ES2371287T3 - Expresión diferencial de la citocina en cáncer humano. - Google Patents

Expresión diferencial de la citocina en cáncer humano. Download PDF

Info

Publication number
ES2371287T3
ES2371287T3 ES07764767T ES07764767T ES2371287T3 ES 2371287 T3 ES2371287 T3 ES 2371287T3 ES 07764767 T ES07764767 T ES 07764767T ES 07764767 T ES07764767 T ES 07764767T ES 2371287 T3 ES2371287 T3 ES 2371287T3
Authority
ES
Spain
Prior art keywords
tumor
cytokine
agent
cells
neutralizing agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07764767T
Other languages
English (en)
Spanish (es)
Inventor
Giorgio Stassi
Christian Gieffers
Oliver Hill
Meinolf Thiemann
Matilde Todaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apogenix AG
Original Assignee
Apogenix AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apogenix AG filed Critical Apogenix AG
Application granted granted Critical
Publication of ES2371287T3 publication Critical patent/ES2371287T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES07764767T 2006-06-21 2007-06-21 Expresión diferencial de la citocina en cáncer humano. Active ES2371287T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06012754 2006-06-21
EP06012754 2006-06-21

Publications (1)

Publication Number Publication Date
ES2371287T3 true ES2371287T3 (es) 2011-12-29

Family

ID=38359749

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07764767T Active ES2371287T3 (es) 2006-06-21 2007-06-21 Expresión diferencial de la citocina en cáncer humano.

Country Status (12)

Country Link
US (1) US20090324616A1 (fr)
EP (1) EP2041576B1 (fr)
JP (1) JP2010514409A (fr)
CN (1) CN101529253A (fr)
AT (1) ATE520032T1 (fr)
AU (1) AU2007263265A1 (fr)
BR (1) BRPI0713484A2 (fr)
CA (1) CA2656379A1 (fr)
DK (1) DK2041576T3 (fr)
ES (1) ES2371287T3 (fr)
RU (1) RU2009101783A (fr)
WO (1) WO2007147600A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2646626A1 (fr) * 2006-03-22 2007-09-27 Apogenix Gmbh Anticorps specifique de l'il-4 humaine pour le traitement du cancer
AU2007271349A1 (en) * 2006-07-06 2008-01-10 Apogenix Gmbh Human IL-4 muteins in combination with chemotherapeutics or pro-apoptotic agents in cancer therapy
DK3409686T3 (da) * 2012-07-18 2022-07-18 Apogenix Ag Sammensætning omfattende en blanding af cd95-fc-isoformer
US11299528B2 (en) 2014-03-11 2022-04-12 D&D Pharmatech Inc. Long acting TRAIL receptor agonists for treatment of autoimmune diseases
EP3209382B1 (fr) * 2014-10-24 2020-11-25 Calidi Biotherapeutics, Inc. Technique d'immunotherapie combinee pour le traitement du cancer
CN115212301A (zh) 2015-08-11 2022-10-21 卡利迪生物治疗有限公司 用以癌症治疗的天花疫苗
EA038551B1 (ru) 2015-12-17 2021-09-14 Дзе Джонс Хопкинс Юниверсити Способ лечения или профилактики системного склероза
KR102508650B1 (ko) 2016-04-07 2023-03-13 더 존스 홉킨스 유니버시티 사멸 수용체 작용제로써 췌장암 및 통증을 치료하기 위한 조성물 및 방법
EP4053557A1 (fr) * 2016-11-24 2022-09-07 Huvet Bio, Inc. Il-29 comme marqueur d'une maladie du pancréas
CA3071661A1 (fr) * 2017-09-06 2019-03-14 Fred Hutchinson Cancer Research Center Recepteurs chimeriques specifiques d'etiquette strep et utilisations de ceux-ci
US11505782B2 (en) 2018-06-04 2022-11-22 Calidi Biotherapeutics, Inc. Cell-based vehicles for potentiation of viral therapy

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643427B2 (en) * 1988-10-31 1993-11-18 Immunex Corporation Interleukin-4 receptors
DE4137333A1 (de) * 1991-11-13 1993-05-19 W Prof Dr Sebald Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung
US6534051B1 (en) * 1992-11-20 2003-03-18 University Of Medicine And Dentistry Of New Jersey Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins
NZ274338A (en) 1993-09-07 1998-02-26 Smithkline Beecham Corp Chimeric and humanised il-4 monoclonal antibodies and their use
DE4423131A1 (de) * 1994-07-01 1996-01-04 Bayer Ag Neue hIL-4-Mutantenproteine als Antagonisten oder partielle Agonisten des humanen Interleukin 4
RU2218348C2 (ru) * 1994-07-05 2003-12-10 Стено Рисерч Груп А/С Полипептид с il-10 подобными свойствами (варианты), конъюгат полипептида, фармацевтическая композиция, способ модуляции иммунного ответа у млекопитающего
HUT76369A (en) * 1994-07-29 1997-08-28 Smithkline Beecham Corp Novel soluble protein compounds
US5710023A (en) * 1996-03-01 1998-01-20 Genetics Institute, Inc. IL-13 cytokine receptor chain
US6664227B1 (en) * 1996-03-01 2003-12-16 Genetics Institute, Llc Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
US20030124125A1 (en) * 1996-04-05 2003-07-03 South Alabama Medical Science Foundation Oncofetal antigen specific T-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10
US6028176A (en) * 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
EP1029550A4 (fr) * 1997-11-10 2001-09-26 Mochida Pharm Co Ltd Medicaments preventifs et therapeutiques pour des affections pulmonaires diffuses
JPH11312463A (ja) * 1998-04-28 1999-11-09 Hitachi Ltd 配線基板およびそれを用いたガス放電型表示装置
CN1981868A (zh) * 2000-03-31 2007-06-20 拜奥根Idec公司 抗细胞因子抗体或拮抗剂与抗-cd20在b细胞淋巴瘤治疗中的联合应用
WO2002004009A2 (fr) * 2000-07-12 2002-01-17 Immunex Corporation Methode de traitement du cancer
US20040023338A1 (en) * 2001-10-26 2004-02-05 Heavner George A. IL-4 mutein proteins, antibodies, compositions, methods and uses
US20040023337A1 (en) * 2001-10-26 2004-02-05 Heavner George A. IL-13 mutein proteins, antibodies, compositions, methods and uses
EP1444989A1 (fr) * 2003-02-07 2004-08-11 Giorgio Dr. Stassi Sensibilisation de cellules à l'apoptose par bloquage selective de cytokines
US7501121B2 (en) * 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
CA2587903A1 (fr) * 2004-11-17 2006-05-26 Amgen Fremont Inc. Anticorps monoclonaux entierement humains diriges contre l'il-13
US20070122855A1 (en) * 2005-11-28 2007-05-31 Targetgen Inc. Methods for diagnosing hepatocellular carcinoma
CA2646626A1 (fr) * 2006-03-22 2007-09-27 Apogenix Gmbh Anticorps specifique de l'il-4 humaine pour le traitement du cancer
AU2007271349A1 (en) * 2006-07-06 2008-01-10 Apogenix Gmbh Human IL-4 muteins in combination with chemotherapeutics or pro-apoptotic agents in cancer therapy

Also Published As

Publication number Publication date
AU2007263265A1 (en) 2007-12-27
CA2656379A1 (fr) 2007-12-27
ATE520032T1 (de) 2011-08-15
WO2007147600A2 (fr) 2007-12-27
US20090324616A1 (en) 2009-12-31
EP2041576A2 (fr) 2009-04-01
BRPI0713484A2 (pt) 2012-11-06
JP2010514409A (ja) 2010-05-06
WO2007147600A3 (fr) 2008-04-10
EP2041576B1 (fr) 2011-08-10
RU2009101783A (ru) 2010-07-27
DK2041576T3 (da) 2011-12-05
CN101529253A (zh) 2009-09-09

Similar Documents

Publication Publication Date Title
ES2371287T3 (es) Expresión diferencial de la citocina en cáncer humano.
Silva-Santos et al. γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer
Wei et al. Tumor microenvironment regulation by the endoplasmic reticulum stress transmission mediator Golgi protein 73 in mice
ES2420582T3 (es) La neutralización de la actividad de CD95 bloquea la invasión de células de glioblastoma in vivo
US20150118244A1 (en) Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
AU2014217611A1 (en) Therapeutic and diagnostic target for cancer comprising DLL3 binding reagents
JP2006519190A (ja) サイトカインを選択的にブロックすることによる、アポトーシスに対する感作細胞
JP7032396B2 (ja) T細胞応答を促進するための方法
JP2016501843A (ja) 癌治療および判断ターゲットとしてのly75
Kiewlich et al. Anti-EphA2 antibodies decrease EphA2 protein levels in murine CT26 colorectal and human MDA-231 breast tumors but do not inhibit tumor growth
KR20140004552A (ko) 페리오스틴에 대한 압타머 및 이를 포함하는 항암제 조성물
CN111781359A (zh) 用于预测免疫疗法的临床效果的方法
KR20210136071A (ko) 암을 치료하는데 있어서 증진된 효능을 위한 il-4/il-13 경로 억제제
Liu et al. Desensitization of T lymphocyte function by CXCR3 ligands in human hepatocellular carcinoma
CN107249636B (zh) 以ckap4作为靶分子的抗肿瘤剂
EP3558359A1 (fr) Immunocytokines avec mécanisme d'activation progressive
US20220056123A1 (en) Use of il-1beta binding antibodies
CA3076997C (fr) Anticorps monoclonal anti-ckap4
Wu Circulating tumor markers of the new millennium: target therapy, early detection, and prognosis
ES2868998T3 (es) Anticuerpo biespecífico que se une a NAALADL2 Y CD3 para el uso como agente terapéutico en el tratamiento del cáncer de próstata
EP2924117B1 (fr) Nouvel anticorps humain contre il-18
US20170247469A1 (en) Modulation of ptpra to treat arthritis
O’Donovan et al. Chemokine-targeted therapies: An opportunity to remodel immune profiles in gastro-oesophageal tumours
CN114908158B (zh) Cdk1在晚期胃肠间质瘤的诊断和治疗中的应用
ES2937862T3 (es) Predicción de respondedores a terapia con ciclofosfamida