ES2399379T3 - Procedimiento de preparación del éster de 2-[4-(4-fluoro-2-metil-1H-indol-5-iloxi)-5-metilpirrolo]2,1-f-[1,2,4-triazin-6-iloxi]-1-metílico del ácido [(1R),2S]-2-aminopropiónico - Google Patents

Procedimiento de preparación del éster de 2-[4-(4-fluoro-2-metil-1H-indol-5-iloxi)-5-metilpirrolo]2,1-f-[1,2,4-triazin-6-iloxi]-1-metílico del ácido [(1R),2S]-2-aminopropiónico Download PDF

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Publication number
ES2399379T3
ES2399379T3 ES07760872T ES07760872T ES2399379T3 ES 2399379 T3 ES2399379 T3 ES 2399379T3 ES 07760872 T ES07760872 T ES 07760872T ES 07760872 T ES07760872 T ES 07760872T ES 2399379 T3 ES2399379 T3 ES 2399379T3
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Spain
Prior art keywords
compound
formula
process according
reaction
solution
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Active
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ES07760872T
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English (en)
Spanish (es)
Inventor
Gerard A. Crispino
Mourad Hamedi
Thomas L. Laporte
John E. Thornton
Jaan A. Pesti
Zhongmin Xu
Paul C. Lobben
David K. Leahy
Jale Muslehiddinoglu
Chiajen Lai
Lori Ann Spangler
Robert P. Discordia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2399379T3 publication Critical patent/ES2399379T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ES07760872T 2006-04-21 2007-04-19 Procedimiento de preparación del éster de 2-[4-(4-fluoro-2-metil-1H-indol-5-iloxi)-5-metilpirrolo]2,1-f-[1,2,4-triazin-6-iloxi]-1-metílico del ácido [(1R),2S]-2-aminopropiónico Active ES2399379T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74530006P 2006-04-21 2006-04-21
US745300P 2006-04-21
PCT/US2007/066911 WO2007124332A1 (en) 2006-04-21 2007-04-19 PROCESS FOR THE PREPARATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER

Publications (1)

Publication Number Publication Date
ES2399379T3 true ES2399379T3 (es) 2013-04-01

Family

ID=38357966

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07760872T Active ES2399379T3 (es) 2006-04-21 2007-04-19 Procedimiento de preparación del éster de 2-[4-(4-fluoro-2-metil-1H-indol-5-iloxi)-5-metilpirrolo]2,1-f-[1,2,4-triazin-6-iloxi]-1-metílico del ácido [(1R),2S]-2-aminopropiónico

Country Status (23)

Country Link
US (1) US7671199B2 (pt)
EP (1) EP2010538B1 (pt)
JP (1) JP5203353B2 (pt)
KR (1) KR101423789B1 (pt)
CN (1) CN101472927B (pt)
AR (1) AR060622A1 (pt)
AU (1) AU2007240453B2 (pt)
BR (1) BRPI0710691A2 (pt)
CA (1) CA2650059A1 (pt)
CL (2) CL2007001141A1 (pt)
DK (1) DK2010538T3 (pt)
EA (1) EA019693B1 (pt)
ES (1) ES2399379T3 (pt)
HR (1) HRP20130099T1 (pt)
IL (1) IL194715A (pt)
MX (1) MX2008013232A (pt)
NO (1) NO20084326L (pt)
PE (1) PE20080193A1 (pt)
PL (1) PL2010538T3 (pt)
PT (1) PT2010538E (pt)
SI (1) SI2010538T1 (pt)
TW (1) TWI378100B (pt)
WO (1) WO2007124332A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009511440A (ja) * 2005-09-27 2009-03-19 ブリストル−マイヤーズ スクイブ カンパニー ［（１Ｒ），２Ｓ］−２−アミノプロピオン酸２−［４−（４−フルオロ−２−メチル−１Ｈ−インドール−５−イルオキシ）−５−メチルピロロ［２，１−ｆ］［１，２，４］トリアジン−６−イルオキシ］−１−メチルエチルエステルの結晶形
US20120135875A1 (en) * 2008-02-29 2012-05-31 Bristol-Myers Squibb Company Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
WO2010071885A1 (en) 2008-12-19 2010-06-24 Cephalon, Inc. Pyrrolotriazines as alk and jak2 inhibitors
WO2020074863A1 (en) 2018-10-08 2020-04-16 Applied Photophysics Limited System and method for analysing the composition of a quenched flow reaction liquid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
TWI272271B (en) * 2002-07-19 2007-02-01 Bristol Myers Squibb Co Process for preparing certain pyrrolotriazine compounds
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
WO2006130657A2 (en) * 2005-05-31 2006-12-07 Bristol-Myers Squibb Company Stereoselective reduction process for the preparation of pyrrolotriazine compounds
JP2009511440A (ja) * 2005-09-27 2009-03-19 ブリストル−マイヤーズ スクイブ カンパニー ［（１Ｒ），２Ｓ］−２−アミノプロピオン酸２−［４−（４−フルオロ−２−メチル−１Ｈ−インドール−５−イルオキシ）−５−メチルピロロ［２，１−ｆ］［１，２，４］トリアジン−６−イルオキシ］−１−メチルエチルエステルの結晶形

Also Published As

Publication number Publication date
HRP20130099T1 (hr) 2013-03-31
AU2007240453A1 (en) 2007-11-01
EP2010538A1 (en) 2009-01-07
CN101472927B (zh) 2012-07-04
PE20080193A1 (es) 2008-03-10
US20070249610A1 (en) 2007-10-25
US7671199B2 (en) 2010-03-02
EA200802171A1 (ru) 2009-08-28
PL2010538T3 (pl) 2013-04-30
MX2008013232A (es) 2008-10-21
JP2009534413A (ja) 2009-09-24
EA019693B1 (ru) 2014-05-30
SI2010538T1 (sl) 2013-06-28
JP5203353B2 (ja) 2013-06-05
PT2010538E (pt) 2013-02-22
KR20090008246A (ko) 2009-01-21
CA2650059A1 (en) 2007-11-01
TW200808799A (en) 2008-02-16
EP2010538B1 (en) 2012-12-05
AR060622A1 (es) 2008-07-02
DK2010538T3 (da) 2013-03-18
IL194715A (en) 2013-10-31
BRPI0710691A2 (pt) 2011-08-23
KR101423789B1 (ko) 2014-07-30
CN101472927A (zh) 2009-07-01
CL2007001141A1 (es) 2008-01-18
AU2007240453B2 (en) 2012-04-12
TWI378100B (en) 2012-12-01
NO20084326L (no) 2008-11-18
WO2007124332A1 (en) 2007-11-01
CL2010000554A1 (es) 2010-10-15

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