CA2651943C - Antiviral drugs for treatment of arenavirus infection - Google Patents
Antiviral drugs for treatment of arenavirus infection Download PDFInfo
- Publication number
- CA2651943C CA2651943C CA2651943A CA2651943A CA2651943C CA 2651943 C CA2651943 C CA 2651943C CA 2651943 A CA2651943 A CA 2651943A CA 2651943 A CA2651943 A CA 2651943A CA 2651943 C CA2651943 C CA 2651943C
- Authority
- CA
- Canada
- Prior art keywords
- methoxy
- phenyl
- benzimidazol
- composition
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US77810706P | 2006-03-02 | 2006-03-02 | |
| US60/778,107 | 2006-03-02 | ||
| PCT/US2007/005263 WO2007103111A2 (en) | 2006-03-02 | 2007-03-02 | Antiviral drugs for treatment of arenavirus infection |
Publications (2)
| Publication Number | Publication Date |
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| CA2651943A1 CA2651943A1 (en) | 2007-09-13 |
| CA2651943C true CA2651943C (en) | 2015-06-30 |
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| CA2651943A Expired - Fee Related CA2651943C (en) | 2006-03-02 | 2007-03-02 | Antiviral drugs for treatment of arenavirus infection |
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|---|---|
| US (2) | US7872037B2 (https=) |
| EP (1) | EP1988776B1 (https=) |
| JP (1) | JP5380078B2 (https=) |
| AP (1) | AP2267A (https=) |
| CA (1) | CA2651943C (https=) |
| ES (1) | ES2395101T3 (https=) |
| WO (1) | WO2007103111A2 (https=) |
| ZA (1) | ZA200807507B (https=) |
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| US8530509B2 (en) | 2003-06-20 | 2013-09-10 | Siga Technologies, Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7687641B2 (en) * | 2003-06-20 | 2010-03-30 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US8410149B2 (en) | 2004-12-06 | 2013-04-02 | Siga Technologies Inc. | Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| CA2590962A1 (en) | 2004-12-06 | 2006-06-15 | Siga Technologies, Inc. | Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| US7994221B2 (en) | 2004-12-06 | 2011-08-09 | Siga Technologies, Inc. | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| EP1984379A4 (en) | 2006-02-01 | 2011-05-18 | Siga Technologies Inc | ANTI-ARENAVIRAL COMPOUNDS |
| US8791110B2 (en) | 2006-02-01 | 2014-07-29 | Siga Technologies, Inc. | Anti-arenaviral compounds |
| US7977365B2 (en) * | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| EP1988776B1 (en) | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| US8871746B2 (en) | 2006-03-02 | 2014-10-28 | Kineta Four, LLC | Antiviral drugs for treatment of arenavirus infection |
| EP1988884A4 (en) * | 2006-03-02 | 2009-09-30 | Siga Technologies Inc | ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENAVIRUS INFECTIONS |
| US20080033755A1 (en) * | 2006-06-07 | 2008-02-07 | Krusz John C | Medical treatment modality for headache, pain, and other medical disorders |
| CN101034257B (zh) * | 2007-04-06 | 2010-09-08 | 上海复旦天臣新技术有限公司 | 用于全息记录的感光薄膜及其制备方法 |
| EP3006425A1 (en) * | 2007-04-23 | 2016-04-13 | Siga Technologies, Inc. | Pharmaceutical composition for use in the treatment and prevention of orthopoxvirus infections and associated diseases |
| JP2010528051A (ja) | 2007-05-23 | 2010-08-19 | シガ・テクノロジーズ・インコーポレーテッド | デング感染症の治療または予防のための抗ウイルス薬 |
| WO2009025743A2 (en) * | 2007-08-17 | 2009-02-26 | University Of Massachusetts Medical School | Use of trail compositions as antiviral agents |
| MX2010002278A (es) | 2007-08-27 | 2010-03-17 | Siga Technologies Inc | Farmacos antivirales para el tratamiento de una infeccion por arenavirus. |
| US8940730B2 (en) | 2007-09-18 | 2015-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| US9101628B2 (en) | 2007-09-18 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and composition of treating a flaviviridae family viral infection |
| US9149463B2 (en) | 2007-09-18 | 2015-10-06 | The Board Of Trustees Of The Leland Standford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| EP2203168B1 (en) * | 2007-09-18 | 2014-07-16 | Stanford University | Compositions for treating a flaviviridae family viral infection |
| EP2240023A4 (en) * | 2008-01-15 | 2010-12-29 | Siga Technologies Inc | ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENA VIRUS INFECTIONS |
| WO2010107739A2 (en) | 2009-03-18 | 2010-09-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a flaviviridae family viral infection |
| US8609663B2 (en) * | 2009-11-18 | 2013-12-17 | University Of Massachusetts | Compounds for modulating TLR2 |
| SG184201A1 (en) | 2010-03-23 | 2012-10-30 | Siga Technologies Inc | Polymorphic forms st-246 and methods of preparation |
| AP3675A (en) | 2012-02-17 | 2016-04-15 | Kineta Four Llc | Antiviral drugs for treatment of arenavirus infection |
| WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
| CN108272838A (zh) * | 2018-03-23 | 2018-07-13 | 三峡大学 | 小花清风藤提取物及其提取方法和应用 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| EP3980015A4 (en) * | 2019-06-06 | 2024-02-21 | University of Maryland, Baltimore | BROAD-SPECTRUM ANTIVIRAL COMPOUNDS TARGETING THE SKI COMPLEX |
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| US4492708A (en) * | 1982-09-27 | 1985-01-08 | Eli Lilly And Company | Antiviral benzimidazoles |
| AU5636900A (en) | 1999-06-30 | 2001-01-31 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| WO2003026587A2 (en) * | 2001-09-26 | 2003-04-03 | Bristol-Myers Squibb Company | Compounds useful for treating hepatitus c virus |
| NZ537156A (en) | 2002-05-23 | 2007-06-29 | Cytopia Pty Ltd | Kinase inhibitors |
| US7687641B2 (en) * | 2003-06-20 | 2010-03-30 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7737168B2 (en) | 2003-06-20 | 2010-06-15 | Siga Technologies, Inc. | Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| CA2534649A1 (en) * | 2003-08-01 | 2005-02-10 | Genelabs Technologies, Inc. | Bicyclic imidazol derivatives against flaviviridae |
| DE10348023A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| JP2007519704A (ja) * | 2004-01-30 | 2007-07-19 | ファイザー・インク | 治療剤の組み合わせ |
| CA2590962A1 (en) | 2004-12-06 | 2006-06-15 | Siga Technologies, Inc. | Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| US7994221B2 (en) | 2004-12-06 | 2011-08-09 | Siga Technologies, Inc. | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| US20070207093A1 (en) | 2005-11-03 | 2007-09-06 | Linquagen Corp. | Hydrazone derivatives and uses thereof |
| EP1984379A4 (en) * | 2006-02-01 | 2011-05-18 | Siga Technologies Inc | ANTI-ARENAVIRAL COMPOUNDS |
| EP1988776B1 (en) | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| EP1988884A4 (en) | 2006-03-02 | 2009-09-30 | Siga Technologies Inc | ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENAVIRUS INFECTIONS |
| US7977365B2 (en) * | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| EP3006425A1 (en) | 2007-04-23 | 2016-04-13 | Siga Technologies, Inc. | Pharmaceutical composition for use in the treatment and prevention of orthopoxvirus infections and associated diseases |
| JP2010528051A (ja) | 2007-05-23 | 2010-08-19 | シガ・テクノロジーズ・インコーポレーテッド | デング感染症の治療または予防のための抗ウイルス薬 |
| MX2010002278A (es) | 2007-08-27 | 2010-03-17 | Siga Technologies Inc | Farmacos antivirales para el tratamiento de una infeccion por arenavirus. |
| EP2240023A4 (en) | 2008-01-15 | 2010-12-29 | Siga Technologies Inc | ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENA VIRUS INFECTIONS |
| AU2009256390A1 (en) | 2008-06-03 | 2009-12-10 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
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2007
- 2007-03-02 EP EP07751991A patent/EP1988776B1/en not_active Not-in-force
- 2007-03-02 ES ES07751991T patent/ES2395101T3/es active Active
- 2007-03-02 CA CA2651943A patent/CA2651943C/en not_active Expired - Fee Related
- 2007-03-02 JP JP2008557379A patent/JP5380078B2/ja not_active Expired - Fee Related
- 2007-03-02 WO PCT/US2007/005263 patent/WO2007103111A2/en not_active Ceased
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- 2007-03-02 US US11/712,918 patent/US7872037B2/en not_active Expired - Fee Related
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2008
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2007103111A2 (en) | 2007-09-13 |
| CA2651943A1 (en) | 2007-09-13 |
| US8629170B2 (en) | 2014-01-14 |
| EP1988776A2 (en) | 2008-11-12 |
| ES2395101T3 (es) | 2013-02-08 |
| US7872037B2 (en) | 2011-01-18 |
| US20070254934A1 (en) | 2007-11-01 |
| JP5380078B2 (ja) | 2014-01-08 |
| ZA200807507B (en) | 2009-08-26 |
| EP1988776A4 (en) | 2010-09-01 |
| EP1988776B1 (en) | 2012-08-08 |
| AP2008004594A0 (en) | 2008-08-31 |
| WO2007103111A8 (en) | 2012-04-12 |
| US20110172281A1 (en) | 2011-07-14 |
| AP2267A (en) | 2011-08-02 |
| WO2007103111A3 (en) | 2007-12-21 |
| JP2009528368A (ja) | 2009-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190304 |