sistema |
| US10401683B2 (en) | 2015-01-14 | 2019-09-03 | Soraa, Inc. | Low blue light displays |
| US9943042B2 (en) | 2015-05-18 | 2018-04-17 | Biological Innovation & Optimization Systems, LLC | Grow light embodying power delivery and data communications features |
| USD760398S1 (en) | 2015-06-12 | 2016-06-28 | Verilux, Inc. | Lamp for light therapy |
| USD760913S1 (en) | 2015-06-12 | 2016-07-05 | Verilux, Inc. | Light therapy luminaire |
| US9844116B2 (en) | 2015-09-15 | 2017-12-12 | Biological Innovation & Optimization Systems, LLC | Systems and methods for controlling the spectral content of LED lighting devices |
| US9788387B2 (en) | 2015-09-15 | 2017-10-10 | Biological Innovation & Optimization Systems, LLC | Systems and methods for controlling the spectral content of LED lighting devices |
| WO2017108976A1 (en) | 2015-12-22 | 2017-06-29 | Essilor International (Compagnie Generale D'optique) | Method and ophtalmic element for stimulating a non-visual physiological effect |
| CA3116257C (en) | 2016-02-22 | 2024-01-16 | Alcon Inc. | Uv-absorbing vinylic monomers and uses thereof |
| EP3419961B1 (en) | 2016-02-22 | 2020-09-02 | Alcon Inc. | Uv/visible-absorbing vinylic monomers and uses thereof |
| AU2017234654B2 (en) | 2016-03-14 | 2022-08-04 | Younger Mfg. Co Dba Younger Optics | Photochromic optical lens with selective blue light attenuation |
| US10595376B2 (en) | 2016-09-13 | 2020-03-17 | Biological Innovation & Optimization Systems, LLC | Systems and methods for controlling the spectral content of LED lighting devices |
| KR20180078956A (ko) * | 2016-12-30 | 2018-07-10 | 공주대학교 산학협력단 | 멜라토닌 량 분석에 기초한 수면 유도 조명 장치 및 방법 |
| KR101848290B1 (ko) * | 2017-08-10 | 2018-04-12 | 주식회사 피앤지아이엔씨 | 크라운 전면부 제조방법 및 그를 이용한 모자 |
| WO2019140309A1 (en) | 2018-01-11 | 2019-07-18 | Ecosense Lighting Inc. | Switchable systems for white light with high color rendering and biological effects |
| WO2019140327A2 (en) | 2018-01-11 | 2019-07-18 | Ecosense Lighting Inc. | Display lighting systems with circadian effects |
| CN110538381B (zh) | 2018-05-29 | 2021-06-22 | 华为技术有限公司 | 光照调整方法及终端 |
| US20200018982A1 (en) * | 2018-07-14 | 2020-01-16 | Beau David Whitaker | Protecting horses and other animals from blue light |
| WO2020064736A1 (en) | 2018-09-25 | 2020-04-02 | Koninklijke Philips N.V. | Controlling light exposure for circadian phase management |
| US11783748B2 (en) | 2018-11-08 | 2023-10-10 | Korrus, Inc. | Display lighting systems with bioactive lighting |
| US20220001200A1 (en) | 2018-11-08 | 2022-01-06 | Ecosense Lighting Inc. | Switchable bioactive lighting |
| US12073775B2 (en) | 2018-11-08 | 2024-08-27 | Korrus, Inc. | Display lighting systems with bioactive lighting |
| KR102135627B1 (ko) * | 2019-01-23 | 2020-07-21 | 국민대학교산학협력단 | 일주기 리듬 관리 장치 및 시스템 |
| US12135472B2 (en) | 2019-04-19 | 2024-11-05 | Mitsui Chemicals, Inc. | Optical material, polymerizable composition for optical material, cured product, optical material, plastic lens, method of producing optical material, and method of using optical material |
| WO2020213717A1 (ja) | 2019-04-19 | 2020-10-22 | 三井化学株式会社 | 光学材料 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1971941A (en) * | 1932-07-22 | 1934-08-28 | Gen Electric | Electric discharge lamp device |
| US3112886A (en) * | 1960-02-01 | 1963-12-03 | Leonard H Kushner | Color control |
| US3826751A (en) * | 1970-12-07 | 1974-07-30 | American Optical Corp | Selective optical filter and method of manufacture |
| US4500810A (en) * | 1980-11-25 | 1985-02-19 | North American Philips Lighting Corporation | Fluorescent lamp having integral light-filtering means and starting aid |
| US4952046A (en) * | 1982-02-26 | 1990-08-28 | Stephens James B | Optical lenses with selective transmissivity functions |
| US4719248A (en) * | 1985-08-08 | 1988-01-12 | Bausch & Lomb Incorporated | Ultraviolet blocking agents for contact lenses |
| US5177509A (en) * | 1987-02-26 | 1993-01-05 | Suntiger, Inc. | Ultraviolet radiation and blue light blocking polarizing lens |
| US4878748A (en) * | 1987-02-26 | 1989-11-07 | Suntiger, Inc. | Ultraviolet radiation and blue light blocking polarizing lens |
| US5167228A (en) * | 1987-06-26 | 1992-12-01 | Brigham And Women's Hospital | Assessment and modification of endogenous circadian phase and amplitude |
| US5274403A (en) * | 1987-08-28 | 1993-12-28 | Gott George M | Lens useful in inhibiting the production of melatonin and lens produced thereby |
| US5083858A (en) * | 1989-04-17 | 1992-01-28 | Girerd Rene J | Photobiologic sunglasses and transmitters |
| US6638963B1 (en) * | 1990-12-04 | 2003-10-28 | Oregon Health And Science University | Methods for treating circadian rhythm disorders |
| US6019476A (en) * | 1996-06-24 | 2000-02-01 | Kirschner; Kevin A. | Full spectrum filtering for fluorescent lighting |
| JP3357803B2 (ja) * | 1996-10-30 | 2002-12-16 | タレックス光学工業株式会社 | 眼鏡用偏光膜および偏光眼鏡 |
| DE19729719A1 (de) | 1997-07-11 | 1998-02-12 | Bock Manfred | Lampenkörper mit Farbmischvorrichtung |
| US6235046B1 (en) * | 1998-01-21 | 2001-05-22 | David W. Gerdt | Passive photonic eye delivery system |
| US6156743A (en) * | 1999-10-18 | 2000-12-05 | Whitcomb; John E. | Method of decreasing fatigue |
| GB2378656A (en) | 2001-08-14 | 2003-02-19 | Stephen Bryce Hayes | Means for modulation of circadian rhythms |
| US6902296B2 (en) * | 2002-06-15 | 2005-06-07 | Searfoss, Iii Robert Lee | Nightlight for phototherapy |
| EP2157471A3 (en) * | 2002-08-28 | 2010-03-03 | Robert Casper | A device for the prevention of melatonin suppression by light at night |
| WO2004088616A1 (ja) * | 2003-03-28 | 2004-10-14 | Sharp Kabushiki Kaisha | 表示装置 |
| US10252079B2 (en) * | 2003-06-06 | 2019-04-09 | Koninklijke Philips N.V. | Hand-held light therapy apparatus |
| US6926405B2 (en) * | 2003-06-06 | 2005-08-09 | Younger Mfg. Co. | Eyewear lens having selective spectral response |
| JP2007534349A (ja) * | 2003-07-14 | 2007-11-29 | エイ． ツェイスラー，チャールズ | 短波長光を利用したサーカディアンサイクルの修正方法 |
| JP4896737B2 (ja) * | 2003-12-29 | 2012-03-14 | アボット・メディカル・オプティクス・インコーポレイテッド | 可視光選択的透過領域を有する眼内レンズ |
| JP4544948B2 (ja) * | 2004-03-26 | 2010-09-15 | シャープ株式会社 | 画像表示制御装置 |
| JP4743835B2 (ja) * | 2004-12-27 | 2011-08-10 | Ｈｏｙａ株式会社 | 光学レンズのコーティング装置 |
-
2007
- 2007-08-02 US US11/833,072 patent/US7748845B2/en not_active Expired - Lifetime
- 2007-12-05 CA CA2695453A patent/CA2695453C/en not_active Expired - Fee Related
- 2007-12-05 EP EP07855478A patent/EP2175930B1/en not_active Not-in-force
- 2007-12-05 WO PCT/CA2007/002196 patent/WO2009015457A1/en not_active Ceased
- 2007-12-05 ES ES07855478T patent/ES2419304T3/es active Active
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- 2007-12-05 KR KR1020107004719A patent/KR101511623B1/ko not_active Expired - Fee Related
- 2007-12-05 DK DK07855478.9T patent/DK2175930T3/da active
- 2007-12-05 JP JP2010518463A patent/JP5506677B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2175930B1 (en) | 2013-03-27 |
| JP5506677B2 (ja) | 2014-05-28 |
| CA2695453A1 (en) | 2009-02-05 |
| US20080065177A1 (en) | 2008-03-13 |
| CA2695453C (en) | 2016-11-29 |
| US7748845B2 (en) | 2010-07-06 |
| EP2175930A1 (en) | 2010-04-21 |
| KR20110000618A (ko) | 2011-01-04 |
| DK2175930T3 (da) | 2013-06-24 |
| AU2007357066B2 (en) | 2014-08-21 |
| WO2009015457A1 (en) | 2009-02-05 |
| AU2007357066A1 (en) | 2009-02-05 |
| EP2175930A4 (en) | 2011-06-29 |
| JP2010535538A (ja) | 2010-11-25 |
| KR101511623B1 (ko) | 2015-04-14 |
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