ES2333804T3 - Peptidos asociados a tumor unidos a moleculas mhc. - Google Patents
Peptidos asociados a tumor unidos a moleculas mhc. Download PDFInfo
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- ES2333804T3 ES2333804T3 ES05752606T ES05752606T ES2333804T3 ES 2333804 T3 ES2333804 T3 ES 2333804T3 ES 05752606 T ES05752606 T ES 05752606T ES 05752606 T ES05752606 T ES 05752606T ES 2333804 T3 ES2333804 T3 ES 2333804T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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Abstract
Un péptido asociado a tumor con una secuencia de aminoácidos compuesto por la secuencia SEQ ID n.º 448 en el protocolo de secuencias adjunto, en donde el péptido muestra la capacidad de unirse a una molécula del complejo mayor de histocompatibilidad (MHC) humano de clase I.
Description
\global\parskip0.930000\baselineskip
Péptidos asociados a tumor unidos a moléculas
MHC.
La presente invención se refiere a péptidos
asociados a tumor con la capacidad de unirse a una molécula del
complejo mayor de histocompatibilidad (MHC) humano de clase I.
Los péptidos de este tipo son utilizados, por
ejemplo, en la inmunoterapia de las enfermedades tumorales.
La identificación de antígenos asociados a
tumores (TAA) mediante componentes del sistema inmune desempeña un
papel fundamental en la destrucción de células tumorales por parte
del sistema inmune. Este mecanismo se basa en la condición de que
entre las células tumorales y las células normales existen
diferencias cualitativas o cuantitativas. Para desencadenar una
respuesta antitumoral, las células tumorales deben expresar a los
antígenos, lo cual provoca una respuesta inmunológica suficiente
para la destrucción del tumor.
Los linfocitos T citotóxicos que expresan la
molécula CD8 (en adelante, CTL) tienen un papel importante en el
rechazo a tumores. Para que se desencadene una reacción inmune de
este tipo a través de los linfocitos T citotóxicos, deben
presentarse proteínas o péptidos foráneos ante los linfocitos T. Los
linfocitos T sólo reconocen a los antígenos como fragmentos de
péptidos cuando éstos son presentados por moléculas MHC en la
superficie de la célula. Estas moléculas MHC (Major
Histocompatibility Complex) son receptoras de péptidos que,
normalmente, los unen dentro de la célula para transportarlos a la
superficie de la célula. Este complejo formado por péptidos y
moléculas MHC es reconocido por los linfocitos T. Las moléculas MHC
del ser humano también se conocen como "antígenos de leucocito
humano" (HLA).
Existen dos clases de moléculas MHC: Las
moléculas MHC de clase I, que aparecen en la mayoría de células con
núcleo, presentan péptidos producidos por degradación proteolítica
de proteínas endógenas. Las moléculas MHC de clase II sólo aparecen
en células especializadas presentadoras de antígenos (APC) y
presentan péptidos de proteínas exógenas que, en el transcurso de
la endocitosis, son absorbidos y transformados por las APC. Los
complejos formados por péptido y MHC de clase I son reconocidos por
linfocitos T CD8^{+} citotóxicos; los complejos formados por
péptido y MHC de clase II son reconocidos por linfocitos T
colaboradores CD4.
Para que un péptido pueda desencadenar una
respuesta celular inmune, debe estar unido a una molécula MHC. Este
proceso depende del alelo de la molécula MHC y de la secuencia de
aminoácidos del péptido. Los péptidos unidos a moléculas MHC de
clase I suelen tener de 8 a 10 residuos y contienen en su secuencia
dos residuos conservados (Anchor), que interactúan con el
surco de unión correspondiente de la molécula MHC.
Para que el sistema inmune pueda desencadenar
una respuesta efectiva de CTL contra los péptidos derivados de
tumor, es necesario que dichos péptidos, además de poder unirse a
las moléculas MHC de clase I expresadas por las células tumorales,
también sean reconocidos por linfocitos T con receptores específicos
de linfocitos T (TCR, T-cell receptor).
El objetivo principal para el desarrollo de una
vacuna antitumoral es la identificación y caracterización de
antígenos asociados a tumores que son reconocidos por CTL
CD8^{+}.
Los antígenos que son reconocidos por linfocitos
T citotóxicos específicos de tumores o sus epítopos pueden ser
moléculas de cualquier clase de proteína como, por ejemplo, encimas,
receptores, factores de transcripción, etc. Otra clase importante
de antígenos asociados a tumores son las estructuras específicas de
tejidos como, por ejemplo, los antígenos CT (cancer testis),
expresados en distintos tipos de tumor y en tejido sano de los
testículos.
Para que las proteínas sean reconocidas por los
linfocitos T citotóxicos como antígenos específicos de tumores y,
por lo tanto, puedan ser aplicadas como tratamiento, deben cumplirse
determinadas condiciones: el antígeno debe estar expresado
fundamentalmente por células tumorales, no por tejido normal o, si
éste lo expresa, debe ser en cantidades inferiores a las de los
tumores. En caso de que el antígeno en cuestión no sólo se exprese
en un tipo de tumor, sino en varios, también es deseable que lo haga
en concentraciones altas. También es esencial la presencia de
epítopos en la secuencia de aminoácidos del antígeno, ya que dichos
péptidos derivados de un antígeno asociado a un tumor ("péptidos
inmunógenos") desencadenan una respuesta de linfocitos T, ya sea
in vitro o in vivo.
Los antígenos asociados a tumores (TAA)
representan, por tanto, el punto de partida para el desarrollo de
una vacuna antitumoral. Los métodos para la identificación y
caracterización de los TAA se basan en la acción de los CTL ya
inducidos en el paciente o en la creación de perfiles de
transcripción diferenciados entre tumores y tejidos normales.
El hallazgo de genes sobreexpresados en tejidos
tumorales o en líneas celulares tumorales humanas, o expresados de
manera selectiva en dichos tejidos o líneas celulares no
proporciona, sin embargo, información precisa sobre la acción de
los antígenos transcritos por estos genes en la inmunoterapia. La
causa de ello es que sólo los péptidos aislados de estos antígenos
son aptos para una acción de ese tipo, ya que sólo los epítopos de
los antígenos -no todo el antígeno- son capaces de provocar una
respuesta de linfocitos T mediante la presentación de MHC. Por eso
es importante seleccionar péptidos de proteínas sobreexpresadas o
expresadas de manera selectiva, presentados con moléculas MHC y así
obtener blancos para el reconocimiento específico de células
primarias o de líneas celulares tumorales de células primarias de
tejido tumoral mediante linfocitos T citotóxicos.
Flad y col. (Direct identification of Major
Histocompatibility Complex Class I-bound
tumor-associated peptide antigens of a renal
carcinoma cell line by a novel mass spectrometric method,
"Cancer Research", Bd. 58, Nr. 24, 15. diciembre de 1998,
páginas 5803-5811) hace referencia a sustancias y
procedimientos para la regulación de genes en una célula,
\hbox{relacionados especialmente con enfermedades y, por tanto,
con un objeto distinto al de la presente invención.}
El documento US 2003-113733
describe la identificación de péptidos ligados a MHC de clase I en
una línea celular RCC. Se aislaron 19 péptidos (véase la tabla de
la página 5807), pero no el presente en la SEQ ID n.º 448, de lo
que se infiere que este péptido no se pudo aislar en dicho
experimento. Además, no todos los péptidos están
"confirmados", sino que se diferencian en sus actividades. En
este sentido, es sorprendente que precisamente el péptido de la SEQ
ID n.º 448 muestra efectos.
Furuya Mitsuko y col. (Expression of
regulator of G protein signalling protein 5 (RGS5) in the tumour
vasculature of human renal cell carcinoma, "Journal of
Pathology", Bd. 203, n.º 1, 18. febrero de 2004
(2004-02-18), páginas
551-558) describen una modificación en la expresión
del RGS5 en la vasculatura del carcinoma humano de células
renales.
El número de registro AB008109 de la base de
datos EMBL, del 14 de abril de 2005 (Seki N y col.) describe la
secuencia humana completa de RNAm para el RGS5. Sin embargo, no se
revelaron segmentos de ácidos nucleicos del gen conforme a la
presente invención y sus aplicaciones.
Ante estos antecedentes, el objetivo de la
presente invención es facilitar al menos una nueva secuencia de
aminoácidos para un péptido con la capacidad de unirse a una
molécula de complejo mayor de histocompatibilidad (MHC) humano de
clase I.
Este objetivo se alcanza conforme a la presente
invención mediante la preparación de un péptido asociado a tumor
con una secuencia de aminoácidos compuesto por la secuencia SEQ ID
n.º 448 en el protocolo de secuencias adjunto, en donde el péptido
muestra la capacidad de unirse a una molécula del complejo mayor de
histocompatibilidad (MHC) humano de clase I.
De esta forma, se alcanza el objetivo que sirve
de base para la presente invención.
Con ello se entiende que el péptido identificado
por el tumor es sintetizado para obtener mayores cantidades y para
su aplicación para el fin descrito más abajo, o transportado en
células para su expresión.
Los inventores pudieron aislar e identificar el
péptido mencionado como ligando específico de moléculas MHC de
clase I a partir de tejido tumoral. Se denominan péptidos
"asociados a tumores" a aquellos aislados e identificados a
partir de material tumoral. Estos péptidos, que son presentados en
tumores auténticos (primarios) están sujetos al procesamiento de
antígenos en una célula tumoral.
El ligando específico se puede aplicar en la
terapia contra el cáncer; por ejemplo para inducir una respuesta
inmune contra células tumorales que expresa el antígeno del que
procede el péptido.
Dicha respuesta inmune en forma de una inducción
de CTL se puede obtener in vivo. Para ello, se administra el
péptido por ejemplo en forma de composición
\hbox{farmacéutica
a un paciente con una enfermedad tumoral asociada a TAA.}
Por otro lado, también se puede desencadenar una
respuesta CTL ex vivo en un tumor que expresa el antígeno
del que procede el péptido. Para ello se incuban las células
precursoras de CTL junto con células presentadoras de antígenos y
el péptido. Finalmente,
\hbox{se cultivan los CTL así
estimulados y se administran al paciente estos CTL
activados.}
También existe la posibilidad de cargar ex
vivo las APC con el péptido y administrar al paciente estas APC
cargadas. El antígeno se expresa en el tejido tumoral del que
procede el péptido. Las APC pueden entonces presentar a los CTL el
péptido y activarlos.
El péptido conforme a la invención también puede
ser aplicado como reactivo diagnóstico.
De esta forma, con el péptido se puede saber si
en una población de CTL existen CTL dirigidos específicamente
contra un péptido o si fueron inducidos por terapia.
Además, con el péptido también se puede
comprobar el aumento de linfocitos T precursores que muestran una
reactividad contra el péptido definido.
Además, el péptido puede ser utilizado como
marcador para seguir el desarrollo de un tumor que expresa el
antígeno des que procede el péptido.
En la tabla 1 adjunta se presentan los péptidos
identificados. En la tabla también se indican las proteínas de las
que proceden los péptidos y las correspondientes posiciones del
péptido en las respectivas proteínas, denominadas o abreviadas
según la simbología aceptada del HUGO Gene Nomenclature
Committee (http://www.gene.ucl.ac.uk/
nomenclature o http://www.ncbi.nlm.nih.gov/LocusLink/). Se mantienen los nombres en inglés de las proteínas, con el fin de evitar traducciones confusas. También se dan los números de registro de la base de datos Genbank del "National Center for Biotechnology Information" del Instituto Nacional de Salud (véase http:\\www.ncbi.nlm.nih.gov).
nomenclature o http://www.ncbi.nlm.nih.gov/LocusLink/). Se mantienen los nombres en inglés de las proteínas, con el fin de evitar traducciones confusas. También se dan los números de registro de la base de datos Genbank del "National Center for Biotechnology Information" del Instituto Nacional de Salud (véase http:\\www.ncbi.nlm.nih.gov).
\newpage
\global\parskip1.000000\baselineskip
Los inventores pudieron aislar los péptidos (o
ligandos) de 8 tumores de células renales y 2 glioblastomas de un
total de 10 pacientes, RCC75, RCC98, RCC100, RCC103, RCC112, RCC115,
RCC116, RCC130 y NCH359, así como NCH361, y de una línea celular de
tumor (J-Y).
Se pudieron identificar 577 ligandos de los
tumores de los pacientes y de la línea celular J-Y,
los cuales tenían relación con los subtipos de HLA A*03, B*07, B*40
(RCC75), A*01, A*03, B*07, B*18 (RCC98), A*02, A*03, B*07, B*18
(RCC100), A*11, A*25, B*15, B*44 (RCC103), A*01, A*31, B*08, B*27
(RCC112), A*02, A*03, B*15, B*18 (RCC115), A*01, A*02, B*27, B*37
(RCC116), A*02, A*24, B*07, B*44 (RCC130), A*03, A*32, B*07, B*35
(NCH359), A*26, B*38 (NCH361) y A*02, B*07
(J-Y).
Algunos de los ligandos provienen de genes de
mantenimiento fuertemente expresados, que en la mayoría de los
tejidos son expresados de forma regular, aunque muchos se distinguen
por su expresión específica de tejido y de tumor.
De esta forma, se pudieron identificar algunos
péptidos procedentes de proteínas, sobreexpresadas en tejido
tumoral. Así, se pudieron identificar, por ejemplo, fragmentos de
Tenascina-C (GLAPSIRTK, SEQ ID n.º 2;).
(Herold-Mende y col,
Clinical Impact and Functional Aspects of
Tenascin-C Expression during Glioma Progression,
2002, "Int. J. Cancer", 98: 362-369)
Los inventores también pudieron identificar,
entre otros, ligandos procedentes de SOX9, (YPHLHNAEL, SEQ ID n.º
7) y RGS5 (LAALPHSCL, SEQ ID n.º 448).
Debido a que las células tumorales primarias no
son adecuadas para el cultivo in vitro, los inventores
escogieron como ejemplo una línea celular tumoral humana para
demostrar de forma adicional que, conforme a la invención, los
péptidos identificados en esta línea celular son adecuados para
activar in vitro linfocitos T citotóxicos. Especialmente,
los inventores pudieron mostrar que, mediante la utilización de un
péptido seleccionado de ejemplo de la línea celular tumoral JY, era
posible generar in vitro linfocitos T citotóxicos (CTL)
específicos para el péptido seleccionado con la secuencia FPSLREAAL
(MAGEA1, posición 294-302) y la SEQ ID n.º 114 y el
alelo HLA B*0702. Con estos CTL pudieron destruirse de forma precisa
células diana KM22, que habían sido cargadas con el péptido con la
secuencia SEQ ID n.º 114. Sin embargo, las células diana KM22
utilizadas como control, no cargadas con el péptido con la
secuencia SEQ ID n.º 114, no fueron reconocidas por los linfocitos
T citotóxicos. Por lo tanto, se pudo mostrar que los linfocitos T
humanos pueden ser activados in vitro con péptidos como
epítopos. Además, se pudo mostrar que los linfocitos T citotóxicos
que lisaron las células T2 cargadas con el péptido con la secuencia
SEQ ID n.º 114, también exprimen interferón-gamma,
que se ha descrito como marcador adecuado para la activación de
linfocitos T.
En una forma de realización preferida, el
péptido puede emplearse para la estimulación de una respuesta
inmune, el cual presenta la secuencia SEQ ID n.º 448 y en el cual
se ha intercambiado, en el C-Terminal, leucina con
valina, isoleucina y alanina, todas las cuales muestran cadenas
laterales no polares.
También es posible utilizar un péptido con la ID
de secuencia n.º 448, que presenta, al menos, otro aminoácido N-
y/o C-terminal o en la que se ha borrado, al menos,
un aminoácido.
El/los aminoácido(s) cambiante(s)
se escoge(n) de tal forma que la variación no influye en la
inmunogenicidad del péptido, es decir, que presenta una afinidad de
unión a la molécula MHC similar y capacidad de estimulación de los
linfocitos T.
Conforme a la presente invención, el péptido
puede ser utilizado para el tratamiento de enfermedades tumorales
y/o enfermedades adenomatosas.
Entre las enfermedades tumorales que se pueden
tratar se encuentran los cánceres de riñón, cerebro, mama,
páncreas, estómago, testículo y/o piel, y enfermedades tumorales del
sistema nervioso. La enumeración de enfermedades tumorales es sólo
un ejemplo y no limita el campo de aplicación. Los inventores
pudieron demostrar mediante experimentos propios que el péptido
conforme a la invención es adecuado para dicha utilización. Se
demostró que CTL generados expresamente, específicos para
determinados péptidos, pudieron destruir de forma efectiva y
selectiva células tumorales.
Para la aplicación de antígenos asociados a
tumores en una vacuna tumoral, son posibles varias formas de
aplicación. So beschrieben Tighe et al., 1998, Gene
vaccination: plasmid DNA is more than just a blueprint,
"Immunol. Today" 19(2):89-97)
describían que el antígeno puede ser administrado como proteína
recombinante con los adyuvantes o los vehículos apropiados o como
ADNc codificante para el antígeno en vectores plasmídicos. En estos
casos, el antígeno debe ser empleado y presentado en el cuerpo del
paciente por células presentadoras de antígenos (APC), con el fin
de que se desencadene una respuesta inmune.
Melief y col. (1996,
Peptide-based cancer vaccines, "Curr. Opin.
Immunol". 8:651-657) muestran otra posibilidad:
la utilización de péptidos sintéticos como vacuna.
En una forma de realización preferida, el
péptido se aplica con adyuvantes o en su forma aislada.
Se puede utilizar como adyuvante, por ejemplo,
el factor estimulante de colonias
granulocito-macrófago (GM-CSF).
Otros ejemplos de adyuvantes son el hidróxido de aluminio o
emulsiones de aceites minerales como, por ejemplo, el adyuvante de
Freund, la saponina o los compuestos de silicio.
La utilización de adyuvantes ofrece la ventaja
de que la respuesta inmune desencadenada por el péptido se puede
reforzar y/o que el péptido se estabiliza.
En otra forma de realización, el péptido se
aplica unido a una célula presentadora de antígeno.
Esta medida presenta la ventaja de que los
péptidos pueden ser presentados al sistema inmune, especialmente a
los linfocitos T citotóxicos (CTL). De esta forma, los CTL pueden
reconocer a las células tumorales y destruirlas selectivamente.
Como células presentadoras de antígenos son apropiadas para dicha
aplicación, por ejemplo, las células dendríticas, los monocitos o
los linfocitos B.
Las células se cargan con el péptido ex
vivo, por ejemplo. Por otro lado, también existe la posibilidad
de transfectar las células con el ADN codificante del péptido o el
ARN correspondiente para llevar a la expresión del péptido en las
células.
Los inventores pudieron mostrar en experimentos
propios que es posible cargar células dendríticas (DC) con péptidos
específicos y que estas células dendríticas cargadas activan CTL
específicas de péptidos. Esto significa que el sistema inmunológico
puede ser estimulado para desarrollar CTL contra los tumores, que
expresan los péptidos correspondientes.
Las células presentadoras de antígenos
portadoras del péptido pueden utilizarse para ello de forma directa,
o bien ser activadas antes de su aplicación, por ejemplo, con la
proteína de choque térmico gp96. Esta proteína de choque térmico
induce la expresión de moléculas MHC de clase I y de moléculas
coestimulantes como la B7 y estimula además la producción de
citocinas. De esta forma, se estimula de forma global el
desencadenamiento de respuestas inmunes.
En otra forma de realización preferida, el
péptido es utilizado para la marcación de leucocitos, especialmente
de linfocitos T.
Esta aplicación es ventajosa cuando el péptido
se utiliza para descubrir si en una población de CTL existen CTL
dirigidos específicamente contra un péptido.
El péptido también se puede aplicar como
marcador en la evaluación de un tratamiento contra una enfermedad
tumoral.
En inmunizaciones u otros tratamientos también
se puede aplicar el péptido para la monitorización. Por lo tanto,
el péptido no sólo es útil para el tratamiento, sino también para el
diagnóstico.
En otra forma de realización preferida, el
péptido se aplica para la preparación de un anticuerpo.
Los anticuerpos policlonales pueden obtenerse de
manera convencional mediante la inmunización de animales con una
inyección del péptido y la posterior tinción de la
inmunoglobulina.
Los anticuerpos monoclonales pueden producirse
por protocolos estándar, como se describe, por ejemplo, en
"Methods Enzymol". (1986), 121, Hybridoma technology and
monoclonal antibodies.
En otro de sus aspectos, la invención también se
refiere a una composición farmacéutica que contiene el péptido.
Esta composición se puede administrar por vía
parenteral, como subcutánea, intradérmica o intramuscular, o por
vía oral. Para ello, los péptidos son suspendidos o disueltos en un
vehículo farmacéuticamente aceptable, preferentemente acuoso.
Además, la composición puede contener coadyuvantes como, por
ejemplo, amortiguadores, aglutinantes, agentes de acoplamiento,
etc.
El péptido también puede administrarse junto con
sustancias inmunoestimulantes como, por ejemplo, citocinas. Se
puede encontrar una descripción completa de adyuvantes para una
composición de este tipo en A. Kibbe, Handbook of Pharmaceutical
Excipients, 3ª Ed, 2000, "American Pharmaceutical Association
and Pharmaceutical Press".
El medio puede aplicarse en la prevención,
profilaxis y/o terapia de enfermedades tumorales y/o
adenomatosas.
El medio farmacéutico que contiene un péptido
con ID de secuencia n.º 448 se administra a un paciente con una
enfermedad tumoral a la que se está asociada el péptido o antígeno
en cuestión. De esta forma, puede desencadenarse una respuesta
inmune específica de tumor en base a CTL específicos de tumor.
La cantidad de péptido existente en la
composición farmacéutica se da en una cantidad terapéuticamente
efectiva.
En otro aspecto, la presente invención hace
referencia a moléculas de ácidos nucleicos que sólo codifican el
péptido conforme a la presente invención.
Las moléculas de ácidos nucleicos pueden ser
moléculas de ADN o ARN y, asimismo, se pueden aplicar en la
inmunoterapia del cáncer. Para ello, el péptido expresado por la
molécula de ácidos nucleicos induce una respuesta inmune contra las
células tumorales que expresan el péptido.
Conforme a la presente invención, las moléculas
de ácidos nucleicos también pueden encontrarse en un vector.
Además, la invención se refiere a células que,
con ayuda de la molécula de ácidos nucleicos, la cual codifica el
péptido, han sido modificadas genéticamente de tal forma que
producen un péptido con el ID de secuencia n.º 448.
Para ello, las células son transfectadas con el
ADN codificante del péptido o el ARN correspondiente, de tal forma
que el péptido es expresado en las células. Para dicha aplicación
son apropiadas como células presentadoras de antígenos, por
ejemplo, las células dendríticas, los monocitos o los linfocitos
B.
A continuación se presentan ejemplos y figuras
que muestran y explican la invención, que hace referencia a un
péptido con la secuencia SEQ ID n.º 448. Muestran los siguiente:
Fig. 1a los controles negativos en relación a la
lisis específica de CTL de células diana KM22 (sin péptido);
Fig. 1b la lisis específica de CTL de células
diana KM22, sensibilizadas con péptido y tratadas con
interferón-gamma.
Fig. 2 la creación de
interferón-gamma mediante linfocitos T específicos
tras la estimulación con células JY o KM22 cargadas con el
péptido.
Fig. 3 la estimulación específica del péptido de
linfocitos T CD8 positivos humanos, y
Fig. 4 el análisis de linfocitos T específicos
del péptido en la sangre de pacientes con cáncer de células
renales.
Fig. 5 el análisis de tetrámero de la
proliferación, impulsada por microesferas, de linfocitos CD8^{+}
específicos de B*0702/IARNLTQQL de sangre periféfica. 4 de 6
donantes sanos analizados (HD155, -159, -161, -177) mostraron
respuestas significativas de linfocitos T (por encima de la línea
roja), que se dirigieron específicamente contra el antígeno de
péptido analizado con secuencia SEQ-ID n.º 233, como
se mostró mediante el análisis de receptores de linfocitos T
específicos del complejo HLA-B*0702/péptido mediante
tinción del tetrámero.
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Ejemplo
1
El departamento de urología de la Universidad de
Tubinga facilitó ocho muestras de pacientes que presentaban tumor
de células del riñón confirmado histológicamente. El paciente
designado como RCC75 poseía la siguiente tipificación de HLA: A*03,
B*07, B*40. El paciente designado como RCC98 poseía la siguiente
tipificación de HLA: A*01, A*03, B*07, B*18, el paciente designado
como RCC100 poseía la siguiente tipificación HLA: A*02, A*03 B*07,
B*18. El paciente designado como RCC103 poseía la siguiente
tipificación HLA: A*11, A*25, B*15, B*44. El paciente designado
como RCC112 poseía la siguiente tipificación HLA: A*01, A*31, B*08,
B*27. El paciente designado como RCC115 poseía la siguiente
tipificación HLA: A*02, A*03, B*15, B*18. El paciente designado
como RCC116 poseía la siguiente tipificación HLA: A*01, A*02, B*27,
B*37. El paciente designado como RCC130 poseía la siguiente
tipificación HLA: A*02, A*24, B*07, B*44.
El departamento de Neurocirugía de la
Universidad de Heidelberg facilitó dos muestras de pacientes que
presentaban glioblastoma confirmado histológicamente. El paciente
designado como NCH359 poseía la siguiente tipificación de HLA:
A*03, A*32, B*07, B*35. El paciente designado como NCH361 poseía la
siguiente tipificación HLA: A*26 y B*38.
Las muestras de tumor sometidas a choque térmico
se procesaron como se describe en Schirle, M. y col.
(Identification of tumor-associated MHC class I
ligands by a novel T cell-independent approach,
2000, "European Journal of Immunology",
30:2216-2225). Los péptidos se aislaron con
protocolos estándar mediante el uso del anticuerpo monoclonal
W6/32, específico para la molécula HLA de clase I, o del anticuerpo
monoclonal BB7.2, específico para HLA-A2.
Barnstable, C.J. y col. (Production of monoclonal antibodies to
group A erythrocytes, HLA and other human cell surface
antigens-new tools for genetic analysis, 1978,
"Cell", 14:9-20) y Parham, P. & Brodsky,
F.M. (Partial purification and some properties of BB7.2. A
cytotoxic monoclonal antibody with specificity for
HLA-A2 and a variant of HLA-A28,
1981, "Hum. Immunol.", 3:277-299) describen la
preparación y uso de estos anticuerpos.
Los péptidos se separaron mediante HPLC en fase
invertida (sistema SMART, \muRPC C2/C18 SC 2.1/19, Amersham
Pharmacia Biotech) y las fracciones obtenidas se analizaron mediante
nano espectrometría de masas ESI. Se procedió como se describe en
Schirle, M. y col, Identification of
tumor-associated MHC class I ligands by a novel T
cell-independent approach, 2000, "European
Journal of Immunology", 30:2216-2225.
Los péptidos obtenidos a partir de tejido
tumoral se identificaron, como se ha mencionado, mediante LC MS
capilar, pero con ligeras modificaciones: 100 \mul de muestra se
cargaron, desmineralizaron y preconcentraron en una precolumna de
300 \mum * 5 mm C18 \mu (LC Packings). El disolvente y la
muestra se administraron con una bomba de inyección (PHD 2000,
Harvard Apparatur, Inc.) con una inyección impermeabilizada de 100
\mul (1710 RNR, Hamilton) a una velocidad de 2 \mul/min. Para
la separación de los péptidos se conectó una columna de
preconcentración a 75 \mum * 250 mm C-18 (LC
Packings). Finalmente, se efectuó un gradiente binario con
25-60% B en 70 min, en el que se redujo la tasa de
flujo de 12 \mul/min a, aproximadamente, 300 \mum/min, mediante
el uso de una conexión TEE (ZT1C, Valco) y una columna de 300 \mum
* 150 mm C-18.
Con el fin de asegurar que el sistema estaba
libre de péptidos sobrantes, se realizó una medición de una muestra
vacía. Se efectuaron fragmentaciones en línea, como se ha descrito,
y los espectros de los fragmentos fueron analizados manualmente.
Los análisis de las bases de datos (NCBInr, EST) se efectuaron con
MASCOT (http://www.
matrixscience.com).
matrixscience.com).
En el protocolo incluido y en la tabla 1
incluida se presentan los ligandos que aparecían unidos a la
molécula HLA de los pacientes RCC75, RCC98, RCC100, RCC103,
RCC112, RCC115, RCC116, RCC130, NCH359 y NCH361.
Los péptidos que estaban asociados a HLA-A*02
presentan el motivo peptídico específico de alelo: así, en la
posición 2 había leucina, valina, isoleucina, alanina o metionina y
en el C-terminal, leucina, valina isoleucina o
alanina. La mayoría de los ligandos procedían de las llamadas
proteínas de mantenimiento, aunque también se identificaron ligandos
de proteínas asociados a tumores. Así, se pudieron identificar, por
ejemplo, fragmentos de Tenascina-C (GLAPSIRTK, SEQ
ID n.º 2; GVLKKVIRH, SEQ ID n.º 20). Herold-Mende y
col, Clinical Impact and Functional Aspects of
Tenascin-C Expression during Glioma
Progression, 2002, "Int. J. Cancer", 98:
362-369 muestran que, en general, la cantidad de
expresión de la proteína de la matriz extracelular
tenascina-C está en correlación con la gravedad de
la enfermedad y la migración de células tumorales al tejido
sano.
Para el análisis de linfocitos T específicos de
péptido, por ejemplo, para el péptido con la secuencia FPSLREAAL
(SEQ ID n.º 114) se tiñeron células mononucleares de sangre
periférica de donantes sanos con los tetrámeros de subtipos
HLA-A* respectivos, los cuales estaban constituidos
por los péptidos respectivos. Para la producción de tetrámeros se
constituyeron in vitro moléculas de subtipos
HLA-B* recombinantes con los péptidos, se depuraron
con gen de filtrado, se biotinilaron y se mezclaron con
estreptavidina para el ligado de los monómeros, como describe
Walter y col, 2003, Cutting Edge: Predetermined Avidity of
Human CD8 T Cells Expanded on Calibrated
MHC/Anti-CD28-Coated
Microspheres, "J. Immunol." 171:
4974-4978.
Fundamentalmente, se valoraron los resultados de
la doble tinción mediante análisis con FACS y se comprobaron las
uniones específicas de péptido-tetrámero (Walter S y
col, 2003, Cutting Edge: Predetermined Avidity of Human
CD8 T Cells Expanded on Calibrated
MHC/Anti-CD28-Coated
Microspheres, "J. Immunol." 171:
4974-4978).
\vskip1.000000\baselineskip
Ejemplo
2
Con el fin de analizar la presentación del
péptido seleccionado mediante células tumorales y el reconocimiento
del péptido meditante CTL, se indujeron CTL in vitro
específicos para los péptidos seleccionados. Para ello se aplicaron
las líneas celulares KM22 y JY.
Los linfocitos T específicos se aislaron de la
sangre de donantes sanos, como se describe en el epígrafe 1.5, y
enriquecidos mediante FACS Sorting.
Los péptidos seleccionados de ejemplo se
sintetizaron mediante la utilización de grupos de protección
F-moc
(9-Fluorenilmetiloxicarbonilo) en un sintetizador de
péptidos (432A, Applied Biosystems, Weiterstadt, Alemania) y
analizados mediante HPLC de fase invertida y espectrometría de
masas. De esta forma, se pudieron preparar suficientes cantidades
del péptido identificado.
\newpage
\global\parskip0.900000\baselineskip
Para la inducción de CTL se
co-incubaron los linfocitos T obtenidos en el
epígrafe 2.1 (5 x 10^{6} linfocitos T por pocillo), mediante
re-estimulación in vitro, en placas de 24
pocillos con 1 x 10^{6} células diana radiadas por pocillo en 1,5
ml de medio de linfocitos T (compuesto por RPMI1640, 25 mM de HEPES
[Life Technologies/Invitrogen, Karlsruhe,Alemania]) con un 10% de
suero AB humano inactivado por calor (CC Pro, Neustadt/Weinstraße,
Alemania), 2 mM de L-Glutamina,50 U/ml de
penicilina, 50 \mug/ml de estreptomicina y 20 \mug/ml de
gentamicina (todo de BioWhittaker/Cambrex, Verviers, Bélgica).
Adicionalmente, se añadieron 5 ng/ml de IL-12 p70
humano (R&D Systems). Después de aproximadamente 4 días de
co-incubación a 37ºC, se añadió medio fresco con 20
U/ml de IL-2 humano (R&D Systems) y se
incubaron las células durante otros 3 o 4 días. Este ciclo de
estimulación se repitió dos
veces.
veces.
Para los ensayos CTL se utilizaron como células
diana líneas celulares de tumor JY y KM22. Las células
sensibilizadas con péptidos fueron sensibilizadas con 50 \mug/ml
de péptido durante 2 horas. Todas las células diana se marcaron en
medio RP10 (RPMI 1640, complementado con un 10% de suero fetal de
ternero inactivado por calor y con antibióticos) durante 1 hora a
37ºC con [^{51}Cr]cromato de sodio (^{51}Cr). Finalmente,
se repartieron 10^{4} células por pocillo en una placa de 96
pocillos con suelo redondeado. Se añadieron distintas cantidades de
CTL hasta alcanzar un volumen de 200 \mul, con una incubación
final de 4 horas a 37ºC. Después se recogieron los resultados (50
\mul/pocillo) y se hizo un recuento en un contador de placas beta.
El porcentaje de la lisis específica se calculó de la siguiente
forma: 100 x (liberación experimental - liberación
espontánea/liberación máxima - liberación espontánea). La liberación
espontánea y la liberación máxima se fijaron en presencia de medio
o de Triton X-100 al 2%.
En ensayos de liberación de ^{51}Cr (véase
epígrafe 2.4) se analizó la actividad citotóxica de CTL inducidos
(véase epígrafe 2.3) frente a células KM22 o JY. Las líneas
celulares KM22 y J-Y son
HLA-B*07^{+}.
Los resultados de este ensayo de liberación se
muestran en las figuras 1a y 1b. En las figuras 1a y 1b se utilizan
las abreviaturas "IFN" para interferón-gamma,
"E:T" para la relación efector/células diana, "Tet+" para
linfocitos T unidos a tetrámeros de
HLA-B*0702/FPSLREAAL y "Tet-" para linfocitos
T que no están unidos a tetrámeros de
HLA-B*0702/FPSLREAAL.
Los resultados muestran que puede conseguirse
una destrucción de las células específica de antígeno con líneas
celulares de CTL obtenidas tras 2 semanas de
re-estimulación:
En la figura 1a se muestra que, con tratamiento
de interferón-gamma, para el alelo HLA B*0702
positivo no se reconocieron células diana KM22 sin péptido mediante
linfocitos T citotóxicos específicos. La figura 1b muestra que, con
tratamiento de interferón-gamma, para el alelo HLA
B*0702 positivo se reconocieron y lisaron células diana KM22, que
presentan al péptido con la secuencia FPSLREAAL del antígeno de
tumor MAGE-1, mediante linfocitos T citotóxicos
específicos.
De esta forma sólo se destruyeron las células
con una cantidad en aumento de CTL, que presentan los péptidos
seleccionados; las células de control cargadas con péptidos
irrelevantes no fueron destruidas. De esta forma, se pudo mostrar
la especificidad de la actividad citolítica.
En otro experimento se mostró que los linfocitos
T citotóxicos que lisaron las células T2 cargadas con el péptido
FPSLREAAL (SEQ ID n.º 114) también expresaron
interferón-gamma, que se ha descrito como marcador
adecuado para la activación de linfocitos T.
En la figura 2 se muestran los resultados de las
mediciones, en las que se probaron células KM22 y JY. Se utilizaron
las mismas abreviaturas que en la figura 1, designándose además
mediante "CD8+" a los linfocitos T que expresan la molécula
receptor CD8 en la superficie de la célula.
Para el análisis de IFN-gamma se
cultivaron 1 x 10^{5} células efectoras y estimuladoras,
sensibilizadas con péptidos, en medio de linfocitos T en placas de
96 pocillos (medio de linfocitos T: RPMI 1640 con 25 mM de HEPES
(Gibco/Invitrogen, Karlsruhe, Alemania; complementado con un 10% de
suero AB humano inactivado por el calor (CC pro, Neustadt/W,
Alemania; 2 mM de L-glutamina, 50 U/ml de
penicilina, 50 \mug/ml de estreptomicina y 20 \mug/ml de
gentamicina (todos de BioWhittaker). La carga de péptidos se efectuó
a 37ºC en medio X-Vivo 15 con los correspondientes
péptidos durante aproximadamente 2 horas.
Después de 1 a 2 horas se añadió GolgiStop
(Betcon Dickinson) y se incubó de 4 a 5 horas. Posteriormente se
impermeabilizaron las células y se tiñeron utilizando el kit
Cytofix/Cytoperm Plus, así como con
anti-CD4-FITC,
anti-IFN-\gamma-PE
y anti-CD8-PerCP, según la
recomendación del fabricante (Betcon Dickinson). Los análisis
citométricos se realizaron utilizando el citómetro FACSCalibur.
Como se puede ver en la figura 2, se formaron en
el tetrámero HLA-B*0702/FPSLREAAL linfocitos T de
unión (=linfocitos T específicos, "Tet+")
interferon-gamma, cuando fueron estimulados mediante
células KM22 o JY, cada una tratada anteriormente con diferentes
cantidades de interferón-gamma y cargadas con el
péptido con la secuencia SEQ-ID n.º 114 (véase la
figura 2, "KM22+FPSLREAAL" y "JY+ FPSLREAAL", con
tratamiento de 5 o 25 \muM de INF, respectivamente). Los
linfocitos T sin especificar (es decir, linfocitos T no unidos a
tetrámero de HLA-B*0702/FPSLREAAL) no formaron
interferón-gamma (="Tet-").
En la figura 2 se muestra, además, que ni los
linfocitos T específicos ("Tet+") ni los no específicos
("Tet-") formaron interferón-gamma cuando
fueron estimulados con un péptido de control inespecífico (ejemplo
en la figura 2: APRTVALTA, SEQ-ID n.º 585) (véase la
figura 2 para "Tet+" y "Tet-": "KM22+APRTVALTA" y
"JY+APRTVALTA", tratados cada vez con 25 \muM de INF).
Para otro análisis de la estimulación específica
de péptido de linfocitos T CD8+ se sintetizó el péptido con la
secuencia LAALPHSCL (SEQ-ID n.º 448) de la proteína
RGS-5 y el péptido de control con la secuencia
ELAGIGILTV (SEQ-ID n.º 578) del antígeno de
melanoma MELAN-A (posición 26-35,
modificada mediante un intercambio de aminoácidos de la alanina en
posición 27 por leucina), uniéndose el péptido de control al alelo
HLA A*02, mediante la utilización estándar de química Fmoc. Se
produjeron moléculas A*02 biotiniladas recombinantes y tetrámeros
MHC fluorescentes, de la forma que se describe en Altman y col.
(Phenotypic analysis of antigen-specific
T-lymphocytes, "Science" 274:94, 1996).
Para la fabricación de células artificiales presentadoras de
antígenos (APC) se resuspendieron partículas de Polystyrol
revestidas de estreptavidina (diámetro de 5,6 \mum) con una
capacidad de unión de 0,064 \mug de microesferas de
Biotin-FITC/mg (Bangs Laboratories, Fishers,
Illinois/EE. UU.) con 2 x 10^{6} partículas/ml en un amortiguador,
con el MCH biotinilado y los anticuerpos, y se incubaron durante 30
min a temperatura ambiente.
Para la estimulación in vitro específica
de antígeno de linfocitos T CD8 humanos, se aislaron de forma
estándar PBMC de capas de leucocitos frescos mediante separación por
gradiente. Los linfocitos T CD8 sin tratar se enriquecieron
mediante agotamiento negativo mediante MACS (Miltenyi Biotec,
Bergisch Gladbach, Alemania). Las estimulaciones in vitro se
efectuaron en placas de 24 pocillos con 5 x 10^{6} células
Responder y 1 x 10^{6} cuentas o 1 x 10^{6} APC tratadas por
pocillo, en 1,5 ml de medio de linfocitos T (véase más arriba). Se
añadieron con microesferas 5 ng/ml de IL-12 p70
humana (R%D Systems, EE. UU.). Después de 3 a 4 días de
co-incubación a 37ºC, se añadió medio fresco y 20
U/ml de IL-2 humano (R&D Systems, EE. UU.) y se
incubaron las células durante otros 3 a 4 días. Este ciclo de
estimulación se repitió dos veces.
Para el análisis de citométrico intracelular y
de la superficie celular, se efectuaron análisis de tetrámero con
tetrámeros MHC fluorescentes más anticuerpos anti CD8 (Hybridom
UKT8) en un FACSCalibur (Becton Dickinson) de cuatro colores.
Los resultados de estos análisis se muestran en
la figura 3. En ella se puede observar, que el péptido de
RGS-5 LAALPHSCL estimula linfocitos T CD8+ humanos
específicos con la secuencia SEQ-ID n.º 448. En la
figura 3 se muestra en la columna izquierda el análisis de
linfocitos T de PBMC, que fueron estimulados con anterioridad dos
veces tal y como se describe más arriba, con un péptido de control
con la secuencia ELAGIGILTV de Melan-A
(SEQ-ID n.º 578). La columna derecha muestra los
análisis de los linfocitos T, que fueron estimulados con el péptido
RGS-5 con la secuencia LAALPHSCL
(SEQ-ID n.º 448).
En la parte superior izquierda de la figura 3 se
muestra que los linfocitos T CD8+ (eje X), estimulados con
complejos de tetrámero MHC-A*02/péptido
Melan-A, no se unen al tetrámero
MHC-A*02 con el péptido con la secuencia LAALPHSCL
(SEQ-ID n.º 448) (eje Y).
En la parte superior derecha de la figura 3 se
muestra que los linfocitos T CD8+, estimulados con péptido
RGS-5 con la secuencia LAALPHSCL/complejos de
tetrámero de MHC-A*02 se unen con el tetrámero
MHC-A*02 (eje Y) con el péptido con la secuencia
LAALPHSCL (SEQ-ID n.º 448). En el cuadrante superior
derecho se pueden ver las células teñidas doblemente (doblemente
positivas).
En la parte izquierda del centro de la figura 3
se muestra que los linfocitos T CD8+ (eje X), que fueron estimulados
con complejos de tetrámero MHC-A*02/péptido
Melan-A, se unen al tetrámero
MHC-A*02 con el péptido con la secuencia ELAGIGILTV
(SEQ-ID n.º 578) (eje Y). En el cuadrante superior
derecho se pueden ver las células teñidas doblemente (doblemente
positivas). En la parte central derecha se muestra que los
linfocitos T CD8+, estimulados con péptido RGS-5
con la secuencia LAALPHSCL/complejos de tetrámero de
MHC-A*02 no se unen con el tetrámero
MHC-A*02 (eje Y) con el péptido con la secuencia
ELAGIGILTV (SEQ-ID n.º 578) de
Melan-A.
En la parte izquierda de la línea inferior de la
figura 3 se muestran partes cuantitativas de los linfocitos T
específicos de MHC-A*02/Melan-A
mediante tinción doble con los dos complejos de
péptido-tetrámero-MHC utilizados
(Melan-A/MHC-A*02 y
RGS-5/MHC-A*02). Tras una
estimulación previa con complejos de tetrámero
MHC-A*02/péptido Melan-A unidos a
células artificiales presentadoras de antígenos, un 19,3% de las
células estimuladas se une específicamente un complejo tetrámero
MHC de péptido Melan-A y HLA-A*02.
En la parte inferior derecha se muestran partes cuantitativas de
los linfocitos T específicos de
RGS-5/MHC-A*02 mediante doble
tinción con los dos complejos de tetrámero MHC utilizados
(Melan-A/MHC-A*02 y
RºGS-5/MHC-A*02). Tras una
estimulación previa con complejos de tetrámero
MHC-A*02/péptido RGS-5 ligados a
células artificiales presentadoras de antígenos, el 8,0% de las
células estimuladas se une específicamente al complejo tetrámero MHC
del péptido RGS-5 con la secuencia LAALPHSCL
(SEQ-ID n.º 448) y HLA-A*02.
En otros experimentos se pudieron comprobar
linfocitos T específicos de péptidos de la sangre de pacientes con
cáncer de células renales, que anteriormente habían sido inmunizados
con células dendríticas con células dendríticas autólogas cargadas
con péptidos.
Para este análisis se efectuó una reacción en
cadena de polimerasa en tiempo real (RT-PCR). Esta
reacción RT-PCR se efectuó tal y como describen
Kammula y col. ("Journal of Immunology" 163:6867, 2000). Para
ello se derritieron PBMC en medio de linfocitos T, se sembraron con
1 x 10^{6} células en 500 \mul de medio y se incubaron durante
la noche a 37ºC y 5% de CO_{2}. A continuación se añadieron los
péptidos sintéticos con 5 \mug/ml durante 3 horas y después se
efectuó una extracción de ARN con Trizol (Invitrogen, Karlsruhe,
Alemania). El ADNc se transcribió mediante la utilización de
cebadores hexámero randomizados (Amersham Biosciences, Freiburg,
Alemania) y M-MLV de transcriptasa inversa (Promega
GmbH, Mannheim, Alemania).
El RT-PCR cuantitativo se
realizó dos veces con un "ABIPrism 7000 Sequence Detection
System" (Applied Biosystems, Darmstadt, Alemania) en relación al
ARNm de IFN-gamma y al ARNm de CD8, aplicándose al
Taqman PCR Master Mix (Applied Biosystems), cebadores específicos y
sondas fluorescentes.
Los resultados describen el número de copias del
ARNm de IFN-gamma, normalizándose los ensayos
referentes al número de copias de ARNm CD8 (como producto genético
de referencia) (índice de estimulación). La expresión del gen en
presencia de los péptidos probados se refiere a la expresión del gen
que se obtuvo en el momento del control (epítopo
HLA-A*02 procedente de HIV1 pol con la secuencia
ILKEPVHGV, SEQ-ID n.º 579) (el número de copia del
control se estableció en 1).
En la figura 4 se muestran los resultados de
estas investigaciones. La ilustración del a figura 4 muestra la
activación ex vivo de los linfocitos T tras la inmunización
del paciente RCC98 con nueve péptidos unidos a HLA, en la Clínica
Universitaria de Tubinga. Los dos primeros bloques de columnas de un
grupo de 11 muestran los controles negativo y positivo del ensayo
con linfocitos T. Las rayas de errores muestran la variación
estándar. Como se menciona más arriba, se utilizó como control
negativo el péptido HIV con la secuencia ILKEPVHGV (del antígeno
viral HIV1 pol, posición 896-904;
SEQ-ID n.º 579). El control negativo no desencadenó
respuesta de linfocitos T alguna, siempre que el paciente fuera
HIV-seronegativo. Como control positivo se utilizó
una mezcla de matriz de gripe 58-66 (GILGFVFTL;
SEQ-ID n.º 580), HCMVA pp65 495-503
(NLVPMVATV; SEQ-ID n.º 581),
EBNA6-EBV 284-293 (LLDFVRFMGV;
SEQ-ID n.º 582), IE63-EBV
259-267 (GLCTLVAML; SEQ-ID n.º 583)
y LMP2-EBV 294-302 (CLGGLLTMV;
SEQ-ID n.º 584), con la que se esperaba una fuerte
respuesta de linfocitos T ("posmix"; máximo en el índice de
estimulación 43,6). Todos los péptidos de control utilizados para la
estimulación de PBMC se aplicaron en una concentración de 5
\mug/ml. Los antecedentes se definieron como desviaciones estándar
de los controles negativos (índice de estimulación de 1,35,
representado por la línea horizontal).
En la figura 4, los siguientes 9 bloques de
columnas muestran de la ilustración la activación de linfocitos T
medida contra nueve péptidos inmunizados. Estos nueve péptidos
fueron cargados juntos de forma subcutánea un total de siete veces
con un intervalo de 14 días, administrados en células dendríticas
autólogas. Por ello, cada bloque de columnas se compone de 8
columnas (antes de la primera inmunización, después de la primera
inmunización, después de la segunda inmunización, etc). Cada bloque
de columnas muestra el desarrollo de la respuesta de los linfocitos
T a lo largo de la inmunización.
Ya a partir de la tercera inmunización se
pudieron observar fuertes respuestas de linfocitos T para GLASFKSFLK
(RGS5 74-83, SEQ-ID n.º 153) y
SLLTSSKGQLQK (ADFP 369-380, SEQ-ID
n.º 289), aumentando en el último péptido la respuesta de los
linfocitos T tras la cuarta inmunización. Tales fluctuaciones en la
respuesta de los linfocitos T a lo largo de una terapia de
inmunización también fueron reconocidas por otros pacientes.
Las respuestas de los linfocitos T fueron claras
para IARNLTQQL (ADFP 313-321; SEQ-ID
n.º 233), GPALGRSFL (TNFSF7 78-86,
SEQ-ID n.º 577) y más débiles para un péptido
conocido de unión a pan-HLA-DR
(PADRE). En estos tres péptidos también se observó un aumento de la
respuesta de los linfocitos T en el transcurso de la terapia de
inmunización (líneas de puntos). Esto demostró que estos tres
últimos péptidos desencadenaron una respuesta de linfocitos T
positiva.
El paciente fue inmunizado en el marco de un
estudio clínico en la Clínica Universitaria de Tubinga. El estudio
clínico fue anunciado y autorizado por escrito por la comisión de
ética de la Universidad de Tubinga. El estudio se llevó a cabo
conforme a las normas y pautas de la ley de medicamentos (AMG) y la
Good Clinical Practice (GCP).
En resumen, los inventores pueden demostrar que
los péptidos identificados producen sustancias muy prometedoras en
la inmunoterapia de una variedad de enfermedades (tumorales).
\newpage
\global\parskip1.000000\baselineskip
Ejemplo
3
1 x 10^{6} PBMC enriquecidas con CD8^{+} por
pocillo de seis donantes sanos de HLA-A*0201^{+}
HD155, HD159, HD161, HD167, HD168 y HD177 se estimularon
semanalmente con microesferas, acopladas a anti-CD28
más antígenos irrelevantes ("Estimulación irrelevante"),
antígenos de tumor B*0702/IARNLTQQL de alta densidad ("HD") o
antígenos de tumor B*0702/IARNLTQQL de baja densidad ("LD"),
como se mostró anteriormente (Walter, S, y col. Cutting
Edge: Predetermined avidity of human CD8 T cells expanded on
calibrated MHC/anti-CD28-coated
microspheres. "J. Immunol".
171(10):4974-8, 2003) estimulados con
pequeñas modificaciones. Tras tres estimulaciones in vitro,
se tiñeron pocillos individuales con anticuerpos CD8 más tetrámero
B*0702/IARNLTQQL. Cada punto representa el porcentaje de tetrámero
positivo dentro de linfocitos CD8^{+} de un pocillo.
En base a la distribución de respuestas
observadas tras la estimulación irrelevante en donantes individuales
se calculó un valor límite significativo y se simbolizó mediante
una línea roja horizontal, utilizando la siguiente fórmula:
\text{Valor
límite = límite superior del 95% de intervalo de confidencia para el
medio + 3 veces el límite} \text{superior del 95% de
intervalo de confidencia para la desviación
estándar.}
Las cifras de las descripciones muestran el
número de pocillos positivos significativos en un total de pocillos
para un estado dado.
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<120> Péptidos asociados a tumor unidos a
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<213> Homo sapiens
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<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
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<400> 2
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<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
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<400> 3
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<210> 4
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<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 4
\vskip1.000000\baselineskip
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\newpage
\vskip0.400000\baselineskip
<210> 5
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 5
\vskip1.000000\baselineskip
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\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 6
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 6
\vskip1.000000\baselineskip
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\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 7
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 7
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 8
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 8
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 9
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 9
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 10
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 10
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 11
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 11
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 12
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 12
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 13
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 13
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 14
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 14
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 15
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 15
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 16
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 16
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 17
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 17
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 18
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 18
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 19
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 19
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 20
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 20
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 21
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 21
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 22
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 22
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 23
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 23
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 24
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 24
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 25
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 25
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 26
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 26
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 27
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 27
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 28
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 28
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 29
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 29
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 30
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 30
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 31
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 31
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 32
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 32
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 33
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 33
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 34
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 34
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 35
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 35
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 36
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 36
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 37
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 37
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 38
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 38
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 39
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 39
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 40
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 40
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 41
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 41
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 42
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 42
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 43
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 43
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 44
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 44
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 45
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 45
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 46
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 46
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 47
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 47
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 48
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 48
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 49
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 49
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 50
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 50
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 51
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 51
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 52
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 52
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 53
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 53
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 54
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 54
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 55
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 55
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 56
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 56
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 57
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 57
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 58
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 58
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 59
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 59
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 60
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 60
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 61
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 61
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 62
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 62
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 63
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 63
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 64
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 64
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 65
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 65
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 66
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 66
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 67
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 67
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 68
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 68
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 69
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 69
\vskip1.000000\baselineskip
\hskip0,8cm
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 70
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 70
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 71
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 71
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 72
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 72
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 73
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 73
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 74
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 74
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 75
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 75
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 76
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 76
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 77
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 77
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 78
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 78
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 79
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 79
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 80
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 80
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 81
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 81
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 82
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 82
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 83
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 83
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 84
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 84
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 85
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 85
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 86
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 86
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 87
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 87
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 88
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 88
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 89
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 89
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 90
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 90
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 91
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 91
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 92
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 92
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 93
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 93
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 94
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 94
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 95
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 95
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 96
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 96
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 97
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 97
\vskip1.000000\baselineskip
\hskip0,8cm
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 98
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 98
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 99
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 99
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 100
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 100
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 101
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 101
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 102
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 102
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 103
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 103
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 104
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 104
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 105
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 105
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 106
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 106
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 107
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 107
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 108
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 108
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 109
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 109
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 110
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 110
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 111
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 111
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 112
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 112
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 113
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 113
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 114
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 114
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 115
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 115
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 116
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 116
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 117
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 117
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 118
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 118
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 119
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 119
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 120
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 120
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 121
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 121
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 122
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 122
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 123
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 123
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 124
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 124
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 125
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 125
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 126
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 126
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 127
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 127
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 128
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 128
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 129
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 129
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 130
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 130
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 131
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 131
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 132
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 132
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 133
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 133
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 134
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 134
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 135
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 135
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 136
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 136
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 137
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 137
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 138
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 138
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 139
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 139
\vskip1.000000\baselineskip
\hskip0,8cm
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 140
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 140
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 141
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 141
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 142
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 142
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 143
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 143
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 144
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 144
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 145
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 145
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 146
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 146
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 147
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 147
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 148
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 148
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 149
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 149
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 150
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 150
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 151
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 151
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 152
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 152
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 153
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 153
\vskip1.000000\baselineskip
\hskip0,8cm
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 154
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 154
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 155
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 155
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 156
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 156
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 157
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 157
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 158
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 158
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 159
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 159
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 160
\vskip0.400000\baselineskip
<211> 7
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 160
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 161
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 161
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 162
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 162
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 163
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 163
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 164
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 164
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 165
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 165
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 166
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 166
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 167
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 167
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 168
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 168
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 169
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 169
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 170
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 170
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 171
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 171
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 172
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 172
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 173
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 173
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 174
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 174
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 175
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 175
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 176
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 176
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 177
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 177
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 178
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 178
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 179
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 179
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 180
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 180
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 181
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 181
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 182
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 182
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 183
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 183
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 184
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 184
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 185
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 185
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 186
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 186
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 187
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 187
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 188
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 188
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 189
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 189
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 190
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 190
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 191
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 191
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 192
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 192
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 193
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 193
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 194
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 194
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 195
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 195
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 196
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 196
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 197
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 197
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 198
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 198
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 199
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 199
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 200
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 200
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 201
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 201
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 202
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 202
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 203
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 203
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 204
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 204
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 205
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 205
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 206
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 206
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 207
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 207
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 208
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 208
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 209
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 209
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 210
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 210
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 211
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 211
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 212
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 212
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 213
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 213
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 214
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 214
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 215
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 215
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 216
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 216
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 217
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 217
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 218
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 218
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 219
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 219
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 220
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 220
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 221
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 221
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 222
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 222
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 223
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 223
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 224
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 224
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 225
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 225
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 226
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 226
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 227
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 227
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 228
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 228
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 229
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 229
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 230
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 230
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 231
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 231
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 232
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 232
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 233
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 233
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 234
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 234
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 235
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 235
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 236
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 236
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 237
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 237
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 238
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 238
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 239
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 239
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 240
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 240
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 241
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 241
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 242
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 242
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 243
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 243
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 244
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 244
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 245
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 245
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 246
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 246
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 247
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 247
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 248
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 248
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 249
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 249
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 250
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 250
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 251
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 251
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 252
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 252
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 253
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 253
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 254
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 254
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 255
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 255
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 256
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 256
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 257
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 257
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 258
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 258
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 259
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 259
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 260
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 260
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 261
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 261
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 262
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 262
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 263
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 263
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 264
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 264
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 265
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 265
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 266
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 266
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 267
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 267
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 268
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 268
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 269
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 269
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 270
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 270
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 271
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 271
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 272
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 272
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 273
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 273
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 274
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 274
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 275
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 275
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 276
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 276
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 277
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 277
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 278
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 278
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 279
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 279
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 280
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 280
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 281
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 281
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 282
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 282
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 283
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 283
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 284
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 284
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 285
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 285
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 286
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 286
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 287
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 287
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 288
\vskip0.400000\baselineskip
<211> 17
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 288
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 289
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 289
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 290
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 290
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 291
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 291
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 292
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 292
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 293
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 293
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 294
\vskip0.400000\baselineskip
<211> 15
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 294
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 295
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 295
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 296
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 296
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 297
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 297
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 298
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 298
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 299
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 299
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 300
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 300
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 301
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 301
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 302
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 302
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 303
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 303
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 304
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 304
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 305
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 305
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 306
\vskip0.400000\baselineskip
<211> 13
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 306
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 307
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 307
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 308
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 308
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 309
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 309
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 310
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 310
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 311
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 311
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 312
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 312
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 313
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 313
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 314
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 314
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 315
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 315
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 316
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 316
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 317
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 317
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 318
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 318
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 319
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 319
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 320
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 320
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 321
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 321
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 322
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 322
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 323
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 323
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 324
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 324
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 325
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 325
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip0.400000\baselineskip
<210> 326
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 326
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 327
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 327
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 328
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 328
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 329
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 329
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 330
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 330
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 331
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 331
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 332
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 332
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 333
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 333
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 334
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 334
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 335
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 335
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 336
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 336
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 337
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 337
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 338
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 338
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 339
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 339
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 340
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 340
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 341
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 341
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 342
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 342
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 343
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 343
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 344
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 344
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 345
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 345
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 346
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 346
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 347
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 347
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 348
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 348
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 349
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 349
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 350
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 350
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 351
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 351
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 352
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 352
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 353
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 353
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 354
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 354
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 355
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 355
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 356
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 356
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 357
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 357
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 358
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 358
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 359
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 359
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 360
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 360
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 361
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 361
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 362
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 362
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 363
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 363
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 364
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 364
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 365
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 365
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 366
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 366
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 367
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 367
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 368
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 368
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 369
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 369
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 370
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 370
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 371
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 371
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 372
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 372
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 373
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 373
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 374
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 374
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 375
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 375
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 376
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 376
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 377
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 377
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 378
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 378
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 379
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 379
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 380
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 380
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 381
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 381
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 382
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 382
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 383
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 383
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 384
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 384
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 385
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 385
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 386
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 386
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 387
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 387
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 388
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 388
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 389
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 389
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 390
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 390
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 391
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 391
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 392
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 392
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 393
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 393
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 394
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 394
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 395
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 395
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 396
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 396
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 397
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 397
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 398
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 398
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 399
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 399
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 400
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 400
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 401
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 401
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 402
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 402
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 403
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 403
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 404
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 404
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 405
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 405
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 406
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 406
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 407
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 407
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 408
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 408
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 409
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 409
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 410
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 410
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 411
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 411
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 412
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 412
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 413
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 413
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 414
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 414
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 415
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 415
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 416
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 416
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 417
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 417
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 418
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 418
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 419
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 419
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 420
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 420
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 421
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 421
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 422
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 422
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 423
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 423
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 424
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 424
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 425
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 425
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 426
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 426
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 427
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 427
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 428
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 428
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 429
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 429
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 430
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 430
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 431
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 431
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 432
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 432
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 433
\vskip0.400000\baselineskip
<211> 7
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 433
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 434
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 434
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 435
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 435
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 436
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 436
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 437
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 437
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 438
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 438
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 439
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 439
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 440
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 440
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 441
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 441
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 442
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 442
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 443
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 443
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 444
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 444
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 445
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 445
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 446
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 446
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 447
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 447
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 448
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 448
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 449
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 449
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 450
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 450
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 451
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 451
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 452
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 452
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 453
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 453
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 454
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 454
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 455
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 455
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 456
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 456
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 457
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 457
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 458
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 458
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 459
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 459
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 460
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 460
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 461
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 461
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 462
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 462
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 463
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 463
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 464
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 464
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 465
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 465
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 466
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 466
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 467
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 467
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 468
\vskip0.400000\baselineskip
<211> 13
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 468
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 469
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 469
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 470
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 470
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 471
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 471
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 472
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 472
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 473
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 473
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 474
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 474
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 475
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 475
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 476
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 476
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 477
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 477
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 478
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 478
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 479
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 479
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 480
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 480
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 481
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 481
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 482
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 482
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 483
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 483
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 484
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 484
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 485
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 485
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 486
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 486
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 487
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 487
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 488
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 488
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 489
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 489
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 490
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 490
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 491
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 491
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 492
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 492
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 493
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 493
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 494
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 494
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 495
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 495
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 496
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 496
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 497
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 497
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 498
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 498
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 499
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 499
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 500
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 500
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 501
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 501
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 502
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 502
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 503
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 503
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 504
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 504
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 505
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 505
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 506
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 506
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 507
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 507
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 508
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 508
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 509
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 509
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 510
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 510
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 511
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 511
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 512
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 512
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 513
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 513
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 514
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 514
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 515
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 515
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 516
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 516
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 517
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 517
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 518
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 518
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 519
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 519
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 520
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 520
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 521
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 521
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 522
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 522
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 523
\vskip0.400000\baselineskip
<211> 12
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 523
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 524
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 524
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 525
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 525
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 526
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 526
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 527
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 527
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 528
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 528
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 529
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 529
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 530
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 530
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 531
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 531
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 532
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 532
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 533
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 533
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 534
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 534
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 535
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 535
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 536
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 536
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 537
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 537
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 538
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 538
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 539
\vskip0.400000\baselineskip
<211> 8
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 539
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 540
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 540
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 541
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 541
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 542
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 542
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 543
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 543
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 544
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 544
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 545
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 545
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 546
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 546
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 547
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 547
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 548
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 548
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 549
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 549
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 550
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 550
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 551
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 551
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 552
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 552
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 553
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 553
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 554
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 554
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 555
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 555
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 556
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 556
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 557
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 557
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 558
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 558
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 559
\vskip0.400000\baselineskip
<211> 14
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 559
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 560
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 560
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 561
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 561
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 562
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 562
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 563
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 563
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 564
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 564
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 565
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\newpage
\vskip0.400000\baselineskip
<400> 565
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 566
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 566
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 567
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 567
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 568
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 568
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 569
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 569
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 570
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 570
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 571
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 571
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 572
\vskip0.400000\baselineskip
<211> 11
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 572
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 573
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 573
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 574
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 574
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 575
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\newpage
\vskip0.400000\baselineskip
<400> 575
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 576
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 576
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 577
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 577
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 578
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<223> Derivado de
Melan-A, posición 26-35, modificado
por un intercambio de aminoácidos de la alanina situada en la
posición 27 por leucina
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 578
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 579
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Virus de la inmunodeficiencia
humana tipo 1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 579
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 580
\vskip0.400000\baselineskip
<211> 9
\newpage
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Virus de la gripe
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 580
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 581
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Citomegalovirus humano
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 581
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 582
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Herpesvirus humano 4
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 582
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 583
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Herpesvirus humano 4
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 583
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 584
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Herpesvirus humano 4
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 584
\vskip1.000000\baselineskip
\hskip0,8cm
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 585
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Homo sapiens
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 585
\vskip1.000000\baselineskip
\hskip0,8cm
Claims (15)
1. Un péptido asociado a tumor con una secuencia
de aminoácidos compuesto por la secuencia SEQ ID n.º 448 en el
protocolo de secuencias adjunto, en donde el péptido muestra la
capacidad de unirse a una molécula del complejo mayor de
histocompatibilidad (MHC) humano de clase I.
2. El péptido conforme a la reivindicación 1,
caracterizado porque la leucina del
C-terminal es sustituida por valina, isoleucina o
alanina.
3. El péptido conforme a la reivindicación 1 o
2, caracterizado porque en N- y/o C-terminal
existe otro aminoácido.
4. El péptido conforme a las reivindicaciones 1
a 3, caracterizado porque un aminoácido es eliminado.
5. La utilización de uno o varios péptidos
conforme a las reivindicaciones 1 a 4 para la preparación de un
medicamento para el tratamiento de enfermedades tumorales y/o
enfermedades adenomatosas.
6. La utilización conforme a la reivindicación
5, caracterizada porque la enfermedad es cáncer renal, de
mama, de páncreas, de estómago, de cerebro, de vejiga, de testículo
y/o una enfermedad tumoral del sistema nervioso.
7. La utilización conforme a las
reivindicaciones 5 o 6, caracterizada porque el péptido es
aplicado junto con un adyuvante.
8. La utilización conforme a las
reivindicaciones 5 o 6, caracterizada porque el péptido se
aplica unido a una célula presentadora de antígeno.
9. La utilización del péptido conforme a
cualquiera de las reivindicaciones 1 a 4 para la marcación de
leucocitos, especialmente de linfocitos T, in vitro.
10. La utilización conforme a la reivindicación
9 para evaluar el desarrollo de una terapia de una enfermedad
tumoral.
11. La utilización del péptido conforme a
cualquiera de las reivindicaciones 1 a 4 para la preparación de un
anticuerpo in vitro.
12. Una composición farmacéutica que contiene
uno o varios péptidos conformes a cualquiera de las reivindicaciones
1 a 4.
13. Una molécula de ácidos nucleicos que sólo
codifica el péptido conforme a cualquiera de las reivindicaciones 1
a 4.
14. Un vector que contiene la molécula de ácidos
nucleicos conforme a la reivindicación 13.
15. Células que, con ayuda de la molécula de
ácidos nucleicos conforme a la reivindicación 13 o con ayuda del
vector conforme a la reivindicación 14, son modificadas
genéticamente de tal forma que producen un péptido conforme a
cualquiera de las reivindicaciones 1 a 4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004026135A DE102004026135A1 (de) | 2004-05-25 | 2004-05-25 | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| DE102004026135 | 2004-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2333804T3 true ES2333804T3 (es) | 2010-03-01 |
Family
ID=34970615
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05752606T Active ES2333804T3 (es) | 2004-05-25 | 2005-05-24 | Peptidos asociados a tumor unidos a moleculas mhc. |
| ES09000315T Active ES2385532T3 (es) | 2004-05-25 | 2005-05-24 | Péptidos asociados a tumor unidos a moléculas MHC |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09000315T Active ES2385532T3 (es) | 2004-05-25 | 2005-05-24 | Péptidos asociados a tumor unidos a moléculas MHC |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8008431B2 (es) |
| EP (2) | EP1761553B1 (es) |
| JP (2) | JP4764874B2 (es) |
| AT (1) | ATE446310T1 (es) |
| AU (1) | AU2005247598B2 (es) |
| CA (2) | CA2568254C (es) |
| CY (2) | CY1109672T1 (es) |
| DE (2) | DE102004026135A1 (es) |
| DK (2) | DK2058323T3 (es) |
| ES (2) | ES2333804T3 (es) |
| PL (2) | PL2058323T3 (es) |
| PT (2) | PT2058323E (es) |
| SI (2) | SI2058323T1 (es) |
| WO (1) | WO2005116051A2 (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090004213A1 (en) * | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| WO2008116468A2 (en) | 2007-03-26 | 2008-10-02 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
| WO2009003493A2 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
| AU2012216641B2 (en) * | 2007-07-27 | 2015-02-05 | Immatics Biotechnologies Gmbh | Novel immunogenic epitopes for immunotherapy |
| HUE025636T2 (en) * | 2007-07-27 | 2016-04-28 | Immatics Biotechnologies Gmbh | New immunogenic epitope for immunotherapy |
| KR101290892B1 (ko) * | 2007-07-27 | 2013-07-31 | 이매틱스 바이오테크놀로지스 게엠베하 | 신경 및 뇌 종양에 대한 신규 면역요법 |
| WO2009039854A2 (en) | 2007-09-27 | 2009-04-02 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
| WO2009054470A1 (ja) * | 2007-10-25 | 2009-04-30 | Toray Industries, Inc. | 免疫誘導剤及びその用途 |
| DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
| DK2105501T3 (da) * | 2008-03-27 | 2015-11-23 | Immatics Biotechnologies Gmbh | Hidtil ukendt immunterapi mod neuronale tumorer og hjernetumorer |
| ATE462442T1 (de) * | 2008-04-30 | 2010-04-15 | Immatics Biotechnologies Gmbh | Neuartige formulierungen von tumor-assoziierten peptiden, welche an menschliche leukozytenantigene der klasse i oder ii für impfungen binden |
| EP2119726B2 (en) * | 2008-05-14 | 2017-11-29 | Immatics Biotechnologies GmbH | Novel and powerful MHC-class II peptides derived from survivin and neurocan |
| TW201000115A (en) * | 2008-06-11 | 2010-01-01 | Oncotherapy Science Inc | IQGAP3 epitope peptides and vaccines containing the same |
| WO2010009735A2 (en) | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
| PL2837383T3 (pl) * | 2008-08-05 | 2017-07-31 | Toray Industries, Inc. | Środek indukujący odporność |
| MX2011001445A (es) | 2008-08-05 | 2011-04-05 | Toray Industries | Metodo para detectar cancer. |
| CA2733223C (en) | 2008-08-05 | 2018-02-27 | Toray Industries, Inc. | Pharmaceutical composition comprising anti-caprin-1 antibody for treatment and prevention of cancers |
| GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| AU2016204711B2 (en) * | 2008-10-01 | 2018-03-01 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumors including neuronal and brain tumors |
| DK2172211T3 (en) * | 2008-10-01 | 2015-02-16 | Immatics Biotechnologies Gmbh | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| WO2010117010A1 (ja) | 2009-04-10 | 2010-10-14 | 北海道公立大学法人札幌医科大学 | 腫瘍マーカーおよびその利用 |
| US8075895B2 (en) * | 2009-09-22 | 2011-12-13 | Janssen Pharmaceutica N.V. | Identification of antigenic peptides from multiple myeloma cells |
| HUE030102T2 (en) | 2010-02-04 | 2017-04-28 | Toray Industries | A pharmaceutical composition comprising anti-caprin-1 antibodies for the treatment and / or prevention of cancer |
| JP5906739B2 (ja) | 2010-02-04 | 2016-04-20 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
| JP5742714B2 (ja) | 2010-02-04 | 2015-07-01 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
| DK2532680T3 (da) | 2010-02-04 | 2015-07-20 | Toray Industries | Medicinsk sammensætning til behandling og/eller forebyggelse af cancer |
| RU2624029C2 (ru) | 2010-02-04 | 2017-06-30 | Торэй Индастриз, Инк. | Лекарственный препарат для лечения и/или профилактики рака |
| DK2532366T3 (da) | 2010-02-04 | 2017-01-02 | Toray Industries | Farmaceutisk sammensætning til behandling og/eller forebyggelse af cancer |
| GB201009222D0 (en) * | 2010-06-02 | 2010-07-21 | Immatics Biotechnologies Gmbh | Improved cancer therapy based on tumour associated antigens derived from cyclin D1 |
| IT1400874B1 (it) * | 2010-07-05 | 2013-07-02 | Univ Degli Studi Genova | Supporto planare avente una superficie ultrapiatta e dispositivo per la rivelazione di antigeni comprendente detto supporto planare. |
| MY170949A (en) * | 2011-07-11 | 2019-09-20 | Cancer Res Initiatives Foundation | A peptide capable of binding with a human leukocyte antigen (hla) molecule, a cancer vaccine derived from said peptide and use of said cancer vaccine |
| JP6187255B2 (ja) | 2012-02-21 | 2017-08-30 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
| DE102012105193B4 (de) * | 2012-06-15 | 2014-04-03 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Stimulation der zellulären Immunantwort gegen das Epstein-Barr-Virus (EBV) |
| CN104497124B (zh) * | 2013-12-23 | 2017-10-03 | 南方医科大学 | Eps8抗肿瘤ctl表位肽及其应用 |
| CN104497123B (zh) * | 2013-12-23 | 2017-10-27 | 南方医科大学 | Eps8抗肿瘤ctl表位肽及其应用 |
| CN104497125B (zh) * | 2013-12-23 | 2018-04-27 | 南方医科大学 | Eps8抗肿瘤ctl表位肽及其应用 |
| GB201505585D0 (en) * | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
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| GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
| PE20230321A1 (es) | 2015-07-01 | 2023-02-22 | Immatics Biotechnologies Gmbh | Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia contra el cancer de ovario y otros tipos de cancer |
| GB201512369D0 (en) * | 2015-07-15 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
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| DE10225144A1 (de) * | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| AU2003258134A1 (en) * | 2002-08-09 | 2004-02-25 | Applera Corporation | Lung cancer target proteins and use thereof |
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| US7507803B2 (en) * | 2002-10-03 | 2009-03-24 | Genimmune N.V. | Optimized multi-epitope constructs and uses thereof |
| US7468254B2 (en) * | 2003-01-21 | 2008-12-23 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
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