WO2022216263A1 - A new toothpaste containing rosa damascena (isparta oil rose) - Google Patents
A new toothpaste containing rosa damascena (isparta oil rose) Download PDFInfo
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- WO2022216263A1 WO2022216263A1 PCT/TR2022/050305 TR2022050305W WO2022216263A1 WO 2022216263 A1 WO2022216263 A1 WO 2022216263A1 TR 2022050305 W TR2022050305 W TR 2022050305W WO 2022216263 A1 WO2022216263 A1 WO 2022216263A1
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- weight
- oil
- toothpaste according
- toothpaste
- isparta
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 60
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 46
- 241000220317 Rosa Species 0.000 title claims abstract description 24
- 244000181025 Rosa gallica Species 0.000 title 1
- 239000003921 oil Substances 0.000 claims abstract description 35
- 239000000203 mixture Substances 0.000 claims abstract description 32
- 230000000694 effects Effects 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 13
- 239000004088 foaming agent Substances 0.000 claims abstract description 11
- 210000000515 tooth Anatomy 0.000 claims abstract description 10
- 239000003381 stabilizer Substances 0.000 claims abstract description 9
- 239000002562 thickening agent Substances 0.000 claims abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 8
- 239000000440 bentonite Substances 0.000 claims abstract description 8
- 229910000278 bentonite Inorganic materials 0.000 claims abstract description 8
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000004927 clay Substances 0.000 claims abstract description 8
- 238000004140 cleaning Methods 0.000 claims abstract description 8
- 210000004195 gingiva Anatomy 0.000 claims abstract description 8
- 239000010665 pine oil Substances 0.000 claims abstract description 8
- 210000001519 tissue Anatomy 0.000 claims abstract description 8
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 7
- 230000002790 anti-mutagenic effect Effects 0.000 claims abstract description 7
- 201000010099 disease Diseases 0.000 claims abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 244000005700 microbiome Species 0.000 claims abstract description 7
- 239000008132 rose water Substances 0.000 claims abstract description 7
- 210000003254 palate Anatomy 0.000 claims abstract description 6
- 235000019198 oils Nutrition 0.000 claims description 33
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 238000005728 strengthening Methods 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000013355 food flavoring agent Nutrition 0.000 claims description 6
- 239000003906 humectant Substances 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 229940080272 sodium coco-sulfate Drugs 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 3
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 3
- 235000013311 vegetables Nutrition 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 230000008961 swelling Effects 0.000 claims description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
- 239000003518 caustics Substances 0.000 abstract description 2
- 239000000126 substance Substances 0.000 description 11
- 239000000284 extract Substances 0.000 description 10
- 238000009472 formulation Methods 0.000 description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 230000009931 harmful effect Effects 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 235000019719 rose oil Nutrition 0.000 description 5
- 239000010666 rose oil Substances 0.000 description 5
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 208000002925 dental caries Diseases 0.000 description 4
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 231100000481 chemical toxicant Toxicity 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 229930014626 natural product Natural products 0.000 description 3
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 239000003082 abrasive agent Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000003217 anti-cancerogenic effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000037123 dental health Effects 0.000 description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 235000019251 heptyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 208000018962 mouth sore Diseases 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- MOZDKDIOPSPTBH-UHFFFAOYSA-N Benzyl parahydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OCC1=CC=CC=C1 MOZDKDIOPSPTBH-UHFFFAOYSA-N 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- ZTJORNVITHUQJA-UHFFFAOYSA-N Heptyl p-hydroxybenzoate Chemical compound CCCCCCCOC(=O)C1=CC=C(O)C=C1 ZTJORNVITHUQJA-UHFFFAOYSA-N 0.000 description 1
- 239000004284 Heptyl p-hydroxybenzoate Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 240000007890 Leonurus cardiaca Species 0.000 description 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 1
- 241000218922 Magnoliophyta Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229940034794 benzylparaben Drugs 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 201000002170 dentin sensitivity Diseases 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 230000004373 eye development Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 208000024693 gingival disease Diseases 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 238000012009 microbiological test Methods 0.000 description 1
- 229930003658 monoterpene Natural products 0.000 description 1
- -1 monoterpene alcohols Chemical class 0.000 description 1
- 235000002577 monoterpenes Nutrition 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000007406 plaque accumulation Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- This invention relates to an antibacterial, anti-inflammatory and anti-mutagenic toothpaste which does not contains any harmful and toxic chemical, consists of natural cleansing products, provides overall oral hygiene and cleaning, including teeth, gingiva and palate, is suitable for oral flora, reduces the microorganism activities in dental and gingival tissues and supports the treatment in case of a disease.
- the invention describes a toothpaste which comprises a composition containing Rosa Damascena (Isparta rose oil) as a therapeutical agent, and a method of production thereof.
- Rosa Damascena Rosa Damascena
- toothpastes Today, the use of toothpastes is common all over the world to destroy all bacteria, viruses and similar microbes in the mouth, including teeth, gingiva and palate, to ensure oral hygiene, and to clean teeth and gingiva. Abrasives, cleansing agents, binders, flavoring sweeteners, preservatives and cleansing agents for preventing dental caries are used in the toothpastes.
- SLS sodium lauryl sulfate
- SLES sodium lauryl ether sulfate
- paraben titanium dioxide
- T1O 2 titanium dioxide
- SLS a very cheap foaming agent
- SLS used in toothpastes may increase the incidence of mouth sores. It is known to cause mouth sores to increase their incidence by changing the nature of the epithelial cells. Studies show that the toothpastes containing SLS and SLES support and increase the formation of mouth ulcers.
- SLS and SLES are carcinogenic, they are known to remain as residues in organs such as brain and eyes, and cause diseases in later ages.
- Paraben used in toothpastes in the art is also known specifically as methyl paraben (E218), propylparaben (E216), ethylparaben (E214), butylparaben, benzylparaben and heptylparaben (E209) and is a chemical which is generally used to prolong shelf life by preventing bacteria and fungi that may occur in cosmetic and care products. As it is absorbed by the skin, it may mix with the whole body, all tissues, even blood and urine. Paraben is a carcinogenic substance and leads to substantial and serious damage to the endocrine system and reproductive systems.
- the toothpaste has the effects of regulating qi, relieving depression, stimulating blood circulation, dissipating blood stasis, regulating menstruation, relieving pain and delaying aging.
- a new formulation containing Isparta rose oil and rose water according to this invention is completely different from the formulation content in the state of the art.
- both formulations have herbal contents, the therapeutic agents used, composition ratios and technical effects are different.
- the cumulative cleansing effect of Isparta rose extracts and fluoride, and the therapeutic effect of Isparta rose extracts, the moisturizing property of Isparta rose extracts and these superior technical effects when combined with other components were studied in the toothpastes of the present invention.
- the object of the invention is to develop an antibacterial, anti-inflammatory and anti- mutagenic toothpaste which does not contains any harmful and toxic chemical, consists of natural cleansing products, provides overall oral hygiene and cleaning, including teeth, gingiva and palate, is suitable for oral flora, reduces the microorganism activities in dental and gingival tissues and supports the treatment in case of a disease.
- Another object of the invention is to develop an antioxidant, anticarcinogenic, anti inflammatory, anti-mutagenic, anti-bacterial, anti-aging toothpaste formula with natural contents, which has useful pharmacological effects for human health and scavenges free radicals.
- Another object of the invention is to prevent the composition from going bad and to provide a prolonged shelf life by combining it with Isparta rose (Rosa Damascena) oil used as a cleansing agent.
- Another object of the invention is to produce a new toothpaste which is effective against caries, effective in tooth sensitivity, contributes to gingival and gingival mucosal health, is effective against all inflammations and diseases that may be possibly present in the soft tissues and tongue in the mouth and supports treatment.
- the object is to shorten the soft tissue healing time by contributing to wound healing after dental applications.
- the invention is an antibacterial, anti-inflammatory and anti-mutagenic toothpaste which provides overall oral hygiene and cleaning, including teeth, gingiva and palate, is suitable for oral flora, reduces the microorganism activities in dental and gingival tissues and supports the treatment in case of a disease, wherein it comprises, in the composition, 0.1 %-1 % by weight of the oil of Isparta oil rose (Rosa Damascena) and 2- 8% by weight of Isparta rose (Rosa Damascena) water as a therapeutic agent, 20%- 30% by weight of water, 5-15% by weight of an abrasive, 1 -4% by weight of a foaming agent, 0.5-3% by weight of a thickener and/or stabilizer, 0.1 -0.3% by weight of fluoride, 0.1 -0.5% by weight of pine oil as a preservative, and 5-10% by weight of bentonite clay.
- Rosa Damascena oil which belongs to the family of flowering plants and whose is produced mainly in Isparta worldwide, has its own characteristics. Owing to the strong antibacterial and strong antioxidant characteristic of the products of Isparta oil rose (Damascena), this has been discovered to help in oral and teeth cleaning. Various components (geraniol, citronellol and nerol which are monoterpene alcohols) have been detected in an extract of Isparta oil rose (Rosa Damascena oil). These have been observed to inhibit different microorganisms.
- rose has an important place in the maintenance of oral and dental health both by preventing caries formation and gingival diseases.
- it may be used in the prevention of viral and fungal diseases due to its antiviral and antifungal activity.
- the extracts and oil of Rosa Damascena oil (Isparta oil rose) are used as therapeutic agents. Optimum rates were determined during the studies, and the product of the invention plays an active role in the healing of oral wounds.
- the composition comprises 6% by weight of oil of Rosa Damascena (Isparta oil rose), 4% by weight of Rosa Damascena water (Isparta rose water), 29.7% by weight of water, 8% by weight of an abrasive, 1.5% by weight of a foaming agent, 1% by weight of a thickener and/or stabilizer, 0.3% by weight of fluoride, 0.2% by weight of pine oil as a preservative, and 7% of bentonite clay.
- Rosa Damascena Rosa Damascena
- Rosa Damascena water Isparta rose water
- 29.7% by weight of water 8% by weight of an abrasive
- 1.5% by weight of a foaming agent 1.5% by weight of a foaming agent
- 1% by weight of a thickener and/or stabilizer 0.3% by weight of fluoride
- 0.2% by weight of pine oil as a preservative 0.2% by weight of pine oil as a preservative
- Corrosive agents are used in the toothpastes for preventing the plaque accumulation and mechanic and chemical removal of dental discolorations.
- all of abrasives used in the toothpastes may be used in this invention, but preferably, calcium carbonate, or sodium bicarbonate is used.
- Foaming agents help the cleaning process by allowing the formulation to foam.
- all of foaming agents used in the toothpastes may be used in this invention, but preferably, sodium coco sulfate is used.
- thickeners and/or stabilizers are used to control stability and consistency.
- xanthan gum is used to achieve favorable viscosity.
- Another feature of the invention is the use of fluoride, which reduces the acid production in the mouth by interfering with the bacterial enzyme activity, prevents the growth of bacteria and provides an antimicrobial effect.
- Isparta rose Rosa Damascena oil has also been observed to contribute to the moisturizing effect in this composition. It helps preventing the hardening of the toothpaste by preventing the moisture loss which may occur in the toothpaste structure.
- Rosa Damascena extracts rose oil and rose water
- Another feature of the toothpaste of the invention is that it comprises 0.1%-0.5%, preferably 0.2%, by weight of a flavoring agent.
- a flavoring agent preferably 0.2%, by weight of a flavoring agent.
- essential peppermint oil is used as a flavoring agent, which gives a natural aroma and an aromatic effect.
- the toothpaste of the invention also contains 1-5%, preferably 2%, by weight of natural oil which cleans the gingiva, strengthens the structure of the teeth and reduces the risk of infection.
- coconut oil is ised as a natural oil.
- the toothpaste of the invention also contains 15-20%, preferably 17.5%, by weight of a humectant which retains moisture and acts as a preservative.
- a humectant which retains moisture and acts as a preservative.
- vegetable glycerin is present in the invention.
- the toothpaste of the invention contains 10-20%, preferably 15%, by weight, of a first strengthening agent.
- a first strengthening agent preferably tricalcium phosphate which has a strengthening effect on tooth enamel
- the toothpaste of the invention contains 8-18%, preferably 13%, by weight, of a second strengthening agent.
- xylitol is used as the second strengthening agent.
- Table 1 An exemplary composition of the toothpaste of the invention
- the production method of the toothpaste composition of the invention essentially comprises the following process steps:
- phase A and phase B are formed separately,
- phase A During formation of phase A: - Mixing the foaming agent and water, then heating this mixture to 80°C,
- phase B Adding oil of Isparta (Rosa Damascena) oil rose, pine oil, flavoring agent, natural oil, During formation of phase B:
- phase C During formation of phase C:
- the toothpaste is produced during 3 phases.
- Phase A Water is taken, Sodium Coco Sulfate is added thereto, and the resulting solution is heated to 80°C by stirring. The solution is cooled down and Sodium Bicarbonate and Xylitol are added thereto. Rose Oil, Pine Oil, Peppermint Oil and Coconut are added to the mixture which is still homogeneous.
- Phase B The xanthan gum is swelled in glycerin. Natural rose water is added to the mixture.
- Phase C Phases A and B are combined in a vessel. Then, bentonite clay, fluoride and Tricalcium Phosphate are added. The mixture is stirred until homogeneous.
Abstract
The invention relates to an antibacterial, anti-inflammatory and anti-mutagenic toothpaste which provides overall oral hygiene and cleaning, including teeth, gingiva and palate, is suitable for oral flora, reduces the microorganism activities in dental and gingival tissues and supports the treatment in case of a disease, and describes a toothpaste composition comprising oil of Isparta oil rose, Isparta rose water, water, a corrosive substance, a foaming agent, a thickener and/or stabilizer, fluoride, pine oil, bentonite clay in the composition, and a production method thereof.
Description
A NEW TOOTHPASTE CONTAINING ROSA DAMASCENA (ISPARTA OIL ROSE)
Technical Field
This invention relates to an antibacterial, anti-inflammatory and anti-mutagenic toothpaste which does not contains any harmful and toxic chemical, consists of natural cleansing products, provides overall oral hygiene and cleaning, including teeth, gingiva and palate, is suitable for oral flora, reduces the microorganism activities in dental and gingival tissues and supports the treatment in case of a disease.
Specifically, the invention describes a toothpaste which comprises a composition containing Rosa Damascena (Isparta rose oil) as a therapeutical agent, and a method of production thereof.
State of the Art
Today, the use of toothpastes is common all over the world to destroy all bacteria, viruses and similar microbes in the mouth, including teeth, gingiva and palate, to ensure oral hygiene, and to clean teeth and gingiva. Abrasives, cleansing agents, binders, flavoring sweeteners, preservatives and cleansing agents for preventing dental caries are used in the toothpastes.
However, various chemicals used in the toothpastes are accumulated in the body and lead to significant health problems. In particular, as young children do not rinse their mouths well, some of these harmful chemicals in the toothpastes may be swallowed, or the chemicals may pass into their bodies through their tongue and oral mucosa.
Sodium lauryl sulfate (SLS), sodium lauryl ether sulfate (SLES), paraben, titanium dioxide (T1O2) and colorant chemicals present in the toothpastes in the market are toxic substances.
SLS, a very cheap foaming agent, is known to prevent eye development in children. In addition, SLS used in toothpastes may increase the incidence of mouth sores. It is known to cause mouth sores to increase their incidence by changing the nature of the
epithelial cells. Studies show that the toothpastes containing SLS and SLES support and increase the formation of mouth ulcers. In addition, as SLS and SLES are carcinogenic, they are known to remain as residues in organs such as brain and eyes, and cause diseases in later ages.
Paraben used in toothpastes in the art is also known specifically as methyl paraben (E218), propylparaben (E216), ethylparaben (E214), butylparaben, benzylparaben and heptylparaben (E209) and is a chemical which is generally used to prolong shelf life by preventing bacteria and fungi that may occur in cosmetic and care products. As it is absorbed by the skin, it may mix with the whole body, all tissues, even blood and urine. Paraben is a carcinogenic substance and leads to substantial and serious damage to the endocrine system and reproductive systems.
In order to overcome the above-mentioned problems, the world, and the health and cosmetics sectors have sought to produce natural products rapidly in line with the demands of their customers. In addition to the high cleaning effect of a toothpaste, consumers are looking for equivalent products which contain natural contents, do not leave bad odor, do not go bad quickly, do not leave a bad taste in the mouth, and do not adversely affect human health.
The leading companies of these fields currently produce products with natural content, but they use chemicals in the excipients in order to achieve the desired stability values and to prevent the rapid degradation of natural products. In addition, chemical contents are commonly used in order to improve odor and taste characteristics and reduce costs.
These drawbacks in the state of the art encouraged the inventor to develop a new toothpaste formulation with a natural content, which is not harmful to health, does not contain toxic chemical additives, but has also a high cleansing effect and supports the healing/treatment of the oral tissues. The inventor intends to develop a new toothpaste formulation containing Isparta rose oil and Isparta rose water, and fluoride, which has optimum cleaning properties and is free of harmful chemicals.
In the state of the art, the invention of the Chinese patent application entitled “Rose healtcare toothpaste” with publication no. CN 105708783(A) discloses a toothpaste
prepared, by weight, from 7-20 units of rose extract, 2-8 units of fructus lycii extract, 2- 4,5 units of chrysanthemum extract, 5-10 units of five-bladed motherwort extract, 5-10 units of radix angelica sinensis, 3-10 parts of brown sugar oil, 9-45 parts of sodium bicarbonate, 0.6-4 parts of acyloxy sodium sulfonate, 3-20 parts of glycerin, 0.3-3 parts of propolis and 0-0.2 parts of sodium benzoate. The toothpaste has the effects of regulating qi, relieving depression, stimulating blood circulation, dissipating blood stasis, regulating menstruation, relieving pain and delaying aging. However, a new formulation containing Isparta rose oil and rose water according to this invention is completely different from the formulation content in the state of the art. Although both formulations have herbal contents, the therapeutic agents used, composition ratios and technical effects are different. The cumulative cleansing effect of Isparta rose extracts and fluoride, and the therapeutic effect of Isparta rose extracts, the moisturizing property of Isparta rose extracts and these superior technical effects when combined with other components were studied in the toothpastes of the present invention.
Description of the Invention
The object of the invention is to develop an antibacterial, anti-inflammatory and anti- mutagenic toothpaste which does not contains any harmful and toxic chemical, consists of natural cleansing products, provides overall oral hygiene and cleaning, including teeth, gingiva and palate, is suitable for oral flora, reduces the microorganism activities in dental and gingival tissues and supports the treatment in case of a disease.
Another object of the invention is to develop an antioxidant, anticarcinogenic, anti inflammatory, anti-mutagenic, anti-bacterial, anti-aging toothpaste formula with natural contents, which has useful pharmacological effects for human health and scavenges free radicals.
Another object of the invention is to prevent the composition from going bad and to provide a prolonged shelf life by combining it with Isparta rose (Rosa Damascena) oil used as a cleansing agent.
Another object of the invention is to produce a new toothpaste which is effective against caries, effective in tooth sensitivity, contributes to gingival and gingival mucosal health, is effective against all inflammations and diseases that may be possibly present
in the soft tissues and tongue in the mouth and supports treatment. In addition, the object is to shorten the soft tissue healing time by contributing to wound healing after dental applications.
Detailed Description of the Invention
The invention is an antibacterial, anti-inflammatory and anti-mutagenic toothpaste which provides overall oral hygiene and cleaning, including teeth, gingiva and palate, is suitable for oral flora, reduces the microorganism activities in dental and gingival tissues and supports the treatment in case of a disease, wherein it comprises, in the composition, 0.1 %-1 % by weight of the oil of Isparta oil rose (Rosa Damascena) and 2- 8% by weight of Isparta rose (Rosa Damascena) water as a therapeutic agent, 20%- 30% by weight of water, 5-15% by weight of an abrasive, 1 -4% by weight of a foaming agent, 0.5-3% by weight of a thickener and/or stabilizer, 0.1 -0.3% by weight of fluoride, 0.1 -0.5% by weight of pine oil as a preservative, and 5-10% by weight of bentonite clay.
Plants are also used for oral hygiene, in addition to human health in many areas. Rosa Damascena oil, which belongs to the family of flowering plants and whose is produced mainly in Isparta worldwide, has its own characteristics. Owing to the strong antibacterial and strong antioxidant characteristic of the products of Isparta oil rose (Damascena), this has been discovered to help in oral and teeth cleaning. Various components (geraniol, citronellol and nerol which are monoterpene alcohols) have been detected in an extract of Isparta oil rose (Rosa Damascena oil). These have been observed to inhibit different microorganisms.
Positive effects of rose on oral and dental health have been achieved. Studies show that rose has an important place in the maintenance of oral and dental health both by preventing caries formation and gingival diseases. In addition, it may be used in the prevention of viral and fungal diseases due to its antiviral and antifungal activity.
In the formulation of the invention, the extracts and oil of Rosa Damascena oil (Isparta oil rose) are used as therapeutic agents. Optimum rates were determined during the studies, and the product of the invention plays an active role in the healing of oral wounds.
Preferably, in the toothpaste of the invention, the composition comprises 6% by weight of oil of Rosa Damascena (Isparta oil rose), 4% by weight of Rosa Damascena water (Isparta rose water), 29.7% by weight of water, 8% by weight of an abrasive, 1.5% by weight of a foaming agent, 1% by weight of a thickener and/or stabilizer, 0.3% by weight of fluoride, 0.2% by weight of pine oil as a preservative, and 7% of bentonite clay.
Corrosive agents are used in the toothpastes for preventing the plaque accumulation and mechanic and chemical removal of dental discolorations. In the art, all of abrasives used in the toothpastes may be used in this invention, but preferably, calcium carbonate, or sodium bicarbonate is used. Furthermore, the abrasiveness of a toothpaste may be determined depending on the hardness, shape and size of the particles, as well as pH value. Therefore, sodium bicarbonate is used in this invention. In the invention, sodium bicarbonate neutralizes the acids formed by providing a basic environment at pH= 8.5 in the mouth, ensuring the intraoral pH balance.
Foaming agents help the cleaning process by allowing the formulation to foam. In the art, all of foaming agents used in the toothpastes may be used in this invention, but preferably, sodium coco sulfate is used.
In toothpastes, thickeners and/or stabilizers are used to control stability and consistency. In said invention, xanthan gum is used to achieve favorable viscosity.
Another feature of the invention is the use of fluoride, which reduces the acid production in the mouth by interfering with the bacterial enzyme activity, prevents the growth of bacteria and provides an antimicrobial effect.
When all components in the current formulation are combined, the moisturizing effect and the therapeutic effect of the oil of Rosa Damascena oil (Isparta oil rose) which is used as an active ingredient have been observed to be increased.
In particular, when it is combined with fluoride, it has been observed to provide remineralization of the demineralized zones on a dental tissue and to increase the negative effect on the cycle of caries formation of the microorganisms. Thus, the
harmful effect of the chemical is reduced and optimized, while providing a high therapeutic effect. A factor that provides this technical effect is the weight ratio of the oil of Isparta oil rose (Rosa Damascena), Isparta rose (Rosa Damascena) water and fluoride used in the invention.
Although vegetable glycerin is used as a humectant in the invention, Isparta rose (Rosa Damascena) oil has also been observed to contribute to the moisturizing effect in this composition. It helps preventing the hardening of the toothpaste by preventing the moisture loss which may occur in the toothpaste structure.
In addition, as Rosa Damascena extracts (rose oil and rose water) are used, there is no need to add any chemical sweetener or essence to the composition of the invention.
In addition to the moisturizing and sweetening effects given above, the more antioxidant, free radical scavenger, anti-carcinogenic, anti-inflammatory, antimutagenic, antibacterial, anti-aging, pharmacological effects of Isparta rose (Rosa Damascena) oil than expected when combined with other components have been observed to provide a superior effect for the composition.
Another feature of the toothpaste of the invention is that it comprises 0.1%-0.5%, preferably 0.2%, by weight of a flavoring agent. Here, essential peppermint oil is used as a flavoring agent, which gives a natural aroma and an aromatic effect.
The toothpaste of the invention also contains 1-5%, preferably 2%, by weight of natural oil which cleans the gingiva, strengthens the structure of the teeth and reduces the risk of infection. In the invention, coconut oil is ised as a natural oil.
The toothpaste of the invention also contains 15-20%, preferably 17.5%, by weight of a humectant which retains moisture and acts as a preservative. Preferably, vegetable glycerin is present in the invention.
Furthermore, the toothpaste of the invention contains 10-20%, preferably 15%, by weight, of a first strengthening agent. In the invention, tricalcium phosphate which has a strengthening effect on tooth enamel, is preferably used as the first strengthening agent.
Furthermore, the toothpaste of the invention contains 8-18%, preferably 13%, by weight, of a second strengthening agent. In the invention, xylitol is used as the second strengthening agent.
Table 1 : An exemplary composition of the toothpaste of the invention
The production method of the toothpaste composition of the invention essentially comprises the following process steps:
Firstly, phase A and phase B are formed separately,
During formation of phase A: - Mixing the foaming agent and water, then heating this mixture to 80°C,
- Cooling the solution obtained in the previous step and adding the abrasive and second strengthening agent thereto,
- Making the mixture homogeneous by stirring,
- Adding oil of Isparta (Rosa Damascena) oil rose, pine oil, flavoring agent, natural oil,
During formation of phase B:
- swelling the thickener and/or stabilizer in the humectant,
- adding natural Isparta rose (Rosa Damascena) water,
During formation of phase C:
- Combining the phases A and B formed according to the process steps given above in a vessel,
- Adding bentonite clay, fluoride and first strengthening agent,
- Stirring the mixture until homogeneous.
An exemplary implementation of the production method of the toothpaste according to the invention is provided below:
In the process, the toothpaste is produced during 3 phases.
Phase A: Water is taken, Sodium Coco Sulfate is added thereto, and the resulting solution is heated to 80°C by stirring. The solution is cooled down and Sodium Bicarbonate and Xylitol are added thereto. Rose Oil, Pine Oil, Peppermint Oil and Coconut are added to the mixture which is still homogeneous.
Phase B: The xanthan gum is swelled in glycerin. Natural rose water is added to the mixture.
Phase C: Phases A and B are combined in a vessel. Then, bentonite clay, fluoride and Tricalcium Phosphate are added. The mixture is stirred until homogeneous.
As no chemical reaction, or high thermal treatment is applied in the production process, the components do not lose their effectiveness and work more efficiently.
The effectiveness tests, stability and microbiological tests of the toothpaste of the invention described in the detailed description above are performed by Natural Products Application and Research Center (SUDUM) of Suleyman Demirel University.
As the test course of the products is ongoing, they could not be included in the scope of the specification.
Moreover, a product suitable for oral flora has been developed by considering the pH and intraoral alkaline balance of the toothpastes in the present invention.
Claims
1. An antibacterial, anti-inflammatory and anti-mutagenic toothpaste which provides overall oral hygiene and cleaning, including teeth, gingiva and palate, is suitable for oral flora, reduces the microorganism activities in dental and gingival tissues and supports the treatment in case of a disease, characterized in that it comprises, in the composition, 0.1 %-1 % by weight of oil of Rosa Damascena and 2-8% by weight of Rosa Damascena water as a therapeutic agent, 20%-30% by weight of water, 5-15% by weight of an abrasive, 1-4% by weight of a foaming agent, 0.5-3% by weight of a thickener and/or stabilizer,
0.1 -0.3% by weight of fluoride, 0.1 -0.5% by weight of pine oil as a preservative, and 5-10% by weight of bentonite clay.
2. Toothpaste according to claim 1 , characterized in that the composition comprises 6% by weight of oil of Rosa Damascena, 4% by weight of Rosa
Damascena water, 29.7% by weight of water, 8% by weight of an abrasive, 1.5% by weight of a foaming agent, 1% by weight of a thickener and/or stabilizer, 0.3% by weight of fluoride, 0.2% by weight of pine oil as a preservative, and 7% of bentonite clay.
3. Toothpaste according to claim 1 or 2, characterized in that the abrasive is sodium bicarbonate and/or calcium carbonate.
4. Toothpaste according to claim 1 or 2, characterized in that it comprises sodium coco sulfate as a foaming agent.
5. Toothpaste according to claim 1 or 2, characterized in that it comprises xanthan gum as a thickener and/or stabilizer.
6. Toothpaste according to claim 1 or 2, characterized in that it comprises 0.1%- 0.5%, preferably 0.2%, by weight of a flavoring agent.
7. Toothpaste according to claim 6, characterized in that it comprises mint oil as a flavoring agent.
8. Toothpaste according to claim 1 or 2, characterized in that it comprises 1 -5%, preferably 2%, by weight of a natural oil.
9. Toothpaste according to claim 8, characterized in that it comprises coconut oil as a natural oil.
10. Toothpaste according to claim 1 or 2, characterized in that it comprises 15-20%, preferably 17.5%, by weight of a humectant.
11. Toothpaste according to claim 10, characterized in that it comprises vegetable glycerin as a humectant.
12. Toothpaste according to claim 1 or 2, characterized in that it comprises 10-20%, preferably 15%, by weight of a first strengthening agent.
13. Toothpaste according to claim 12, characterized in that it comprises tricalcium phosphate as a first strengthening agent.
14. Toothpaste according to claim 1 or 2, characterized in that it comprises 8-18%, preferably 13%, by weight of a second strengthening agent.
15. Toothpaste according to claim 14, characterized in that it comprises xylitol as a second strengthening agent.
16. A production method for a toothpaste according to any one of the preceding claims, characterized in that it comprises the following process steps:
During formation of phase A:
- Mixing the foaming agent and water, then heating this mixture to 80°C,
- Cooling the solution obtained in the previous step and adding the abrasive and second strengthening agent thereto,
- Making the mixture homogeneous by stirring,
- Adding oil of Isparta (Rosa Damascena)oil rose, pine oil, flavoring agent, natural oil,
During formation of phase B:
- Swelling the thickener and/or stabilizer in the humectant,
- Adding Isparta (Rosa Damascena) rose water,
During formation of phase C:
- Combining the phases A and B formed according to the process steps given above in a vessel,
- Adding bentonite clay, fluoride and first strengthening agent, - Stirring the mixture until homogeneous.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2021/006136A TR202106136A2 (en) | 2021-04-06 | 2021-04-06 | A NEW TOOTHPASTE WITH ROSA DAMESCANA (ISPARTA OIL ROSE) |
| TR2021/006136 TR2021006136A2 (en) | 2021-04-06 | A NEW TOOTHPASTE WITH ROSA DAMESCANA (ISPARTA OIL ROSE) |
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| Publication Number | Publication Date |
|---|---|
| WO2022216263A1 true WO2022216263A1 (en) | 2022-10-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/TR2022/050305 WO2022216263A1 (en) | 2021-04-06 | 2022-04-06 | A new toothpaste containing rosa damascena (isparta oil rose) |
Country Status (2)
| Country | Link |
|---|---|
| TR (1) | TR202106136A2 (en) |
| WO (1) | WO2022216263A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06279303A (en) * | 1993-03-25 | 1994-10-04 | Nippon Flour Mills Co Ltd | Glucosyltransferase inhibitor |
| CN112274465A (en) * | 2020-10-26 | 2021-01-29 | 曹静娟 | Formula and preparation method of gastrodia elata toothpaste |
| CN112353739A (en) * | 2020-11-23 | 2021-02-12 | 上海健康医学院 | Chinese herbal medicine toothpaste and production method thereof |
| WO2021035087A1 (en) * | 2019-08-20 | 2021-02-25 | Evolved By Nature, Inc. | Silk personal care compositions |
-
2021
- 2021-04-06 TR TR2021/006136A patent/TR202106136A2/en unknown
-
2022
- 2022-04-06 WO PCT/TR2022/050305 patent/WO2022216263A1/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06279303A (en) * | 1993-03-25 | 1994-10-04 | Nippon Flour Mills Co Ltd | Glucosyltransferase inhibitor |
| WO2021035087A1 (en) * | 2019-08-20 | 2021-02-25 | Evolved By Nature, Inc. | Silk personal care compositions |
| CN112274465A (en) * | 2020-10-26 | 2021-01-29 | 曹静娟 | Formula and preparation method of gastrodia elata toothpaste |
| CN112353739A (en) * | 2020-11-23 | 2021-02-12 | 上海健康医学院 | Chinese herbal medicine toothpaste and production method thereof |
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|---|---|
| TR202106136A2 (en) | 2021-06-21 |
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