WO2003034977A3 - Combination therapy for treating disease - Google Patents

Combination therapy for treating disease Download PDF

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Publication number
WO2003034977A3
WO2003034977A3 PCT/IB2002/005794 IB0205794W WO03034977A3 WO 2003034977 A3 WO2003034977 A3 WO 2003034977A3 IB 0205794 W IB0205794 W IB 0205794W WO 03034977 A3 WO03034977 A3 WO 03034977A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen
immune response
binding agent
host immune
patient
Prior art date
Application number
PCT/IB2002/005794
Other languages
French (fr)
Other versions
WO2003034977A2 (en
Inventor
Birgit C Schultes
Christopher F Nicodemus
Antoine Noujaim
Original Assignee
Altarex Medical Corp
Birgit C Schultes
Christopher F Nicodemus
Antoine Noujaim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altarex Medical Corp, Birgit C Schultes, Christopher F Nicodemus, Antoine Noujaim filed Critical Altarex Medical Corp
Priority to AU2002358246A priority Critical patent/AU2002358246B2/en
Priority to DE10297379T priority patent/DE10297379T5/en
Priority to AT0923902A priority patent/AT500649A1/en
Priority to GB0409191A priority patent/GB2397018B/en
Priority to CA2464947A priority patent/CA2464947C/en
Publication of WO2003034977A2 publication Critical patent/WO2003034977A2/en
Priority to US10/831,886 priority patent/US8038994B2/en
Priority to NO20042166A priority patent/NO20042166L/en
Publication of WO2003034977A3 publication Critical patent/WO2003034977A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are methods for treating cancer comprising administering a xenotypic monoclonal antibody and a chemotherapeutic drug to a patient suffering from cancer. Also disclosed is a method for inducing a host immune response in a patient against a multi-epitopic in vivo tumor antigen in present in the host serum, which antigen does not elicit a host immune response, comprising administering to the patient a chemotherapeutic drug and a composition comprising a binding agent that specifically binds to a first epitope on the antigen and allowing the binding agent to form a binding agent/antigen pair, wherein a host immune response is elicited against a second epitope on the antigen.
PCT/IB2002/005794 1996-05-15 2002-10-28 Combination therapy for treating disease WO2003034977A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2002358246A AU2002358246B2 (en) 2001-10-26 2002-10-28 Combination therapy for treating disease
DE10297379T DE10297379T5 (en) 2001-10-26 2002-10-28 Combination therapy for disease treatment
AT0923902A AT500649A1 (en) 2001-10-26 2002-10-28 COMBINATION THERAPY FOR DISEASE TREATMENT
GB0409191A GB2397018B (en) 2001-10-26 2002-10-28 Combination therapy for treating disease
CA2464947A CA2464947C (en) 2001-10-26 2002-10-28 Combination therapy for treating disease
US10/831,886 US8038994B2 (en) 1996-05-15 2004-04-26 Combination therapy for treating disease
NO20042166A NO20042166L (en) 2001-10-26 2004-05-25 Combination therapy for the treatment of disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33924001P 2001-10-26 2001-10-26
US60/339,240 2001-10-26

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/IB1996/000461 Continuation-In-Part WO1997042973A1 (en) 1996-05-15 1996-05-15 Method and composition for reconforming multi-epitopic antigens to initiate an immune response
US08913290 Continuation-In-Part 1996-05-15
US10/831,886 Continuation-In-Part US8038994B2 (en) 1996-05-15 2004-04-26 Combination therapy for treating disease

Publications (2)

Publication Number Publication Date
WO2003034977A2 WO2003034977A2 (en) 2003-05-01
WO2003034977A3 true WO2003034977A3 (en) 2004-05-27

Family

ID=23328122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/005794 WO2003034977A2 (en) 1996-05-15 2002-10-28 Combination therapy for treating disease

Country Status (9)

Country Link
AT (1) AT500649A1 (en)
AU (1) AU2002358246B2 (en)
CA (1) CA2464947C (en)
CH (1) CH696871A5 (en)
DE (1) DE10297379T5 (en)
ES (1) ES2304264A1 (en)
GB (1) GB2397018B (en)
NO (1) NO20042166L (en)
WO (1) WO2003034977A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8038994B2 (en) 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
WO2008091643A2 (en) * 2007-01-23 2008-07-31 Altarex Medical Corp. In vitro culture system to evaluate synergy in targeting immune suppressive pathways concurrent to immunotherapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012217A1 (en) * 1999-08-18 2001-02-22 Altarex Corp. Therapeutic antibody against muc-1 antigen and methods for their use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163868C (en) * 1993-05-27 2008-01-08 Uwe Wagner Monoclonal anti-idiotypic anti-ca125 antibodies and pharmaceutical compositions containing them
ES2193240T3 (en) * 1996-05-15 2003-11-01 Altarex Inc METHOD AND COMPOSITION TO RECONFORM MULTI-EPITHOPIC ANTIGENS TO START AN IMMUNE RESPONSE.
ES2329437T3 (en) * 1999-06-25 2009-11-26 Genentech, Inc. ANTI-ERBB2 ANTIBODIES HUMANIZED AND TREATMENT WITH ANTI-ERBB2 ANTIBODIES.
EP1198251B1 (en) * 1999-07-23 2006-11-29 Glaxo Group Limited Combination of an anti-ep-cam antibody with a chemotherapeutic agent
US6627196B1 (en) * 1999-08-27 2003-09-30 Genentech, Inc. Dosages for treatment with anti-ErbB2 antibodies
DK1254374T3 (en) * 2000-02-08 2007-09-03 Altarex Medical Corp Method for diagnosing the effectiveness of xenotype antibody therapy
AU2002335932B2 (en) * 2001-03-21 2007-11-01 Altarex Medical Corp. Therapeutic compositions that alter the immune response

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012217A1 (en) * 1999-08-18 2001-02-22 Altarex Corp. Therapeutic antibody against muc-1 antigen and methods for their use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOLD D.V. ET AL.: "Characterization of monoclonal antibody PAM4 reactive with a pancreatic cancer mucin", INT. J. CANCER, vol. 57, 1994, pages 204 - 210, XP002963400 *
NG B. ET AL.: "Radiosensitization of tumor-targeted radioimmunotherapy with prolonged topotecan infusion in human breast cancer xenografts", CANCER RESEARCH, vol. 61, 1 April 2001 (2001-04-01), pages 2996 - 3001, XP002963364 *

Also Published As

Publication number Publication date
DE10297379T5 (en) 2004-10-14
CA2464947A1 (en) 2003-05-01
CH696871A5 (en) 2008-01-15
ES2304264A1 (en) 2008-10-01
AT500649A1 (en) 2006-02-15
GB0409191D0 (en) 2004-05-26
NO20042166L (en) 2004-05-25
GB2397018A (en) 2004-07-14
AU2002358246B2 (en) 2008-02-28
GB2397018B (en) 2006-05-31
WO2003034977A2 (en) 2003-05-01
CA2464947C (en) 2012-05-22

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