ES2318478T3 - Inhibidores de quinesina mitotica. - Google Patents
Inhibidores de quinesina mitotica. Download PDFInfo
- Publication number
- ES2318478T3 ES2318478T3 ES05732607T ES05732607T ES2318478T3 ES 2318478 T3 ES2318478 T3 ES 2318478T3 ES 05732607 T ES05732607 T ES 05732607T ES 05732607 T ES05732607 T ES 05732607T ES 2318478 T3 ES2318478 T3 ES 2318478T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- group
- alkyl
- pyrimidin
- pyrido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 230000000394 mitotic effect Effects 0.000 title description 7
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 81
- 125000003118 aryl group Chemical group 0.000 claims abstract description 49
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 43
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 43
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 24
- 239000001257 hydrogen Substances 0.000 claims abstract description 23
- 125000000547 substituted alkyl group Chemical group 0.000 claims abstract description 18
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- 150000003839 salts Chemical class 0.000 claims abstract description 16
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- 108010063296 Kinesin Proteins 0.000 claims abstract description 13
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- 125000000304 alkynyl group Chemical group 0.000 claims abstract description 11
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- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims abstract description 6
- 125000005129 aryl carbonyl group Chemical group 0.000 claims abstract description 6
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims abstract description 6
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims abstract description 4
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- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 3
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- ZBJDITQFBYJTLK-UHFFFAOYSA-N n-(3-aminopropyl)-n-[1-(3-benzyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-2-yl)propyl]-4-bromobenzamide Chemical compound N1=C2CCCCN2C(=O)C(CC=2C=CC=CC=2)=C1C(CC)N(CCCN)C(=O)C1=CC=C(Br)C=C1 ZBJDITQFBYJTLK-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56023504P | 2004-04-06 | 2004-04-06 | |
| US560235P | 2004-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2318478T3 true ES2318478T3 (es) | 2009-05-01 |
Family
ID=34964986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05732607T Expired - Lifetime ES2318478T3 (es) | 2004-04-06 | 2005-04-06 | Inhibidores de quinesina mitotica. |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20080249112A1 (https=) |
| EP (1) | EP1732926B1 (https=) |
| JP (1) | JP4895220B2 (https=) |
| KR (1) | KR20060135035A (https=) |
| CN (1) | CN1984912A (https=) |
| AT (1) | ATE419249T1 (https=) |
| AU (1) | AU2005233576A1 (https=) |
| BR (1) | BRPI0509653A (https=) |
| CA (1) | CA2561904A1 (https=) |
| DE (1) | DE602005012069D1 (https=) |
| ES (1) | ES2318478T3 (https=) |
| PL (1) | PL1732926T3 (https=) |
| PT (1) | PT1732926E (https=) |
| RU (1) | RU2006138864A (https=) |
| WO (1) | WO2005100357A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3947758B2 (ja) * | 2003-03-07 | 2007-07-25 | アストラゼネカ アクチボラグ | 新規縮合ヘテロサイクル及びその使用 |
| AR050920A1 (es) * | 2003-03-07 | 2006-12-06 | Astrazeneca Ab | Enantiomeros de heterociclos fusionados seleccionados y usos de los mismos |
| ATE419249T1 (de) * | 2004-04-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Inhibitoren von mitotischem kinesin |
| KR101170925B1 (ko) * | 2004-06-18 | 2012-08-07 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 암 치료용 키네신 방추 단백질 (ｋｓｐ) 억제제로서의ｎ-(1-(1-벤질-4-페닐-1ｈ-이미다졸-2-일)-2,2-디메틸프로필)벤자미드 유도체 및 관련 화합물 |
| RU2007106552A (ru) * | 2004-07-22 | 2008-08-27 | Астразенека Аб (Se) | Конденсированные пиримидоны, пригодные для лечения и предотвращения злокачественного новообразования |
| US20060041128A1 (en) * | 2004-08-18 | 2006-02-23 | Astrazeneca Ab | Selected fused heterocyclics and uses thereof |
| CN101027309B (zh) * | 2004-08-18 | 2010-10-27 | 阿斯利康(瑞典)有限公司 | 所选择的稠合嘧啶酮的对映体和在治疗和预防癌症中的用途 |
| AU2007323998B2 (en) * | 2006-11-13 | 2011-09-22 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
| AU2008205169B2 (en) * | 2007-01-05 | 2012-02-02 | Novartis Ag | Imidazole derivatives as kinesin spindle protein inhibitors (Eg-5) |
| WO2010042392A2 (en) * | 2008-10-06 | 2010-04-15 | Merck & Co., Inc. | Hiv integrase inhibitors |
| US10786578B2 (en) | 2014-08-05 | 2020-09-29 | Novartis Ag | CKIT antibody drug conjugates |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2157285B (en) | 1984-04-11 | 1987-10-28 | Erba Farmitalia | 1h, 7h-pyrazolo1, 5-a pyrimidine-7-one derivatives and process for their preparation |
| US20050107404A1 (en) | 2001-12-06 | 2005-05-19 | Fraley Mark E. | Mitotic kinesin inhibitors |
| CA2485148A1 (en) * | 2002-05-09 | 2003-11-20 | Cytokinetics, Inc. | Pyrimidinone compounds, compositions and methods |
| EP1513820A4 (en) | 2002-05-23 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| AU2003256805A1 (en) * | 2002-07-23 | 2004-02-09 | Cytokinetics, Inc. | Compounds compositions and methods |
| WO2004064741A2 (en) * | 2003-01-17 | 2004-08-05 | Cytokinetics Inc. | Compounds, compositions, and methods |
| US7345046B2 (en) * | 2003-05-30 | 2008-03-18 | Chiron Corporation | Heteroaryl-fused pyrimidinyl compounds as anticancer agents |
| WO2004113335A2 (en) | 2003-06-20 | 2004-12-29 | Chiron Corporation | Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents |
| ATE419249T1 (de) * | 2004-04-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Inhibitoren von mitotischem kinesin |
-
2005
- 2005-04-06 AT AT05732607T patent/ATE419249T1/de active
- 2005-04-06 KR KR1020067021822A patent/KR20060135035A/ko not_active Withdrawn
- 2005-04-06 PL PL05732607T patent/PL1732926T3/pl unknown
- 2005-04-06 AU AU2005233576A patent/AU2005233576A1/en not_active Abandoned
- 2005-04-06 WO PCT/US2005/011642 patent/WO2005100357A1/en not_active Ceased
- 2005-04-06 RU RU2006138864/04A patent/RU2006138864A/ru not_active Application Discontinuation
- 2005-04-06 PT PT05732607T patent/PT1732926E/pt unknown
- 2005-04-06 US US11/547,834 patent/US20080249112A1/en not_active Abandoned
- 2005-04-06 DE DE602005012069T patent/DE602005012069D1/de not_active Expired - Lifetime
- 2005-04-06 US US11/100,923 patent/US7504405B2/en not_active Expired - Fee Related
- 2005-04-06 ES ES05732607T patent/ES2318478T3/es not_active Expired - Lifetime
- 2005-04-06 BR BRPI0509653-7A patent/BRPI0509653A/pt not_active IP Right Cessation
- 2005-04-06 CN CNA2005800174322A patent/CN1984912A/zh active Pending
- 2005-04-06 EP EP05732607A patent/EP1732926B1/en not_active Expired - Lifetime
- 2005-04-06 CA CA002561904A patent/CA2561904A1/en not_active Abandoned
- 2005-04-06 JP JP2007507466A patent/JP4895220B2/ja not_active Expired - Fee Related
-
2009
- 2009-03-04 US US12/398,118 patent/US20090171082A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050228002A1 (en) | 2005-10-13 |
| JP2007532554A (ja) | 2007-11-15 |
| RU2006138864A (ru) | 2008-05-20 |
| US7504405B2 (en) | 2009-03-17 |
| JP4895220B2 (ja) | 2012-03-14 |
| CN1984912A (zh) | 2007-06-20 |
| ATE419249T1 (de) | 2009-01-15 |
| US20090171082A1 (en) | 2009-07-02 |
| AU2005233576A1 (en) | 2005-10-27 |
| BRPI0509653A (pt) | 2007-10-09 |
| EP1732926B1 (en) | 2008-12-31 |
| US20080249112A1 (en) | 2008-10-09 |
| PL1732926T3 (pl) | 2009-06-30 |
| WO2005100357A1 (en) | 2005-10-27 |
| DE602005012069D1 (de) | 2009-02-12 |
| CA2561904A1 (en) | 2005-10-27 |
| PT1732926E (pt) | 2009-04-03 |
| KR20060135035A (ko) | 2006-12-28 |
| EP1732926A1 (en) | 2006-12-20 |
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