ES2337435B8 - Compuestos potenciadores de la actividad de glicosidasas mutantes. - Google Patents
Compuestos potenciadores de la actividad de glicosidasas mutantes. Download PDFInfo
- Publication number
- ES2337435B8 ES2337435B8 ES200802988A ES200802988A ES2337435B8 ES 2337435 B8 ES2337435 B8 ES 2337435B8 ES 200802988 A ES200802988 A ES 200802988A ES 200802988 A ES200802988 A ES 200802988A ES 2337435 B8 ES2337435 B8 ES 2337435B8
- Authority
- ES
- Spain
- Prior art keywords
- activity
- mutant
- glycosidases
- compounds
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000694 effects Effects 0.000 title abstract 4
- 102000005744 Glycoside Hydrolases Human genes 0.000 title abstract 3
- 108010031186 Glycoside Hydrolases Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000003389 potentiating effect Effects 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 102000004547 Glucosylceramidase Human genes 0.000 abstract 1
- 108010017544 Glucosylceramidase Proteins 0.000 abstract 1
- 208000015439 Lysosomal storage disease Diseases 0.000 abstract 1
- 108010006519 Molecular Chaperones Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 102000005936 beta-Galactosidase Human genes 0.000 abstract 1
- 108010005774 beta-Galactosidase Proteins 0.000 abstract 1
- 102000006995 beta-Glucosidase Human genes 0.000 abstract 1
- 108010047754 beta-Glucosidase Proteins 0.000 abstract 1
- 230000002860 competitive effect Effects 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Compuestos potenciadores de la actividad de
glicosidasas mutantes, con actividad inhibidoras de enzimas
glicosidasas y también se refiere a un procedimiento para la
activación de \beta-glucosidasa mutante
(\beta-glucocerebrosidasa) y
\beta-galactosidasa mutante en pacientes que
padecen trastornos de almacenamiento lisosómico mediante la
administración de dichos compuestos inhibidores competitivos de las
enzimas, caracterizados por una especificidad de unión muy alta y
una relación favorable entre su concentración para actividad de
chaperona farmacológica y su concentración para actividad
inhibidora.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200802988A ES2337435B8 (es) | 2008-10-22 | 2008-10-22 | Compuestos potenciadores de la actividad de glicosidasas mutantes. |
PCT/ES2009/070449 WO2010046517A1 (es) | 2008-10-22 | 2009-10-21 | Compuestos potenciadores de la actividad de glicosidasas mutantes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200802988A ES2337435B8 (es) | 2008-10-22 | 2008-10-22 | Compuestos potenciadores de la actividad de glicosidasas mutantes. |
Publications (3)
Publication Number | Publication Date |
---|---|
ES2337435A1 ES2337435A1 (es) | 2010-04-23 |
ES2337435B2 ES2337435B2 (es) | 2011-01-25 |
ES2337435B8 true ES2337435B8 (es) | 2011-07-19 |
Family
ID=42082773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200802988A Expired - Fee Related ES2337435B8 (es) | 2008-10-22 | 2008-10-22 | Compuestos potenciadores de la actividad de glicosidasas mutantes. |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2337435B8 (es) |
WO (1) | WO2010046517A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2370852B1 (es) * | 2010-06-04 | 2012-10-30 | Consejo Superior De Investigaciones Científicas (Csic) | Derivados sp2, imnoazúcar como inhibidores de las alfa-glicosidasas. |
WO2016120808A1 (en) | 2015-01-28 | 2016-08-04 | Minoryx Therapeutics S.L. | Heteroarylaminoisoquinolines, methods for their preparation and therapeutic uses thereof |
BR112019013593A2 (pt) | 2016-12-28 | 2020-01-07 | Minoryx Therapeutics S.L. | Compostos de isoquinolina, métodos para sua preparação, e usos terapêuticos dos mesmos em afecções associadas à alteração da atividade de beta galactosidase |
WO2020023390A1 (en) | 2018-07-25 | 2020-01-30 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
CN111006928B (zh) * | 2019-12-26 | 2023-08-08 | 武汉三鹰生物技术有限公司 | 一种应用于免疫组织化学的封闭液及其使用方法 |
US20230391796A1 (en) * | 2020-09-25 | 2023-12-07 | Universidad De Sevilla (Us) -University Of Seville (Us) | Glycosidase inhibitors and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3722827A1 (de) * | 1987-07-07 | 1989-01-19 | Schering Ag | Anellierte imino-azole und imino-azine, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung |
DE4002366A1 (de) * | 1990-01-25 | 1991-08-01 | Schering Ag | Verfahren und zwischenprodukte zur herstellung von anellierten iminothiazolen |
-
2008
- 2008-10-22 ES ES200802988A patent/ES2337435B8/es not_active Expired - Fee Related
-
2009
- 2009-10-21 WO PCT/ES2009/070449 patent/WO2010046517A1/es active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ES2337435A1 (es) | 2010-04-23 |
ES2337435B2 (es) | 2011-01-25 |
WO2010046517A1 (es) | 2010-04-29 |
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