ATE504303T1 - Kombination aus roscovitine und cs-682 oder seinem metaboliten cndac - Google Patents

Kombination aus roscovitine und cs-682 oder seinem metaboliten cndac

Info

Publication number
ATE504303T1
ATE504303T1 AT04805910T AT04805910T ATE504303T1 AT E504303 T1 ATE504303 T1 AT E504303T1 AT 04805910 T AT04805910 T AT 04805910T AT 04805910 T AT04805910 T AT 04805910T AT E504303 T1 ATE504303 T1 AT E504303T1
Authority
AT
Austria
Prior art keywords
metabolite
combination
pentofuranosyl
arabino
dioxy
Prior art date
Application number
AT04805910T
Other languages
English (en)
Inventor
Simon Green
Roger Sleigh
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Application granted granted Critical
Publication of ATE504303T1 publication Critical patent/ATE504303T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT04805910T 2003-12-04 2004-12-03 Kombination aus roscovitine und cs-682 oder seinem metaboliten cndac ATE504303T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0328180.5A GB0328180D0 (en) 2003-12-04 2003-12-04 Combination
PCT/GB2004/005081 WO2005053699A1 (en) 2003-12-04 2004-12-03 Combination of a cdk inhibitor and cs-682 or a metabolite thereof

Publications (1)

Publication Number Publication Date
ATE504303T1 true ATE504303T1 (de) 2011-04-15

Family

ID=29764611

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04805910T ATE504303T1 (de) 2003-12-04 2004-12-03 Kombination aus roscovitine und cs-682 oder seinem metaboliten cndac

Country Status (10)

Country Link
US (1) US7772207B2 (de)
EP (1) EP1711185B1 (de)
JP (1) JP4778910B2 (de)
AT (1) ATE504303T1 (de)
DE (1) DE602004032178D1 (de)
DK (1) DK1711185T3 (de)
ES (1) ES2361550T3 (de)
GB (1) GB0328180D0 (de)
PT (1) PT1711185E (de)
WO (1) WO2005053699A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
US20050072118A1 (en) 2003-10-03 2005-04-07 Griggs Samuel D. Netting chutes with ribbed flooring for manual and/or automated clipping packaging apparatus
GB0226583D0 (en) * 2002-11-14 2002-12-18 Cyclacel Ltd Compounds
GB0229581D0 (en) * 2002-12-19 2003-01-22 Cyclacel Ltd Use
GB0523041D0 (en) * 2005-11-11 2005-12-21 Cyclacel Ltd Combination
GB0609530D0 (en) * 2006-05-12 2006-06-21 Cyclacel Ltd Combination
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US7863255B2 (en) * 2008-04-29 2011-01-04 Taiho Pharmaceutical Co., Ltd. Methods of administering antitumor agent comprising deoxycytidine derivative
NZ589719A (en) 2008-06-09 2012-08-31 Cyclacel Ltd Combinations of sapacitabine or cndac with dna methyltransferase inhibitors such as decitabine and procaine
WO2012140436A1 (en) 2011-04-14 2012-10-18 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
JP6286421B2 (ja) * 2012-05-15 2018-02-28 サイクラセル リミテッド サパシタビン及びセリシクリブの投与レジメン
CN117731786A (zh) 2013-07-12 2024-03-22 皮拉马尔企业有限公司 用于治疗黑素瘤的药物组合
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2079413C (en) * 1991-09-30 2003-09-09 Masakatsu Kaneko Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
CA2430376A1 (en) * 2000-12-08 2002-06-13 David J. Carini Semicarbazides and their uses as cyclin dependent kinase inhibitors
US6949558B2 (en) * 2001-11-07 2005-09-27 Yale University Enhancement of taxane-based chemotherapy by a CDK1 antagonist
WO2003077999A1 (en) * 2002-03-15 2003-09-25 Cyclacel Limited Combination ofa cdk inhibitor and 5-fu for the treatment of cancer
WO2003082337A1 (en) * 2002-03-27 2003-10-09 Cyclacel Limited Combination comprising a cdk inhibitor and doxorubicin

Also Published As

Publication number Publication date
EP1711185A1 (de) 2006-10-18
DE602004032178D1 (de) 2011-05-19
GB0328180D0 (en) 2004-01-07
US7772207B2 (en) 2010-08-10
US20070270442A1 (en) 2007-11-22
JP4778910B2 (ja) 2011-09-21
EP1711185B1 (de) 2011-04-06
DK1711185T3 (da) 2011-06-14
WO2005053699A1 (en) 2005-06-16
PT1711185E (pt) 2011-05-12
ES2361550T3 (es) 2011-06-20
JP2007513132A (ja) 2007-05-24

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