ES2326469T5 - Uso de hepcidina para preparar un medicamento para tratar trastornos de la homeostasis del hierro - Google Patents
Uso de hepcidina para preparar un medicamento para tratar trastornos de la homeostasis del hierro Download PDFInfo
- Publication number
- ES2326469T5 ES2326469T5 ES02754742.1T ES02754742T ES2326469T5 ES 2326469 T5 ES2326469 T5 ES 2326469T5 ES 02754742 T ES02754742 T ES 02754742T ES 2326469 T5 ES2326469 T5 ES 2326469T5
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- hepcidin
- iron
- mice
- usf2
- gene
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- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/90—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving iron binding capacity of blood
Landscapes
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| EP01401377 | 2001-05-25 | ||
| EP01401377 | 2001-05-25 | ||
| EP01401537A EP1262187A1 (en) | 2001-05-25 | 2001-06-14 | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
| EP01401537 | 2001-06-14 | ||
| EP02290795 | 2002-03-29 | ||
| EP02290795 | 2002-03-29 | ||
| PCT/EP2002/006924 WO2002098444A2 (en) | 2001-05-25 | 2002-05-24 | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
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| ES2326469T3 ES2326469T3 (es) | 2009-10-13 |
| ES2326469T5 true ES2326469T5 (es) | 2018-05-28 |
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| ES02754742.1T Expired - Lifetime ES2326469T5 (es) | 2001-05-25 | 2002-05-24 | Uso de hepcidina para preparar un medicamento para tratar trastornos de la homeostasis del hierro |
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| ES09004579.0T Expired - Lifetime ES2693050T3 (es) | 2001-05-25 | 2002-05-24 | Uso de hepcidina para preparar un medicamento para tratar trastornos de la homeostasis del hierro |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7169758B2 (OSRAM) |
| EP (2) | EP2186524B1 (OSRAM) |
| JP (4) | JP4944360B2 (OSRAM) |
| CN (2) | CN1612746B (OSRAM) |
| AT (1) | ATE427114T1 (OSRAM) |
| AU (1) | AU2002321105A1 (OSRAM) |
| CA (1) | CA2448382C (OSRAM) |
| CY (1) | CY1120241T1 (OSRAM) |
| DE (1) | DE60231804D1 (OSRAM) |
| ES (2) | ES2693050T3 (OSRAM) |
| TR (1) | TR201806761T4 (OSRAM) |
| WO (1) | WO2002098444A2 (OSRAM) |
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| DE60231804D1 (de) | 2001-05-25 | 2009-05-14 | Inst Nat Sante Rech Med | Verwendung von hepcidin zur herstellung eines arzneimittels zur behandlung von eisenhomöostase störungen |
| US8017737B2 (en) | 2002-11-19 | 2011-09-13 | Hasan Kulaksiz | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor |
| EP1578254B1 (en) | 2002-11-19 | 2013-03-06 | DRG International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor |
| US7411048B2 (en) | 2002-11-19 | 2008-08-12 | Drg International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids |
| DE10349124A1 (de) | 2003-10-22 | 2005-05-19 | Roche Diagnostics Gmbh | Differenzialdiagnostik mit Hepcidin |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| KR100679100B1 (ko) * | 2004-10-29 | 2007-02-06 | 엘지.필립스 엘시디 주식회사 | 수평 전계 인가형 액정 표시 패널 및 그 제조방법 |
| US7968091B2 (en) | 2005-02-16 | 2011-06-28 | The General Hospital Corporation | Methods and compositions to regulate iron metabolism |
| EP2275543A3 (en) * | 2006-04-12 | 2011-03-09 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to hepcidin |
| WO2008011158A2 (en) * | 2006-07-21 | 2008-01-24 | Amgen Inc. | Method of detecting and/ or measuring hepcidin in a sample |
| AU2007299629C1 (en) * | 2006-09-21 | 2012-05-10 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the HAMP gene |
| US20110053268A1 (en) * | 2006-10-17 | 2011-03-03 | Naohisa Tomosugi | Method for diagnosis of abnormal iron metabolism using active hepcidin as indicator |
| JP2010517529A (ja) * | 2007-02-02 | 2010-05-27 | アムジエン・インコーポレーテツド | ヘプシジン及びヘプシジン抗体 |
| US8895002B2 (en) | 2007-04-09 | 2014-11-25 | The General Hospital Corporation | Hemojuvelin fusion proteins and uses thereof |
| US8187827B2 (en) | 2007-05-31 | 2012-05-29 | Naohisa Tomosugi | Diagnostic methods for acute ischemic disease using activated hepcidin as an indicator |
| ES2385772T3 (es) | 2007-10-02 | 2012-07-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Anticuerpos específicos para la hepcidina humana |
| WO2009055078A2 (en) | 2007-10-26 | 2009-04-30 | University Of Utah Research Foundation | Identification of the hepcidin binding site on ferroportin |
| CL2008003190A1 (es) | 2007-11-02 | 2009-09-04 | Lilly Co Eli | Anticuerpo que se enlaza selectivamente a hepcidina-25 humana madura; polinucleotido codificante, vector y celula huesped que lo comprende; uso medico para tratar la anemia, incrementar nivel de hierro, conteo de rediculocito, celulas rojas, hemoglobina, o hematocritos; proceso de produccion; composicion farmaceutica. |
| CA2722600C (en) | 2008-05-01 | 2014-01-21 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| PT2328931E (pt) * | 2008-08-06 | 2013-11-07 | Lilly Co Eli | Anticorpos selectivos anti-hepcidina-25 e utilizações dos mesmos |
| US20100068737A1 (en) * | 2008-09-16 | 2010-03-18 | University Of Tennessee Research Foundation | Enzyme-linked Immunosorbent Assay (ELISA) for Canine Hepcidin |
| US8318167B2 (en) * | 2008-11-13 | 2012-11-27 | The General Hospital Corporation | Methods and compositions for regulating iron homeostasis by modulation of BMP-6 |
| US8999935B2 (en) * | 2009-02-11 | 2015-04-07 | New York University | Treatment of osteoporosis in peri- and post-menopausal women with hepcidin |
| DE102009034150A1 (de) * | 2009-07-20 | 2011-01-27 | Fresenius Medical Care Deutschland Gmbh | Adsorbens zur Adsorption von Hepcidin |
| EP2467361A1 (de) | 2009-08-20 | 2012-06-27 | Vifor (International) Ag | Neue chinolin-hepcidin-antagonisten |
| AR077958A1 (es) | 2009-08-27 | 2011-10-05 | Vifor Int Ag | Quinoxalinonas antagonistas de la hepcidina |
| AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
| BR112012005119A2 (pt) | 2009-09-07 | 2016-11-22 | Vifor Int Ag | novos antagonistas de hepcidina etanodiaminas |
| TW201111379A (en) | 2009-09-09 | 2011-04-01 | Vifor Int Ag | Novel thiazole-and oxazole-hepcidine-antagonists |
| US20120214803A1 (en) | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| EP2723861A4 (en) | 2011-06-21 | 2014-12-10 | Alnylam Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR INHIBITING HEPCIDINE ANTIMICROBIAL PEPTIDE (HAMP) OR THE ASSOCIATED GENE EXPRESSION |
| US9518901B2 (en) * | 2011-06-29 | 2016-12-13 | Kabushiki Kaisha Dnaform | Pretreatment method of biological sample, detection method of RNA, and pretreatment kit |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| BR112015022123B1 (pt) | 2013-03-15 | 2022-08-09 | Intrinsic Lifesciences, Llc | Anticorpos, fragmentos de ligação ao antígeno dos mesmos que se ligam especificamente à hepcidina ou um peptídeo de hepcidina, uso, meio contentor e kit |
| WO2014147246A1 (en) | 2013-03-21 | 2014-09-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression |
| AU2015321462B2 (en) | 2014-09-22 | 2020-04-30 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| WO2016057242A1 (en) * | 2014-10-10 | 2016-04-14 | The Board Of Regents Of The University Of Texas System | HIF-2α INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS |
| BR112018013833A2 (pt) * | 2016-01-08 | 2018-12-11 | La Jolla Pharmaceutical Company | métodos de administração de hepcidina |
| WO2018165186A1 (en) * | 2017-03-07 | 2018-09-13 | Intrinsic Lifesciences Llc | Assessment of chronic iron deficiency |
| WO2019165252A1 (en) * | 2018-02-23 | 2019-08-29 | La Jolla Pharmaceutical Company | Compositions comprising hepcidin and methods of use thereof |
| US12011489B2 (en) | 2022-03-30 | 2024-06-18 | Christopher Key | Compositions and methods for treating inflammatory disease |
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|---|---|---|---|---|
| FR2766207B1 (fr) * | 1997-07-11 | 2000-12-08 | Rhone Poulenc Agrochimie | Gene chimere codant pour la drosomycine, vecteur le contenant pour la transformation des cellules vegetales et plantes transformees obtenues resistantes aux maladies |
| FR2770853B1 (fr) * | 1997-11-07 | 1999-12-31 | Rhone Poulenc Agrochimie | Gene codant pour la thanatine, vecteur le contenant et plantes transformees obtenues resistantes aux maladies |
| US7232889B2 (en) * | 1999-03-08 | 2007-06-19 | Genentech, Inc. | PRO300 antibodies |
| WO2000056879A1 (en) * | 1999-03-22 | 2000-09-28 | Universität Zürich | TRANSFORMING GROWTH FACTOR (TFG) β SUPERFAMILY ANTAGONISTS |
| DE60231804D1 (de) * | 2001-05-25 | 2009-05-14 | Inst Nat Sante Rech Med | Verwendung von hepcidin zur herstellung eines arzneimittels zur behandlung von eisenhomöostase störungen |
| EP1578254B1 (en) † | 2002-11-19 | 2013-03-06 | DRG International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor |
| US7411048B2 (en) * | 2002-11-19 | 2008-08-12 | Drg International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids |
| US8017737B2 (en) * | 2002-11-19 | 2011-09-13 | Hasan Kulaksiz | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor |
| US7968091B2 (en) * | 2005-02-16 | 2011-06-28 | The General Hospital Corporation | Methods and compositions to regulate iron metabolism |
| CA2960817A1 (en) * | 2006-09-16 | 2008-03-20 | Soy Labs Llc | Products and methods using soy 2s albumin |
| JP2010517529A (ja) † | 2007-02-02 | 2010-05-27 | アムジエン・インコーポレーテツド | ヘプシジン及びヘプシジン抗体 |
| ES2385772T3 (es) † | 2007-10-02 | 2012-07-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Anticuerpos específicos para la hepcidina humana |
| WO2009097461A1 (en) | 2008-01-29 | 2009-08-06 | Neoguide Systems Inc. | Apparatus and methods for automatically controlling an endoscope |
| WO2010065815A2 (en) † | 2008-12-05 | 2010-06-10 | The Regents Of The University Of California | Mini-hepcidin peptides and methods of using thereof |
| AU2012327226C1 (en) | 2011-12-09 | 2017-03-02 | The Regents Of The University Of California | Modified mini-hepcidin peptides and methods of using thereof |
| CN106456703A (zh) | 2014-04-07 | 2017-02-22 | 摩坚瑟生物技术股份有限公司 | 铁调素模拟肽及其用途 |
| JP2017523959A (ja) | 2014-06-27 | 2017-08-24 | プロタゴニスト セラピューティクス， インコーポレイテッド | ヘプシジンおよびミニ−ヘプシジンアナログおよびその使用 |
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2002
- 2002-05-24 DE DE60231804T patent/DE60231804D1/de not_active Expired - Lifetime
- 2002-05-24 EP EP09004579.0A patent/EP2186524B1/en not_active Expired - Lifetime
- 2002-05-24 WO PCT/EP2002/006924 patent/WO2002098444A2/en not_active Ceased
- 2002-05-24 ES ES09004579.0T patent/ES2693050T3/es not_active Expired - Lifetime
- 2002-05-24 TR TR2018/06761T patent/TR201806761T4/en unknown
- 2002-05-24 ES ES02754742.1T patent/ES2326469T5/es not_active Expired - Lifetime
- 2002-05-24 AT AT02754742T patent/ATE427114T1/de not_active IP Right Cessation
- 2002-05-24 JP JP2003501483A patent/JP4944360B2/ja not_active Expired - Fee Related
- 2002-05-24 CA CA2448382A patent/CA2448382C/en not_active Expired - Lifetime
- 2002-05-24 CN CN028148150A patent/CN1612746B/zh not_active Expired - Fee Related
- 2002-05-24 CN CN201010232752.2A patent/CN101884780B/zh not_active Expired - Fee Related
- 2002-05-24 AU AU2002321105A patent/AU2002321105A1/en not_active Abandoned
- 2002-05-24 US US10/478,987 patent/US7169758B2/en not_active Expired - Lifetime
- 2002-05-24 EP EP02754742.1A patent/EP1392345B2/en not_active Expired - Lifetime
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2006
- 2006-11-21 US US11/602,402 patent/US9234903B2/en not_active Expired - Fee Related
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2009
- 2009-01-15 JP JP2009006614A patent/JP5717319B2/ja not_active Expired - Lifetime
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2011
- 2011-12-01 JP JP2011263858A patent/JP2012111755A/ja active Pending
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2014
- 2014-04-24 JP JP2014090333A patent/JP5847231B2/ja not_active Expired - Lifetime
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2015
- 2015-06-23 US US14/747,926 patent/US9782453B2/en not_active Expired - Fee Related
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2017
- 2017-08-09 US US15/672,616 patent/US10004784B2/en not_active Expired - Lifetime
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2018
- 2018-05-18 CY CY20181100516T patent/CY1120241T1/el unknown
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