ATE397091T1 - Verfahren und zusammensetzungen zur vorhersage der irinotecantoxizität - Google Patents
Verfahren und zusammensetzungen zur vorhersage der irinotecantoxizitätInfo
- Publication number
- ATE397091T1 ATE397091T1 AT04753702T AT04753702T ATE397091T1 AT E397091 T1 ATE397091 T1 AT E397091T1 AT 04753702 T AT04753702 T AT 04753702T AT 04753702 T AT04753702 T AT 04753702T AT E397091 T1 ATE397091 T1 AT E397091T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- irinotecantoxicity
- predicting
- ironotecan
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000034415 irinotecan toxicity Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101710205316 UDP-glucuronosyltransferase 1A1 Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47482603P | 2003-05-30 | 2003-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE397091T1 true ATE397091T1 (de) | 2008-06-15 |
Family
ID=33511633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04753702T ATE397091T1 (de) | 2003-05-30 | 2004-05-28 | Verfahren und zusammensetzungen zur vorhersage der irinotecantoxizität |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7807350B2 (enExample) |
| EP (1) | EP1629111B1 (enExample) |
| JP (1) | JP2006526412A (enExample) |
| AT (1) | ATE397091T1 (enExample) |
| CA (1) | CA2527320A1 (enExample) |
| DE (1) | DE602004014135D1 (enExample) |
| ES (1) | ES2308208T3 (enExample) |
| WO (1) | WO2004108954A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007055261A1 (ja) * | 2005-11-10 | 2007-05-18 | The New Industry Research Organization | Ｕｇｔ１ａ１遺伝子多型の検査法 |
| KR101153058B1 (ko) | 2006-11-30 | 2012-06-04 | 아크레이 가부시키가이샤 | Ｕｇｔ1ａ1 유전자 증폭용 프라이머 셋트, 그것을 포함하는 ｕｇｔ1ａ1 유전자 증폭용 시약 및 그 용도 |
| CN107858429A (zh) * | 2017-11-10 | 2018-03-30 | 广州金域医学检验集团股份有限公司 | 用于检测ugt1a1基因启动子区ta重复多态性的扩增引物、方法及应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994022846A1 (en) | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Compounds enhancing antitumor activity of other cytotoxic agents |
| EP0721328A4 (en) | 1993-09-27 | 1997-09-17 | Smithkline Beecham Corp | CAMPTOTHECIN FORMULATIONS |
| US5786344A (en) | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| US5972614A (en) * | 1995-12-06 | 1999-10-26 | Genaissance Pharmaceuticals | Genome anthologies for harvesting gene variants |
| DE69734237T2 (de) | 1996-03-01 | 2006-07-06 | The University Court Of The University Of Dundee, Dundee | Versuchsystem für einen Arzneimittelversuch |
| US6287834B1 (en) * | 1996-05-17 | 2001-09-11 | Endorecherche, Inc. | Characterization and use of an isolated uridine diphospho-glucuronosyltransferase |
| DE19744676A1 (de) | 1997-10-10 | 1999-04-15 | Forschungszentrum Borstel Zent | Kombinationspräparate für die Therapie von Tumoren |
| WO1999057322A2 (en) | 1998-05-07 | 1999-11-11 | Axys Pharmaceuticals, Inc. | Genotyping the human udp-glucuronosyltransferase 1 (ugt1) gene |
| US6448003B1 (en) * | 1998-06-10 | 2002-09-10 | Dna Sciences Laboratories, Inc. | Genotyping the human phenol sulfotransferbase 2 gene STP2 |
| US6407117B1 (en) * | 1998-06-18 | 2002-06-18 | The George Washington University | Method of administering camptothecin compounds for the treatment of cancer with reduced side effects |
| US6319678B1 (en) * | 1998-06-26 | 2001-11-20 | Panvera Corporation | Process for glucuronidation screening |
| US6586175B1 (en) * | 1998-07-28 | 2003-07-01 | Dna Sciences Laboratories, Inc. | Genotyping the human UDP-glucuronosyltransferase 2B7 (UGT2B7) gene |
| US6395481B1 (en) * | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
| AU2001255397A1 (en) | 2000-04-18 | 2001-10-30 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the ugt1a1 gene |
| EP1325152A2 (en) | 2000-07-14 | 2003-07-09 | F. Hoffmann-La Roche Ag | Method for detecting pre-disposition to hepatotoxicity |
| AU2002245039A1 (en) | 2000-11-28 | 2002-07-30 | Dna Sciences Laboratories, Inc. | Genetic typing of human genes and related materials and methods |
| EP1352970B1 (en) | 2000-12-12 | 2010-06-02 | Nagoya Industrial Science Research Institute | Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabloized per se by ugt1a1 or whose intermediate is metabolized by the enzyme |
| DE10100238A1 (de) * | 2001-01-05 | 2002-08-22 | Hannover Med Hochschule | Verfahren zur Vorhersage des Gefährdungspotentials für Karzinomerkrankungen und entzündliche Darmerkrankungen und zugehörige Tests |
| WO2002059375A2 (en) * | 2001-01-26 | 2002-08-01 | University Of Chicago | Determination of ugt2b7 gene polymorphisms for predicting ugt2b7 substrate toxicity and for optimising drug dosage |
| WO2003013534A2 (en) | 2001-07-23 | 2003-02-20 | Epidauros Biotechnologie Ag | Methods for the treatment of cancer with irinotecan based on cyp3a5 |
| JP4096037B2 (ja) | 2002-08-12 | 2008-06-04 | 国立大学法人滋賀医科大学 | グルクロン酸転移酵素遺伝子の変異解析による薬剤代謝活性の予測方法 |
| US20040203034A1 (en) * | 2003-01-03 | 2004-10-14 | The University Of Chicago | Optimization of cancer treatment with irinotecan |
-
2004
- 2004-05-28 JP JP2006515008A patent/JP2006526412A/ja active Pending
- 2004-05-28 CA CA002527320A patent/CA2527320A1/en not_active Abandoned
- 2004-05-28 EP EP04753702A patent/EP1629111B1/en not_active Expired - Lifetime
- 2004-05-28 WO PCT/US2004/016920 patent/WO2004108954A1/en not_active Ceased
- 2004-05-28 ES ES04753702T patent/ES2308208T3/es not_active Expired - Lifetime
- 2004-05-28 DE DE602004014135T patent/DE602004014135D1/de not_active Expired - Fee Related
- 2004-05-28 AT AT04753702T patent/ATE397091T1/de not_active IP Right Cessation
- 2004-05-28 US US10/558,510 patent/US7807350B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1629111A1 (en) | 2006-03-01 |
| CA2527320A1 (en) | 2004-12-16 |
| JP2006526412A (ja) | 2006-11-24 |
| ES2308208T3 (es) | 2008-12-01 |
| EP1629111B1 (en) | 2008-05-28 |
| DE602004014135D1 (de) | 2008-07-10 |
| WO2004108954A1 (en) | 2004-12-16 |
| US20070197574A1 (en) | 2007-08-23 |
| US7807350B2 (en) | 2010-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |