ES2323981T3 - Tiazolopirimidinas para uso en terapia. - Google Patents
Tiazolopirimidinas para uso en terapia. Download PDFInfo
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- ES2323981T3 ES2323981T3 ES06744265T ES06744265T ES2323981T3 ES 2323981 T3 ES2323981 T3 ES 2323981T3 ES 06744265 T ES06744265 T ES 06744265T ES 06744265 T ES06744265 T ES 06744265T ES 2323981 T3 ES2323981 T3 ES 2323981T3
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
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- 239000012184 mineral wax Substances 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
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- 230000036473 myasthenia Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- ACTNHJDHMQSOGL-UHFFFAOYSA-N n',n'-dibenzylethane-1,2-diamine Chemical compound C=1C=CC=CC=1CN(CCN)CC1=CC=CC=C1 ACTNHJDHMQSOGL-UHFFFAOYSA-N 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000012053 oil suspension Substances 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 125000005544 phthalimido group Chemical class 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
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- 238000013105 post hoc analysis Methods 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 description 1
- 229960001233 pregabalin Drugs 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000021317 sensory perception Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910001467 sodium calcium phosphate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
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- 239000000600 sorbitol Substances 0.000 description 1
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- 239000010935 stainless steel Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
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- 238000003786 synthesis reaction Methods 0.000 description 1
- 108060008037 tachykinin Proteins 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
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- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000021542 voluntary musculoskeletal movement Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0512554 | 2005-06-20 | ||
| GBGB0512554.7A GB0512554D0 (en) | 2005-06-20 | 2005-06-20 | Compounds for use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2323981T3 true ES2323981T3 (es) | 2009-07-28 |
Family
ID=34855848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06744265T Active ES2323981T3 (es) | 2005-06-20 | 2006-06-19 | Tiazolopirimidinas para uso en terapia. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8349845B2 (zh) |
| EP (1) | EP1896031B1 (zh) |
| JP (1) | JP5055474B2 (zh) |
| KR (1) | KR20080076897A (zh) |
| CN (1) | CN101355947B (zh) |
| AT (1) | ATE419853T1 (zh) |
| AU (1) | AU2006260714B2 (zh) |
| BR (1) | BRPI0614386A2 (zh) |
| CA (1) | CA2612865C (zh) |
| DE (1) | DE602006004735D1 (zh) |
| DK (1) | DK1896031T3 (zh) |
| ES (1) | ES2323981T3 (zh) |
| GB (1) | GB0512554D0 (zh) |
| HK (1) | HK1108842A1 (zh) |
| IL (1) | IL188061A0 (zh) |
| NO (1) | NO20080049L (zh) |
| NZ (1) | NZ564170A (zh) |
| PT (1) | PT1896031E (zh) |
| WO (1) | WO2006136806A1 (zh) |
| ZA (1) | ZA200711062B (zh) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5564591A (en) * | 1978-11-10 | 1980-05-15 | Teijin Ltd | Thiazolo 3, 2-a pyrimidine derivative, its preparation, and drug comprising it |
| JPS5566592A (en) * | 1978-11-13 | 1980-05-20 | Teijin Ltd | 7-alkoxythiazolo 3,2-a pyrimidine derivative, its preparation, and drug containing the same |
| EP0050671B1 (en) * | 1980-04-28 | 1985-03-20 | Teijin Limited | Thiazolo(3,2-a)pyrimidine derivatives, process for preparing same, and drug containing same |
-
2005
- 2005-06-20 GB GBGB0512554.7A patent/GB0512554D0/en not_active Ceased
-
2006
- 2006-06-19 NZ NZ564170A patent/NZ564170A/en unknown
- 2006-06-19 CN CN2006800219991A patent/CN101355947B/zh active Active
- 2006-06-19 EP EP06744265A patent/EP1896031B1/en active Active
- 2006-06-19 CA CA2612865A patent/CA2612865C/en active Active
- 2006-06-19 JP JP2008517583A patent/JP5055474B2/ja not_active Expired - Fee Related
- 2006-06-19 AT AT06744265T patent/ATE419853T1/de active
- 2006-06-19 DE DE602006004735T patent/DE602006004735D1/de not_active Expired - Fee Related
- 2006-06-19 PT PT06744265T patent/PT1896031E/pt unknown
- 2006-06-19 ES ES06744265T patent/ES2323981T3/es active Active
- 2006-06-19 KR KR1020087001186A patent/KR20080076897A/ko not_active Application Discontinuation
- 2006-06-19 WO PCT/GB2006/002248 patent/WO2006136806A1/en active Application Filing
- 2006-06-19 ZA ZA200711062A patent/ZA200711062B/xx unknown
- 2006-06-19 AU AU2006260714A patent/AU2006260714B2/en active Active
- 2006-06-19 US US11/917,425 patent/US8349845B2/en active Active
- 2006-06-19 BR BRPI0614386-5A patent/BRPI0614386A2/pt not_active Application Discontinuation
- 2006-06-19 DK DK06744265T patent/DK1896031T3/da active
-
2007
- 2007-12-11 IL IL188061A patent/IL188061A0/en unknown
-
2008
- 2008-01-04 NO NO20080049A patent/NO20080049L/no not_active Application Discontinuation
- 2008-03-17 HK HK08103060.1A patent/HK1108842A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2612865C (en) | 2013-03-26 |
| EP1896031A1 (en) | 2008-03-12 |
| ZA200711062B (en) | 2010-06-30 |
| IL188061A0 (en) | 2011-08-01 |
| US8349845B2 (en) | 2013-01-08 |
| US20100216819A1 (en) | 2010-08-26 |
| CN101355947B (zh) | 2013-06-05 |
| EP1896031B1 (en) | 2009-01-07 |
| AU2006260714A1 (en) | 2006-12-28 |
| KR20080076897A (ko) | 2008-08-20 |
| NZ564170A (en) | 2011-03-31 |
| JP2008543918A (ja) | 2008-12-04 |
| CA2612865A1 (en) | 2006-12-28 |
| GB0512554D0 (en) | 2005-07-27 |
| AU2006260714B2 (en) | 2008-11-13 |
| JP5055474B2 (ja) | 2012-10-24 |
| HK1108842A1 (en) | 2008-05-23 |
| PT1896031E (pt) | 2009-04-15 |
| CN101355947A (zh) | 2009-01-28 |
| WO2006136806A1 (en) | 2006-12-28 |
| BRPI0614386A2 (pt) | 2011-03-22 |
| DK1896031T3 (da) | 2009-05-11 |
| DE602006004735D1 (de) | 2009-02-26 |
| NO20080049L (no) | 2008-01-17 |
| ATE419853T1 (de) | 2009-01-15 |
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