RU2289412C2 - Method for regeneration of hunan epidermis - Google Patents

Abstract

FIELD: medicine, cosmetology.

SUBSTANCE: claimed method includes application of mask based on natural ion exchanger minerals or sorbents with addition of sterile fly larva ground to paste-like state in ratio of 1:2.5, wherein mineral part size is not more than 1 mm. Before application composition is agitated up to full paste absorption and dries for 30-40 min followed by application on skin surface.

EFFECT: mask with prolonged hemolymph storage time and increased effectiveness.

1 dwg, 4 cl

Description

The invention relates to medicine, physiology, gerontology and human cosmetology, and more particularly to methods for restoring human epidermal tissues (skin).

Human skin, being a specific (largest) human organ, usually accurately reflects the true state (age) of the body. In addition, with age, as well as under the influence of adverse factors, the skin prematurely ages and loses its original attractiveness.

The problem of skin rejuvenation in humans is solved by a variety of methods - from surgery (lifting) to the use of chemically synthesized cosmetic products, bringing a temporary improvement in its appearance, followed by accelerated degradation (Decina A.N. Live cosmetics for smart people. Principles of choosing cosmetic preparations. Guidelines. Novosibirsk, 1997, p. 27).

And this is while in Nature there are all the necessary components for creating not only cosmetic, but also medical preparations. The sources of these components are usually plants, animals, seafood and microorganisms. The most effective is considered to be a method of skin rejuvenation using placental masks and preparations isolated from embryonic raw materials. The description of these drugs and their advertising are widely represented on the Internet, for example, on the sites www.imedic, www.l-a.ru. The effect is achieved by a high content in the placenta and embryonic tissues of the biologically active substances of juvenile hormones, enzymes and vitamins.

However, this method has the following disadvantages. Firstly, the very high cost of a skin rejuvenation course. Secondly, the moral and ethical side of this method of obtaining raw materials for the production of the drug. For the long-term preservation of the drug, preservatives are added to it, which significantly reduce the effectiveness of the drug. Preparations without the use of preservatives require immediate use after their preparation. What is now called the placental mask is just a kind of placenta extract, the production of which uses technologies that destroy almost all biologically active substances of the placenta. If the biologically active substances of the placenta were preserved, then these masks would be very dangerous for use, since viruses and other microorganisms are much more stable than biological substances of the placenta, then many masks would be infected. If you take the placenta of a full-term or, especially, a postponed child, then it will have substances that block anti-aging and regenerative functions. Therefore, when using these masks, you can achieve rapid aging of the skin (see the newspaper "New Siberia" No. 30 dated July 26, 2002).

There is a known method of skin rejuvenation, in which larvae of houseflies are introduced into the anti-wrinkle cream (see the journal Agrarian Russia. 2000 No. 5, p. 57), which we adopted as an analogue. However, this method has the following disadvantages. The cream contains chemical preservatives. The use of natural components in the manufacture of cosmetic products is not possible without the use of various preservatives and stabilizers. Existing preservatives have a negative effect on the skin condition and often have a longer effect on the body than the beneficial substances of the drug.

There is a known method of rejuvenating human skin, which we adopted as a prototype by applying face masks based on phytolithic complexes of minerals of the zeolite and bentonite group, to which medicinal plants are added (Mayanskaya NN, Novoselov YB. Sanogenetic principles of exposure to the body based on natural minerals. Publishing house of the Novosibirsk State Medical Academy, Novosibirsk, 2001, pp. 30-32).

However, this method is significantly inferior in effectiveness to the methods in which the embryonic tissues of animals, humans or the placenta are used.

The technical task is to reduce the cost of the production method of the drug for the regeneration of human skin with an efficiency not inferior to preparations from embryonic tissues or placenta.

The problem is solved by the method of creating a preparation for the mask, in which hemolymph of housefly larvae is added to the minerals of the zeolite and bentonite group, for example zeolite.

Larvae at the age containing the largest number of biologically active substances are sterilized in a disinfectant solution or, for example, subjected to ionizing radiation. Methods of sterilizing biological objects, including larvae of synanthropic flies, are known and are not the subject of the invention. After sterilization, housefly larvae are crushed to a pasty state and mixed with minerals of the zeolite or bentonite group in a ratio of 1: 2.5 and dried at a temperature of no higher than 40 ° C for 30-40 minutes. The particle size of the minerals must be within 1 mm. The ratio of the paste from the larvae and the mineral in the ratio of 1: 2.5 is justified by the fact that the zeolite can absorb exactly the amount of hemolymph into its pores without residue. At an air temperature of not more than 40 ° C, the destruction of biologically active substances does not occur. Subject to the above conditions, the drying of the drug does not require a longer period of time.

If the size of the mineral particles is more than 1 mm, wounds may form on the surface of the skin, in addition, larger particles may not stick to the skin and crumble from it. Smaller particles can, sticking tightly to the surface of the skin, dehydrate it, thereby worsening the condition of the skin.

The inventive method differs from the prototype in that the increase in the effectiveness of the drug is achieved by the absorption of hemolymph by zeolites of housefly larvae containing a more complete set of biologically active substances than plant materials. The properties of the extract from housefly larvae are to increase the turgor pressure of epidermal cells, relieve hormonal deficiency and eliminate “residual skin deformation”, suppress the development of pathogenic microflora. In contrast to the currently existing methods for immobilizing biologically active substances, our method allows us to use the healing and regenerative properties of zeolites and other natural ion exchangers and sorbents in combination with biologically active substances obtained from housefly larvae, not inferior in efficiency to placental masks and preparations from embryonic fabrics, but much cheaper in production (2-3 orders of magnitude). In particular, the healing properties of protein-lipid concentrate (BLA) obtained from housefly larvae were discovered. (Gudilin I.I., Kondratov A.F. et al. Biotechnology of organic waste processing and ecology. - Novosibirsk, 1999. - p. 391).

According to many scientists, 21st century antibiotics will be isolated from insects, in particular from larvae of flies that are capable of suppressing pathogenic microorganisms living in the most adverse environments. Biosurgery, based on the use of wound fly larvae for healing purulent wounds and ulcers of various origins, shows more effective results than traditional medicine using traditional medicines. The terms of treatment are halved, the wounds are healed without scarring. In addition, the larvae of flies synthesize and secrete substances that can even cope with such a pathogen as Staphylococcus aureus, against which modern antibiotics are powerless (Internet data).

A large number of copyright certificates and patents for methods of cultivating housefly larvae and plants for their implementation are known. One of these plants was manufactured and mounted in the bio-workshop of the Problem Laboratory of the Novosibirsk Agrarian University (RF Patent No. 2050138).

The use of distinctive features, namely the immobilization of the biologically active hemolymph of housefly larvae on zeolites, is not known to the authors and the applicant.

The essence of the invention is illustrated by the following description of the production technology of the drug.

The drawing shows the formulas of ecdysone (a), zeolite (b), juvenile hormone (c) and the immobilization of hormones on zeolite (d, e).

The larvae are sterilized in a disinfectant solution or, for example, subjected to ionizing radiation. Methods for sterilizing biological objects are known and are not the subject of the invention. After sterilization, the housefly larvae are crushed to a pasty state and mixed with minerals of the zeolite or bentonite group in a ratio of 1: 2.5 and dried at a temperature not exceeding 40 ° C for 30-40 minutes. The particle size of the minerals must be within 1 mm. The ratio of the paste from the larvae and the mineral in the ratio of 1: 2.5 is justified by the fact that the zeolite can absorb exactly the same amount of hemolymph into its pores without residue. At an air temperature of not more than 40 ° C, the destruction of biologically active substances does not occur. Subject to the above conditions, the drying of the drug does not require a longer period of time.

If the size of the mineral particles is more than 1 mm, wounds may form on the surface of the skin, in addition, larger particles may not stick to the skin and crumble from it. Smaller particles can, sticking tightly to the surface of the skin, dehydrate it, thereby worsening the condition of the skin.

Zeolites of the Kholinsky deposit (Buryatia) and natural montmorillonite clays were used as minerals.

For the basic object, we took the method of immobilization of biologically active substances on cellulose (Decina AN, Living cosmetics for smart people. Principles of choosing cosmetic preparations. Guidelines. Novosibirsk, 1997, p. 27).

However, the following disadvantages are inherent in this method, namely, the low shelf life of the drug due to the disinfectant properties of cellulose. Cellulose does not have the healing and regenerative properties of zeolites, consisting in the ability of zeolites to supply a complex of necessary trace elements and absorb on themselves with the subsequent removal of low molecular weight metabolic toxins from the epidermis (skin) tissue.

Claims (4)

1. The method of regeneration of the epidermis of a person’s face, which consists in using a mask based on natural minerals — ion exchangers or sorbents, characterized in that sterile housefly larvae, crushed to a paste-like state, are added to the mask in a ratio of 1: 2.5, and the particle size minerals should be within 1 mm, while before use, the composition is mixed until the paste is completely absorbed and dried for 30-40 minutes, and then applied to the skin surface. 2. The method according to claim 1, characterized in that zeolites or bentonites are used as natural minerals - ion exchangers and sorbents. 3. The method according to claim 2, characterized in that the zeolites use zeolites Kholinsky deposits. 4. The method according to claim 2, characterized in that as bentonites use natural montmoril clay.