ES2332584T3 - Metodo y composicion para solubilizar un compuesto biologicamente activo con baja solubilidad en agua. - Google Patents

Metodo y composicion para solubilizar un compuesto biologicamente activo con baja solubilidad en agua. Download PDF

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Publication number
ES2332584T3
ES2332584T3 ES02737899T ES02737899T ES2332584T3 ES 2332584 T3 ES2332584 T3 ES 2332584T3 ES 02737899 T ES02737899 T ES 02737899T ES 02737899 T ES02737899 T ES 02737899T ES 2332584 T3 ES2332584 T3 ES 2332584T3
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ES
Spain
Prior art keywords
lipid
substance
container
pharmacological
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02737899T
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English (en)
Spanish (es)
Inventor
Steve Leigh
Mathew Louis Steven Leigh
Peter Van Hoogevest
Henricus Tiemessen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phares Pharmaceutical Research NV
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Phares Pharmaceutical Research NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phares Pharmaceutical Research NV filed Critical Phares Pharmaceutical Research NV
Application granted granted Critical
Publication of ES2332584T3 publication Critical patent/ES2332584T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ES02737899T 2001-03-27 2002-03-26 Metodo y composicion para solubilizar un compuesto biologicamente activo con baja solubilidad en agua. Expired - Lifetime ES2332584T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01302841 2001-03-27
EP01302841 2001-03-27

Publications (1)

Publication Number Publication Date
ES2332584T3 true ES2332584T3 (es) 2010-02-09

Family

ID=8181836

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02737899T Expired - Lifetime ES2332584T3 (es) 2001-03-27 2002-03-26 Metodo y composicion para solubilizar un compuesto biologicamente activo con baja solubilidad en agua.

Country Status (11)

Country Link
US (2) US20040115255A1 (https=)
EP (1) EP1389089B1 (https=)
JP (3) JP2004524368A (https=)
AT (1) ATE440593T1 (https=)
AU (1) AU2002312777B2 (https=)
CA (1) CA2442539C (https=)
DE (1) DE60233484D1 (https=)
DK (1) DK1389089T3 (https=)
ES (1) ES2332584T3 (https=)
PT (1) PT1389089E (https=)
WO (1) WO2002080883A2 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7444383B2 (en) 2000-06-17 2008-10-28 Microsoft Corporation Bounded-deferral policies for guiding the timing of alerting, interaction and communications using local sensory information
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6869617B2 (en) 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
DE10203923B4 (de) * 2002-01-31 2011-06-01 Klinipharm Gmbh Verfahren zur Erhöhung der Wasserlöslichkeit lipophiler Wirkstoffe, Herstellung von hochkonzentrierten wässrigen Zusammensetzungen dieser Wirkstoffe, derartige Produkte und ihre Verwendung
CA2539486A1 (en) * 2003-10-02 2005-04-07 Sembiosys Genetics Inc. Methods for preparing oil bodies comprising active ingredients
WO2005065677A1 (ja) * 2004-01-09 2005-07-21 Otsuka Pharmaceutical Factory, Inc. パクリタキセルまたはドセタキセルを溶解または分散させるための脂肪乳剤
EP1748759B1 (en) * 2004-04-27 2013-03-27 Javeri, Indu Methods of enhancing solubility in water of hydrophobic compounds by micellar dispersions
US7345093B2 (en) 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US7659310B2 (en) 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
ES2660172T3 (es) * 2004-05-19 2018-03-21 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Composición inyectable que comprende desoxicolato de sodio
AU2005302255A1 (en) * 2004-10-28 2006-05-11 Alza Corporation Lyophilized liposome formulations and method
CN101137395B (zh) * 2005-03-14 2012-10-31 株式会社大塚制药工场 含有水难溶性药物的医药组合物
JP5342834B2 (ja) * 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
EP3415151A1 (en) * 2008-05-23 2018-12-19 The University of British Columbia Modified drugs for use in liposomal nanoparticles
LT2344198T (lt) * 2008-09-27 2021-02-25 Jina Pharmaceuticals Inc. Farmaciniai preparatai lipidų pagrindu, skirti vietiniam naudojimui
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
CA2781529C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes comprising docetaxel
US20170340563A1 (en) * 2009-09-23 2017-11-30 Curirx Inc. Methods for the Preparation of Liposomes Comprising Drugs
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
CN101926757B (zh) * 2010-09-01 2013-01-02 北京大学 一种难溶性药物的液体组合物及其制备方法
BR112013014291A2 (pt) * 2010-12-08 2016-09-20 Hoffmann La Roche formulação lipossômica de calcetrapib
US20120237492A1 (en) 2011-02-18 2012-09-20 Kythera Biopharmaceuticals, Inc. Treatment of submental fat
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
US20150157610A1 (en) * 2012-05-23 2015-06-11 Osaka University Pharmaceutical composition for treating inflammatory disease
EP2682106A1 (en) 2012-07-03 2014-01-08 Phares Pharmaceutical Research N.V. Method of solubilizing biologically active compounds
CA3007438C (en) 2015-12-07 2025-05-13 Elka Touitou COMPOSITIONS OF THERAPEUTIC SUBSTANCES, RELATED PROCESSES AND USES
MD3532067T2 (ro) 2016-10-28 2022-10-31 Servier Lab Formă farmaceutică lipozomală pentru utilizare în tratamentul cancerului
EP3634385A4 (en) * 2017-05-12 2021-03-03 Curinanorx, LLC LIPOSOME PREPARATION PROCESSES INCLUDING MEDICINAL PRODUCTS

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
JPH0753661B2 (ja) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
DE3883206T3 (de) * 1987-09-07 2003-11-13 Teijin Ltd., Osaka Arzneistoff enthaltende fettemulsion des typs "kurz vor gebrauch hergestellt" sowie verfahren zur herstellung einer arzneihaltigen fettemulsion.
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US5741513A (en) * 1990-02-08 1998-04-21 A. Natterman & Cie. Gmbh Alcoholic aqueous gel-like phospholipid composition, its use and topical preparations containing it
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
AU660288B2 (en) * 1990-07-31 1995-06-22 Transave, Inc. Accumulation of amino acids and peptides into liposomes
CA2157489A1 (en) * 1993-03-04 1994-09-15 Masaaki Numata Lewis-associated compound, process for producing the same, and anti-inflammatory
DE19609538A1 (de) * 1996-03-11 1997-09-18 Basf Ag Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung
EP0699068B1 (en) * 1993-05-21 2001-12-19 The Liposome Company, Inc. Reduction of liposome-induced adverse physiological reactions
EP0633024A1 (en) * 1993-07-09 1995-01-11 Ciba-Geigy Ag Topically administrable zinc phthalocyanine compositions
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
DE69503629T2 (de) * 1994-05-23 1998-11-26 B. Braun Medical Inc., Bethlehem, Pa. 18018 Vorrichtung zur herstellung einer formulierung
JP2740153B2 (ja) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー 混合ミセル
US6447800B2 (en) * 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6056973A (en) * 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
EP0974364A4 (en) * 1996-10-25 2000-12-20 Yoshitomi Pharmaceutical METHOD FOR PREVENTING THE PREPARATION OF MEDICINAL PRODUCTS
DE59710082D1 (de) * 1996-12-13 2003-06-18 Vesifact Ag Baar Kosmetische Präparate in Form einer Nanodispersion
GB9726916D0 (en) * 1997-12-19 1998-02-18 Danbiosyst Uk Nasal formulation
WO2000002534A1 (fr) * 1998-07-10 2000-01-20 Welfide Corporation Kit a preparer avant usage avec preparation contenant un medicament et solvant destine a cette fin
DE19843968A1 (de) * 1998-09-24 2000-04-13 Hans Dietl Taxane enthaltende pharmazeutische Zubereitung zur intravenösen Applikation und Verfahren zu ihrer Herstellung
US6682758B1 (en) * 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
EP1985285A3 (en) * 1999-04-01 2009-08-12 Hana Biosciences, Inc. Compositions and methods for treating lymphoma
US20030144570A1 (en) * 1999-11-12 2003-07-31 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
US20020001613A1 (en) * 2000-02-08 2002-01-03 Susan Niemiec Method of manufacturing liposomes

Also Published As

Publication number Publication date
US20040115255A1 (en) 2004-06-17
EP1389089A2 (en) 2004-02-18
DE60233484D1 (de) 2009-10-08
JP2010013461A (ja) 2010-01-21
US20080131499A1 (en) 2008-06-05
CA2442539A1 (en) 2002-10-17
AU2002312777B2 (en) 2007-07-05
ATE440593T1 (de) 2009-09-15
PT1389089E (pt) 2009-11-30
AU2002312777A2 (en) 2002-10-21
WO2002080883A2 (en) 2002-10-17
DK1389089T3 (da) 2009-12-21
WO2002080883A3 (en) 2003-12-11
CA2442539C (en) 2011-11-08
JP2004524368A (ja) 2004-08-12
EP1389089B1 (en) 2009-08-26
JP2012207042A (ja) 2012-10-25

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