ES2357405T3 - Detección de antígenos. - Google Patents
Detección de antígenos. Download PDFInfo
- Publication number
- ES2357405T3 ES2357405T3 ES06726468T ES06726468T ES2357405T3 ES 2357405 T3 ES2357405 T3 ES 2357405T3 ES 06726468 T ES06726468 T ES 06726468T ES 06726468 T ES06726468 T ES 06726468T ES 2357405 T3 ES2357405 T3 ES 2357405T3
- Authority
- ES
- Spain
- Prior art keywords
- substrate
- red blood
- cells
- blood
- bound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000427 antigen Substances 0.000 title claims abstract description 37
- 108091007433 antigens Proteins 0.000 title claims abstract description 37
- 102000036639 antigens Human genes 0.000 title claims abstract description 37
- 238000001514 detection method Methods 0.000 title claims abstract description 17
- 210000004369 blood Anatomy 0.000 claims abstract description 72
- 239000008280 blood Substances 0.000 claims abstract description 72
- 238000000034 method Methods 0.000 claims abstract description 52
- 239000000758 substrate Substances 0.000 claims description 51
- 210000003743 erythrocyte Anatomy 0.000 claims description 47
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 19
- 239000010931 gold Substances 0.000 claims description 19
- 229910052737 gold Inorganic materials 0.000 claims description 19
- 239000011230 binding agent Substances 0.000 claims description 16
- 238000009739 binding Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 230000027455 binding Effects 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000010790 dilution Methods 0.000 claims description 5
- 239000012895 dilution Substances 0.000 claims description 5
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000000017 hydrogel Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000013545 self-assembled monolayer Substances 0.000 claims description 3
- JXUKBNICSRJFAP-UHFFFAOYSA-N triethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CCO[Si](OCC)(OCC)CCCOCC1CO1 JXUKBNICSRJFAP-UHFFFAOYSA-N 0.000 claims description 3
- ZPZDIFSPRVHGIF-UHFFFAOYSA-N 3-aminopropylsilicon Chemical compound NCCC[Si] ZPZDIFSPRVHGIF-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 2
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- 210000004027 cell Anatomy 0.000 abstract description 47
- 239000000523 sample Substances 0.000 description 22
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 230000005284 excitation Effects 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 210000004408 hybridoma Anatomy 0.000 description 5
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- 230000009257 reactivity Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000000862 absorption spectrum Methods 0.000 description 4
- 238000009582 blood typing Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 4
- 229910000077 silane Inorganic materials 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
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- 210000002966 serum Anatomy 0.000 description 3
- 238000000018 DNA microarray Methods 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 101710160107 Outer membrane protein A Proteins 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 108010026552 Proteome Proteins 0.000 description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
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- 239000003795 chemical substances by application Substances 0.000 description 2
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- 238000009295 crossflow filtration Methods 0.000 description 2
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- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
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- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
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- 239000002523 lectin Substances 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
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- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
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- 241000894006 Bacteria Species 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 101000642431 Homo sapiens Pre-mRNA-splicing factor SPF27 Proteins 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 102100036347 Pre-mRNA-splicing factor SPF27 Human genes 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 210000001616 monocyte Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
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- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0506183.3A GB0506183D0 (en) | 2005-03-24 | 2005-03-24 | Antigen detection |
| GB0506183 | 2005-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2357405T3 true ES2357405T3 (es) | 2011-04-26 |
Family
ID=34566514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06726468T Active ES2357405T3 (es) | 2005-03-24 | 2006-03-23 | Detección de antígenos. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8748355B2 (enExample) |
| EP (1) | EP1861719B1 (enExample) |
| JP (1) | JP4834075B2 (enExample) |
| AT (1) | ATE489632T1 (enExample) |
| AU (1) | AU2006226120B2 (enExample) |
| CA (1) | CA2602114C (enExample) |
| DE (1) | DE602006018432D1 (enExample) |
| ES (1) | ES2357405T3 (enExample) |
| GB (1) | GB0506183D0 (enExample) |
| WO (1) | WO2006100477A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0618496D0 (en) * | 2006-09-20 | 2006-11-01 | Common Services Agency | Blood typing |
| FR2917174B1 (fr) * | 2007-06-08 | 2021-02-12 | Bio Rad Pasteur | Analyse multiple d'echantillons sanguins |
| GB201014805D0 (en) * | 2010-09-07 | 2010-10-20 | Multi Sense Technologies Ltd | Microfluidics based assay device |
| GB201403115D0 (en) | 2014-02-21 | 2014-04-09 | Qbd Qs Ip Ltd | Red blood cell detection |
| JP6746059B2 (ja) | 2015-01-14 | 2020-08-26 | バイオ−ラッド ラボラトリーズ，インコーポレイティド | 血液分析の系および方法 |
| GB201611442D0 (en) | 2016-06-30 | 2016-08-17 | Lumiradx Tech Ltd | Fluid control |
| CN109804234B (zh) * | 2016-08-18 | 2023-03-17 | 皮瑞克生物医学有限公司 | 血液单元测试试剂盒 |
| FR3106900B1 (fr) * | 2020-02-04 | 2024-10-04 | Innobiochips | Procédé de capture et d’identification d’agglutinats cellulaires pour la détection d’anticorps anti-érythrocytaires multiplexe |
| CN113092793A (zh) * | 2021-04-16 | 2021-07-09 | 江苏力博医药生物技术股份有限公司 | 一种检测Rh血型抗原的方法、系统及其应用 |
| CN114354869A (zh) * | 2021-12-30 | 2022-04-15 | 杭州春来科技有限公司 | 水质监测分析系统及方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4368047A (en) * | 1981-04-27 | 1983-01-11 | University Of Utah Research Foundation | Process for conducting fluorescence immunoassays without added labels and employing attenuated internal reflection |
| DE8137962U1 (de) * | 1981-12-28 | 1982-06-16 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Mikrotiterplatte zur blutgruppendiagnostik |
| US5026905A (en) * | 1984-08-28 | 1991-06-25 | Syntex (U.S.A.) Inc. | Fluorescent dyes |
| EP0223978B1 (en) | 1985-10-11 | 1992-08-19 | Abbott Laboratories | Diagnostic test |
| US4851210A (en) * | 1986-05-22 | 1989-07-25 | Genelabs Incorporated | Blood typing device |
| US5338689A (en) * | 1987-08-24 | 1994-08-16 | Stiftung Fur Diagnostische Forschung | Method and card for detecting antigens and/or antibodies |
| US5585246A (en) * | 1993-02-17 | 1996-12-17 | Biometric Imaging, Inc. | Method for preparing a sample in a scan capillary for immunofluorescent interrogation |
| US5552064A (en) * | 1993-02-26 | 1996-09-03 | Ortho Diagnostic Systems, Inc. | Column agglutination assay and device using biphasic centrifugation |
| US6405074B1 (en) * | 1997-08-29 | 2002-06-11 | Bhaskar Banerjee | Detection of cancer using cellular autofluorescence |
| AU9477398A (en) * | 1997-09-10 | 1999-03-29 | Burnham Institute, The | Methods of identifying molecules that home to angiogenic vasculature in tumors |
| DE60141454D1 (de) * | 2000-03-14 | 2010-04-15 | Micronics Inc | Mikrofluid-analysekassette |
| US7264973B2 (en) * | 2000-10-30 | 2007-09-04 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant optical biosensor |
| US7026131B2 (en) * | 2000-11-17 | 2006-04-11 | Nagaoka & Co., Ltd. | Methods and apparatus for blood typing with optical bio-discs |
| DE60141171D1 (de) | 2000-11-27 | 2010-03-11 | Intelligent Medical Devices Ll | Klinische intelligente diagnostische vorrichtungen und verfahren |
| EP1360473B1 (en) | 2001-01-23 | 2009-04-15 | Dublin City University | A luminescence based sensor |
| GB0121700D0 (en) * | 2001-09-07 | 2001-10-31 | Univ Leicester | Detection of fluorescence |
| CA2459703A1 (en) | 2001-09-11 | 2003-03-20 | Dublin City University | A luminescence-based sensor assembly |
| WO2003043403A2 (en) * | 2001-11-19 | 2003-05-30 | Burstein Technologies, Inc. | Methods and apparatus for blood typing with optical bio-discs |
-
2005
- 2005-03-24 GB GBGB0506183.3A patent/GB0506183D0/en not_active Ceased
-
2006
- 2006-03-23 AT AT06726468T patent/ATE489632T1/de not_active IP Right Cessation
- 2006-03-23 DE DE602006018432T patent/DE602006018432D1/de active Active
- 2006-03-23 WO PCT/GB2006/001044 patent/WO2006100477A1/en not_active Ceased
- 2006-03-23 ES ES06726468T patent/ES2357405T3/es active Active
- 2006-03-23 US US11/886,245 patent/US8748355B2/en not_active Expired - Fee Related
- 2006-03-23 CA CA2602114A patent/CA2602114C/en not_active Expired - Fee Related
- 2006-03-23 EP EP06726468A patent/EP1861719B1/en not_active Not-in-force
- 2006-03-23 JP JP2008502470A patent/JP4834075B2/ja not_active Expired - Fee Related
- 2006-03-23 AU AU2006226120A patent/AU2006226120B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006226120B2 (en) | 2011-08-18 |
| GB0506183D0 (en) | 2005-05-04 |
| JP2008537105A (ja) | 2008-09-11 |
| EP1861719B1 (en) | 2010-11-24 |
| CA2602114A1 (en) | 2006-09-28 |
| ATE489632T1 (de) | 2010-12-15 |
| US8748355B2 (en) | 2014-06-10 |
| US20080318798A1 (en) | 2008-12-25 |
| EP1861719A1 (en) | 2007-12-05 |
| WO2006100477A1 (en) | 2006-09-28 |
| AU2006226120A1 (en) | 2006-09-28 |
| DE602006018432D1 (de) | 2011-01-05 |
| CA2602114C (en) | 2014-02-11 |
| JP4834075B2 (ja) | 2011-12-07 |
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