WO2009054470A1 - 免疫誘導剤及びその用途 - Google Patents

免疫誘導剤及びその用途 Download PDF

Info

Publication number
WO2009054470A1
WO2009054470A1 PCT/JP2008/069265 JP2008069265W WO2009054470A1 WO 2009054470 A1 WO2009054470 A1 WO 2009054470A1 JP 2008069265 W JP2008069265 W JP 2008069265W WO 2009054470 A1 WO2009054470 A1 WO 2009054470A1
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
immune response
specific
cell
ability
Prior art date
Application number
PCT/JP2008/069265
Other languages
English (en)
French (fr)
Inventor
Fumiyoshi Okano
Asuka Yoshizawa
Original Assignee
Toray Industries, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries, Inc. filed Critical Toray Industries, Inc.
Priority to JP2008550573A priority Critical patent/JPWO2009054470A1/ja
Publication of WO2009054470A1 publication Critical patent/WO2009054470A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00119—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46449—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/47—Brain; Nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

特定のペプチドを有効成分として含有する免疫誘導剤が開示されている。該ペプチドは、ヒト悪性脳腫瘍に過剰に発現しているGPNMB中の特定の領域に存在する部分ペプチドであり、抗原提示細胞により提示されて、該ペプチドに特異的な細胞障害性Ｔ細胞を活性化及び増殖させる能力（免疫誘導活性）を有する。さらに、該ペプチドに特異的な細胞障害性Ｔ細胞は、GPNMBを発現する癌細胞を障害する能力を有する。このため、該ペプチドは、癌の治療及び／又は予防剤並びに抗原提示細胞の処理剤として利用可能な免疫誘導剤の調製に有用である。
PCT/JP2008/069265 2007-10-25 2008-10-23 免疫誘導剤及びその用途 WO2009054470A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008550573A JPWO2009054470A1 (ja) 2007-10-25 2008-10-23 免疫誘導剤及びその用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-277287 2007-10-25
JP2007277287 2007-10-25

Publications (1)

Publication Number Publication Date
WO2009054470A1 true WO2009054470A1 (ja) 2009-04-30

Family

ID=40579572

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069265 WO2009054470A1 (ja) 2007-10-25 2008-10-23 免疫誘導剤及びその用途

Country Status (2)

Country Link
JP (1) JPWO2009054470A1 (ja)
WO (1) WO2009054470A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021020047A1 (ja) 2019-07-29 2021-02-04 国立大学法人新潟大学 免疫誘導剤及び老化関連疾患の予防又は治療用医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005116051A2 (de) * 2004-05-25 2005-12-08 Immatics Biotechnologies Gmbh An mhc-moleküle bindende tumor-assoziierte peptide
JP2006124353A (ja) * 2004-11-01 2006-05-18 Miyazaki Prefecture 肝臓疾患治療剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005116051A2 (de) * 2004-05-25 2005-12-08 Immatics Biotechnologies Gmbh An mhc-moleküle bindende tumor-assoziierte peptide
JP2006124353A (ja) * 2004-11-01 2006-05-18 Miyazaki Prefecture 肝臓疾患治療剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LENNERZ, V. ET AL.: "The response of autologous T cells to a human melanoma is dominated by mutated neoantigens", PROC NATL ACAD SCI U S A, vol. 102, no. 44, 2005, pages 16013 - 8 *
YUTAKA KAWAKAMI: "Shuyo Men'eki Kiko to Shuyo Kogen", IGAKU NO AYUMI, vol. 194, no. 14, 2000, pages 1208 - 1215 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021020047A1 (ja) 2019-07-29 2021-02-04 国立大学法人新潟大学 免疫誘導剤及び老化関連疾患の予防又は治療用医薬組成物
EP3991743A4 (en) * 2019-07-29 2023-08-23 Juntendo Educational Foundation IMMUNE INDUCER AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF AGING-RELATED DISEASES

Also Published As

Publication number Publication date
JPWO2009054470A1 (ja) 2011-03-10

Similar Documents

Publication Publication Date Title
UA105210C2 (ru) Противораковая вакцина и ее применение
SG166093A1 (en) Inhibitors of brutonæs tyrosine kinase
WO2005123908A3 (en) Novel cancer cell lines and uses thereof
PH12015500940A1 (en) Bruton`s tyrosine kinase inhibitors
MX2014009219A (es) Compuestos de purinona como inhibidores de quinasas.
IL211299A (en) Medications containing polypeptide to induce, increase or increase tumor immune response, and their use in the preparation of cancer drugs
WO2008096831A1 (ja) 癌の治療剤
MXPA05008406A (es) Compuestos de amida tri(ciclo)-sustituida.
WO2007067682A3 (en) In vivo cell surface engineering
SI2102331T1 (sl) Antitumorsko cepivo, izvedeno iz normalnih kemično modificiranih CD4+ celic
EP4279513A3 (en) Cytotoxicity-inducing therapeutic agent
MX2007010996A (es) Nuevas composiciones de liposomas.
MX2010010954A (es) Farmaco contra cancer de higado.
WO2006085115A3 (en) Therapeutic uses of tomato extracts
WO2013061083A3 (en) Therapeutic agents and uses thereof
TW200642682A (en) A combination of medical drugs to augment the anti-cancer effect of chemotherapy
WO2004080394A3 (en) Stat3 antagonists and their use as vaccines against cancer
NZ576590A (en) Tissue targeted antigenic activation of the immune response to treat cancers
IL200517A0 (en) Agent for use in the case of fructose intolerance
WO2009032256A3 (en) Apc activators in combination with a cytokine-secreting cell and methods of use thereof
WO2005037995A3 (en) Use of cox-2 inhibitor to prevent t-cell anergy induced by dendritic cell therapy
WO2019098759A3 (ko) 형질전환된 인간세포 및 이의 용도
WO2009054470A1 (ja) 免疫誘導剤及びその用途
UA105944C2 (uk) Комбінація теоброміну з деконгестантом і її застосування для лікування кашлю
WO2004078126A3 (en) Compositions and methods with enhanced therapeutic activity

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2008550573

Country of ref document: JP

Kind code of ref document: A

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08842279

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08842279

Country of ref document: EP

Kind code of ref document: A1