ES2347808T3 - Ciclopentanonas 2,3,4-sustituidas como agentes terapeuticos. - Google Patents
Ciclopentanonas 2,3,4-sustituidas como agentes terapeuticos. Download PDFInfo
- Publication number
- ES2347808T3 ES2347808T3 ES05852061T ES05852061T ES2347808T3 ES 2347808 T3 ES2347808 T3 ES 2347808T3 ES 05852061 T ES05852061 T ES 05852061T ES 05852061 T ES05852061 T ES 05852061T ES 2347808 T3 ES2347808 T3 ES 2347808T3
- Authority
- ES
- Spain
- Prior art keywords
- enyl
- oxo
- hydroxy
- cyclopentylsulfanyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 COC(CSCCCS[C@@]([C@](CC1)*=C[C@@](CCc2cc(cccc3)c3[s]2)O)C1=O)=O Chemical compound COC(CSCCCS[C@@]([C@](CC1)*=C[C@@](CCc2cc(cccc3)c3[s]2)O)C1=O)=O 0.000 description 5
- OFSGCVWFJWJQTF-KQKPCWFXSA-N CC(CC[C@@H](CCC1=O)[C@H]1SCCCSCC(OC)=O)(CCc1cc(cccc2)c2cc1)O Chemical compound CC(CC[C@@H](CCC1=O)[C@H]1SCCCSCC(OC)=O)(CCc1cc(cccc2)c2cc1)O OFSGCVWFJWJQTF-KQKPCWFXSA-N 0.000 description 1
- CATMQDBOEKESJG-WLHNNPSGSA-N CC(CCc1ccc(cccc2)c2c1)(/C=C/[C@@H]([C@@H](CC1=O)O)[C@H]1SCCCSCC(OC)=O)O Chemical compound CC(CCc1ccc(cccc2)c2c1)(/C=C/[C@@H]([C@@H](CC1=O)O)[C@H]1SCCCSCC(OC)=O)O CATMQDBOEKESJG-WLHNNPSGSA-N 0.000 description 1
- RJTJVVYSTUQWNI-UHFFFAOYSA-N CCc1cc2ccccc2cc1 Chemical compound CCc1cc2ccccc2cc1 RJTJVVYSTUQWNI-UHFFFAOYSA-N 0.000 description 1
- NUYKQQQYOFAPFF-FSZOWFHXSA-N COC(CSCCCS[C@H]([C@H]([C@H](CO)C1)/C=C/C(CCc2cc(cccc3)c3cc2)O)C1=O)=O Chemical compound COC(CSCCCS[C@H]([C@H]([C@H](CO)C1)/C=C/C(CCc2cc(cccc3)c3cc2)O)C1=O)=O NUYKQQQYOFAPFF-FSZOWFHXSA-N 0.000 description 1
- SZSMMBMLEOVHTG-RZAGOWLISA-N C[C@H](C[C@H](CCC(C)(CCc1cc(cccc2)c2cc1)O)[C@H]1SCCCSCC(O)=O)C1=O Chemical compound C[C@H](C[C@H](CCC(C)(CCc1cc(cccc2)c2cc1)O)[C@H]1SCCCSCC(O)=O)C1=O SZSMMBMLEOVHTG-RZAGOWLISA-N 0.000 description 1
- NEJZCHUWLJWBAF-TWGXDOSXSA-N OC(CCc1cc(cccc2)c2cc1)/C=C/[C@@H]([C@@H](CC1=O)/C=C/O)[C@H]1SCCCSCC(O)=O Chemical compound OC(CCc1cc(cccc2)c2cc1)/C=C/[C@@H]([C@@H](CC1=O)/C=C/O)[C@H]1SCCCSCC(O)=O NEJZCHUWLJWBAF-TWGXDOSXSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US997039 | 2004-11-23 | ||
| US10/997,039 US7183324B2 (en) | 2004-11-23 | 2004-11-23 | 2,3,4-substituted cyclopentanones as therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2347808T3 true ES2347808T3 (es) | 2010-11-04 |
| ES2347808T9 ES2347808T9 (es) | 2011-06-13 |
Family
ID=36087629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05852061T Expired - Lifetime ES2347808T3 (es) | 2004-11-23 | 2005-11-21 | Ciclopentanonas 2,3,4-sustituidas como agentes terapeuticos. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7183324B2 (https=) |
| EP (1) | EP1814848B9 (https=) |
| JP (1) | JP5114205B2 (https=) |
| AT (1) | ATE475643T1 (https=) |
| AU (1) | AU2005309605B2 (https=) |
| BR (1) | BRPI0518299A2 (https=) |
| CA (1) | CA2588599A1 (https=) |
| DE (1) | DE602005022613D1 (https=) |
| DK (1) | DK1814848T3 (https=) |
| ES (1) | ES2347808T3 (https=) |
| WO (1) | WO2006058063A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7872045B2 (en) | 2001-06-14 | 2011-01-18 | Allergan, Inc. | Combination therapy for glaucoma treatment |
| US20050222094A1 (en) * | 2001-06-14 | 2005-10-06 | Burk Robert M | Treatment of inflammatory bowel disease |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| TWI386208B (zh) * | 2005-04-18 | 2013-02-21 | Allergan Inc | 治療性的經取代環戊酮 |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| EP2147672A4 (en) | 2007-05-08 | 2011-11-02 | Nat University Corp Hamamatsu University School Of Medicine | CYTOTOXIC T CELL ACTIVATOR WITH AN EP4 AGONIST |
| US7781465B2 (en) * | 2007-08-21 | 2010-08-24 | Allergan, Inc. | Therapeutic oxazolidinones and thiazolidinones |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| WO2011047048A1 (en) | 2009-10-14 | 2011-04-21 | Gemmus Pharma, Inc. | Combination therapy treatment for viral infections |
| CN103167875A (zh) * | 2010-08-17 | 2013-06-19 | 阿勒根公司 | 用于治疗角膜浑浊的ep2或ep4激动剂 |
| KR102456567B1 (ko) | 2013-08-09 | 2022-10-19 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
| CN105682645B (zh) | 2013-10-31 | 2019-09-06 | 阿勒根公司 | 含前列腺酰胺的眼内植入物及其使用方法 |
| CN106928121B (zh) * | 2015-12-29 | 2020-05-12 | 暨南大学 | 3-取代-苯并五元杂环-2-羰基化合物的高效制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| DE2715838A1 (de) | 1977-04-05 | 1978-10-19 | Schering Ag | Neue prostanderivate und verfahren zu ihrer herstellung |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4131738A (en) | 1977-07-05 | 1978-12-26 | The Upjohn Company | 6-Hydroxy-PGE1 compounds |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US6043275A (en) | 1998-04-16 | 2000-03-28 | Ono Pharmaceutical Co., Ltd. | 3,7-dithiaprostanoic acid derivative |
| KR20010074981A (ko) | 1998-09-14 | 2001-08-09 | 우에노 도시오 | ω치환된 페닐프로스타그란딘 Ｅ 유도체 및 그 유도체를유효 성분으로 하는 약제 |
| OA12533A (en) | 2000-11-27 | 2006-06-05 | Pfizer Prod Inc | Ep4 receptor selective agonists in the treatment of osteoporosis. |
| US6410591B1 (en) | 2001-05-08 | 2002-06-25 | Allergan Sales, Inc. | 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| JP4520738B2 (ja) | 2001-06-14 | 2010-08-11 | アラーガン インコーポレイテッド | 眼圧降下剤としての３、７、または３および７チアまたはオキサプロスタン酸誘導体 |
| US20030027853A1 (en) | 2001-06-14 | 2003-02-06 | Allergan Sales, Inc. | 3, 7or3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| US7101906B2 (en) * | 2004-11-16 | 2006-09-05 | Allergan, Inc. | 2,3,4-substituted cyclopentanones as therapeutic agents |
-
2004
- 2004-11-23 US US10/997,039 patent/US7183324B2/en not_active Expired - Lifetime
-
2005
- 2005-11-21 CA CA002588599A patent/CA2588599A1/en not_active Abandoned
- 2005-11-21 EP EP05852061A patent/EP1814848B9/en not_active Expired - Lifetime
- 2005-11-21 WO PCT/US2005/042428 patent/WO2006058063A1/en not_active Ceased
- 2005-11-21 DK DK05852061.0T patent/DK1814848T3/da active
- 2005-11-21 BR BRPI0518299-9A patent/BRPI0518299A2/pt not_active Application Discontinuation
- 2005-11-21 JP JP2007543434A patent/JP5114205B2/ja not_active Expired - Fee Related
- 2005-11-21 AT AT05852061T patent/ATE475643T1/de not_active IP Right Cessation
- 2005-11-21 ES ES05852061T patent/ES2347808T3/es not_active Expired - Lifetime
- 2005-11-21 AU AU2005309605A patent/AU2005309605B2/en not_active Ceased
- 2005-11-21 DE DE602005022613T patent/DE602005022613D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005309605A1 (en) | 2006-06-01 |
| US7183324B2 (en) | 2007-02-27 |
| DK1814848T3 (da) | 2010-11-08 |
| ATE475643T1 (de) | 2010-08-15 |
| BRPI0518299A2 (pt) | 2008-11-11 |
| AU2005309605B2 (en) | 2012-08-23 |
| CA2588599A1 (en) | 2006-06-01 |
| JP5114205B2 (ja) | 2013-01-09 |
| DE602005022613D1 (en) | 2010-09-09 |
| US20060111430A1 (en) | 2006-05-25 |
| EP1814848A1 (en) | 2007-08-08 |
| EP1814848B1 (en) | 2010-07-28 |
| EP1814848B9 (en) | 2011-12-21 |
| WO2006058063A1 (en) | 2006-06-01 |
| ES2347808T9 (es) | 2011-06-13 |
| JP2008520737A (ja) | 2008-06-19 |
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