JP2013518808A - 骨形成タンパク質のｐＨを制御するための緩衝液 - Google Patents

骨形成タンパク質のｐＨを制御するための緩衝液 Download PDF

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Publication number
JP2013518808A
JP2013518808A JP2012529917A JP2012529917A JP2013518808A JP 2013518808 A JP2013518808 A JP 2013518808A JP 2012529917 A JP2012529917 A JP 2012529917A JP 2012529917 A JP2012529917 A JP 2012529917A JP 2013518808 A JP2013518808 A JP 2013518808A
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JP
Japan
Prior art keywords
solution
bmp
item
solid composition
glycylglycine
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Pending
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JP2012529917A
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English (en)
Japanese (ja)
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JP2013518808A5 (https=
Inventor
デイビッド ハイル，
グレッグ ストローマイヤー，
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Stryker Corp
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Stryker Corp
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Publication of JP2013518808A publication Critical patent/JP2013518808A/ja
Publication of JP2013518808A5 publication Critical patent/JP2013518808A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2012529917A 2009-09-17 2010-09-17 骨形成タンパク質のｐＨを制御するための緩衝液 Pending JP2013518808A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24338309P 2009-09-17 2009-09-17
US61/243,383 2009-09-17
PCT/US2010/049229 WO2011035094A1 (en) 2009-09-17 2010-09-17 Buffers for controlling the ph of bone morphogenetic proteins

Publications (2)

Publication Number Publication Date
JP2013518808A true JP2013518808A (ja) 2013-05-23
JP2013518808A5 JP2013518808A5 (https=) 2013-09-26

Family

ID=43037185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012529917A Pending JP2013518808A (ja) 2009-09-17 2010-09-17 骨形成タンパク質のｐＨを制御するための緩衝液

Country Status (7)

Country Link
US (3) US20110224410A1 (https=)
EP (1) EP2352750B1 (https=)
JP (1) JP2013518808A (https=)
AU (1) AU2010295509A1 (https=)
CA (1) CA2774024A1 (https=)
ES (1) ES2387379T3 (https=)
WO (1) WO2011035094A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022533635A (ja) * 2019-05-16 2022-07-25 イントラクト、ファーマ、リミテッド 安定剤としてジペプチドを含むタンパク質組成物

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Publication number Priority date Publication date Assignee Title
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
CN114276407B (zh) * 2021-12-29 2023-08-15 浙江旅游职业学院 一种采用ph偏移技术从骨或壳内提取蛋白质的设备及方法
CN116549656A (zh) * 2023-05-25 2023-08-08 深圳奥礼生物科技有限公司 一种提高司美格鲁肽在肠道中稳定性的组合物

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EP1348450A2 (en) * 2002-03-29 2003-10-01 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
EP1374905A1 (en) * 2002-06-25 2004-01-02 Ethicon, Inc. Injectable microdispersions for medical applications

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WO2000023123A1 (en) * 1998-10-19 2000-04-27 Synthes Ag Chur Hardenable ceramic hydraulic cement
WO2001078687A1 (en) * 2000-04-18 2001-10-25 Peptron Inc. Injectable sustained release pharmaceutical composition and processes for preparing the same
EP1348450A2 (en) * 2002-03-29 2003-10-01 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
EP1374905A1 (en) * 2002-06-25 2004-01-02 Ethicon, Inc. Injectable microdispersions for medical applications

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JPN6014042813; Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｍｅｄｉｃａｌ　Ｍａｔｅｒｉａｌｓ　Ｒｅｓｅａｒｃｈ，　２００２，　Ｖｏｌ．６２，　Ｎｏ．２，　ｐ．１６９-１７４ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022533635A (ja) * 2019-05-16 2022-07-25 イントラクト、ファーマ、リミテッド 安定剤としてジペプチドを含むタンパク質組成物
JP7696831B2 (ja) 2019-05-16 2025-06-23 イントラクト、ファーマ、リミテッド 安定剤としてジペプチドを含むタンパク質組成物

Also Published As

Publication number Publication date
EP2352750B1 (en) 2012-06-13
US20140336114A1 (en) 2014-11-13
ES2387379T3 (es) 2012-09-21
CA2774024A1 (en) 2011-03-24
AU2010295509A1 (en) 2012-04-19
US20110224410A1 (en) 2011-09-15
US20130172254A1 (en) 2013-07-04
EP2352750A1 (en) 2011-08-10
AU2010295509A2 (en) 2012-05-03
WO2011035094A1 (en) 2011-03-24

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