ES2327935T3 - Introduccion de un aerosol en un circuito de un ventilador. - Google Patents
Introduccion de un aerosol en un circuito de un ventilador. Download PDFInfo
- Publication number
- ES2327935T3 ES2327935T3 ES04819171T ES04819171T ES2327935T3 ES 2327935 T3 ES2327935 T3 ES 2327935T3 ES 04819171 T ES04819171 T ES 04819171T ES 04819171 T ES04819171 T ES 04819171T ES 2327935 T3 ES2327935 T3 ES 2327935T3
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- Prior art keywords
- pharmaceutical formulation
- aerosol
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- aerosolized
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
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- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Catching Or Destruction (AREA)
Applications Claiming Priority (2)
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| US52301103P | 2003-11-17 | 2003-11-17 | |
| US523011P | 2003-11-17 |
Publications (1)
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| ES2327935T3 true ES2327935T3 (es) | 2009-11-05 |
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| ES04819171T Expired - Lifetime ES2327935T3 (es) | 2003-11-17 | 2004-11-17 | Introduccion de un aerosol en un circuito de un ventilador. |
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| EP (1) | EP1684720B1 (https=) |
| JP (1) | JP4933262B2 (https=) |
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| AU (1) | AU2004291172B2 (https=) |
| BR (1) | BRPI0416654A (https=) |
| CA (1) | CA2545219C (https=) |
| DE (1) | DE602004021279D1 (https=) |
| ES (1) | ES2327935T3 (https=) |
| WO (1) | WO2005048982A2 (https=) |
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| TW465235B (en) | 1998-09-17 | 2001-11-21 | United Video Properties Inc | Electronic program guide with digital storage |
| US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
| US7600511B2 (en) | 2001-11-01 | 2009-10-13 | Novartis Pharma Ag | Apparatus and methods for delivery of medicament to a respiratory system |
| MXPA02010884A (es) | 2000-05-05 | 2003-03-27 | Aerogen Ireland Ltd | Aparato y metodo para el suministro de medicamentos al sistema respiratorio. |
| US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
| FR2858236B1 (fr) | 2003-07-29 | 2006-04-28 | Airox | Dispositif et procede de fourniture de gaz respiratoire en pression ou en volume |
| AU2005228826B2 (en) | 2004-03-31 | 2008-05-08 | Fisher & Paykel Healthcare Limited | A patient ventilating and aspirating system |
| US7946291B2 (en) * | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
| US7267121B2 (en) | 2004-04-20 | 2007-09-11 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| US7290541B2 (en) | 2004-04-20 | 2007-11-06 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| US8028697B2 (en) | 2005-04-28 | 2011-10-04 | Trudell Medical International | Ventilator circuit and method for the use thereof |
| EP1893273B1 (en) | 2005-05-18 | 2014-06-25 | Nektar Therapeutics | Adapter for use with aerosolization device for endobronchial therapy |
| US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| US7838532B2 (en) * | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| EP1896662B1 (en) | 2005-05-25 | 2014-07-23 | AeroGen, Inc. | Vibration systems and methods |
| US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
| WO2007041156A2 (en) | 2005-09-29 | 2007-04-12 | Nektar Therapeutics | Antibiotic formulations, unit doses, kits, and methods |
| DE102006004528A1 (de) * | 2006-02-01 | 2007-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Adapter für Inhalationsgeräte zur Behandlung von künstlich beatmeten Patienten |
| MX2008010222A (es) * | 2006-02-10 | 2008-10-17 | Pari Pharma Gmbh | Antibioticos nebulizados para terapia de inhalacion. |
| DE102006006183A1 (de) | 2006-02-10 | 2007-08-16 | Pari GmbH Spezialisten für effektive Inhalation | Inhalationstherapievorrichtung für die Anwendung bei Frühgeborenen und Kleinkindern |
| US20080035141A1 (en) * | 2006-06-16 | 2008-02-14 | Warner W R | Aerosolized therapy kit |
| US20080027372A1 (en) * | 2006-07-31 | 2008-01-31 | Stanley Baldwin | Medication port for a ventilation machine |
| US20090241948A1 (en) * | 2007-03-28 | 2009-10-01 | Dermot Joseph Clancy | Humidification in breathing circuits |
| US20080243050A1 (en) * | 2007-03-28 | 2008-10-02 | John Sylvester Power | Insufflation of Body Cavities |
| EP2157992B1 (en) * | 2007-06-15 | 2016-12-14 | iDTx Systems, Inc. | A drug delivery and monitoring system for a ventilator |
| US8550075B2 (en) * | 2007-06-28 | 2013-10-08 | Resmed Limited | Removable and/or replaceable humidifier |
| MX2010003263A (es) * | 2007-09-25 | 2010-06-02 | Novartis Ag | Tratamiento de trastornos pulmonares con medicamentos aerosolizados tales como vancomicina. |
| EP2231244B1 (en) * | 2007-12-19 | 2016-06-01 | Neores AB | A nebulising device for use in a cpap-system |
| ES2565219T3 (es) | 2008-03-17 | 2016-04-01 | Discovery Laboratories, Inc. | Adaptador de circuito de ventilación y sistema proximal de administración de aerosol |
| DE202009019112U1 (de) | 2008-03-28 | 2016-07-28 | Stamford Devices Limited | Aerosoleinführgerät zur Befeuchtung in Atmungskreisläufen |
| AU2015264908B2 (en) * | 2008-05-09 | 2017-06-29 | Pari Pharma Gmbh | Nebuliser for Ventilation Machines and a Ventilation Machine Comprising such a Nebuliser |
| DE102008022987A1 (de) | 2008-05-09 | 2009-11-12 | Pari Pharma Gmbh | Vernebler für Beatmungsmaschinen und Beatmungsmaschine mit einem solchen Vernebler |
| AU2013201359B2 (en) * | 2008-05-09 | 2015-09-17 | Pari Pharma Gmbh | Atomizer for Ventilation Machines and Ventilation Machine Comprising said Atomizer |
| US8457706B2 (en) | 2008-05-16 | 2013-06-04 | Covidien Lp | Estimation of a physiological parameter using a neural network |
| US8561606B2 (en) * | 2008-06-05 | 2013-10-22 | Carefusion 2200, Inc. | Heat and moisture exchange unit |
| US20100071688A1 (en) * | 2008-09-22 | 2010-03-25 | Daniel Patrick Dwyer | Universal Self-Closing Metered Dose Inhaler Adaptor |
| US8302602B2 (en) | 2008-09-30 | 2012-11-06 | Nellcor Puritan Bennett Llc | Breathing assistance system with multiple pressure sensors |
| CA2739893C (en) | 2008-10-07 | 2016-10-04 | Mpex Pharmaceuticals, Inc. | Inhalation of levofloxacin for reducing lung inflammation |
| KR101959873B1 (ko) | 2008-10-07 | 2019-03-19 | 랩터 파마슈티컬스 인코포레이티드 | 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형 |
| EP2626098B1 (en) | 2008-10-22 | 2020-08-19 | Trudell Medical International | Modular aerosol delivery system |
| US8434479B2 (en) | 2009-02-27 | 2013-05-07 | Covidien Lp | Flow rate compensation for transient thermal response of hot-wire anemometers |
| WO2011029059A1 (en) | 2009-09-04 | 2011-03-10 | Mpex Pharmaceuticals, Inc. | Use of aerosolized levofloxacin for treating cystic fibrosis |
| US8439036B2 (en) | 2009-12-01 | 2013-05-14 | Covidien Lp | Exhalation valve assembly with integral flow sensor |
| US8469030B2 (en) | 2009-12-01 | 2013-06-25 | Covidien Lp | Exhalation valve assembly with selectable contagious/non-contagious latch |
| US8469031B2 (en) | 2009-12-01 | 2013-06-25 | Covidien Lp | Exhalation valve assembly with integrated filter |
| US8439037B2 (en) | 2009-12-01 | 2013-05-14 | Covidien Lp | Exhalation valve assembly with integrated filter and flow sensor |
| USD655809S1 (en) | 2010-04-27 | 2012-03-13 | Nellcor Puritan Bennett Llc | Valve body with integral flow meter for an exhalation module |
| USD655405S1 (en) | 2010-04-27 | 2012-03-06 | Nellcor Puritan Bennett Llc | Filter and valve body for an exhalation module |
| USD653749S1 (en) | 2010-04-27 | 2012-02-07 | Nellcor Puritan Bennett Llc | Exhalation module filter body |
| US8869793B1 (en) * | 2010-05-18 | 2014-10-28 | Idtx Systems, Inc. | Compact self-contained automated MDI adapters or units for ventilators |
| US9629971B2 (en) | 2011-04-29 | 2017-04-25 | Covidien Lp | Methods and systems for exhalation control and trajectory optimization |
| KR20140025534A (ko) | 2011-07-12 | 2014-03-04 | 카르데아스 파마 인코퍼레이티드 | 아미카신과 포스포마이신 조합물의 제형 및 인공호흡기 관련 폐렴(vap)과 인공호흡기 관련 기도(vat) 기관지염의 치료 방법 및 시스템 |
| US9212673B2 (en) | 2011-09-30 | 2015-12-15 | Carefusion 207, Inc. | Maintaining a water level in a humidification component |
| US8733348B2 (en) | 2011-09-30 | 2014-05-27 | Carefusion 207, Inc. | Humidifying respiratory gases |
| US9205220B2 (en) | 2011-09-30 | 2015-12-08 | Carefusion 207, Inc. | Fluted heater wire |
| US10168046B2 (en) | 2011-09-30 | 2019-01-01 | Carefusion 207, Inc. | Non-metallic humidification component |
| US9364624B2 (en) | 2011-12-07 | 2016-06-14 | Covidien Lp | Methods and systems for adaptive base flow |
| US9498589B2 (en) | 2011-12-31 | 2016-11-22 | Covidien Lp | Methods and systems for adaptive base flow and leak compensation |
| US9272113B2 (en) * | 2012-03-30 | 2016-03-01 | Carefusion 207, Inc. | Transporting liquid in a respiratory component |
| US9144658B2 (en) | 2012-04-30 | 2015-09-29 | Covidien Lp | Minimizing imposed expiratory resistance of mechanical ventilator by optimizing exhalation valve control |
| USD716439S1 (en) | 2012-05-30 | 2014-10-28 | Resmed Paris Sas | Connector for ventilator |
| WO2013181459A1 (en) * | 2012-05-30 | 2013-12-05 | The University Of Kansas | Inhalation device, systems, and methods for administering powdered medicaments to mechanically ventilated subjects |
| US10143818B2 (en) | 2013-01-22 | 2018-12-04 | Fisher & Paykel Healthcare Limited | Dual-connector wye piece |
| USD731049S1 (en) | 2013-03-05 | 2015-06-02 | Covidien Lp | EVQ housing of an exhalation module |
| USD731048S1 (en) | 2013-03-08 | 2015-06-02 | Covidien Lp | EVQ diaphragm of an exhalation module |
| USD692556S1 (en) | 2013-03-08 | 2013-10-29 | Covidien Lp | Expiratory filter body of an exhalation module |
| USD736905S1 (en) | 2013-03-08 | 2015-08-18 | Covidien Lp | Exhalation module EVQ housing |
| USD701601S1 (en) | 2013-03-08 | 2014-03-25 | Covidien Lp | Condensate vial of an exhalation module |
| USD693001S1 (en) | 2013-03-08 | 2013-11-05 | Covidien Lp | Neonate expiratory filter assembly of an exhalation module |
| USD731065S1 (en) | 2013-03-08 | 2015-06-02 | Covidien Lp | EVQ pressure sensor filter of an exhalation module |
| USD744095S1 (en) | 2013-03-08 | 2015-11-24 | Covidien Lp | Exhalation module EVQ internal flow sensor |
| EP4223339B1 (en) | 2013-03-14 | 2025-01-29 | Fisher & Paykel Healthcare Limited | Catheter mount with suction port |
| US9950135B2 (en) | 2013-03-15 | 2018-04-24 | Covidien Lp | Maintaining an exhalation valve sensor assembly |
| CA2922337A1 (en) | 2013-08-26 | 2015-03-05 | Cardeas Pharma Corporation | Formulations of aminoglycosides and fosfomycin in a combination having improved chemical properties |
| US20160339198A1 (en) * | 2013-12-11 | 2016-11-24 | De Motu Cordis | Medicament Apparatus And Method |
| KR102267997B1 (ko) | 2013-12-23 | 2021-06-23 | 쥴 랩스, 인크. | 기화 디바이스 시스템 및 방법 |
| USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
| US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| EP3129086B1 (en) | 2014-04-11 | 2020-06-17 | Stamford Devices Limited | A high flow nasal therapy system |
| US10173025B2 (en) | 2014-04-21 | 2019-01-08 | Idtx Systems, Inc. | Automated drug delivery systems |
| CA160775S (en) | 2014-08-11 | 2015-09-29 | Ploom Inc | Electronic vaporization device with cartridge |
| US20170246417A1 (en) | 2014-09-17 | 2017-08-31 | Fisher & Paykel Healthcare Limited | Connectors for respiratory assistance systems |
| US10561814B2 (en) | 2014-11-19 | 2020-02-18 | Idtx Systems, Inc. | Automated drug dispensing systems with automated HME bypass for ventilator circuits |
| USD775345S1 (en) | 2015-04-10 | 2016-12-27 | Covidien Lp | Ventilator console |
| CN106924852B (zh) * | 2015-12-29 | 2019-06-21 | 北京谊安医疗系统股份有限公司 | 一种活瓣罩 |
| WO2017139675A1 (en) | 2016-02-11 | 2017-08-17 | Pax Labs, Inc. | Securely attaching cartridges for vaporizer devices |
| WO2017184546A1 (en) * | 2016-04-18 | 2017-10-26 | Temple University-Of The Commonwealth System Of Higher Education | Respiratory adapter and method of use |
| USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
| USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
| USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
| DE102016112822A1 (de) | 2016-07-13 | 2018-01-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Atemgesteuerte Applikation von pulverförmigem Aerosol bei der Beatmung oder Atemunterstützung eines Patienten |
| US10864338B2 (en) * | 2017-05-19 | 2020-12-15 | Austere Medical Group, Llc | Rescue breathing apparatus |
| CN111050830A (zh) * | 2017-06-23 | 2020-04-21 | 费雪派克医疗保健有限公司 | 用于呼吸辅助系统的连接器 |
| US11547813B2 (en) * | 2017-07-07 | 2023-01-10 | Koninklijke Philips N.V. | Aerosol medicament delivery adapter and system for dispensing medicament into a ventilation circuit |
| US20190038852A1 (en) | 2017-08-02 | 2019-02-07 | Teleflex Medical Incorporated | Medical nebulizer for fast drug delivery |
| USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
| WO2019115771A1 (en) | 2017-12-15 | 2019-06-20 | Pari Pharma Gmbh | Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method |
| USD936825S1 (en) | 2018-03-09 | 2021-11-23 | Hu-Friedy Mfg Co., Llc | Capnography fitting |
| US20210038851A1 (en) * | 2018-03-09 | 2021-02-11 | Accutron, Inc. | Capnography fitting |
| KR102215835B1 (ko) * | 2018-11-09 | 2021-02-16 | (주)리젠케어 | 자기청소기능을 가지는 기도삽관튜브 |
| EP4537885B1 (en) * | 2018-12-06 | 2026-04-01 | Stamford Devices Limited | Coupling part with integrated aerosol generator for use in a breathing circuit |
| WO2020191499A1 (en) * | 2019-03-27 | 2020-10-01 | Spiro-Tech Medical Inc. | Method and apparatus for measuring airway resistance |
| WO2020225817A1 (en) * | 2019-05-08 | 2020-11-12 | Respinova Ltd. | A system for delivering inhaled therapies |
| US11896767B2 (en) | 2020-03-20 | 2024-02-13 | Covidien Lp | Model-driven system integration in medical ventilators |
| KR102361810B1 (ko) | 2021-04-26 | 2022-02-14 | 엔텍메디칼(주) | 인공호흡기의 약물 주입 구조 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5007420A (en) * | 1981-08-10 | 1991-04-16 | Bird F M | Ventilator having an oscillatory inspiratory phase and method |
| US5116088A (en) * | 1981-08-10 | 1992-05-26 | Bird F M | Ventilator having an oscillatory inspiratory phase and method |
| US4529003A (en) * | 1983-03-21 | 1985-07-16 | Syntex, Inc. | Manifold |
| US4838259A (en) * | 1986-01-27 | 1989-06-13 | Advanced Pulmonary Technologies, Inc. | Multi-frequency jet ventilation technique and apparatus |
| US5165392A (en) * | 1991-07-16 | 1992-11-24 | Small Jr John C | Accuvent aerosol delivery system |
| DE4217327A1 (de) * | 1992-05-26 | 1993-12-02 | Petra Isabel Kaiser | Endotrachealtubus-Konnektor mit Spendevorrichtung für Suspensionen in Treibmitteln für den medizinischen Gebrauch |
| JPH07116256A (ja) * | 1993-10-26 | 1995-05-09 | Senko Ika Kogyo Kk | 呼吸装置の通気管路 |
| US5666946A (en) * | 1994-07-13 | 1997-09-16 | Respirogenics Corporation | Apparatus for delivering drugs to the lungs |
| US6041777A (en) * | 1995-12-01 | 2000-03-28 | Alliance Pharmaceutical Corp. | Methods and apparatus for closed-circuit ventilation therapy |
| US5813401A (en) * | 1996-10-15 | 1998-09-29 | Radcliff; Janet H. | Nebulizer automatic control valve |
| US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6946117B1 (en) * | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
| US6630169B1 (en) * | 1999-03-31 | 2003-10-07 | Nektar Therapeutics | Particulate delivery systems and methods of use |
| US6539937B1 (en) * | 2000-04-12 | 2003-04-01 | Instrumentarium Corp. | Method of maximizing the mechanical displacement of a piezoelectric nebulizer apparatus |
| MXPA02010884A (es) * | 2000-05-05 | 2003-03-27 | Aerogen Ireland Ltd | Aparato y metodo para el suministro de medicamentos al sistema respiratorio. |
| US7971588B2 (en) * | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
| SE0100066D0 (sv) * | 2001-01-10 | 2001-01-10 | Siemens Elema Ab | Handventilationsblåsa |
| DE10118146A1 (de) * | 2001-04-11 | 2002-10-17 | Michael Kandler | Vorrichtung zur künstlichen Beatmung |
| JP2005511211A (ja) * | 2001-12-05 | 2005-04-28 | ニュファームクス， エルエルシー | ヘリオックスを用いるエアロゾル化した薬物の吸入のための医療デバイスおよび方法 |
| US6978779B2 (en) * | 2002-04-19 | 2005-12-27 | Instrumentarium Corp. | Vibrating element liquid discharging apparatus having gas pressure sensing |
| US7607436B2 (en) * | 2002-05-06 | 2009-10-27 | The Research Foundation Of State University Of New York | Methods, devices and formulations for targeted endobronchial therapy |
| EP1515768B1 (en) | 2002-05-07 | 2013-11-06 | The State University of New York at Stony Brook | Devices for targeted endobronchial therapy |
| US20050271660A1 (en) * | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| EP1713441A2 (en) * | 2004-02-12 | 2006-10-25 | Nektar Therapeutics | Interleukin-13 antagonist powders, spray-dried particles, and methods |
| US7290541B2 (en) * | 2004-04-20 | 2007-11-06 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| US7267121B2 (en) * | 2004-04-20 | 2007-09-11 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| US7870857B2 (en) * | 2005-05-23 | 2011-01-18 | Aeon Research And Technology, Inc. | Patient interface assemblies for use in ventilator systems to deliver medication to a patient |
-
2004
- 2004-11-17 WO PCT/US2004/038503 patent/WO2005048982A2/en not_active Ceased
- 2004-11-17 JP JP2006540021A patent/JP4933262B2/ja not_active Expired - Fee Related
- 2004-11-17 EP EP04819171A patent/EP1684720B1/en not_active Expired - Lifetime
- 2004-11-17 KR KR1020067011606A patent/KR101137052B1/ko not_active Expired - Fee Related
- 2004-11-17 US US10/991,092 patent/US8375947B2/en not_active Expired - Fee Related
- 2004-11-17 DE DE602004021279T patent/DE602004021279D1/de not_active Expired - Lifetime
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- 2004-11-17 BR BRPI0416654-0A patent/BRPI0416654A/pt not_active Application Discontinuation
- 2004-11-17 CA CA2545219A patent/CA2545219C/en not_active Expired - Fee Related
- 2004-11-17 ES ES04819171T patent/ES2327935T3/es not_active Expired - Lifetime
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| EP1684720B1 (en) | 2009-05-27 |
| US20050139211A1 (en) | 2005-06-30 |
| AU2004291172A1 (en) | 2005-06-02 |
| WO2005048982A3 (en) | 2005-07-28 |
| KR101137052B1 (ko) | 2012-04-24 |
| JP4933262B2 (ja) | 2012-05-16 |
| JP2007511297A (ja) | 2007-05-10 |
| CA2545219A1 (en) | 2005-06-02 |
| BRPI0416654A (pt) | 2007-01-16 |
| AU2004291172B2 (en) | 2010-11-11 |
| DE602004021279D1 (de) | 2009-07-09 |
| US8375947B2 (en) | 2013-02-19 |
| KR20060124626A (ko) | 2006-12-05 |
| ATE432064T1 (de) | 2009-06-15 |
| WO2005048982A2 (en) | 2005-06-02 |
| EP1684720A2 (en) | 2006-08-02 |
| CA2545219C (en) | 2013-08-20 |
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