ES2416804B1 - Composition of natural products for topical application - Google Patents

Composition of natural products for topical application Download PDF

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Publication number
ES2416804B1
ES2416804B1 ES201200006A ES201200006A ES2416804B1 ES 2416804 B1 ES2416804 B1 ES 2416804B1 ES 201200006 A ES201200006 A ES 201200006A ES 201200006 A ES201200006 A ES 201200006A ES 2416804 B1 ES2416804 B1 ES 2416804B1
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composition according
topical application
composition
treatment
weight
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ES2416804A1 (en
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Roberto TUDINI
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Priority to ES201200006A priority Critical patent/ES2416804B1/en
Priority to PCT/ES2012/070897 priority patent/WO2013098449A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]

Abstract

Composición de productos naturales para aplicación tópica que se caracteriza por incorporar Portulaca oleracea (verdolaga) con una proporción que varía entre 91.75% y 95.43%, combinado con otras sustancias de origen natural como Hypericum perforatum (hipérico), Triticum aestivum (trigo), Malva spp. (malva), Urtica urens (ortiga) y Arnica montana (árnica), que aumentan la capacidad restauradora de los tejidos y cuya proporción varía entre 0.1% y 2%, cada una.#Esta composición de aplicación tópica se puede presentar en forma de gel, emulsión, crema o spray, y puede ser usado en quemaduras, pieles erosionadas, úlceras de decúbito, lesiones por psoriasis, lesiones cutáneas por herpes zóster, úlceras producidas por pie diabético, en irritaciones oculares en forma de colirio, como eficaz coagulante, para la preparación de una composición cosmética o dermatológica y en el área veterinaria.Composition of natural products for topical application characterized by incorporating Portulaca oleracea (purslane) with a proportion that varies between 91.75% and 95.43%, combined with other naturally occurring substances such as Hypericum perforatum (hypericum), Triticum aestivum (wheat), Malva spp. (mallow), Urtica urens (nettle) and Arnica montana (arnica), which increase the restorative capacity of tissues and whose proportion varies between 0.1% and 2%, each. # This topical application composition can be presented in the form of gel, emulsion, cream or spray, and can be used in burns, eroded skin, pressure sores, psoriasis lesions, skin lesions by shingles, ulcers caused by diabetic foot, eye irritations in the form of eye drops, as an effective coagulant, for the preparation of a cosmetic or dermatological composition and in the veterinary area.

Description

Composición de productos naturales para aplicación tópica Composition of natural products for topical application

Objeto de la invención La presente invención se relaciona con una composición para aplicación tópica, que se caracteriza por incorporar componentes naturales como la Portulaca oleracea (verdolaga), Hypericum perforawm (hipérico), Triticum aestivum (trigo), Malva spp. (malva), Urtica urens (ortiga) y Amica montana (árnica). Estado de la técnica/Antecendentes de la invención La verdolaga es de origen natural, por lo tanto es una sustancia biocompatible que se obtiene del extracto de un vegetal llamado Portulaca oLeracea. El extracto posee un buen efecto antiirritante y antiinflamatorio, cuando se usa por vía tópica. El extracto de Por/u/aca oleracea se ha utilizado con éxilo en variadas l:ondiciones de la piel como quemaduras, picaduras de insecto, dolor, inflamaciones, heridas, úlceras, prurito, eczema y abscesos (Pedro Sánchez Sambucety el al. Las plantas silvestres. Los remedios históricos dennatológicos Med. Cutan Iber. Lat. 2003, 31(5): 337-346). Podemos citar como antecedentes los siguientes documentos pertenecientes al estado de la técnica: la solicitud de patente con núm. KR20010096669 "Cosmetic composition containing plant extract mixture having skin whitening and cell proliferation effects" cuyo solicitante es COSMECCA KOREA ca LTD, la patente KR20060124927 "Water soluble film for skin care and wound repair and method for their preparation" cuyo solicitante es GENIC CO LTD, y la solicitud de patente ES201050012 "Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo", cuyo solicitante es GYNOPHARM, S.A. En la primera patente se promulga la invención de una composición cosmética que contiene un extracto obtenido de una mezcla vegetal donde interviene la Porllllaca oleracea con una proporción desde un 15 al 25% en peso. La segunda patente, posterior a la primera, promulga la invención de una película soluble en agua para el cuidado de la cara y reparadora de heridas que comprende, entre otros componentes, extracto de Portu/aca oleracea como un agente que promueve la afinidad con la piel y cuya proporción varía entre el 0.1-10% en peso.   Object of the invention The present invention relates to a composition for topical application, which is characterized by incorporating natural components such as Portulaca oleracea (purslane), Hypericum perforawm (hypericum), Triticum aestivum (wheat), Malva spp. (mallow), Urtica urens (nettle) and Amica montana (arnica). State of the art / Background of the invention Purslane is of natural origin, therefore it is a biocompatible substance that is obtained from the extract of a vegetable called Portulaca oLeracea. The extract has a good anti-irritant and anti-inflammatory effect, when used topically. The extract of Por / u / aca oleracea has been used with success in various conditions: skin conditions such as burns, insect bites, pain, inflammations, wounds, ulcers, pruritus, eczema and abscesses (Pedro Sánchez Sambucety al. wild plants: Dennatological historical remedies Med. Cutan Iber. Lat. 2003, 31 (5): 337-346). We can cite as background the following documents pertaining to the state of the art: the patent application with no. KR20010096669 "Cosmetic composition containing plant extract mixture having skin whitening and cell proliferation effects" whose applicant is COSMECCA KOREA ca LTD, patent KR20060124927 "Water soluble film for skin care and wound repair and method for their preparation" whose applicant is GENIC CO LTD, and patent application ES201050012 "Chitosan gel for dermatological applications, process for obtaining and using it", whose applicant is GYNOPHARM, SA The first patent promulgates the invention of a cosmetic composition containing an extract obtained from a vegetable mixture in which Porllllaca oleracea intervenes with a proportion from 15 to 25% by weight. The second patent, after the first, promulgates the invention of a water-soluble film for the care of the face and wound repair comprising, among other components, Portu / aca oleracea extract as an agent that promotes affinity with the skin and whose proportion varies between 0.1-10% by weight.

El tercer documento citado, promulga la invención de un gel de quitosano en el que interviene la Portu/aca oleracea en proporción definida entre 0.1 y 90%. En todos los casos citados interviene la Portulaca oleracea con una proporción inferior al91 %. Descripción de la invención Para llevar a cabo la presente invención se usaron diversas mezclas para obtener soluciones en porcentajes que varían entre 91.75% a un 95.43% de Portulaca oleracea, combinado ,con otros componentes que le confieren características terapéuticas apropiadas al producto. La solución de la invención se obtuvo disolviendo Portulaca oleracea en ácido gluc6nico (C6HI207), cuya proporción varía del 1 al 2%. y añadiendo agua destilada en un porcentaje que varía entre el 1 Y 3% en peso con una pequeña dosis de sal común, inferior al 0.001% en peso. Las propiedades de la invención se mejordron a través de la adición de diversas sustancias de origen vegetal (Hypericum perforalum, TriIicum aes¡ivum, Malva spp., Urtica urens y Amica montana). Su aplicación se realizó en pieles que presentaban todo tipo de quemaduras, úlceras por decúbi to y psoriasis y en general en pieles erosionadas. The third document cited promulgates the invention of a chitosan gel in which Portu / aca oleracea intervenes in a defined proportion between 0.1 and 90%. In all the cases mentioned, Portulaca oleracea intervenes with a proportion less than 91%. Description of the invention Various mixtures were used to carry out the present invention to obtain solutions in percentages that vary between 91.75% to 95.43% of Portulaca oleracea, combined, with other components that give it characteristics Therapeutics appropriate to the product. The solution of the invention was obtained by dissolving Portulaca oleracea in acid gluconic (C6HI207), whose proportion varies from 1 to 2%. and adding water distilled in a percentage that varies between 1 and 3% by weight with a small dose of common salt, less than 0.001% by weight. The properties of the invention are improved through the addition of various substances of plant origin (Hypericum perforalum, TriIicum aesivum, Malva spp., Urtica urens and Amica montana). Its application was performed on skins that presented all types of burns, ulcers by decubitus and psoriasis and in general in eroded skin.

Sorprendentemente, su aplicación pennitió la regeneración y cicatrización de los tejidos dañados. Ventajosamente, se realizó su aplicación en lesiones cutáneas sometidas a herpes zóster, obteniéndose una rápida regeneración y cicatrización de los tejidos. Su aplicación se llevó a cabo en úlceras producidas por el pie diabético, obteniéndose también en este caso una rápida cicatrización y regeneración de los tejidos. Ventajosamente, su aplicación se realizó en irritaciones oculares comprobando la mejoraría de dicha lesión. Otra ventaja que presenta la invención es su uso como coagulante. Ventajosamente, la invención se aplicó con éxito en afecciones similares sobre la piel de animales. Finalmente resaltar que la invención se puede presentar en forma de gel, emulsión, crema o spray. Descripción de los dibujos: En la secuencia de fotografías que aparecen a continuación se aprecia el efecto de la solución sobre la piel dañada. La Figura 1 muestra la lesión cutánea localizada en la mano derecha. Surprisingly, its application hindered the regeneration and healing of damaged tissues. Advantageously, its application was made in skin lesions subjected to herpes zoster, obtaining rapid regeneration and scarring of tissues. Its application was carried out in ulcers produced by the diabetic foot, obtaining also in this case a rapid healing and regeneration of tissues. Advantageously, its application was performed in eye irritations checking the would improve from such injury. Another advantage of the invention is its use as a coagulant. Advantageously, the invention was successfully applied to similar skin conditions. of animals. Finally, it should be noted that the invention can be presented in the form of a gel, emulsion, cream or spray Description of the drawings: In the sequence of photographs that appear below, the effect of the solution on damaged skin. Figure 1 shows the skin lesion located in the right hand.

La Figura 2 muestra la mejora de la zona afectada tras la aplicación de la invención . Figure 2 shows the improvement of the affected area after the application of the invention.

La Figura 3 muestra la lesión cutánea localizada en la mano izquierda. Figure 3 shows the skin lesion located in the left hand.

La Figura 4 muestra la mejora de la zona afectada tras la aplicación de la invención. Figure 4 shows the improvement of the affected area after the application of the invention.

Realización de la invención Embodiment of the invention

5 5
En un recipiente de acero inoxidable, con agua destilada, se agrega una pequeña In a steel bowl stainless, with distilled water, be add a small

dosis de sal común y el ácido glucónico, dose of common salt and gluconic acid,
se homogeneíza y posteriormente con be homogenous and then with

agitación continua se continuous agitation is
agrega toda la Portulaca oleracea incluida en la fónnula, add all the Portulaca oleracea included in the formula

lentamente, hasta completa disolución. slowly, until completely dissolved.

Posteriormente se adiciona una o más de las sustancias que aumentan la capacidad Subsequently one or more of the substances that increase the capacity is added

10 10
restauradora de los tejidos (a título de ejemplo se cita Hypericum perforatum, restorer of the fabrics (by way of example be Hypericum perforatum quote,

Triticum aestivum, Malva spp., Urtica urens y Amica montana). Triticum aestivum, Malva spp., Urtica urens and Amica montana).

Posterionnente se almacena en un recipiente cerrado a la espera del fraccionamiento. It is then stored in a closed container pending fractionation.

Las composiciones señaladas en esta patente son a modo de ejemplo y no limitan el The compositions indicated in this patent are by way of example and do not limit the

alcance y protección del invento. scope and protection of the invention.

IS IS
Ejemplo 1 Example 1

Extracto de Portulaca oleracea Portulaca oleracea extract
92.17% 92.17%

Ácido glucónico Gluconic acid
1.38% 1.38%

Agua destilada Distilled water
2.76% 2.76%

Hypericum perforatum Hypericum perforatum
0.46% 0.46%

20 twenty
Triticum aestivum 1.38% Triticum aestivum 1.38%

Malva spp. Malva spp.
1.84% 1.84%

Ejemplo 2 Example 2

Extracto de Portulaca oleracea Portulaca oleracea extract
93.28% 93.28%

Ácido glucónico Gluconic acid
1.74% 1.74%

25 25
Agua destilada 1.40% Distilled water 1.40%

Hypericllm perforatllm Hypericllm perforatllm
1.87% 1.87%

Malva spp. Malva spp.
0.93% 0.93%

Urtica urens Urtica urens
0.78% 0.78%

Ejemplo 3 Example 3

30 30
Extracto de Portulaca oleracea 94.23% Portulaca oleracea extract 94.23%

Ácido glucónico Gluconic acid
1.65% 1.65%

Agua destilada Distilled water
2.00% 2.00%

Triticum aestivum Triticum aestivum
0.47% 0.47%

Árnica Arnica
1.65% 1.65%

Claims (16)

REIVINDICACIONES 1. Composición para aplicación tópica. caracterizada porque: a) Contiene extracto de Portulaca oleracea. b) El extracto de Portulaca oleracea es disuelta mediante la adición de un 1. Composition for topical application. characterized in that: a) Contains extract of Portulaca oleracea. b) Portulaca oleracea extract is dissolved by the addition of a solvente. e) Contiene una O más sustancias de origen natural que aumentan la capacidad restauradora de los tejidos. d) Contiene agua destilada. solvent. e) Contains one or more substances of natural origin that increase the restorative capacity of tissues. d) Contains distilled water.
2. 2.
Composición según la reivindicación 1, caracterizada porque la Portulaca oleracea es el principal constituyente de la solución y se encuentra en proporciones que vañan entre el 91.75% y 95.43% en peso. Composition according to claim 1, characterized in that Portulaca oleracea is the main constituent of the solution and is found in proportions that vary between 91.75% and 95.43% by weight.
3. 3.
Composición según cualquiera de las reivindicaciones 1 a 2, caracterizada porque el solvente es un ácido glucónico (C6H1207) en una proporción que varía entre el 1 % Y 2% en peso. Composition according to any one of claims 1 to 2, characterized in that the solvent is a gluconic acid (C6H1207) in a proportion that varies between 1% and 2% by weight.
4. Four.
Composición según cualquiera de las reivindicaciones 1 a 3, caracterizada porque las suslancias de origen nalural que mejoran la capacidad restauradora de tejidos, se seleccionan de Hypericum perforatum, Triticum aestivum, Malva spp., Urtica urells y Amica montana. Composition according to any one of claims 1 to 3, characterized in that the substance of nalural origin that improves tissue restorative capacity is selected from Hypericum perforatum, Triticum aestivum, Malva spp., Urtica urells and Amica montana.
5. 5.
Composición según cualquiera de las reivindicaciones 1 a 4, caracterizada porque las sustancias de origen natural están comprendidas en una proporción que varía entre 0.1 y 2% en peso, cada una. Composition according to any one of claims 1 to 4, characterized in that the substances of natural origin are comprised in a proportion that varies between 0.1 and 2% by weight, each.
6. 6.
Composición según cualquiera de las reivindicaciones l a 5, caracterizada por incluir agua destilada en un porcentaje que varía entre el 1 y 3% en peso y que contiene una pequeña dosis de sal común, inferior al 0.001 % en peso. Composition according to any of claims 1 to 5, characterized by including distilled water in a percentage that varies between 1 and 3% by weight and containing a small dose of common salt, less than 0.001% by weight.
7. 7.
Composición según cualquiera de las reivindicaciones I a 6, caracterizada porque la Portulaca oleracea se combina con otros elementos de origen naturaL Composition according to any of claims I to 6, characterized in that the Portulaca oleracea is combined with other elements of natural origin
8. 8.
Composición según cualquiera de las reivindicaciones 1 a 7. para la utilización en el tratamiento de todo tipo de quemaduras y pieles erosionadas por aplicación tópica sobre la superficie afectada. Composition according to any one of claims 1 to 7. for use in the treatment of all types of burns and skin eroded by topical application on the affected surface.
9. 9.
Composición según cualquiera de las reivindicaciones 1 a 7, para la utilización en el tratamiento de úlceras de decúbito por aplicación tópica sobre la superficie afectada. Composition according to any of claims 1 to 7, for use in the treatment of pressure ulcers by topical application on the affected surface.
10. 10.
Composición según cualquiera de las reivindicaciones 1 a 7. para la utilización en el tratamiento de lesiones por psoriasis por aplicación tópica sobre la superficie afectada. Composition according to any one of claims 1 to 7. for use in the treatment of psoriasis lesions by topical application on the affected surface.
tI. Composición según cualquiera de las reivindicaciones 1 a 7, para la ulilización en el tratamiento de lesiones cutáneas ocasionadas por herpes zóster por aplicación tópica sobre la superficie afectada. you. Composition according to any one of claims 1 to 7, for the ulilization in the treatment of skin lesions caused by shingles by topical application on the affected surface.
12. 12.
Composición según cualquiera de las reivindicaciones 1 a 7, para la utilización en el tratamiento de úlceras producidas por el pie diabético por aplicación tópica sobre la superficie afectada. Composition according to any one of claims 1 to 7, for use in the treatment of ulcers produced by the diabetic foot by topical application on the affected surface.
13. 13.
Composición según cualquiera de las reivindicaciones 1 a 7, para la utilización en el tratamiento de irritaciones oculares al aplicarse como colirio. Composition according to any one of claims 1 to 7, for use in the treatment of eye irritations when applied as eye drops.
14. 14.
Composición según cualquiera de las reivindicaciones 1 a 7, para la utilización como un eficaz coagulante. Composition according to any one of claims 1 to 7, for use as an effective coagulant.
15. fifteen.
Composición según cualquiera de las reivindicaciones 1 a 7, para la utilización en la preparación de una composición cosmética o dermatológica. Composition according to any one of claims 1 to 7, for use in the preparation of a cosmetic or dermatological composition.
16. 16.
Composición según cualquiera de las reivindicaciones 1 a 7, para la utilización en el área veterinaria. Composition according to any of claims 1 to 7, for use in the veterinary area.
17. 17.
Composición según cualquiera de las rei vindicaciones 1 a 7, caracterizado porque se presenta en forma de gel, emulsión, crema o spray. Composition according to any of claims 1 to 7, characterized in that it is presented in the form of a gel, emulsion, cream or spray.
ES201200006A 2011-12-28 2011-12-28 Composition of natural products for topical application Withdrawn - After Issue ES2416804B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES201200006A ES2416804B1 (en) 2011-12-28 2011-12-28 Composition of natural products for topical application
PCT/ES2012/070897 WO2013098449A1 (en) 2011-12-28 2012-12-21 Composition of natural products for topical application

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Application Number Priority Date Filing Date Title
ES201200006A ES2416804B1 (en) 2011-12-28 2011-12-28 Composition of natural products for topical application

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ES2416804A1 ES2416804A1 (en) 2013-08-02
ES2416804B1 true ES2416804B1 (en) 2014-06-04

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WO (1) WO2013098449A1 (en)

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CN104415050A (en) * 2013-08-31 2015-03-18 何伊仁 External spray for treating viral herpes
CN104623443A (en) * 2015-02-15 2015-05-20 山东省文登整骨医院 Traditional Chinese medicine for treating skin erosion
CN105194452A (en) * 2015-10-29 2015-12-30 青岛海之源智能技术有限公司 Valaciclovir hydrochloride compound sustained-release tablets and preparation method thereof
GR1009042B (en) * 2016-03-15 2017-05-25 Μιχαλης Νικολαου Σταμπος A set of face and body mask and gel

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KR100540463B1 (en) * 1998-11-17 2006-04-20 주식회사 엘지생활건강 Composition containing portulaca oleracea L. extract for anti-inflammation and anti-irritation
KR20020001911A (en) * 2000-05-12 2002-01-09 성재갑 Cosmetic composition containing portulaca oleracea L. extract for anti-inflammation and anti-irritation
KR100441596B1 (en) * 2001-06-30 2004-07-23 주식회사 코스메카코리아 cosmetic composition containing plant extract complex
US7060303B2 (en) * 2002-12-31 2006-06-13 Avon Products, Inc. Use of purslane to treat facial wrinkles
EP1604647B1 (en) * 2004-05-12 2008-05-07 Chisso Corporation Cosmetic composition containing polyorganosiloxane-containing epsilon-polylysine polymer, and polyhydric alcohol, and production thereof
KR20080079740A (en) * 2007-02-28 2008-09-02 권혁조 Cosmetic composition for atopy skin
KR20090063381A (en) * 2007-12-14 2009-06-18 주식회사 엘지생활건강 Skin care cosmetic composition for improving and preventing wrinkle
KR101123653B1 (en) * 2009-06-26 2012-03-20 대전보건대학 산학협력단 Cosmetic composition for controlling anti-acne

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