ES2393262T3 - Diagnóstico y estratificación de riesgo de diabetes mellitus mediante MR-proADM - Google Patents
Diagnóstico y estratificación de riesgo de diabetes mellitus mediante MR-proADM Download PDFInfo
- Publication number
- ES2393262T3 ES2393262T3 ES07866202T ES07866202T ES2393262T3 ES 2393262 T3 ES2393262 T3 ES 2393262T3 ES 07866202 T ES07866202 T ES 07866202T ES 07866202 T ES07866202 T ES 07866202T ES 2393262 T3 ES2393262 T3 ES 2393262T3
- Authority
- ES
- Spain
- Prior art keywords
- diabetes mellitus
- markers
- diagnosis
- marker
- proadm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 43
- 238000003745 diagnosis Methods 0.000 title claims abstract description 25
- 238000013517 stratification Methods 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 25
- 238000000338 in vitro Methods 0.000 claims abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 239000003550 marker Substances 0.000 claims description 17
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 13
- -1 for example Proteins 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- 230000002792 vascular Effects 0.000 claims description 5
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 4
- 206010048554 Endothelial dysfunction Diseases 0.000 claims description 4
- 102100034296 Natriuretic peptides A Human genes 0.000 claims description 4
- 230000008694 endothelial dysfunction Effects 0.000 claims description 4
- 238000011156 evaluation Methods 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- 102100032752 C-reactive protein Human genes 0.000 claims description 3
- 208000008960 Diabetic foot Diseases 0.000 claims description 3
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 3
- 230000004087 circulation Effects 0.000 claims description 3
- 230000008482 dysregulation Effects 0.000 claims description 3
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 3
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims description 3
- 230000001631 hypertensive effect Effects 0.000 claims description 3
- 230000002757 inflammatory effect Effects 0.000 claims description 3
- 208000017169 kidney disease Diseases 0.000 claims description 3
- 201000006370 kidney failure Diseases 0.000 claims description 3
- 201000001119 neuropathy Diseases 0.000 claims description 3
- 230000007823 neuropathy Effects 0.000 claims description 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 3
- 238000004393 prognosis Methods 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
- 102400000345 Angiotensin-2 Human genes 0.000 claims description 2
- 101800000733 Angiotensin-2 Proteins 0.000 claims description 2
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 claims description 2
- 102400000667 Brain natriuretic peptide 32 Human genes 0.000 claims description 2
- 101800002247 Brain natriuretic peptide 45 Proteins 0.000 claims description 2
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 2
- 102000004420 Creatine Kinase Human genes 0.000 claims description 2
- 108010042126 Creatine kinase Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102400000686 Endothelin-1 Human genes 0.000 claims description 2
- 101800004490 Endothelin-1 Proteins 0.000 claims description 2
- 102400000921 Gastrin Human genes 0.000 claims description 2
- 108010052343 Gastrins Proteins 0.000 claims description 2
- 102000003815 Interleukin-11 Human genes 0.000 claims description 2
- 108090000177 Interleukin-11 Proteins 0.000 claims description 2
- 102000015696 Interleukins Human genes 0.000 claims description 2
- 108010063738 Interleukins Proteins 0.000 claims description 2
- 102400000569 Myeloperoxidase Human genes 0.000 claims description 2
- 108090000235 Myeloperoxidases Proteins 0.000 claims description 2
- 102100030856 Myoglobin Human genes 0.000 claims description 2
- 108010062374 Myoglobin Proteins 0.000 claims description 2
- 102400001263 NT-proBNP Human genes 0.000 claims description 2
- 101710187800 Natriuretic peptides A Proteins 0.000 claims description 2
- 102100036836 Natriuretic peptides B Human genes 0.000 claims description 2
- 101710187802 Natriuretic peptides B Proteins 0.000 claims description 2
- 108010069820 Pro-Opiomelanocortin Proteins 0.000 claims description 2
- 239000000683 Pro-Opiomelanocortin Substances 0.000 claims description 2
- 102100028427 Pro-neuropeptide Y Human genes 0.000 claims description 2
- 102100027467 Pro-opiomelanocortin Human genes 0.000 claims description 2
- 108010048233 Procalcitonin Proteins 0.000 claims description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
- 229950006323 angiotensin ii Drugs 0.000 claims description 2
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000011161 development Methods 0.000 claims description 2
- 238000003748 differential diagnosis Methods 0.000 claims description 2
- 239000002934 diuretic Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940074383 interleukin-11 Drugs 0.000 claims description 2
- 229940047122 interleukins Drugs 0.000 claims description 2
- 230000001452 natriuretic effect Effects 0.000 claims description 2
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 claims description 2
- CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 claims description 2
- 108010072272 proendothelin 1 Proteins 0.000 claims description 2
- 108010088603 proneuropeptide Y Proteins 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 108010001670 prosomatostatin Proteins 0.000 claims description 2
- GGYTXJNZMFRSLX-UHFFFAOYSA-N prosomatostatin Chemical compound C1CCC(C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NCC(=O)NC2C(NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C4=CC=CC=C4NC=3)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(C(=O)NC(CO)C(=O)NC(CSSC2)C(O)=O)C(C)O)C(C)O)=O)N1C(=O)C(C)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(N)CO GGYTXJNZMFRSLX-UHFFFAOYSA-N 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 239000012634 fragment Substances 0.000 description 7
- 102000004877 Insulin Human genes 0.000 description 6
- 108090001061 Insulin Proteins 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 229940125396 insulin Drugs 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 208000037921 secondary disease Diseases 0.000 description 6
- 206010022489 Insulin Resistance Diseases 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 102000004379 Adrenomedullin Human genes 0.000 description 3
- 101800004616 Adrenomedullin Proteins 0.000 description 3
- ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 206010054044 Diabetic microangiopathy Diseases 0.000 description 2
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- 150000001413 amino acids Chemical group 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 150000001841 cholesterols Chemical class 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 201000009101 diabetic angiopathy Diseases 0.000 description 2
- 230000003284 homeostatic effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- CUKWUWBLQQDQAC-VEQWQPCFSA-N (3s)-3-amino-4-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s,3s)-1-[[(2s)-1-[(2s)-2-[[(1s)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-ox Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 CUKWUWBLQQDQAC-VEQWQPCFSA-N 0.000 description 1
- 102000011690 Adiponectin Human genes 0.000 description 1
- 108010076365 Adiponectin Proteins 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 101000690940 Homo sapiens Pro-adrenomedullin Proteins 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 206010054805 Macroangiopathy Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000001280 Prediabetic State Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 238000013210 evaluation model Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 102000046663 human ADM Human genes 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 238000012125 lateral flow test Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 201000009104 prediabetes syndrome Diseases 0.000 description 1
- 102000034567 proadrenomedullin Human genes 0.000 description 1
- 108010012004 proadrenomedullin Proteins 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006052916A DE102006052916A1 (de) | 2006-11-08 | 2006-11-08 | Diagnose und Risikostratifizierung von Diabetes mellitus mittels MR-proADM |
| DE102006052916 | 2006-11-08 | ||
| PCT/DE2007/002018 WO2008055491A2 (de) | 2006-11-08 | 2007-11-08 | Diagnose und risikostratifizierung von diabetes mellitus mittels mr-proadm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2393262T3 true ES2393262T3 (es) | 2012-12-19 |
Family
ID=39277540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07866202T Active ES2393262T3 (es) | 2006-11-08 | 2007-11-08 | Diagnóstico y estratificación de riesgo de diabetes mellitus mediante MR-proADM |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20100035275A1 (enExample) |
| EP (1) | EP2097748B1 (enExample) |
| JP (2) | JP5275247B2 (enExample) |
| CN (2) | CN101568833B (enExample) |
| DE (1) | DE102006052916A1 (enExample) |
| ES (1) | ES2393262T3 (enExample) |
| WO (1) | WO2008055491A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| AU2007233320B2 (en) | 2006-04-04 | 2013-12-12 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| DE102007009751A1 (de) | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| JP5711131B2 (ja) * | 2008-10-07 | 2015-04-30 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 最初の有害事象の予測のためのバイオマーカー |
| EP2180322A1 (en) * | 2008-10-22 | 2010-04-28 | BRAHMS Aktiengesellschaft | Prognostic biomarkers for the progression of primary chronic kidney disease |
| US20110262939A1 (en) * | 2008-10-31 | 2011-10-27 | B.R.A.H.M.S Gmbh | Methods and assays for classifying foodstuff and/or beverage and/or diet and/or nutrition regimen and/or medicament in view of an effect on the cardiovascular system |
| EP2356451A1 (en) * | 2008-10-31 | 2011-08-17 | B.R.A.H.M.S GmbH | In vitro-method for the diagnosis, prognosis, monitoring and therapy follow-up of disorders associated with the metabolic syndrome, a cardiovascular disease and/or insulin resistance |
| WO2010054810A1 (en) * | 2008-11-11 | 2010-05-20 | B.R.A.H.M.S Ag | Prognosis and risk assessment in patients suffering from heart failure by determining the level of adm and bnp |
| US8450069B2 (en) | 2009-06-08 | 2013-05-28 | Singulex, Inc. | Highly sensitive biomarker panels |
| EP2470910B1 (en) * | 2009-08-28 | 2017-01-11 | B.R.A.H.M.S GmbH | Procalcitonin for the prognosis of adverse events |
| RU2618437C2 (ru) * | 2010-11-01 | 2017-05-03 | Б.Р.А.Х.М.С Гмбх | Оценка прогноза и риска пациентов с неспецифическими жалобами |
| CN105148269A (zh) * | 2011-02-21 | 2015-12-16 | 菲布他丁有限合伙公司 | 治疗和诊断疾病的方法 |
| EP2533052A1 (en) * | 2011-06-07 | 2012-12-12 | B.R.A.H.M.S GmbH | Diagnostic use of proSomatostatin |
| CN104714020B (zh) * | 2013-12-12 | 2016-05-25 | 张曼 | 尿液内源性α胰蛋白酶抑制剂重链H4在2型糖尿病合并冠心病中的应用 |
| WO2017089474A1 (en) * | 2015-11-27 | 2017-06-01 | Brahms Gmbh | MR-proADM AS MARKER FOR THE EXTRACELLULAR VOLUME STATUS OF A SUBJECT |
| US20190178894A1 (en) * | 2016-08-09 | 2019-06-13 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
| CN109564226A (zh) * | 2016-08-09 | 2019-04-02 | B.R.A.H.M.S 有限公司 | 作为指示器官功能障碍的标志物的组蛋白和/或proADM |
| EP3438668A1 (en) * | 2017-08-04 | 2019-02-06 | B.R.A.H.M.S GmbH | Diagnosis and risk stratification of fungal infections |
| EP3682247B1 (en) * | 2017-09-13 | 2022-02-09 | B.R.A.H.M.S GmbH | Proadrenomedullin as a marker for abnormal platelet levels |
| WO2019098351A1 (ja) * | 2017-11-17 | 2019-05-23 | 学校法人東海大学 | 糖尿病合併症用マーカー |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11512087A (ja) * | 1995-08-18 | 1999-10-19 | アメリカ合衆国 | ヒトの病理学及び生理学における、アドレノメジュリン（ａｍ）及び遺伝子関連産物（ｐａｍｐ）の機能的役割 |
| DE19847690A1 (de) * | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
| US6756783B2 (en) * | 1999-06-01 | 2004-06-29 | Merlin Technology, Inc | Multi-frequency boring tool locating system and method |
| ATE313802T1 (de) * | 1999-09-10 | 2006-01-15 | Us Gov Health & Human Serv | Bestimmung von adrenomedullin-bindenden proteinen |
| DE10316583A1 (de) * | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| JP2007523844A (ja) * | 2003-04-25 | 2007-08-23 | ジェノバ・リミテッド | 心臓血管障害において減少する分泌ポリペプチド種 |
| EP1619505B1 (en) * | 2004-07-22 | 2008-04-16 | BRAHMS Aktiengesellschaft | Method for the diagnosis of critically ill patients |
| GB2418995B (en) * | 2004-09-29 | 2006-08-16 | Bookham Technology Plc | Apodised binary grating |
| FI20050011A7 (fi) * | 2005-01-05 | 2006-07-06 | Oy Jurilab Ltd | Menetelmä ja testipakkaus tyypin 2 diabetes mellituksen riskin havaitsemiseksi |
-
2006
- 2006-11-08 DE DE102006052916A patent/DE102006052916A1/de not_active Withdrawn
-
2007
- 2007-11-08 EP EP07866202A patent/EP2097748B1/de active Active
- 2007-11-08 CN CN200780041709.4A patent/CN101568833B/zh active Active
- 2007-11-08 WO PCT/DE2007/002018 patent/WO2008055491A2/de not_active Ceased
- 2007-11-08 US US12/514,194 patent/US20100035275A1/en not_active Abandoned
- 2007-11-08 ES ES07866202T patent/ES2393262T3/es active Active
- 2007-11-08 CN CN201410442798.5A patent/CN104198735B/zh active Active
- 2007-11-08 JP JP2009535557A patent/JP5275247B2/ja active Active
-
2012
- 2012-10-25 JP JP2012235494A patent/JP2013047689A/ja active Pending
-
2016
- 2016-02-26 US US15/055,406 patent/US20160169912A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5275247B2 (ja) | 2013-08-28 |
| DE102006052916A1 (de) | 2008-05-15 |
| EP2097748A2 (de) | 2009-09-09 |
| CN104198735B (zh) | 2018-01-30 |
| HK1203090A1 (en) | 2015-10-16 |
| JP2013047689A (ja) | 2013-03-07 |
| CN101568833A (zh) | 2009-10-28 |
| WO2008055491A3 (de) | 2008-08-21 |
| CN101568833B (zh) | 2014-09-10 |
| HK1137805A1 (en) | 2010-08-06 |
| WO2008055491A2 (de) | 2008-05-15 |
| CN104198735A (zh) | 2014-12-10 |
| JP2010509575A (ja) | 2010-03-25 |
| EP2097748B1 (de) | 2012-08-08 |
| US20100035275A1 (en) | 2010-02-11 |
| US20160169912A1 (en) | 2016-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2393262T3 (es) | Diagnóstico y estratificación de riesgo de diabetes mellitus mediante MR-proADM | |
| US9012151B2 (en) | Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin | |
| Mueller et al. | Biochemical diagnosis of impaired left ventricular ejection fraction-comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and amino terminal proBNP (NT-proBNP) | |
| Potocki et al. | Mid-regional pro-adrenomedullin in acute heart failure: a better biomarker or just another biomarker? | |
| Takeishi | Biomarkers in heart failure | |
| WO2006087373A1 (en) | Use of nt-proanp/nt-probnp ratio for diagnosing cardiac dysfunctions | |
| EP1889073A1 (en) | Use of nt-proanp and nt-probnp for diagnosing cardiac diseases | |
| US20100151504A1 (en) | Diagnosis and risk classification of acute coronary syndrome by means of ct-proet-1 in combination with nt-probnp | |
| US10732188B2 (en) | NT-proANP and NT-proBNP for the diagnosis of stroke | |
| US20110263438A1 (en) | Diagnosis and complication risk assessment of pancreatic diabetes using procalcitonin | |
| DK2596010T3 (en) | SIGNAL biomarkers | |
| Singhal et al. | Bedside biomarkers in pediatric cardio renal injuries in emergency | |
| ES2713098T3 (es) | Diagnóstico de insuficiencia cardíaca | |
| Peller et al. | Are adipokines associated with atrial fibrillation in type 2 diabetes? | |
| EP2626704B1 (en) | Diagnosis of pancreatic diabetes in patients with normal blood leucocyte counts using procalcitonin | |
| WO2009150253A1 (en) | Assessment of complications of patients with type 1 diabetes | |
| HK1203090B (en) | Diagnosis and risk assessment of pancreatic diabetes using mr-proadm | |
| Lasota et al. | Copeptin in heart failure | |
| Indumathi et al. | A review on application of biomarkers in heart failure | |
| Alan et al. | Use of biomarkers in evaluation of patients with heart failure | |
| El-Shafae et al. | Association between Growth Differentiation Factor 15 and Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus | |
| Sethi et al. | Care Unit and Perioperative Period | |
| Simic-Ogrizovic et al. | Risk factors associated with coronary artery calcification should be examined before kidney transplantation | |
| HK1137805B (en) | Diagnosis and risk assessment of pancreatic diabetes using mr-proadm | |
| Loboda et al. | Value of urinary adiponectin, VCAM-1 and RBP 4 in early diagnosis of kidney damage in children with type 1 diabetes mellitus |