CA2515584A1 - 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors - Google Patents
8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors Download PDFInfo
- Publication number
- CA2515584A1 CA2515584A1 CA002515584A CA2515584A CA2515584A1 CA 2515584 A1 CA2515584 A1 CA 2515584A1 CA 002515584 A CA002515584 A CA 002515584A CA 2515584 A CA2515584 A CA 2515584A CA 2515584 A1 CA2515584 A1 CA 2515584A1
- Authority
- CA
- Canada
- Prior art keywords
- aza
- bicyclo
- octane
- methyl
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 230000001561 neurotransmitter reuptake Effects 0.000 title claims abstract description 11
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- -1 hydroxy, amino Chemical group 0.000 claims description 70
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- 125000001424 substituent group Chemical group 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 7
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- 230000009870 specific binding Effects 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 150000004685 tetrahydrates Chemical class 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
- 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
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- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300213 | 2003-02-12 | ||
| DKPA200300213 | 2003-02-12 | ||
| US44810603P | 2003-02-20 | 2003-02-20 | |
| US60/448,106 | 2003-02-20 | ||
| PCT/EP2004/050107 WO2004072071A1 (en) | 2003-02-12 | 2004-02-10 | 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2515584A1 true CA2515584A1 (en) | 2004-08-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002515584A Abandoned CA2515584A1 (en) | 2003-02-12 | 2004-02-10 | 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
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| Country | Link |
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| EP (1) | EP1594868B1 (enExample) |
| JP (1) | JP2006517568A (enExample) |
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| CA (1) | CA2515584A1 (enExample) |
| DE (1) | DE602004024033D1 (enExample) |
| DK (1) | DK1594868T3 (enExample) |
| ES (1) | ES2335664T3 (enExample) |
| MX (1) | MXPA05008314A (enExample) |
| NZ (1) | NZ541249A (enExample) |
| WO (1) | WO2004072071A1 (enExample) |
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| JP2005500371A (ja) * | 2001-08-08 | 2005-01-06 | ニューロサーチ、アクティーゼルスカブ | 置換されたアミン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| EP1779851A1 (en) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
| JP5194607B2 (ja) * | 2006-07-26 | 2013-05-08 | 大正製薬株式会社 | ソーシャルインターラクションの低下予防・改善剤 |
| DE102007046887A1 (de) | 2007-09-28 | 2009-04-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von (1R,5S)-Anhydroecgoninestersalzen |
| WO2009065845A1 (en) * | 2007-11-20 | 2009-05-28 | Neurosearch A/S | A method for treating over-eating disorders |
| US8101642B2 (en) | 2008-06-05 | 2012-01-24 | Sk Biopharmaceuticals Co., Ltd. | 3-substituted propanamine compounds |
| US8546576B2 (en) | 2008-06-06 | 2013-10-01 | Sk Biopharmaceuticals Co., Ltd. | 3 or 4-substituted piperidine compounds |
| WO2010086612A1 (en) | 2009-01-29 | 2010-08-05 | Cambrex Karlskoga Ab | Process for preparing enantiomerically enriched alkaloids |
| US9637470B2 (en) | 2013-02-22 | 2017-05-02 | Baylor College Of Medicine | Treatment for substance use disorders and stress disorders |
Family Cites Families (10)
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| NZ241481A (en) * | 1991-02-04 | 1994-06-27 | Hoechst Roussel Pharma | Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| TR199800780T2 (xx) | 1995-11-02 | 1998-07-21 | Neurosearch A/S | Kayna�m�� tropan t�revleri, haz�rlan��lar� ve kullan�mlar�. |
| ZA971525B (en) | 1996-02-22 | 1997-10-21 | Neurosearch As | Tropane derivatives, their preparation and use. |
| WO1999065492A1 (en) * | 1998-06-19 | 1999-12-23 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| EP1358177B1 (en) * | 2000-10-13 | 2006-08-02 | NeuroSearch A/S | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
| WO2002076440A2 (en) * | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| EP1406900B1 (en) * | 2001-07-06 | 2006-10-04 | Neurosearch A/S | Novel compounds, their preparation and use |
| JP2005500371A (ja) * | 2001-08-08 | 2005-01-06 | ニューロサーチ、アクティーゼルスカブ | 置換されたアミン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
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- 2004-02-10 JP JP2006502018A patent/JP2006517568A/ja not_active Ceased
Also Published As
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| NZ541249A (en) | 2008-04-30 |
| AU2004212166A1 (en) | 2004-08-26 |
| DK1594868T3 (da) | 2010-03-15 |
| US7247643B2 (en) | 2007-07-24 |
| MXPA05008314A (es) | 2005-10-05 |
| DE602004024033D1 (de) | 2009-12-24 |
| AU2004212166B2 (en) | 2010-07-29 |
| EP1594868B1 (en) | 2009-11-11 |
| ES2335664T3 (es) | 2010-03-31 |
| ATE448223T1 (de) | 2009-11-15 |
| JP2006517568A (ja) | 2006-07-27 |
| EP1594868A1 (en) | 2005-11-16 |
| WO2004072071A1 (en) | 2004-08-26 |
| US20060122218A1 (en) | 2006-06-08 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20120613 |