ES2387379T3 - Tampones para controlar el pH de las proteínas morfogenéticas óseas - Google Patents
Tampones para controlar el pH de las proteínas morfogenéticas óseas Download PDFInfo
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- ES2387379T3 ES2387379T3 ES10755307T ES10755307T ES2387379T3 ES 2387379 T3 ES2387379 T3 ES 2387379T3 ES 10755307 T ES10755307 T ES 10755307T ES 10755307 T ES10755307 T ES 10755307T ES 2387379 T3 ES2387379 T3 ES 2387379T3
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- bmp
- glycylglycine
- solution
- salt
- bone morphogenetic
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| US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9051389B2 (en) | 2013-01-25 | 2015-06-09 | Warsaw Orthopedic, Inc. | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) |
| US9169308B2 (en) | 2013-01-25 | 2015-10-27 | Warsaw Orthopedic, Inc. | Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies |
| US8956829B2 (en) | 2013-01-25 | 2015-02-17 | Warsaw Orthopedic, Inc. | Human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US8945872B2 (en) | 2013-01-25 | 2015-02-03 | Warsaw Orthopedic, Inc. | Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein |
| GB201906917D0 (en) * | 2019-05-16 | 2019-07-03 | Intract Pharma Ltd | Novel compositions |
| CN114276407B (zh) * | 2021-12-29 | 2023-08-15 | 浙江旅游职业学院 | 一种采用ph偏移技术从骨或壳内提取蛋白质的设备及方法 |
| CN116549656A (zh) * | 2023-05-25 | 2023-08-08 | 深圳奥礼生物科技有限公司 | 一种提高司美格鲁肽在肠道中稳定性的组合物 |
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| IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US6919308B2 (en) | 1988-04-08 | 2005-07-19 | Stryker Corporation | Osteogenic devices |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| JPH06500466A (ja) | 1990-06-15 | 1994-01-20 | カーネギー インスチチューション オブ ワシントン | Ｇｄｆ―１ |
| US5656593A (en) | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
| US6506729B1 (en) | 1991-03-11 | 2003-01-14 | Curis, Inc. | Methods and compositions for the treatment and prevention of Parkinson's disease |
| US6949505B1 (en) | 1991-03-11 | 2005-09-27 | Curis, Inc. | Morphogen-induced dendritic growth |
| US6800603B2 (en) | 1991-03-11 | 2004-10-05 | Curis, Inc. | Morphogen-induced neural cell adhesion |
| US5674844A (en) | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US5849686A (en) | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| ATE238417T1 (de) | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| DK0625989T3 (da) | 1992-02-12 | 2000-06-26 | Bioph Biotech Entw Pharm Gmbh | DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer |
| JPH08503198A (ja) | 1992-11-03 | 1996-04-09 | クリエイティブ バイオモレキュルズ，インコーポレイテッド | Ｏｐ−３誘導形態形成 |
| EP0678101A4 (en) | 1993-01-12 | 1997-07-16 | Univ Johns Hopkins Med | FACTOR-9 OF GROWTH AND DIFFERENTIATION. |
| JP3645258B2 (ja) | 1993-01-12 | 2005-05-11 | ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−５ |
| DK0690873T3 (da) | 1993-03-19 | 2003-09-29 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-8 |
| BR9406715A (pt) | 1993-05-12 | 1996-02-06 | Genetics Inst | Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-11) polipeptideo de proteina-11 morfogenética de osso purificada (BMP-11) e molécula de DNA quimérica |
| EP0698095B1 (en) | 1993-05-12 | 2004-04-28 | Genetics Institute, LLC | Bmp-10 compositions |
| CA2165776A1 (en) | 1993-07-09 | 1995-01-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-6 |
| EP0725796A4 (en) | 1993-10-08 | 1999-12-01 | Univ Johns Hopkins | Growth differentiation factor-10 |
| DE4334646C1 (de) | 1993-10-12 | 1994-09-29 | Quinting Friedhelm | Durchsichtige Analog-Zeituhr |
| JP3300500B2 (ja) | 1993-10-12 | 2002-07-08 | 新日本製鐵株式会社 | 疲労強度、降伏強度および被削性に優れる熱間鍛造用鋼の製造方法 |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| US5399677A (en) | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
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| CA2194660C (en) | 1994-07-08 | 2009-09-29 | Se-Jin Lee | Growth differentiation factor-11 |
| WO1996014335A1 (en) | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
| US5635372A (en) | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
| KR20000064752A (ko) | 1996-03-22 | 2000-11-06 | 더 제네랄 호스피탈 코포레이션 | 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법 |
| US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
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| JP3762222B2 (ja) | 1998-10-07 | 2006-04-05 | ストライカー・コーポレーション | 改変型ＴＧＦ−βスーパーファミリータンパク質 |
| US6846906B1 (en) | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| JP2002527208A (ja) * | 1998-10-19 | 2002-08-27 | ジンテーズ アクチエンゲゼルシャフト クール | 硬化可能なセラミック水硬セメント |
| WO2001078687A1 (en) * | 2000-04-18 | 2001-10-25 | Peptron Inc. | Injectable sustained release pharmaceutical composition and processes for preparing the same |
| US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| US7005136B2 (en) * | 2002-03-29 | 2006-02-28 | Ethicon, Inc. | Bone replacement materials utilizing bioabsorbable liquid polymers |
| US7026374B2 (en) * | 2002-06-25 | 2006-04-11 | Aruna Nathan | Injectable microdispersions for medical applications |
| US7459527B2 (en) | 2004-03-31 | 2008-12-02 | Xencor, Inc. | BMP-7 variants with improved properties |
| WO2005113585A2 (en) | 2004-05-20 | 2005-12-01 | Acceleron Pharma Inc. | Modified tgf-beta superfamily polypeptides |
| ES2369629T3 (es) | 2004-05-25 | 2011-12-02 | Stryker Corporation | Uso de op-1 para tratar defectos del cartílago. |
| WO2007087053A2 (en) | 2005-12-22 | 2007-08-02 | Centocor, Inc | Bmp-7 variant compositions, methods and uses |
-
2010
- 2010-09-17 EP EP10755307A patent/EP2352750B1/en not_active Not-in-force
- 2010-09-17 WO PCT/US2010/049229 patent/WO2011035094A1/en not_active Ceased
- 2010-09-17 US US12/884,414 patent/US20110224410A1/en not_active Abandoned
- 2010-09-17 AU AU2010295509A patent/AU2010295509A1/en not_active Abandoned
- 2010-09-17 CA CA2774024A patent/CA2774024A1/en not_active Abandoned
- 2010-09-17 JP JP2012529917A patent/JP2013518808A/ja active Pending
- 2010-09-17 ES ES10755307T patent/ES2387379T3/es active Active
-
2012
- 2012-09-14 US US13/615,829 patent/US20130172254A1/en not_active Abandoned
-
2013
- 2013-11-25 US US14/088,623 patent/US20140336114A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2352750B1 (en) | 2012-06-13 |
| US20140336114A1 (en) | 2014-11-13 |
| CA2774024A1 (en) | 2011-03-24 |
| AU2010295509A1 (en) | 2012-04-19 |
| US20110224410A1 (en) | 2011-09-15 |
| US20130172254A1 (en) | 2013-07-04 |
| EP2352750A1 (en) | 2011-08-10 |
| AU2010295509A2 (en) | 2012-05-03 |
| WO2011035094A1 (en) | 2011-03-24 |
| JP2013518808A (ja) | 2013-05-23 |
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