ES2389740T3 - Nuevos compuestos y procedimientos para su producción - Google Patents
Nuevos compuestos y procedimientos para su producción Download PDFInfo
- Publication number
- ES2389740T3 ES2389740T3 ES07824891T ES07824891T ES2389740T3 ES 2389740 T3 ES2389740 T3 ES 2389740T3 ES 07824891 T ES07824891 T ES 07824891T ES 07824891 T ES07824891 T ES 07824891T ES 2389740 T3 ES2389740 T3 ES 2389740T3
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- ES
- Spain
- Prior art keywords
- strain
- ansamycin
- deactivated
- initiator unit
- geldanamicin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims description 108
- 238000004519 manufacturing process Methods 0.000 title claims description 40
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 46
- 150000003839 salts Chemical class 0.000 claims abstract description 28
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
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- QTQAWLPCGQOSGP-VKNBREQOSA-N [(3r,5r,6s,7r,8e,10r,11r,12z,14e)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate Chemical compound N1C(=O)\C(C)=C\C=C/[C@@H](OC)[C@H](OC(N)=O)\C(C)=C\[C@@H](C)[C@H](O)[C@H](OC)C[C@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-VKNBREQOSA-N 0.000 claims description 103
- QPEJHSFTZVMSJH-UHFFFAOYSA-N 3-amino-5-hydroxybenzoic acid Chemical compound NC1=CC(O)=CC(C(O)=O)=C1 QPEJHSFTZVMSJH-UHFFFAOYSA-N 0.000 claims description 89
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Hospice & Palliative Care (AREA)
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- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0622342 | 2006-11-09 | ||
| GBGB0622342.4A GB0622342D0 (en) | 2006-11-09 | 2006-11-09 | Novel compounds and methods for their production |
| GB0720875A GB0720875D0 (en) | 2007-10-24 | 2007-10-24 | Novel compounds and methods for their production |
| GB0720875 | 2007-10-24 | ||
| PCT/GB2007/050679 WO2008056188A2 (en) | 2006-11-09 | 2007-11-09 | Novel compounds and methods for their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2389740T3 true ES2389740T3 (es) | 2012-10-31 |
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|---|---|---|---|
| ES07824891T Active ES2389740T3 (es) | 2006-11-09 | 2007-11-09 | Nuevos compuestos y procedimientos para su producción |
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| Country | Link |
|---|---|
| US (1) | US8492370B2 (enExample) |
| EP (1) | EP1973883B1 (enExample) |
| JP (1) | JP2010509306A (enExample) |
| KR (1) | KR20090075856A (enExample) |
| AU (1) | AU2007319014B2 (enExample) |
| BR (1) | BRPI0718564A2 (enExample) |
| CA (1) | CA2669047A1 (enExample) |
| ES (1) | ES2389740T3 (enExample) |
| MX (1) | MX2009004775A (enExample) |
| WO (1) | WO2008056188A2 (enExample) |
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| JP2010516282A (ja) * | 2007-01-26 | 2010-05-20 | コーサン バイオサイエンシーズ， インコーポレイテッド | 工学的生合成によるマクロラクタム |
| KR101097850B1 (ko) | 2009-02-24 | 2011-12-23 | 한국생명공학연구원 | 젤다나마이신 생합성 조절유전자 변이주 및 이를 이용한 젤다나마이신 생산방법 |
| CN117695374B (zh) * | 2024-01-25 | 2024-09-06 | 超越健康科技(浙江)有限公司 | 一种用于治疗帕金森病的生物药物 |
Family Cites Families (9)
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| CA2127457A1 (en) * | 1992-01-06 | 1993-07-22 | Walter P. Cullen | Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone |
| ATE433961T1 (de) | 2002-02-08 | 2009-07-15 | Conforma Therapeutics Corp | Ansamycine mit verbesserten pharmakologischen und biologischen eigenschaften |
| US7282493B2 (en) * | 2003-12-23 | 2007-10-16 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| WO2005061461A1 (ja) | 2003-12-24 | 2005-07-07 | Kyowa Hakko Kogyo Co., Ltd. | ヒートショックプロテイン90（hsp90）ファミリー蛋白質阻害剤 |
| WO2006098761A2 (en) * | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| CN101213178A (zh) * | 2005-06-29 | 2008-07-02 | 协和发酵工业株式会社 | 苯环型安莎霉素衍生物 |
| CA2628728A1 (en) | 2005-12-24 | 2007-07-05 | Biotica Technology Ltd. | 21-deoxymacbecin analogues useful as antitumor agents |
| CN101012196A (zh) * | 2006-12-27 | 2007-08-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 芳香化格尔德霉素类衍生物及其制备方法和用途 |
| JP2010516282A (ja) * | 2007-01-26 | 2010-05-20 | コーサン バイオサイエンシーズ， インコーポレイテッド | 工学的生合成によるマクロラクタム |
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2007
- 2007-11-09 MX MX2009004775A patent/MX2009004775A/es active IP Right Grant
- 2007-11-09 KR KR1020097009593A patent/KR20090075856A/ko not_active Ceased
- 2007-11-09 WO PCT/GB2007/050679 patent/WO2008056188A2/en not_active Ceased
- 2007-11-09 JP JP2009535815A patent/JP2010509306A/ja active Pending
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| AU2007319014B2 (en) | 2013-03-28 |
| CA2669047A1 (en) | 2008-05-15 |
| MX2009004775A (es) | 2009-05-21 |
| EP1973883B1 (en) | 2012-07-11 |
| US8492370B2 (en) | 2013-07-23 |
| KR20090075856A (ko) | 2009-07-09 |
| AU2007319014A1 (en) | 2008-05-15 |
| BRPI0718564A2 (pt) | 2014-03-11 |
| WO2008056188A2 (en) | 2008-05-15 |
| WO2008056188A3 (en) | 2008-07-31 |
| US20110021481A1 (en) | 2011-01-27 |
| JP2010509306A (ja) | 2010-03-25 |
| EP1973883A2 (en) | 2008-10-01 |
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