ES2361550T3 - Combinación de la roscovitina y de cs-682 o de su metabolito cndac. - Google Patents

Combinación de la roscovitina y de cs-682 o de su metabolito cndac. Download PDF

Info

Publication number
ES2361550T3
ES2361550T3 ES04805910T ES04805910T ES2361550T3 ES 2361550 T3 ES2361550 T3 ES 2361550T3 ES 04805910 T ES04805910 T ES 04805910T ES 04805910 T ES04805910 T ES 04805910T ES 2361550 T3 ES2361550 T3 ES 2361550T3
Authority
ES
Spain
Prior art keywords
cyano
arabino
roscovitine
cytosine
dioxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES04805910T
Other languages
English (en)
Spanish (es)
Inventor
Simon Green
Roger Neil Sleigh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cyclacel Ltd
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Application granted granted Critical
Publication of ES2361550T3 publication Critical patent/ES2361550T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
ES04805910T 2003-12-04 2004-12-03 Combinación de la roscovitina y de cs-682 o de su metabolito cndac. Active ES2361550T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0328180.5A GB0328180D0 (en) 2003-12-04 2003-12-04 Combination
GB0328180 2003-12-04

Publications (1)

Publication Number Publication Date
ES2361550T3 true ES2361550T3 (es) 2011-06-20

Family

ID=29764611

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04805910T Active ES2361550T3 (es) 2003-12-04 2004-12-03 Combinación de la roscovitina y de cs-682 o de su metabolito cndac.

Country Status (10)

Country Link
US (1) US7772207B2 (pt)
EP (1) EP1711185B1 (pt)
JP (1) JP4778910B2 (pt)
AT (1) ATE504303T1 (pt)
DE (1) DE602004032178D1 (pt)
DK (1) DK1711185T3 (pt)
ES (1) ES2361550T3 (pt)
GB (1) GB0328180D0 (pt)
PT (1) PT1711185E (pt)
WO (1) WO2005053699A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
US20050072118A1 (en) 2003-10-03 2005-04-07 Griggs Samuel D. Netting chutes with ribbed flooring for manual and/or automated clipping packaging apparatus
GB0226583D0 (en) * 2002-11-14 2002-12-18 Cyclacel Ltd Compounds
GB0229581D0 (en) * 2002-12-19 2003-01-22 Cyclacel Ltd Use
GB0523041D0 (en) * 2005-11-11 2005-12-21 Cyclacel Ltd Combination
GB0609530D0 (en) * 2006-05-12 2006-06-21 Cyclacel Ltd Combination
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US7863255B2 (en) * 2008-04-29 2011-01-04 Taiho Pharmaceutical Co., Ltd. Methods of administering antitumor agent comprising deoxycytidine derivative
CN102088969B (zh) * 2008-06-09 2013-06-12 西克拉塞尔有限公司 沙帕他滨或cndac与dna甲基转移酶抑制剂如地西他滨和普鲁卡因的组合
EP2696878B1 (en) 2011-04-14 2019-07-10 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
JP6286421B2 (ja) * 2012-05-15 2018-02-28 サイクラセル リミテッド サパシタビン及びセリシクリブの投与レジメン
CA2917742C (en) 2013-07-12 2020-04-14 Piramal Enterprises Limited A pharmaceutical combination for the treatment of melanoma
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2085557C1 (ru) * 1991-09-30 1997-07-27 Санкио Компани Лимитед Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
AU2002228849A1 (en) * 2000-12-08 2002-06-18 Bristol-Myers Squibb Pharma Company Semicarbazides and their uses as cyclin dependent kinase inhibitors
WO2003039536A1 (en) * 2001-11-07 2003-05-15 Yale University Enhancement of taxane-based chemotherapy by a cdk1 antagonist
EP1485168A1 (en) * 2002-03-15 2004-12-15 Cyclacel Limited Combination of a cdk inhibitor and 5-fu for the treatment of cancer
EP1487495A1 (en) * 2002-03-27 2004-12-22 Cyclacel Limited Combination comprising a cdk inhibitor and doxorubicin

Also Published As

Publication number Publication date
PT1711185E (pt) 2011-05-12
EP1711185B1 (en) 2011-04-06
EP1711185A1 (en) 2006-10-18
GB0328180D0 (en) 2004-01-07
JP4778910B2 (ja) 2011-09-21
WO2005053699A1 (en) 2005-06-16
DE602004032178D1 (de) 2011-05-19
US7772207B2 (en) 2010-08-10
DK1711185T3 (da) 2011-06-14
ATE504303T1 (de) 2011-04-15
JP2007513132A (ja) 2007-05-24
US20070270442A1 (en) 2007-11-22

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