CN101568833B - 使用MR-proADM的糖尿病诊断和风险分级 - Google Patents

使用MR-proADM的糖尿病诊断和风险分级 Download PDF

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Publication number
CN101568833B
CN101568833B CN200780041709.4A CN200780041709A CN101568833B CN 101568833 B CN101568833 B CN 101568833B CN 200780041709 A CN200780041709 A CN 200780041709A CN 101568833 B CN101568833 B CN 101568833B
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diabetes
use according
proadm
marker
diagnosis
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CN101568833A (zh
Inventor
A·博格曼
N·莫根塔勒
J·帕帕索提里奥
J·斯塔克
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BRAHMS GmbH
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BRAHMS GmbH
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200780041709.4A 2006-11-08 2007-11-08 使用MR-proADM的糖尿病诊断和风险分级 Active CN101568833B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410442798.5A CN104198735B (zh) 2006-11-08 2007-11-08 使用MR‑proADM的糖尿病诊断和风险分级

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006052916A DE102006052916A1 (de) 2006-11-08 2006-11-08 Diagnose und Risikostratifizierung von Diabetes mellitus mittels MR-proADM
DE102006052916.2 2006-11-08
PCT/DE2007/002018 WO2008055491A2 (de) 2006-11-08 2007-11-08 Diagnose und risikostratifizierung von diabetes mellitus mittels mr-proadm

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410442798.5A Division CN104198735B (zh) 2006-11-08 2007-11-08 使用MR‑proADM的糖尿病诊断和风险分级

Publications (2)

Publication Number Publication Date
CN101568833A CN101568833A (zh) 2009-10-28
CN101568833B true CN101568833B (zh) 2014-09-10

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CN200780041709.4A Active CN101568833B (zh) 2006-11-08 2007-11-08 使用MR-proADM的糖尿病诊断和风险分级
CN201410442798.5A Active CN104198735B (zh) 2006-11-08 2007-11-08 使用MR‑proADM的糖尿病诊断和风险分级

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Country Link
US (2) US20100035275A1 (enExample)
EP (1) EP2097748B1 (enExample)
JP (2) JP5275247B2 (enExample)
CN (2) CN101568833B (enExample)
DE (1) DE102006052916A1 (enExample)
ES (1) ES2393262T3 (enExample)
WO (1) WO2008055491A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906857B2 (en) * 2005-12-01 2014-12-09 B.R.A.H.M.S. Gmbh Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP2016394A4 (en) 2006-04-04 2013-04-24 Singulex Inc METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES
DE102007009751A1 (de) 2007-02-28 2008-09-04 B.R.A.H.M.S Aktiengesellschaft Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens
ES2795003T3 (es) * 2008-10-07 2020-11-20 Brahms Gmbh Biomarcador para la predicción de los primeros eventos adversos
EP2180322A1 (en) * 2008-10-22 2010-04-28 BRAHMS Aktiengesellschaft Prognostic biomarkers for the progression of primary chronic kidney disease
US20110262939A1 (en) * 2008-10-31 2011-10-27 B.R.A.H.M.S Gmbh Methods and assays for classifying foodstuff and/or beverage and/or diet and/or nutrition regimen and/or medicament in view of an effect on the cardiovascular system
CN102203608B (zh) * 2008-10-31 2016-11-23 B.R.A.H.M.S有限公司 用于与代谢综合征、心血管疾病和/或胰岛素抗性相关的病症的诊断、预后、监测和治疗追踪的体外方法
JP5584695B2 (ja) * 2008-11-11 2014-09-03 ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング Ａｄｍ及びｂｎｐのレベルを決定することによる心疾患に罹患した患者の予後診断及びリスク評価
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
CN102472752B (zh) * 2009-08-28 2015-08-19 B.R.A.H.M.S有限公司 用于不良事件的预后的降钙素原
RU2017110678A (ru) * 2010-11-01 2019-01-24 Б.Р.А.Х.М.С Гмбх Оценка прогноза и риска пациентов с неспецифическими жалобами
AU2012219582A1 (en) * 2011-02-21 2013-08-22 Fibrostatin S.L. Methods for treating and diagnosing disease
EP2533052A1 (en) * 2011-06-07 2012-12-12 B.R.A.H.M.S GmbH Diagnostic use of proSomatostatin
CN104714020B (zh) * 2013-12-12 2016-05-25 张曼 尿液内源性α胰蛋白酶抑制剂重链H4在2型糖尿病合并冠心病中的应用
CN119199150A (zh) * 2015-11-27 2024-12-27 B.R.A.H.M.S 有限公司 作为对象的细胞外容量状态的标志物的MR-proADM
RU2765212C2 (ru) * 2016-08-09 2022-01-26 Б.Р.А.Х.М.С. Гмбх Гистоны и/или proadm в качестве маркеров, свидетельствующих о неблагоприятном событии
JP7194673B2 (ja) * 2016-08-09 2022-12-22 ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 臓器障害を示すマーカーとしてのヒストンおよび／またはｐｒｏＡＤＭ
EP3438668A1 (en) * 2017-08-04 2019-02-06 B.R.A.H.M.S GmbH Diagnosis and risk stratification of fungal infections
EP3682247B1 (en) * 2017-09-13 2022-02-09 B.R.A.H.M.S GmbH Proadrenomedullin as a marker for abnormal platelet levels
US11892456B2 (en) * 2017-11-17 2024-02-06 Tokai University Educational System Method of examining diabetic complication

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007214A1 (en) * 1995-08-18 1997-02-27 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Functional role of adrenomedullin (am) and the gene-related product (pamp) in human pathology and physiology

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19847690A1 (de) * 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen
US6756783B2 (en) * 1999-06-01 2004-06-29 Merlin Technology, Inc Multi-frequency boring tool locating system and method
ES2254220T3 (es) * 1999-09-10 2006-06-16 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Determinacion de proteinas de enlace con la adrnomedulina.
DE10316583A1 (de) * 2003-04-10 2004-10-28 B.R.A.H.M.S Aktiengesellschaft Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
WO2004097423A1 (en) * 2003-04-25 2004-11-11 Genova Ltd. Secreted polypeptide species reduced cardiovascular disorders
ES2300681T3 (es) * 2004-07-22 2008-06-16 Brahms Aktiengesellschaft Procedimiento para el diagnostico y tratamiento de pacientes criticos con endotelina, agonistas de endotelina y antagonistas de adrenomedulina.
GB2418995B (en) * 2004-09-29 2006-08-16 Bookham Technology Plc Apodised binary grating
FI20050011L (fi) * 2005-01-05 2006-07-06 Jurilab Ltd Oy Menetelmä ja testipakkaus tyypin 2 diabetes mellituksen riskin havaitsemiseksi

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007214A1 (en) * 1995-08-18 1997-02-27 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Functional role of adrenomedullin (am) and the gene-related product (pamp) in human pathology and physiology

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Jerzy Beltowski ET AL..ADRENOMEDULLIN – WHAT DO WE KNOW 10 YEARS SINCE ITS DISCOVERY?.《POLISH JOURNAL OF PHARMACOLOGY》.2004,第56卷第5-27页. *
NILS G. MORGENTHALER ET AL..Measurement of Midregional Proadrenomedullin in Plasma with an Immunoluminometric Assay.《CLINICAL CHEMISTRY》.2005,第51卷(第10期),第1824页. *

Also Published As

Publication number Publication date
JP5275247B2 (ja) 2013-08-28
DE102006052916A1 (de) 2008-05-15
CN101568833A (zh) 2009-10-28
CN104198735B (zh) 2018-01-30
JP2010509575A (ja) 2010-03-25
US20100035275A1 (en) 2010-02-11
WO2008055491A2 (de) 2008-05-15
CN104198735A (zh) 2014-12-10
HK1203090A1 (en) 2015-10-16
WO2008055491A3 (de) 2008-08-21
HK1137805A1 (en) 2010-08-06
US20160169912A1 (en) 2016-06-16
JP2013047689A (ja) 2013-03-07
ES2393262T3 (es) 2012-12-19
EP2097748A2 (de) 2009-09-09
EP2097748B1 (de) 2012-08-08

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