ES2395101T3 - Medicamentos antivirales para tratamiento de infecciones por arenavirus - Google Patents

Medicamentos antivirales para tratamiento de infecciones por arenavirus Download PDF

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Publication number
ES2395101T3
ES2395101T3 ES07751991T ES07751991T ES2395101T3 ES 2395101 T3 ES2395101 T3 ES 2395101T3 ES 07751991 T ES07751991 T ES 07751991T ES 07751991 T ES07751991 T ES 07751991T ES 2395101 T3 ES2395101 T3 ES 2395101T3
Authority
ES
Spain
Prior art keywords
substituted
heteroaryl
aryl
alkyl
nrs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07751991T
Other languages
English (en)
Spanish (es)
Inventor
Dennis E. Hruby
Tove Bolken
Sean Amberg
Dongcheng Dai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DAI DONCHENG
Siga Technologies Inc
Original Assignee
DAI DONCHENG
Siga Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DAI DONCHENG, Siga Technologies Inc filed Critical DAI DONCHENG
Application granted granted Critical
Publication of ES2395101T3 publication Critical patent/ES2395101T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES07751991T 2006-03-02 2007-03-02 Medicamentos antivirales para tratamiento de infecciones por arenavirus Active ES2395101T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77810706P 2006-03-02 2006-03-02
US778107P 2006-03-02
PCT/US2007/005263 WO2007103111A2 (en) 2006-03-02 2007-03-02 Antiviral drugs for treatment of arenavirus infection

Publications (1)

Publication Number Publication Date
ES2395101T3 true ES2395101T3 (es) 2013-02-08

Family

ID=38475385

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07751991T Active ES2395101T3 (es) 2006-03-02 2007-03-02 Medicamentos antivirales para tratamiento de infecciones por arenavirus

Country Status (8)

Country Link
US (2) US7872037B2 (https=)
EP (1) EP1988776B1 (https=)
JP (1) JP5380078B2 (https=)
AP (1) AP2267A (https=)
CA (1) CA2651943C (https=)
ES (1) ES2395101T3 (https=)
WO (1) WO2007103111A2 (https=)
ZA (1) ZA200807507B (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8530509B2 (en) 2003-06-20 2013-09-10 Siga Technologies, Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7687641B2 (en) * 2003-06-20 2010-03-30 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US8410149B2 (en) 2004-12-06 2013-04-02 Siga Technologies Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
CA2590962A1 (en) 2004-12-06 2006-06-15 Siga Technologies, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US7994221B2 (en) 2004-12-06 2011-08-09 Siga Technologies, Inc. Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
EP1984379A4 (en) 2006-02-01 2011-05-18 Siga Technologies Inc ANTI-ARENAVIRAL COMPOUNDS
US8791110B2 (en) 2006-02-01 2014-07-29 Siga Technologies, Inc. Anti-arenaviral compounds
US7977365B2 (en) * 2006-03-02 2011-07-12 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
EP1988776B1 (en) 2006-03-02 2012-08-08 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
US8871746B2 (en) 2006-03-02 2014-10-28 Kineta Four, LLC Antiviral drugs for treatment of arenavirus infection
EP1988884A4 (en) * 2006-03-02 2009-09-30 Siga Technologies Inc ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENAVIRUS INFECTIONS
US20080033755A1 (en) * 2006-06-07 2008-02-07 Krusz John C Medical treatment modality for headache, pain, and other medical disorders
CN101034257B (zh) * 2007-04-06 2010-09-08 上海复旦天臣新技术有限公司 用于全息记录的感光薄膜及其制备方法
EP3006425A1 (en) * 2007-04-23 2016-04-13 Siga Technologies, Inc. Pharmaceutical composition for use in the treatment and prevention of orthopoxvirus infections and associated diseases
JP2010528051A (ja) 2007-05-23 2010-08-19 シガ・テクノロジーズ・インコーポレーテッド デング感染症の治療または予防のための抗ウイルス薬
WO2009025743A2 (en) * 2007-08-17 2009-02-26 University Of Massachusetts Medical School Use of trail compositions as antiviral agents
MX2010002278A (es) 2007-08-27 2010-03-17 Siga Technologies Inc Farmacos antivirales para el tratamiento de una infeccion por arenavirus.
US8940730B2 (en) 2007-09-18 2015-01-27 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions of treating a Flaviviridae family viral infection
US9101628B2 (en) 2007-09-18 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Methods and composition of treating a flaviviridae family viral infection
US9149463B2 (en) 2007-09-18 2015-10-06 The Board Of Trustees Of The Leland Standford Junior University Methods and compositions of treating a Flaviviridae family viral infection
EP2203168B1 (en) * 2007-09-18 2014-07-16 Stanford University Compositions for treating a flaviviridae family viral infection
EP2240023A4 (en) * 2008-01-15 2010-12-29 Siga Technologies Inc ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENA VIRUS INFECTIONS
WO2010107739A2 (en) 2009-03-18 2010-09-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions of treating a flaviviridae family viral infection
US8609663B2 (en) * 2009-11-18 2013-12-17 University Of Massachusetts Compounds for modulating TLR2
SG184201A1 (en) 2010-03-23 2012-10-30 Siga Technologies Inc Polymorphic forms st-246 and methods of preparation
AP3675A (en) 2012-02-17 2016-04-15 Kineta Four Llc Antiviral drugs for treatment of arenavirus infection
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
CN108272838A (zh) * 2018-03-23 2018-07-13 三峡大学 小花清风藤提取物及其提取方法和应用
US12419865B2 (en) 2018-12-06 2025-09-23 Arisan Therapeutics Inc. Compounds for the treatment of arenavirus infection
EP3980015A4 (en) * 2019-06-06 2024-02-21 University of Maryland, Baltimore BROAD-SPECTRUM ANTIVIRAL COMPOUNDS TARGETING THE SKI COMPLEX

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
AU5636900A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
WO2003026587A2 (en) * 2001-09-26 2003-04-03 Bristol-Myers Squibb Company Compounds useful for treating hepatitus c virus
NZ537156A (en) 2002-05-23 2007-06-29 Cytopia Pty Ltd Kinase inhibitors
US7687641B2 (en) * 2003-06-20 2010-03-30 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7737168B2 (en) 2003-06-20 2010-06-15 Siga Technologies, Inc. Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
CA2534649A1 (en) * 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
DE10348023A1 (de) 2003-10-15 2005-05-19 Imtm Gmbh Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
JP2007519704A (ja) * 2004-01-30 2007-07-19 ファイザー・インク 治療剤の組み合わせ
CA2590962A1 (en) 2004-12-06 2006-06-15 Siga Technologies, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US7994221B2 (en) 2004-12-06 2011-08-09 Siga Technologies, Inc. Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US20070207093A1 (en) 2005-11-03 2007-09-06 Linquagen Corp. Hydrazone derivatives and uses thereof
EP1984379A4 (en) * 2006-02-01 2011-05-18 Siga Technologies Inc ANTI-ARENAVIRAL COMPOUNDS
EP1988776B1 (en) 2006-03-02 2012-08-08 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
EP1988884A4 (en) 2006-03-02 2009-09-30 Siga Technologies Inc ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENAVIRUS INFECTIONS
US7977365B2 (en) * 2006-03-02 2011-07-12 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
EP3006425A1 (en) 2007-04-23 2016-04-13 Siga Technologies, Inc. Pharmaceutical composition for use in the treatment and prevention of orthopoxvirus infections and associated diseases
JP2010528051A (ja) 2007-05-23 2010-08-19 シガ・テクノロジーズ・インコーポレーテッド デング感染症の治療または予防のための抗ウイルス薬
MX2010002278A (es) 2007-08-27 2010-03-17 Siga Technologies Inc Farmacos antivirales para el tratamiento de una infeccion por arenavirus.
EP2240023A4 (en) 2008-01-15 2010-12-29 Siga Technologies Inc ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENA VIRUS INFECTIONS
AU2009256390A1 (en) 2008-06-03 2009-12-10 Siga Technologies, Inc. Small molecule inhibitors for the treatment or prevention of dengue virus infection

Also Published As

Publication number Publication date
WO2007103111A2 (en) 2007-09-13
CA2651943A1 (en) 2007-09-13
US8629170B2 (en) 2014-01-14
EP1988776A2 (en) 2008-11-12
US7872037B2 (en) 2011-01-18
US20070254934A1 (en) 2007-11-01
JP5380078B2 (ja) 2014-01-08
CA2651943C (en) 2015-06-30
ZA200807507B (en) 2009-08-26
EP1988776A4 (en) 2010-09-01
EP1988776B1 (en) 2012-08-08
AP2008004594A0 (en) 2008-08-31
WO2007103111A8 (en) 2012-04-12
US20110172281A1 (en) 2011-07-14
AP2267A (en) 2011-08-02
WO2007103111A3 (en) 2007-12-21
JP2009528368A (ja) 2009-08-06

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