ES2308208T3 - Metodos y composiciones para predecir la toxicidad del irinotecano. - Google Patents
Metodos y composiciones para predecir la toxicidad del irinotecano. Download PDFInfo
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- ES2308208T3 ES2308208T3 ES04753702T ES04753702T ES2308208T3 ES 2308208 T3 ES2308208 T3 ES 2308208T3 ES 04753702 T ES04753702 T ES 04753702T ES 04753702 T ES04753702 T ES 04753702T ES 2308208 T3 ES2308208 T3 ES 2308208T3
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- ugt1a1
- patient
- methods
- genotype
- glucuronidation
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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| US47482603P | 2003-05-30 | 2003-05-30 | |
| US474826P | 2003-05-30 |
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| ES2308208T3 true ES2308208T3 (es) | 2008-12-01 |
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| ES04753702T Expired - Lifetime ES2308208T3 (es) | 2003-05-30 | 2004-05-28 | Metodos y composiciones para predecir la toxicidad del irinotecano. |
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| JP (1) | JP2006526412A (enExample) |
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| DE (1) | DE602004014135D1 (enExample) |
| ES (1) | ES2308208T3 (enExample) |
| WO (1) | WO2004108954A1 (enExample) |
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| WO2007055261A1 (ja) * | 2005-11-10 | 2007-05-18 | The New Industry Research Organization | Ｕｇｔ１ａ１遺伝子多型の検査法 |
| KR101153058B1 (ko) | 2006-11-30 | 2012-06-04 | 아크레이 가부시키가이샤 | Ｕｇｔ1ａ1 유전자 증폭용 프라이머 셋트, 그것을 포함하는 ｕｇｔ1ａ1 유전자 증폭용 시약 및 그 용도 |
| CN107858429A (zh) * | 2017-11-10 | 2018-03-30 | 广州金域医学检验集团股份有限公司 | 用于检测ugt1a1基因启动子区ta重复多态性的扩增引物、方法及应用 |
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| WO1994022846A1 (en) | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Compounds enhancing antitumor activity of other cytotoxic agents |
| EP0721328A4 (en) | 1993-09-27 | 1997-09-17 | Smithkline Beecham Corp | CAMPTOTHECIN FORMULATIONS |
| US5786344A (en) | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| US5972614A (en) * | 1995-12-06 | 1999-10-26 | Genaissance Pharmaceuticals | Genome anthologies for harvesting gene variants |
| DE69734237T2 (de) | 1996-03-01 | 2006-07-06 | The University Court Of The University Of Dundee, Dundee | Versuchsystem für einen Arzneimittelversuch |
| US6287834B1 (en) * | 1996-05-17 | 2001-09-11 | Endorecherche, Inc. | Characterization and use of an isolated uridine diphospho-glucuronosyltransferase |
| DE19744676A1 (de) | 1997-10-10 | 1999-04-15 | Forschungszentrum Borstel Zent | Kombinationspräparate für die Therapie von Tumoren |
| WO1999057322A2 (en) | 1998-05-07 | 1999-11-11 | Axys Pharmaceuticals, Inc. | Genotyping the human udp-glucuronosyltransferase 1 (ugt1) gene |
| US6448003B1 (en) * | 1998-06-10 | 2002-09-10 | Dna Sciences Laboratories, Inc. | Genotyping the human phenol sulfotransferbase 2 gene STP2 |
| US6407117B1 (en) * | 1998-06-18 | 2002-06-18 | The George Washington University | Method of administering camptothecin compounds for the treatment of cancer with reduced side effects |
| US6319678B1 (en) * | 1998-06-26 | 2001-11-20 | Panvera Corporation | Process for glucuronidation screening |
| US6586175B1 (en) * | 1998-07-28 | 2003-07-01 | Dna Sciences Laboratories, Inc. | Genotyping the human UDP-glucuronosyltransferase 2B7 (UGT2B7) gene |
| US6395481B1 (en) * | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
| AU2001255397A1 (en) | 2000-04-18 | 2001-10-30 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the ugt1a1 gene |
| EP1325152A2 (en) | 2000-07-14 | 2003-07-09 | F. Hoffmann-La Roche Ag | Method for detecting pre-disposition to hepatotoxicity |
| AU2002245039A1 (en) | 2000-11-28 | 2002-07-30 | Dna Sciences Laboratories, Inc. | Genetic typing of human genes and related materials and methods |
| EP1352970B1 (en) | 2000-12-12 | 2010-06-02 | Nagoya Industrial Science Research Institute | Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabloized per se by ugt1a1 or whose intermediate is metabolized by the enzyme |
| DE10100238A1 (de) * | 2001-01-05 | 2002-08-22 | Hannover Med Hochschule | Verfahren zur Vorhersage des Gefährdungspotentials für Karzinomerkrankungen und entzündliche Darmerkrankungen und zugehörige Tests |
| WO2002059375A2 (en) * | 2001-01-26 | 2002-08-01 | University Of Chicago | Determination of ugt2b7 gene polymorphisms for predicting ugt2b7 substrate toxicity and for optimising drug dosage |
| WO2003013534A2 (en) | 2001-07-23 | 2003-02-20 | Epidauros Biotechnologie Ag | Methods for the treatment of cancer with irinotecan based on cyp3a5 |
| JP4096037B2 (ja) | 2002-08-12 | 2008-06-04 | 国立大学法人滋賀医科大学 | グルクロン酸転移酵素遺伝子の変異解析による薬剤代謝活性の予測方法 |
| US20040203034A1 (en) * | 2003-01-03 | 2004-10-14 | The University Of Chicago | Optimization of cancer treatment with irinotecan |
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- 2004-05-28 CA CA002527320A patent/CA2527320A1/en not_active Abandoned
- 2004-05-28 EP EP04753702A patent/EP1629111B1/en not_active Expired - Lifetime
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Also Published As
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| EP1629111A1 (en) | 2006-03-01 |
| CA2527320A1 (en) | 2004-12-16 |
| JP2006526412A (ja) | 2006-11-24 |
| EP1629111B1 (en) | 2008-05-28 |
| DE602004014135D1 (de) | 2008-07-10 |
| WO2004108954A1 (en) | 2004-12-16 |
| ATE397091T1 (de) | 2008-06-15 |
| US20070197574A1 (en) | 2007-08-23 |
| US7807350B2 (en) | 2010-10-05 |
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