ES2390499T3 - Composiciones y métodos para la inhibición de la angiogénesis por sirna - Google Patents
Composiciones y métodos para la inhibición de la angiogénesis por sirna Download PDFInfo
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- ES2390499T3 ES2390499T3 ES07812121T ES07812121T ES2390499T3 ES 2390499 T3 ES2390499 T3 ES 2390499T3 ES 07812121 T ES07812121 T ES 07812121T ES 07812121 T ES07812121 T ES 07812121T ES 2390499 T3 ES2390499 T3 ES 2390499T3
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/00—Structure or type of the nucleic acid
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| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| WO2008045576A2 (en) * | 2006-10-12 | 2008-04-17 | Yijia Liu | Compositions and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases |
| JP2011510750A (ja) * | 2008-01-29 | 2011-04-07 | クライマン、ギルバート・エイチ | 薬物送達デバイス、キット及びそれらの方法 |
| CA2746527A1 (en) | 2008-09-22 | 2010-03-25 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| JP5832293B2 (ja) * | 2008-12-04 | 2015-12-16 | オプコ ファーマシューティカルズ、エルエルシー | 血管新生促進ｖｅｇｆイソ型を選択的に抑制する組成物および方法 |
| US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| EP3028707A1 (en) * | 2009-05-01 | 2016-06-08 | Ophthotech Corporation | Methods for treating or preventing ophthalmological diseases |
| RU2012127772A (ru) * | 2009-12-04 | 2014-01-10 | ОПКО ОФТЭЛМИКС, ЭлЭлСи | Композиции и способы для ингибирования vegf |
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| CN106074591B (zh) * | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | 眼部症候中的rna干扰 |
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| US20150037422A1 (en) * | 2012-02-22 | 2015-02-05 | Trustees Of Tufts College | Compositions and methods for ocular delivery of a therapeutic agent |
| TWI775096B (zh) * | 2012-05-15 | 2022-08-21 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
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| NZ540779A (en) * | 2002-11-01 | 2008-05-30 | Univ Pennsylvania | Compositions and methods for siRNA inhibition of HIF-1 alpha |
| EP2305812A3 (en) * | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| DE602004028587D1 (de) * | 2003-01-16 | 2010-09-23 | Univ Pennsylvania | ZUSAMMENSETZUNGEN UND VERFAHREN ZUR siRNA-HEMMUNG VON ICAM-1 |
| CA2522730A1 (en) * | 2003-04-18 | 2004-11-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for sirna inhibition of angiopoietin 1 and 2 and their receptor tie2 |
| US20050019927A1 (en) * | 2003-07-13 | 2005-01-27 | Markus Hildinger | DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER |
| AU2005222902B2 (en) * | 2004-03-12 | 2010-06-10 | Alnylam Pharmaceuticals, Inc. | iRNA agents targeting VEGF |
| US20060182783A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
| ATE466081T1 (de) * | 2005-12-22 | 2010-05-15 | Opko Ophthalmics Llc | Zusammensetzungen und verfahren zur regulierung eines komplementsystems |
| EP1982176A1 (en) * | 2006-01-30 | 2008-10-22 | Dako Denmark A/S | High-speed quantification of antigen specific t-cells in whole blood by flow cytometry |
-
2007
- 2007-06-12 PT PT07812121T patent/PT2029746E/pt unknown
- 2007-06-12 DK DK07812121.7T patent/DK2029746T3/da active
- 2007-06-12 ES ES07812121T patent/ES2390499T3/es active Active
- 2007-06-12 US US11/761,940 patent/US20080152654A1/en not_active Abandoned
- 2007-06-12 EP EP11171243A patent/EP2383341A1/en not_active Ceased
- 2007-06-12 JP JP2009515610A patent/JP2009540011A/ja active Pending
- 2007-06-12 EP EP07812121A patent/EP2029746B1/en active Active
- 2007-06-12 WO PCT/US2007/071029 patent/WO2007146953A2/en not_active Ceased
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2008
- 2008-12-08 IL IL195803A patent/IL195803A0/en unknown
-
2012
- 2012-10-02 CY CY20121100913T patent/CY1113291T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2029746A2 (en) | 2009-03-04 |
| WO2007146953A2 (en) | 2007-12-21 |
| CY1113291T1 (el) | 2016-04-13 |
| PT2029746E (pt) | 2012-10-15 |
| JP2009540011A (ja) | 2009-11-19 |
| WO2007146953A8 (en) | 2009-11-19 |
| EP2383341A1 (en) | 2011-11-02 |
| US20080152654A1 (en) | 2008-06-26 |
| DK2029746T3 (da) | 2012-10-08 |
| WO2007146953A3 (en) | 2008-03-06 |
| IL195803A0 (en) | 2011-08-01 |
| EP2029746B1 (en) | 2012-07-04 |
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