ES2335664T3 - Derivados de 8-aza-biciclo(3.2.1)octano y su uso como inhibidores de la reabsorcion de neurotransmisores de monoaminas. - Google Patents
Derivados de 8-aza-biciclo(3.2.1)octano y su uso como inhibidores de la reabsorcion de neurotransmisores de monoaminas. Download PDFInfo
- Publication number
- ES2335664T3 ES2335664T3 ES04709633T ES04709633T ES2335664T3 ES 2335664 T3 ES2335664 T3 ES 2335664T3 ES 04709633 T ES04709633 T ES 04709633T ES 04709633 T ES04709633 T ES 04709633T ES 2335664 T3 ES2335664 T3 ES 2335664T3
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- Prior art keywords
- aza
- bicyclo
- octane
- methyl
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
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- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 210000003568 synaptosome Anatomy 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Child & Adolescent Psychology (AREA)
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- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK200300213 | 2003-02-12 | ||
| DKPA200300213 | 2003-02-12 | ||
| US44810603P | 2003-02-20 | 2003-02-20 | |
| US448106P | 2003-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2335664T3 true ES2335664T3 (es) | 2010-03-31 |
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| JP (1) | JP2006517568A (enExample) |
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| MX (1) | MXPA05008314A (enExample) |
| NZ (1) | NZ541249A (enExample) |
| WO (1) | WO2004072071A1 (enExample) |
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| JP2005500371A (ja) * | 2001-08-08 | 2005-01-06 | ニューロサーチ、アクティーゼルスカブ | 置換されたアミン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| EP1779851A1 (en) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
| JP5194607B2 (ja) * | 2006-07-26 | 2013-05-08 | 大正製薬株式会社 | ソーシャルインターラクションの低下予防・改善剤 |
| DE102007046887A1 (de) | 2007-09-28 | 2009-04-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von (1R,5S)-Anhydroecgoninestersalzen |
| WO2009065845A1 (en) * | 2007-11-20 | 2009-05-28 | Neurosearch A/S | A method for treating over-eating disorders |
| US8101642B2 (en) | 2008-06-05 | 2012-01-24 | Sk Biopharmaceuticals Co., Ltd. | 3-substituted propanamine compounds |
| US8546576B2 (en) | 2008-06-06 | 2013-10-01 | Sk Biopharmaceuticals Co., Ltd. | 3 or 4-substituted piperidine compounds |
| WO2010086612A1 (en) | 2009-01-29 | 2010-08-05 | Cambrex Karlskoga Ab | Process for preparing enantiomerically enriched alkaloids |
| US9637470B2 (en) | 2013-02-22 | 2017-05-02 | Baylor College Of Medicine | Treatment for substance use disorders and stress disorders |
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| NZ241481A (en) * | 1991-02-04 | 1994-06-27 | Hoechst Roussel Pharma | Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| TR199800780T2 (xx) | 1995-11-02 | 1998-07-21 | Neurosearch A/S | Kayna�m�� tropan t�revleri, haz�rlan��lar� ve kullan�mlar�. |
| ZA971525B (en) | 1996-02-22 | 1997-10-21 | Neurosearch As | Tropane derivatives, their preparation and use. |
| WO1999065492A1 (en) * | 1998-06-19 | 1999-12-23 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| EP1358177B1 (en) * | 2000-10-13 | 2006-08-02 | NeuroSearch A/S | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
| WO2002076440A2 (en) * | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| EP1406900B1 (en) * | 2001-07-06 | 2006-10-04 | Neurosearch A/S | Novel compounds, their preparation and use |
| JP2005500371A (ja) * | 2001-08-08 | 2005-01-06 | ニューロサーチ、アクティーゼルスカブ | 置換されたアミン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
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Also Published As
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| NZ541249A (en) | 2008-04-30 |
| AU2004212166A1 (en) | 2004-08-26 |
| DK1594868T3 (da) | 2010-03-15 |
| US7247643B2 (en) | 2007-07-24 |
| MXPA05008314A (es) | 2005-10-05 |
| DE602004024033D1 (de) | 2009-12-24 |
| CA2515584A1 (en) | 2004-08-26 |
| AU2004212166B2 (en) | 2010-07-29 |
| EP1594868B1 (en) | 2009-11-11 |
| ATE448223T1 (de) | 2009-11-15 |
| JP2006517568A (ja) | 2006-07-27 |
| EP1594868A1 (en) | 2005-11-16 |
| WO2004072071A1 (en) | 2004-08-26 |
| US20060122218A1 (en) | 2006-06-08 |
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