ES2304264A1 - Terapia de combinacion para tratar enfermedades. - Google Patents
Terapia de combinacion para tratar enfermedades. Download PDFInfo
- Publication number
- ES2304264A1 ES2304264A1 ES200450028A ES200450028A ES2304264A1 ES 2304264 A1 ES2304264 A1 ES 2304264A1 ES 200450028 A ES200450028 A ES 200450028A ES 200450028 A ES200450028 A ES 200450028A ES 2304264 A1 ES2304264 A1 ES 2304264A1
- Authority
- ES
- Spain
- Prior art keywords
- antigen
- antibody
- alt
- patient
- precedents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 11
- 238000002648 combination therapy Methods 0.000 title description 2
- 239000000427 antigen Substances 0.000 claims abstract description 51
- 102000036639 antigens Human genes 0.000 claims abstract description 51
- 108091007433 antigens Proteins 0.000 claims abstract description 51
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- 201000011510 cancer Diseases 0.000 claims abstract description 34
- 239000002246 antineoplastic agent Substances 0.000 claims abstract description 23
- 229940044683 chemotherapy drug Drugs 0.000 claims abstract description 22
- 238000001727 in vivo Methods 0.000 claims abstract description 7
- 230000028993 immune response Effects 0.000 claims description 17
- 241001529936 Murinae Species 0.000 claims description 15
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- OOIBFPKQHULHSQ-UHFFFAOYSA-N (3-hydroxy-1-adamantyl) 2-methylprop-2-enoate Chemical compound C1C(C2)CC3CC2(O)CC1(OC(=O)C(=C)C)C3 OOIBFPKQHULHSQ-UHFFFAOYSA-N 0.000 description 2
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- 101710113436 GTPase KRas Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
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- 102100037850 Interferon gamma Human genes 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
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- 230000006698 induction Effects 0.000 description 2
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- 108090000288 Glycoproteins Proteins 0.000 description 1
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- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102000005157 Somatostatin Human genes 0.000 description 1
- 108010056088 Somatostatin Proteins 0.000 description 1
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- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
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- 190000008236 carboplatin Chemical compound 0.000 description 1
- 230000007681 cardiovascular toxicity Effects 0.000 description 1
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- 229960004316 cisplatin Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
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- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 229960003668 docetaxel Drugs 0.000 description 1
- 229940035756 doxorubicin injection Drugs 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
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- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
- 229960005277 gemcitabine Drugs 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000008348 humoral response Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 208000004235 neutropenia Diseases 0.000 description 1
- 229950007283 oregovomab Drugs 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000003439 radiotherapeutic effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 101150047061 tag-72 gene Proteins 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
- 229960002190 topotecan hydrochloride Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33924001P | 2001-10-26 | 2001-10-26 | |
| US60/339,240 | 2001-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2304264A1 true ES2304264A1 (es) | 2008-10-01 |
Family
ID=23328122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200450028A Pending ES2304264A1 (es) | 2001-10-26 | 2002-10-28 | Terapia de combinacion para tratar enfermedades. |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT500649A1 (de) |
| AU (1) | AU2002358246B2 (de) |
| CA (1) | CA2464947C (de) |
| CH (1) | CH696871A5 (de) |
| DE (1) | DE10297379T5 (de) |
| ES (1) | ES2304264A1 (de) |
| GB (1) | GB2397018B (de) |
| NO (1) | NO20042166L (de) |
| WO (1) | WO2003034977A2 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8038994B2 (en) | 1996-05-15 | 2011-10-18 | Quest Pharmatech Inc. | Combination therapy for treating disease |
| WO2008091643A2 (en) * | 2007-01-23 | 2008-07-31 | Altarex Medical Corp. | In vitro culture system to evaluate synergy in targeting immune suppressive pathways concurrent to immunotherapy |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027637A1 (en) * | 1993-05-27 | 1994-12-08 | Uwe Wagner | Monoclonal anti-idiotypic anti-ca125 antibodies and pharmaceutical compositions containing them |
| WO1997042973A1 (en) * | 1996-05-15 | 1997-11-20 | Altarex, Corp. | Method and composition for reconforming multi-epitopic antigens to initiate an immune response |
| WO2001012217A1 (en) * | 1999-08-18 | 2001-02-22 | Altarex Corp. | Therapeutic antibody against muc-1 antigen and methods for their use |
| WO2001015730A1 (en) * | 1999-08-27 | 2001-03-08 | Genentech, Inc. | DOSAGES FOR TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
| WO2002076384A2 (en) * | 2001-03-21 | 2002-10-03 | Altarex Corp. | Therapeutic compositions that alter the immune response |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL146954A0 (en) * | 1999-06-25 | 2002-08-14 | Genentech Inc | HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
| JP2003505432A (ja) * | 1999-07-23 | 2003-02-12 | グラクソ グループ リミテッド | 抗ｅｐ−ｃａｍ抗体と化学療法剤との組合せ |
| PT1254374E (pt) * | 2000-02-08 | 2007-07-20 | Altarex Medical Corp | Método para diagnosticar a eficácia de uma terapia com anticorpos xenotípicos |
-
2002
- 2002-10-28 AU AU2002358246A patent/AU2002358246B2/en not_active Ceased
- 2002-10-28 CH CH00729/04A patent/CH696871A5/de not_active IP Right Cessation
- 2002-10-28 ES ES200450028A patent/ES2304264A1/es active Pending
- 2002-10-28 DE DE10297379T patent/DE10297379T5/de not_active Withdrawn
- 2002-10-28 AT AT0923902A patent/AT500649A1/de not_active Application Discontinuation
- 2002-10-28 GB GB0409191A patent/GB2397018B/en not_active Expired - Fee Related
- 2002-10-28 CA CA2464947A patent/CA2464947C/en not_active Expired - Lifetime
- 2002-10-28 WO PCT/IB2002/005794 patent/WO2003034977A2/en not_active Application Discontinuation
-
2004
- 2004-05-25 NO NO20042166A patent/NO20042166L/no not_active Application Discontinuation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027637A1 (en) * | 1993-05-27 | 1994-12-08 | Uwe Wagner | Monoclonal anti-idiotypic anti-ca125 antibodies and pharmaceutical compositions containing them |
| WO1997042973A1 (en) * | 1996-05-15 | 1997-11-20 | Altarex, Corp. | Method and composition for reconforming multi-epitopic antigens to initiate an immune response |
| WO2001012217A1 (en) * | 1999-08-18 | 2001-02-22 | Altarex Corp. | Therapeutic antibody against muc-1 antigen and methods for their use |
| WO2001015730A1 (en) * | 1999-08-27 | 2001-03-08 | Genentech, Inc. | DOSAGES FOR TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
| WO2002076384A2 (en) * | 2001-03-21 | 2002-10-03 | Altarex Corp. | Therapeutic compositions that alter the immune response |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2464947A1 (en) | 2003-05-01 |
| AU2002358246B2 (en) | 2008-02-28 |
| CA2464947C (en) | 2012-05-22 |
| GB2397018A (en) | 2004-07-14 |
| WO2003034977A3 (en) | 2004-05-27 |
| AT500649A1 (de) | 2006-02-15 |
| CH696871A5 (de) | 2008-01-15 |
| GB0409191D0 (en) | 2004-05-26 |
| WO2003034977A2 (en) | 2003-05-01 |
| DE10297379T5 (de) | 2004-10-14 |
| GB2397018B (en) | 2006-05-31 |
| NO20042166L (no) | 2004-05-25 |
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