ES2403305T3 - Modulación de la expresión de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 para el tratamiento de enfermedades oculares - Google Patents

Modulación de la expresión de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 para el tratamiento de enfermedades oculares Download PDF

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Publication number
ES2403305T3
ES2403305T3 ES06795009T ES06795009T ES2403305T3 ES 2403305 T3 ES2403305 T3 ES 2403305T3 ES 06795009 T ES06795009 T ES 06795009T ES 06795009 T ES06795009 T ES 06795009T ES 2403305 T3 ES2403305 T3 ES 2403305T3
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ES
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Prior art keywords
anip
seq
beta
hsd1
expression
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Active
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ES06795009T
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English (en)
Spanish (es)
Inventor
Ana Isabel JIMÉNEZ ANTÓN
Ángela Sesto Yagüe
Mª CONCEPCIÓN JIMÉNEZ GÓMEZ
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Sylentis SA
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Sylentis SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01146—11-Beta-hydroxysteroid dehydrogenase (1.1.1.146)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES06795009T 2005-10-25 2006-10-25 Modulación de la expresión de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 para el tratamiento de enfermedades oculares Active ES2403305T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0521716 2005-10-25
GBGB0521716.1A GB0521716D0 (en) 2005-10-25 2005-10-25 Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
PCT/GB2006/050352 WO2007049074A2 (en) 2005-10-25 2006-10-25 Modulation of 11beta-hydroxysteroid dehydrogenase 1 expression for the treatment of ocular diseases

Publications (1)

Publication Number Publication Date
ES2403305T3 true ES2403305T3 (es) 2013-05-17

Family

ID=35458653

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06795009T Active ES2403305T3 (es) 2005-10-25 2006-10-25 Modulación de la expresión de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 para el tratamiento de enfermedades oculares

Country Status (12)

Country Link
US (1) US8188057B2 (https=)
EP (2) EP1941037B1 (https=)
JP (2) JP5398262B2 (https=)
CN (1) CN101346467B (https=)
AU (1) AU2006307690B2 (https=)
CA (1) CA2627272C (https=)
ES (1) ES2403305T3 (https=)
GB (1) GB0521716D0 (https=)
IN (1) IN2015DN03331A (https=)
MX (1) MX2008005409A (https=)
RU (1) RU2420582C2 (https=)
WO (1) WO2007049074A2 (https=)

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CN101976979A (zh) * 2010-10-25 2011-02-16 北京印刷学院 抛物柱面聚光半圆柱面闭合腔体采光太阳能发电装置
CN101969282A (zh) * 2010-10-25 2011-02-09 北京印刷学院 抛物柱面聚光凹形闭合腔体采光太阳能发电装置
MY181251A (en) * 2013-09-13 2020-12-21 Ionis Pharmaceuticals Inc Modulators of complement factor b
US10752896B2 (en) * 2015-09-08 2020-08-25 Sylentis Sau siRNA and their use in methods and compositions for inhibiting the expression of the NRARP gene
CN106702003B (zh) * 2017-02-28 2021-02-12 固安博健生物技术有限公司 Hsdl1在诊治骨肉瘤中的应用
CN109022436B (zh) * 2018-06-07 2021-04-09 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） 特异抑制3β-HSD基因表达的shRNA重组载体构建与应用
JP6617191B1 (ja) * 2018-12-03 2019-12-11 三井金属鉱業株式会社 溶液中の目的成分を分離又は分析するための方法及び装置
CN120204234B (zh) * 2025-05-28 2025-08-19 温州医科大学附属眼视光医院 11β-HSD1通路活性抑制剂在制备治疗青光眼睫状体炎综合征药物上的应用

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Also Published As

Publication number Publication date
MX2008005409A (es) 2008-11-26
AU2006307690B2 (en) 2012-07-12
RU2008120702A (ru) 2009-12-10
CN101346467A (zh) 2009-01-14
IN2015DN03331A (https=) 2015-10-23
US8188057B2 (en) 2012-05-29
EP2354229A3 (en) 2012-12-05
EP1941037A2 (en) 2008-07-09
RU2420582C2 (ru) 2011-06-10
WO2007049074A3 (en) 2007-08-02
CA2627272C (en) 2015-12-01
EP2354229A2 (en) 2011-08-10
WO2007049074A2 (en) 2007-05-03
JP2013176395A (ja) 2013-09-09
JP5398262B2 (ja) 2014-01-29
CA2627272A1 (en) 2007-05-03
JP2009513617A (ja) 2009-04-02
US20110160277A1 (en) 2011-06-30
GB0521716D0 (en) 2005-11-30
HK1120830A1 (en) 2009-04-09
EP1941037B1 (en) 2013-01-16
AU2006307690A1 (en) 2007-05-03
CN101346467B (zh) 2013-03-13

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