CN104415050A - External spray for treating viral herpes - Google Patents

External spray for treating viral herpes Download PDF

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Publication number
CN104415050A
CN104415050A CN201310406312.8A CN201310406312A CN104415050A CN 104415050 A CN104415050 A CN 104415050A CN 201310406312 A CN201310406312 A CN 201310406312A CN 104415050 A CN104415050 A CN 104415050A
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CN
China
Prior art keywords
herpes
external spray
spray
pain
viral herpes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201310406312.8A
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Chinese (zh)
Inventor
何伊仁
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Individual
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Individual
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Publication date
Application filed by Individual filed Critical Individual
Priority to CN201310406312.8A priority Critical patent/CN104415050A/en
Publication of CN104415050A publication Critical patent/CN104415050A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

Abstract

The invention discloses an external spray for treating viral herpes and relates to a medicine. According to the technical scheme disclosed by the invention, 100cc of the external spray is prepared by the following steps: preparing 15-25mg of poly I-C, 40-60mg of chlorpheniramine, 1500-2800mg of acyclovir, 2,000-2800mg of lidocaine, 15-25mg of vitamin B12, 25-50mg of menthol, 200-300mg of chloramphenicol and the balance of ethanol; and bottling. The spray is used in a spraying manner. The viral herpes is clustered red hill herpes caused when viruses invade the skin or mucosa or superficial nerves; the viral herpes is distributed into a belt along the nerve positions sometimes, and therefore the group of cases are named herpes zoster; the elder and weak patients are serious in pain; some after pain symptoms last for several years; and the patients are painful. The invention aims at providing the external spray for treating viral herpes. The external spray is used for treating skin diseases such as viral herpes and has the effects of restraining viruses, relieving symptoms and shortening the course; and a new medical method is provided.

Description

A kind of external spraying agent for the treatment of virus infected herpes
Technical field
The invention belongs to medical pharmaceutical technology sectors, be specifically related to a kind of external spraying agent for the treatment of virus infected herpes.
Background technology
Virus infected herpes refers to that virus infringement skin or mucosa or shallow table are neural, become the red papulovesicle of tufted, also have and distribute along nerve location in banded, so this group case is called herpes zoster, old patient pain quite very, the rear something lost pain symptom had lasts for several years, agonizing, although there is a lot of external-applied ointment to put wiping on the skin, effect is not satisfactory eventually, experience is drawn by practice, a kind of external spraying agent for the treatment of virus infected herpes of the present invention, effectively can shorten the course of disease, relief of symptoms, improve and symptom management development, have clinical practice meaning.
Summary of the invention
The object of the invention is to provide a kind of external spraying agent for the treatment of virus infected herpes, be used for treating the dermatosiss such as virus infected herpes, it has suppression virus, and relief of symptoms shortens the effect of the course of disease, adds medical new method.
Technical scheme of the present invention is: get polyinosini 15--25mg, chlorphenamine 40--60mg, acycloguanosine 1500--2800mg, lignocaine 2000-2800mg, vitamin B12 15--25mg, Mentholum 25-50mg, chloromycetin 200-300mg, ethanol adds to 100cc, and bottling spraying uses.
Advantage of the present invention is that preparation is easy, and curative effect is reliable, and in prescription, polyinosini is efficient interferon inducers, has broad-spectrum antiviral and immunosuppressive action.Acycloguanosine can suppress virus replication, synergism is had with prodrug compatibility, vitamin B12 and polyinosini coupling promote that albumen synthesis suppresses virus, outside lignocaine local anesthesia alleviating pain, still have and promote penetrance and diffusibility effect, chlorphenamine anti-allergic drug, antihistamine effect is stronger, Mentholum fragrance and cool pain-alleviating, ethanol sterilizing blood vessel dilating and skin again, is conducive to drug osmotic.
Detailed description of the invention
Technical scheme of the present invention is: get polyinosini 15--25mg, chlorphenamine 40--60mg, acycloguanosine 1500--2800mg, lignocaine 2000-2800mg, vitamin B12 15--25mg, Mentholum 25-50mg, chloromycetin 200-300mg, ethanol adds to 100cc, and bottling spraying uses.
Further illustrate effect of the present invention, using method by several concrete instance below: topical spray, every day 4 times, take the circumstances into consideration increase and decrease, until recovery from illness.
Example 1: patient week XX, man, 67 years old, because left flank portion pain was examined over 3 days.Main suit involved back without side of body portion pain under obvious inducement before 3 days, sometimes in property of burning, lay awake all night, and there is no positive sign find through x line and ultrasound diagnosis.Body Lian: see there is the little pimple of kermesinus under patient's left breast, about about 3mm size, slightly in tufted, remaining not different from.Tentative diagnosis: herpes zoster.Process: each 0.5g of acyclovir tablets, each 6 of taraxacum weber, every day 4 times, a kind of spray (hereinafter referred to as spray) 100cc*1 bottle for the treatment of virus infected herpes of the present invention, spray puts affected part on the skin, every day 4 times, if hurt like hell, secondary can be sprayed more.Next day, patient told, and after spray medicine, pain subtracts, and just herpes increases many, so Fu Guan affected part, really adds again two bunches, advises patient, need not worry, on time medication.Further consultation after 5 days, is shown in that herpes is moved back, and part eschar remains, and pain disappears.
Example 2: patient Zheng XX, man, 42 years old, because scrotum pain is gone to a doctor for 4 days.Have a medical check-up: patient's scrotum coronary sulcus position, see cluster vesicle sample pimple, blush around pimple, between collection bunch, skin is normal, and main suit's pain involves lower abdomen, slightly itches.Clinical diagnosis: virus infected herpes.Process: each 300mg of ribavirin granule, every day 3 times, each 5 of the clear sheet of Lian Pushuan, every day 4 times, spray 100ml*1 bottle, every day, affected part spray was put on the skin 4-6 time.Further consultation after 4 days, most of eschar falls, and pain disappears substantially, and sb.'s illness took a favorable turn, advises and continues to strengthen treatment.
Example 3: the strict XX of patient, female, 74 years old, have a headache and go to a doctor for 3 days in left side.Main suit's left side headache, the dry and astringent distending pain of left side eyelid, night, pain can not be fallen asleep.Have a medical check-up: tempori sinistro is shown in several pieces of red papules, and size is about about 3mm, left eyelid is slightly swollen, conjunctival congestion, photophobia.Diagnosis: herpes zoster.Therapeutic Method: spray 100mg*1 bottle, external affected part, each 0.5mg of benzylpenicillin potassium sheet, every day 3 times, each 0.5g of acyclovir, every day 4 times, methylcobalamin tablet each 0,1g, every day 3 times, further consultation after 4 days, herpes calms down disappearance, and pain is removed, and clinical announcement more.
A kind of spray for the treatment of virus infected herpes of the present invention, integrates antiviral. and antiallergic and anti-inflammatory analgesic adhesive, as a kind of external adjuvant, through Clinical practice, truly have the effect shortening the course of disease, and easy to use, and toxic and side effects is relatively less, can supply Clinical Selection.

Claims (1)

1. treat the external spraying agent of virus infected herpes for one kind, it is characterized in that technical scheme of the present invention is: get polyinosini 15--25mg, chlorphenamine 40--60mg, acycloguanosine 1500--2800mg, lignocaine 2000-2800mg, vitamin B12 15--25mg, Mentholum 25-50mg, chloromycetin 200-300mg, ethanol adds to 100cc, and bottling spraying uses.
CN201310406312.8A 2013-08-31 2013-08-31 External spray for treating viral herpes Pending CN104415050A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310406312.8A CN104415050A (en) 2013-08-31 2013-08-31 External spray for treating viral herpes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310406312.8A CN104415050A (en) 2013-08-31 2013-08-31 External spray for treating viral herpes

Publications (1)

Publication Number Publication Date
CN104415050A true CN104415050A (en) 2015-03-18

Family

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Family Applications (1)

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Country Status (1)

Country Link
CN (1) CN104415050A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109260247A (en) * 2018-10-23 2019-01-25 渭南新秦药物研究有限责任公司 A kind of skin antiseptic and preparation method thereof acting on herpesviral

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1355013A (en) * 2000-11-24 2002-06-26 广东医学院医药科技开发中心 Skin disinfectant with disinfecting and anti-infection functions
CN1415297A (en) * 2002-10-17 2003-05-07 北京昭衍新药研究中心 Pharmic compsn. of local administration for treating herpes zoster
EP1374883A1 (en) * 2002-06-21 2004-01-02 Roland. Dr. Lingg Nasal spray containing a plant extract for the treatment of diseases such as herpes zoster, hematoma, mastitis and cardiovasculatory weakness
CN101628116A (en) * 2009-08-10 2010-01-20 宋泽龙 Pharmaceutical composition for treating herpes zoster
WO2013098449A1 (en) * 2011-12-28 2013-07-04 Tudini Roberto Composition of natural products for topical application
CN103251683A (en) * 2013-06-08 2013-08-21 马群 External medicine for treating herpes zoster

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1355013A (en) * 2000-11-24 2002-06-26 广东医学院医药科技开发中心 Skin disinfectant with disinfecting and anti-infection functions
EP1374883A1 (en) * 2002-06-21 2004-01-02 Roland. Dr. Lingg Nasal spray containing a plant extract for the treatment of diseases such as herpes zoster, hematoma, mastitis and cardiovasculatory weakness
CN1415297A (en) * 2002-10-17 2003-05-07 北京昭衍新药研究中心 Pharmic compsn. of local administration for treating herpes zoster
CN101628116A (en) * 2009-08-10 2010-01-20 宋泽龙 Pharmaceutical composition for treating herpes zoster
WO2013098449A1 (en) * 2011-12-28 2013-07-04 Tudini Roberto Composition of natural products for topical application
CN103251683A (en) * 2013-06-08 2013-08-21 马群 External medicine for treating herpes zoster

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
凌峰: "聚肌胞原液外涂治疗带状疱疹15例疗效观察", 《实用全科医学》 *
程海冬: "1%氯霉素酒精治疗带状疱疹效果好", 《中华护理杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109260247A (en) * 2018-10-23 2019-01-25 渭南新秦药物研究有限责任公司 A kind of skin antiseptic and preparation method thereof acting on herpesviral

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Application publication date: 20150318