KR20200031441A - composition for eyelid or periocular region washing and pad comprising thesame - Google Patents

Abstract

The present invention relates to a composition for cleaning eyelids or periocular regions, and a pad comprising the same. The present invention can be used to remove deposited wastes from eyelids and periocular regions, protect the skin from external stimulation elements, and prevent blepharitis, Demodex, etc., and the pad comprising the composition for cleaning eyelids or periocular regions is easy to use because only necessary parts can be wiped without the need for separate cleaning.

Description

Composition for eyelid or periocular region washing and pad comprising the same

It relates to a composition for cleaning the eyelids or around the eyes and a pad comprising the same.

The eyelids are two wrinkled skins that cover the front part of the eyeball, protecting the eyes from the outside and distributing the appropriate tears on the surface of the eyes. Many eye diseases can be prevented by clearing the eyelids and periphery of the stomach and making the tears secreted normally.

On the other hand, as fine dust increases and fatigue increases, tears are not properly secreted around the eyelids, and when wastes increase, bacteria are likely to multiply around the eyelids or eyes. If this phenomenon persists, the eye product increases in the short term, and conjunctivitis, blepharitis, stye, etc. may appear. In particular, it is necessary to prevent diseases such as the above by cleaning and protecting the eye area when performing ophthalmic surgery or dry eye syndrome.

One aspect provides a composition for cleaning the eyelid or periphery.

Another aspect provides a pad comprising a composition for cleaning the eyelids or the periphery.

0.03 to 1% by weight of tea tree oil, 0.03 to 1% by weight of lavender oil, 0.1 to 5% by weight of TEA-Cocoyl Glutamate, 0.1 to 10% by weight of hyaluronate, aloe Eyelids containing 0.05 to 1% by weight of Vera leaf extract, 0.05 to 1% by weight of hydrolyzed collagen, 0.05 to 1% by weight of a screen extract, 0.05 to 1% by weight of a gusset extract, and 0.05 to 1% by weight of a green tea extract as an active ingredient Or to provide a composition for cleaning around the eyes.

The tea tree oil is an oil component of a plant whose scientific name is Melaleuca alternifolia, and the method of obtaining extracts the leaves of this plant by steam distillation, terpinene-4-ol. 4-ol). The main components contained in tea tree oil may be alcohol-based such as terpinene-4-ol, linalool, and monoterpene-based such as terpinene, pinene. . The tea tree oil may have an effect of sterilizing action, sebum dissolving action, exfoliation action, immune stimulation action, and the like. The tea tree oil may remove eyelids or hair follicles around the eyes, and may remove staphylococcus, one of the causes of eyelid inflammation. The tea tree oil may be commercially available CAS No. 68647-73-4, and if the content of tea tree oil is too small, its effect is negligible, and when the content is high, economic cost may be excessive.

The lavender oil is an oil component of a plant that is an evergreen perennial plant of the genus Lamiaceae, and the method of obtaining can extract flowers and leaves of this plant by steam distillation. The main components contained in lavender oil may be esters such as linalyl acetate and lavandulyl acetate, and alcohols such as linolol and geraniol. The lavender oil may have effects such as stress relief, sound sleep, fatigue relief, skin soothing, and pain relief. The lavender oil can be used for skin inflammation. The lavender oil may be commercially available CAS No. 8000-28-0, if the content of lavender oil is too small, the effect is negligible, and if the content is high, the economic cost may be excessive.

The T-A-Cocoyl Glutamate may be N-palm fatty acid acyl-L-glutamic acid triethanolamine, and may contain 28% to 32% of an active ingredient when quantifying. The T-co-coil glutamate is an amino acid-based anionic weakly acidic surfactant component and may be made by combining amino acids and natural fatty acids. The T-co-coil glutamate may be used as a surfactant and a detergent. The T-co-coil glutamate may be commercially available CAS number 68411-96-1.

The hyaluronate may be hyaluronic acid or a salt of hyaluronic acid, and may be one of glucosamine glycans. Hyaluronic acid consists of N-acetyl glucosamine and Glucuronic acid, which are present in the extracellular matrix. The hyaluronate is involved in tissue moisture retention, cell growth factor and storage and diffusion of nutrients, and can be synthesized by keratinocytes and fibroblasts. The hyaluronate can be used for anti-aging skin care such as improving skin wrinkles as well as moisturizing and maintaining skin elasticity. The hyaluronate may be commercially available CAS number 9004-61-9.

The aloe vera leaf extract (Aloe Barbadensis Leaf Extract) may be a substance extracted from the leaves of a plant of the lily family Aloe vera. The aloe vera leaf extract is used as a moisturizer, skin softener, and skin conditioning agent, and can locally promote skin regeneration and relieve pain. The aloe vera leaf extract may be commercially available CAS number 481-72-1.

The hydrolyzed collagen may be hydrolyzed collagen, hydrolyzed collagen, water-soluble collagen, or marine collagen. The hydrolyzed collagen may be hydrolyzed collagen or a salt thereof obtained by hydrolyzing the bone or skin of a cow or a pig with acid, alkali, or enzymes, respectively or in combination. The hydrolyzed collagen may contain nitrogen (N: 14.01) 12.0 to 22.0% when quantified. The hydrolyzed collagen can be used for moisturizing, moisturizing and regenerating skin. The hydrolyzed collagen may be commercially available CAS number 91081-56-0.

The centella asiatica extract is an ingredient obtained by extracting from the outpost of centella asiatica, and the centella asiatica may be horseshoe or clam. As the centella extract contains asiaticoside, madecassoside, asiatic acid, madecassic acid, valerin and trace amounts of alkaloid, etc. It is excellent for treating wounds and can promote collagen production with substances that regenerate skin tissue. The asiaticoside and madecassoside may exhibit skin wound and chronic ulcer treatment activity. The centella extract can be used for skin elasticity enhancement, wound healing, collagen synthesis promotion, etc. through the aforementioned pharmacological action. The centella extract may be a commercially available CAS number 84696-21-9.

The Machihyeon extract (Portulaca oleracea Extract) may be a machihyeon (Portulaca oleracea), that is, may be extracted from the outpost of purslane, which is one year from the purslane. The Machi Prefecture extract may contain l-norepinephrine, vitamins A, B1, B2, C and tocopherol, carotene, omega-3 fatty acids, glutathione, glutamic acid, malic acid, citric acid, and the like. The Machi Prefecture is effective for skin moisturizing, anti-inflammatory effect, skin cleansing, anti-allergic, antibacterial, atopic and dry skin, and has effects such as skin aging relief, skin irritation relief, and according to the content of active ingredients such as omega-3 It can have a related effect that works. The Machi Prefecture extract may be commercially available CAS number 90083-07-01.

The green tea extract (Camellia Sinensis Leaf Extract) may be an extract obtained by extracting the leaves of a tea tree (Thea sinensis Linnaeus) with an ethanol butylene glycol mixture. The green tea extract may contain tannin (in terms of tannic acid equivalent) of 0.3 to 0.6w / v% when quantified. The green tea extract soothes the skin and has antiseptic, antioxidant, and anti-inflammatory properties, and can be used as an antioxidant, astringent, fragrance, skin softener, skin moisturizer, skin conditioning agent, and skin protectant. The green tea extract may be a commercially available CAS number 84650-60-2.

The composition is 0.5 to 20% by weight of dipropylene glycol, 0.06 to 6% by weight of 1,2-hexanediol, 0.2 to 20% by weight of glycerin, 0.2 to 20% by weight of methylgluceth-20, 0.1 to 20 of pageage-35 castor oil 10% by weight, PEG-60 hydrogenated castor oil 0.3 to 20% by weight, allantoin 0.01 to 0.5% by weight, methylpropanediol 0.1 to 5% by weight, hydroxyacetophenone 0.03 to 1% by weight, ethylhexylglycerin 0.1 to It may be a composition for cleaning the eyelids or around the eyes that further comprises 5% by weight.

The dipropylene glycol (Dipropilene Glycol) may be a moisturizer with a light moisturizing effect that prevents moisture from evaporating from the skin through hydrogen bonding when used on the skin. The dipropylene glycol can be used as a humectant and a wetting agent together with other glycols and glycerol. The dipropylene glycol may be a commercially available CAS number 110-98-5, or 25265-71-8.

The 1,2-hexanediol may be used as a preservative to prevent the decay of organic substances in microorganisms in cosmetics, and may be used as a solvent, antibacterial agent, and moisturizer. The 1,2-hexanediol may be commercially available CAS number 6920-22-5.

The glycerin may be used as a moisturizer, skin protectant, skin conditioning agent, viscosity reducing agent, etc., and may be commercially available CAS No. 56-81-5.

The methyl gluceth-20 may be obtained by addition polymerization of ethylene oxide to methyl glucoside. The methylglucose-20 maintains moisture in the skin and protects the skin by preventing contaminants in the external environment, and thus may be used as a skin moisturizer or skin conditioning agent. The methylglucose-20 may be commercially available CAS number 68239-42-9.

The PEG-35 castor oil may be a polyethylene glycol derivative component of castor oil or a nonionic surfactant component derived from a product obtained by hydrogenating castor oil (caster oil). The PEG-35 castor oil may be used as an emulsifier or a surfactant as a solubilizer. The PG-35 castor oil may be commercially available CAS number 61788-85-0.

The allantoin is a natural substance extracted from perennial grass, such as comfrey, an oak tree, and a sprout of wheat, and can be obtained by purifying uric acid oxide produced by catabolism, which is a process of decomposing a polymer organic material into a low-molecular substance. The allantoin is effective in the treatment of damaged skin such as acne skin or atopic skin because it directly or indirectly activates cell activity, and can be used as a skin conditioning agent, skin protectant, and the like. The allantoin may be a commercially available CAS number 97-59-6.

The methylpropanediol may be used as a solvent for dissolving other components in cosmetics, and may function to penetrate and deliver nutrients and active ingredients. The methylpropanediol may be used as a solvent, solvent, and moisturizer, and may be commercially available CAS No. 2163-42-0.

The hydroxyacetophenone is a natural ingredient extracted from the perennial grass, comfrey, oak, and wheat germ. It can improve the moisturizing function on the skin and strengthen the skin barrier by calming and protecting the irritated skin. have. The hydroxyacetophenone may be used as an antioxidant, and may be commercially available CAS number 99-93-4.

The ethylhexyl glycerin is glyceryl ether, and may be used as a skin moisturizer, deodorant, emulsion stabilizer, skin conditioning agent, surfactant, and the like. The ethylhexyl glycerin may be commercially available CAS number 70445-33-9.

The composition may contain preservatives, stabilizers, surfactants, thickeners, solubilizers, moisturizers, emollients, preservatives, disinfectants, emulsifiers, antioxidants, pH adjusters, organic and inorganic pigments, flavoring agents, coolants, or limitations in addition to the ingredients described above. It may further include additives commonly used in the art. The compounding amount of the additional component can be easily selected by those skilled in the art within a range that does not impair the objects and effects of the present invention, and the blending amount is 0.001 to 30% by weight, specifically 0.01 to 10% by weight based on the total weight of the composition. You can.

The composition, including the above components, can be used to remove waste products caused by deposited dust, snow, and fine dust around the eyelids and eyes, and to prevent blepharitis, folliculitis, and the like. The composition is used before and after ophthalmic surgery to prevent infectious diseases before and after surgery, to cleanse the eye makeup, to maintain cleanliness of the eyes when there are many secretions around the eyes, to prevent the instillation of foreign substances before ophthalmic solvents, It can be used for the purpose of preventing the invasion of bacteria, such as snow stings, when protecting the eyes from dust, dust, fine dust, etc. when the eyes are itchy or somber. The composition can be worn with confidence even by contact lens wearers.

The properties of the composition may be transparent in the liquid phase. The pH of the composition may be 4 to 7. In addition, the composition may be stable at 5 ° C, 25 ° C, or 40 ° C for 7 days.

Another aspect provides a pad for cleaning the eyelid or periphery comprising the composition. The pad may be a soft cotton material, a non-woven sheet or a natural cotton sheet. The pad may be in the form of a circle or a rectangle. When the pad is rectangular, the width may be 3 cm to 15 cm, and the length may be 3 cm to 15 cm. Preferably, the pad may be 11.5 cm wide and 9 cm long. The pad may have a multi-seat structure, or may have a structure formed by folding a rectangular shape in multiple layers. The pad can be folded 1, 2, 3, 4, 5, or 6 times in one rectangle.

The pad for cleaning the eyelid or the periphery of the eye may include 0.5 to 5.0 ml of the composition. Preferably, the pad for cleaning the eyelid or the periphery of the eye may include 1.0 to 2.0 ml of the composition.

The pad may be used to partially wipe away the part with waste, the part with inflammation, or the itchy without the need for separate cleaning. In addition, it is very convenient because it does not require a separate eye drop for disposable use.

The composition for cleaning the eyelids or the periphery of the eye according to an aspect may be used to remove the eyelids and deposited wastes around the eye, protect the skin from external stimulation elements, and prevent blepharitis, folliculitis, and the like.

The pad comprising the composition for cleaning the eyelids or the periphery of the eye according to another aspect is easy to use because it can wipe only the necessary parts without the need for separate cleaning.

Hereinafter, the present invention will be described in more detail through examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.

Example  1. the eyelid or Around the eyes  Preparation of cleaning composition

After preparing a component by weight as shown in Table 1 below, and uniformly mixed and stirred at room temperature, a composition for cleaning the eyelid or the periphery of the eye according to the present invention was prepared.

Raw materials or  ingredient And quantity weight% Dipropylene glycol 5.000 1.2-hexanediol 0.600 glycerin 2.000 Methylglucose-20 2.000 Tea tree oil 0.040 Lavender oil 0.030 PG-35 Castor Oil 1.000 TA-Cocoil Glutamate 0.500 PG-60 Hydrogenated Castor Oil 3.000 Purified water 80.880 Allantoin 0.050 Bio-hyaluronate 1% 1.000 Green, bottle, and horse mackerel extract 0.300 Hydrolyzed collagen extract 0.100 Aloe vera leaf extract 0.100 Methyl propane diol 0.700 Hydroxyacetphenone 0.300 Ethylhexylglycerin 1.000

Example  2. Eyelid or Around the eyes  Preparation of pad comprising cleaning composition

1.3 ml, 1.6 ml, and 2.0 ml of the composition for cleaning the eyelids or the periphery of the eyelid prepared in Example 1 were put on a disposable pad to prepare a pad comprising the composition for cleaning the eyelids or the periphery.

Experimental example  One. Sensory testing  exam

Compositions for cleaning the eyelids or the periphery of the eyelids prepared according to Examples 1 and 2, and pads and comparative examples containing the same, using physiological saline for 15 volunteers regardless of age and gender, feeling of use, and degree of washing ( The results obtained by evaluating the 5-point scale method for the degree of waste removal), the degree of hydration, the degree of inflammation relief, and the degree of eye irritation are shown in Table 2 below.

Experiment item Example Comparative example (physiological saline) Usability 4.7 3.0 Degree of cleaning (degree of waste removal) 4.5 2.4 Moisture supply degree 4.8 1.2 Degree of inflammation relief 4.5 1.2 Degree of eye irritation 4.9 3.2 5: Very satisfied, 4: Satisfied, 3: Moderate, 2: Dissatisfied, 1: Very dissatisfied

Claims (5)

0.03 to 1% by weight of tea tree oil, 0.03 to 1% by weight of lavender oil, 0.1 to 5% by weight of tea-cocoyl glutamate, 0.1 to 10% by weight of hyaluronate, 0.05 to 1 of aloe vera leaf extract For washing the eyelids or the periphery of the eye, including as an active ingredient weight%, hydrolyzed collagen 0.05 to 1% by weight, folding screen extracts to 0.05 to 1% by weight, wagon extract to 0.05 to 1% by weight, and green tea extract 0.05 to 1% by weight Composition. The method according to claim 1, The composition is dipropylene glycol 0.5 to 20% by weight, 1,2-hexanediol 30% 0.2 to 20% by weight, glycerin 0.2 to 20% by weight, methylgluce-20 0.2 to 20% by weight, blood Easy-35 castor oil 0.1 to 10% by weight, PEG-60 hydrogenated castor oil 0.3 to 20% by weight, allantoin 0.01 to 0.5% by weight, methylpropanediol 0.1 to 5% by weight, hydroxyacetophenone 0.03 to 1% by weight %, Ethylhexyl glycerin 0.1 to 5% by weight of the eyelid or eyelid cleaning composition further comprising. The method according to claim 1, wherein the composition is a pH 4 to 7 eyelid or eyelid cleaning composition. A pad for cleaning the eyelids or the periphery of the eye, comprising the composition according to claim 1. The method according to claim 4, wherein the composition is 2 ml eyelid or eye area cleaning pad.