ES2343444T3 - Sales de benzodiazepina de actuacion corta y sus formas polimorficas. - Google Patents

Sales de benzodiazepina de actuacion corta y sus formas polimorficas. Download PDF

Info

Publication number
ES2343444T3
ES2343444T3 ES07733519T ES07733519T ES2343444T3 ES 2343444 T3 ES2343444 T3 ES 2343444T3 ES 07733519 T ES07733519 T ES 07733519T ES 07733519 T ES07733519 T ES 07733519T ES 2343444 T3 ES2343444 T3 ES 2343444T3
Authority
ES
Spain
Prior art keywords
salt
salt according
compound
formula
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07733519T
Other languages
English (en)
Spanish (es)
Inventor
Gary Stuart Tilbrook
Louisa Jane Quegan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paion UK Ltd
Original Assignee
Paion UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion UK Ltd filed Critical Paion UK Ltd
Application granted granted Critical
Publication of ES2343444T3 publication Critical patent/ES2343444T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES07733519T 2006-07-10 2007-07-10 Sales de benzodiazepina de actuacion corta y sus formas polimorficas. Active ES2343444T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0613693 2006-07-10
GBGB0613693.1A GB0613693D0 (en) 2006-07-10 2006-07-10 Benzodiazepine salts (3)

Publications (1)

Publication Number Publication Date
ES2343444T3 true ES2343444T3 (es) 2010-07-30

Family

ID=36926778

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07733519T Active ES2343444T3 (es) 2006-07-10 2007-07-10 Sales de benzodiazepina de actuacion corta y sus formas polimorficas.

Country Status (9)

Country Link
US (1) US8642588B2 (ja)
EP (1) EP2089378B1 (ja)
JP (1) JP5394238B2 (ja)
AT (1) ATE461927T1 (ja)
CA (1) CA2657369C (ja)
DE (1) DE602007005515D1 (ja)
ES (1) ES2343444T3 (ja)
GB (1) GB0613693D0 (ja)
WO (1) WO2008007081A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2081921T3 (pl) 2006-07-10 2011-03-31 Paion Uk Ltd Krótko działające sole benzodiazepiny i ich formy polimorficzne
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN102964349A (zh) * 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途
ES2651389T3 (es) * 2012-05-22 2018-01-26 Paion Uk Limited Composiciones que comprenden benzodiazepinas de acción corta
SG11201501358SA (en) 2012-08-31 2015-04-29 Paion Uk Ltd Method for administering hypnotic/sedative agent
AR094963A1 (es) * 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CN103232454A (zh) * 2013-05-05 2013-08-07 王元青 治疗精神疾病的药物
CN104146970A (zh) * 2013-05-05 2014-11-19 王元青 治疗精神疾病的冻干粉针剂
CN103230595B (zh) * 2013-05-05 2014-10-08 李友香 治疗精神疾病的组合物
CN103202815B (zh) * 2013-05-05 2014-09-24 李友香 治疗精神疾病的注射剂
CN106632342B (zh) * 2015-08-07 2019-01-25 成都倍特药业有限公司 苯并二氮杂*衍生物的2-萘磺酸盐及晶型和它们的制备方法
BR112018071082A2 (pt) 2016-04-14 2019-02-05 Paion Uk Ltd benzodiazepinas nasais e inaladas oralmente
CN108503644B (zh) * 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933794A (en) 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4724237A (en) 1984-06-26 1988-02-09 Merck & Co., Inc. 2-substituted-aminomethyl-1,4-benzodiazepines
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
AU678503B2 (en) 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
US5834464A (en) 1994-11-18 1998-11-10 Merck & Co., Inc. Imidazolinobenzodiazepines
DE59607274D1 (de) 1995-01-06 2001-08-16 Hoffmann La Roche Hydroxymethyl-imidazodiazepine und deren ester
WO1996023790A1 (de) 1995-02-02 1996-08-08 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepine
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
SI21850A (sl) 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
PL2081921T3 (pl) 2006-07-10 2011-03-31 Paion Uk Ltd Krótko działające sole benzodiazepiny i ich formy polimorficzne

Also Published As

Publication number Publication date
US20100075955A1 (en) 2010-03-25
GB0613693D0 (en) 2006-08-16
EP2089378A1 (en) 2009-08-19
ATE461927T1 (de) 2010-04-15
WO2008007081A1 (en) 2008-01-17
CA2657369C (en) 2014-12-09
CA2657369A1 (en) 2008-01-17
EP2089378B1 (en) 2010-03-24
JP2009542787A (ja) 2009-12-03
JP5394238B2 (ja) 2014-01-22
US8642588B2 (en) 2014-02-04
DE602007005515D1 (de) 2010-05-06

Similar Documents

Publication Publication Date Title
ES2343444T3 (es) Sales de benzodiazepina de actuacion corta y sus formas polimorficas.
ES2352360T3 (es) Sales de benzodiazepina de actuación corta y sus formas polimórficas.
ES2705063T3 (es) Un cristal que comprende una sal de ácido L-málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida para su uso como un medicamento
US20210261556A1 (en) Short-acting benzodiazepine salts and their polymorphic forms
ES2552386T3 (es) Composiciones de {3-[5-(4-cloro-fenil)-1H-pirrol[2,3-b]piridin-3-carbonil]-2,4-difluoro-fenil}-amida del ácido propano-1-sulfónico y usos de las mismas
AU2008334924A1 (en) Solid forms of Tenofovir disoproxil
AU2021203085B2 (en) Crystalline forms of quinolone analogs and their salts
US9957282B2 (en) Crystalline forms of quinolone analogs and their salts
ES2766324T3 (es) Formas salinas de Alfa-TEA: composiciones y usos para tratar enfermedades
CA3125909C (en) Crystalline forms of neurotrophin mimetic compounds and their salts
AU2015312828B2 (en) Salt of cephalosporin derivative, crystalline solid form of same and method for producing same
JP2015535842A (ja) ニューロトロフィン模倣化合物の結晶形及びその塩
JP2013529224A (ja) 結晶性エザチオスタット塩酸塩非溶媒和物
CN108948018B (zh) 苯并二氮*衍生物及其盐和相关晶体形式、制备方法和用途
CN114853762A (zh) 一种咪唑并三嗪类化合物的固体形式及其制备方法和用途
ES2666335T3 (es) Forma polimórfica de Icotinib y usos de la misma
RU2802964C2 (ru) Твердые формы 2-(5-(4-(2-морфолиноэтокси)фенил)пиридин-2-ил)-n-бензилацетамида
CN107446015B (zh) 香豆素衍生物及其制备方法和用途
ES2389589T3 (es) Sal de fumarato de 1,4-diazabiciclo[3.2.2]nonano-4-carboxilato de 4-bromefelino, sus formas cristalinas, su preparación y su utilización en terapéutica
ES2204306B1 (es) Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen.
ES2656699T3 (es) Formas polimorfas de maleato de Icotinib y utilizaciones de las mismas