ES2326248B1 - COSMETICS GENERATED FROM SILK WORM EXTRACTS. - Google Patents

Abstract

Cosmetics generated from extracts of silkworm.

The invention consists of cosmetics generated from silkworm extracts, ( Bombix mori L.), obtained by various procedures and their application in preparations of cosmetic products with various forms of presentation.

The procedures for obtaining the extract of Silkworm can be: 1) By dilated, crushed worm and spin of the resulting product; 2) Through lyophilization of worm bodies and 3) By autolysis enzymatic silkworm.

The base product of the silkworm extract, It can be presented in the form of physiological serum, natural oil or white or yellow powder.

It is a cosmetic product with matter silk worm extract based, with vehicle, a physiological serum or a natural vegetable oil, with properties rejuvenating and regenerating, and presented under different Applicable forms on the skin: oils, balms or creams.

Description

Cosmetics generated from extracts of silkworm.

The present invention relates to a cosmetic product containing as a treating material the extract of silkworm bodies, preferably of the type ( Bombix mori L), resulting in a product with excellent rejuvenating and regenerating properties. According to another characteristic of the invention, the product can be presented in various forms applicable to the skin, either as oils, balms, or different types of cream or any other form that is easily absorbable by the skin.

Traditional Chinese medicine has used the silkworm and products derived from its different phases evolutionary, alone, mixed or combined with different plants to the treatment of diseases and ailments. The diseases of the skin have been the preferred goal of this treatment, aimed essentially to infectious, inflammatory and degenerative processes. Other diseases have also been treated under observation, diagnosis and way of doing oriental medicines, especially traditional Chinese medicine, with good results therapeutic although their approaches cannot be transposed to ours

The revised bibliography reveals that in the current treaties of Chinese Medicine are still maintained traditional uses of treatments with products derived from silkworm.

On the other hand, there is evidence that of the great war offensives, wounded abandoned during days and with injuries very infested by worms, they healed quickly, without infection and with good scars, no keloids

In this sense, experiences on effectiveness of the adipose bodies of different worms were performed collecting worms and taking them to aseptic environment, where after of crushed, filtered and poured the resulting fatty liquid on compresses, they were applied on very infected wounds, purulent, and even gangrenous. Results were obtained identical to those who had been able to observe the injuries with colonies of living worms. In the case of applications of liquids from larval firings, it was not about  a simple detergent, mechanical action, but more than anything else bacteriostatic and cytophylactic processes (1), or regeneration of skin cells.

Studies on insect adipose tissues of the big families: beetles, hymenoptera, neuroptera, Lepidoptera, diptera, orthoptera, arachnids, conclude with the following laws of regenerative activity:

a) Adipose bodies of wood and stem mining mines and underground larvae, that require more time for their development, than those that live on the plants or off the ground.

b) The tissues are always less active adipose larvae and especially larvae Acéfalas, than those that develop more quickly.

c) The longer the larva requires to acquire its full development, shorter is the life of the insect and The greater the activity of their adipose bodies.

d) Larval life is always longer than of the perfect insect, even if the latter spends the winter. A exception to this rule is that of insects that live in community: bees, ants and termites.

In the metamorphosis of insects, construction materials of the new elements are located in the mass of dissociated adipose tissues, playing the role of a true post-embryonic vitelo (tissue). The new cells are always develop depending on these tissues or bodies adipose

Further investigations of these tissues adipose highlight its remarkable accelerating properties of the cellular reproduction, far superior, for example, to royal jelly, or to embryonic extracts, as well as qualities cytophylactic (1), very net.

They have tried to isolate the different Compounds of this complex. It can be concluded, by experiences physiological, that there would be new products, hormonal type, or at least they would behave as such, without having their usual physical and chemical characteristics, including strepogenin, (2) or Wooley growth factor.

Currently, the silkworm and the products derived from its evolutionary phases are being used in the research of new drugs, antibiotics, vaccines and in the elaboration of oils, which by its composition and characteristics are apply directly or serve for the preparation of new Dermopharmacy products.

In another sense, it has been shown that polyphenolic derivatives of plant origin have activity anticancer because they are able to inhibit the production of photoproducts that appear on the skin after UVB exposure (type B ultraviolet rays) and who are responsible for the alterations of cell growth, aging the skin, the appearance of wrinkles and spots, etc.

The voracity of the silkworm larva towards the mulberry leaf, days before its transformation into chrysalis, suggests that they have been incorporated into it and concentrated large amount of polyphenolic substances (especially resveratrol (3) among others), present on the sheet of mulberry, along with other substances that could be in chrysalis at the time of preparation of the extract and resulting beneficial for human skin.

In own investigations, the conclusion that silkworm extract is able to reduce the inflammatory response of the mouse skin exposed to UV (rays ultraviolet). One of the most striking effects is the reduction of thickness of the skin fold (60% with respect to the control) and a decreased incidence and multiplicity of injuries Suspicious of malignancy. It can be concluded that in the presence of ESC (silkworm chrysalis extract) the skin has less tendency to show suspicious lesions of malignancy.

The above makes the worm extract silk, for its properties, (see attached analysis in Table 1), be an ideal candidate, usable to improve the appearance of those skins that have a tendency to dermal alterations, based on abnormal growths of the corneal layer (psoriasis and diseases similar), from pigmentation (spots, moles, lentigines, etc.) to which would help to recover its smoothness and luminosity; favors the disappearance of spots and helps to "unload" the skin of so that a younger look is achieved.

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TABLE 1 Quantitative analysis of chrysalis of silk

one

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For a cosmetological use of this product is also of interest the large amount of vitamins that owns, (see Table 2). The vitamins of adipose tissues, they can give a poor epidermis nutrition extremely appropriate and facilitate cell renewal.

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TABLE 2 Chemical analysis

2

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B vitamins are used to the treatments of all dermatoses and only the vitamins of living substances are completely assimilable by the epidermis giving maximum efficiency.

In accordance with the present invention, the adipose bodies serve as the base material for products Cosmetics that have been developed.

In obtaining from the silkworm, the higher product activity is always observed during the state of development that precedes metamorphosis and ends with a Last move

The optimal dates for obtaining are:

one)

For the caterpillar (or worm), between the penultimate and the last molt, when Transforms into a chrysalis. Period: Spring

2)

For the chrysalis, some days before the hatching of the insect perfect. Period: Summer and early fall.

As a summary, three can be distinguished characteristic factors of this substance:

A factor of metabolism.

A factor of increase.

A factor of rejuvenation and longevity.

The composition of the invention is described, to non-limiting reference title, in the preparation examples following:

Example one

Process

The tissues are dilated and crushed, then this crushing is centrifuged . The fatty granules that constitute this dissociated adipose tissue itself, escape from the cells and an oily, whitish or greenish yellow substance is obtained, which can never be heated above 40 ° C. Preparations can be made based on this oily, centrifuged, homogenized and fresh substance, located in sealed ampoules or bottles.

By freeze - drying this product, a white or yellow powder is obtained, which can be solubilized at the time of use, in a physiological serum or in a vegetable oil. It is preferable to keep and use the lyophilized substance, dried under vacuum, at low temperatures.

All the oils of stone fruits can be used (sweet almonds, for example), allowing a serum and place it in sealed ampoules or jars

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Example 2

Process

To obtain it, the enzymatic autolysis procedure (4 and 5), obtained thanks to the endocellular protidases (6) of the treated insect, can also be used.

This enzymatic autolysis has the advantage, (contrary to chemical hydrolysis), to preserve oligopeptides (7), which are endowed with physiological properties specific.

This procedure allows obtaining the product in aseptic conditions of the environment, since the organisms bacterial and the enzymatic action of these bacteria It makes impossible. This achieves a perfect conservation of the product obtained.

Like the previous one, the preparations can be made from this creamy, homogenized and fresh substance, located in sealed ampoules or jars.

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Example 3

Product and forms

Obtaining a basic product of the worm silk presented in physiological serum and natural vegetable oil, in ampoules or bottles, for skin treatment, type "rejuvenating extract". This serum, for its adjustment You can have several ways:

one)

How make-up balm, astringent lotion, colored or natural.

2)

How mask to bring blood to the surface of the skin.

3)

How cream, post-embryonic tissue dissociated in fig juice concentrated.

4)

How cream to close the pores.

5)

How cream in tube for the eyes, to suppress the bags of the eyes

6)

How moisturizing product

The foregoing refers to by way of merely illustrative example, but in no case limiting, the same results can be obtained through procedures not described

Quotes

(one)

Cytophylactic.- Substance or product with regeneration capacity of skin cells

(2)

Strepogenin, discovered in 1919 by Wooley, is found in the adipose tissues of the silkworm, and is one of the oligopeptides it contains. It is a growth stimulating substance, and was released by partial hydrolysis of casein using 1N HC1 (Sprince and Wooley, 1944). Because of their activity against Streptococcus faecalis and by extension, peptides with microbial growth stimulating activity were called steptogenins.

(3)

Resveratrol.- Polyphenol, phytoalexin, with anti-inflammatory, antioxidant and anti-cancer Relevant content in food, grapes and their derivatives, wine and must, nuts, oysters and peanut.

(4)

Autolysis.- Biological process by the that a cell destroys itself, caused by the enzymes that it It contains.

(5)

Enzyme.- Substances of nature proteins that have the ability to facilitate and accelerate reactions Chemicals in organic tissues. They do not react chemically with the substances on which they act.

(6)

Protidases Enzymes receive the Name based on your specific activity. Enzymes cataloged by its action inside the hydrolases, since they produce the rupture of the molecule by fixing water, and they are inside from the group of amidases, (protidases and proteinase), to act About the amides.

(7)

Oligopeptides.- Set of amino acids linked by peptide bonds, in numbers less than 10. When the set of bound amino acids exceeds 50, it called protein

Claims (5)

1. Cosmetics generated from extracts of the adipose bodies of the silkworm, characterized by being based on a physiological serum or a vegetable oil. 2. Cosmetics generated from extracts of silkworm, these extracts in the form of white powder or yellow, which can be solubilized at the time of use, either in physiological serum or in a vegetable oil. 3. Procedure for obtaining the silkworm extract characterized in that the silkworm is dilated, crushed, crushed and centrifuged and a substance is obtained, which preferably should not be heated to a temperature above 40 ° C, to produce generated cosmetics from silkworm extracts, according to claim 1. 4. Procedure for obtaining the silkworm extract characterized by lyophilization of the silkworm bodies, resulting from a white or yellow powder that can be solubilized at the time of use, either in physiological serum or in a Vegetable oil for cosmetics generated from silkworm extracts, according to claim 2. 5. Procedure for obtaining the silkworm extract, characterized by enzymatic autolysis or self-decomposition of the fatty worm adipose bodies, in which specific physiological properties are preserved, to perform cosmetics generated from silkworm extracts, according to claim 1.