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Laboratoires Francais de Chimiotherapie SA
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Laboratoires Francais de Chimiotherapie SA
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Publication of ES230040A1publicationCriticalpatent/ES230040A1/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Abstract
A process for obtaining the Δ 1-dehydrocortisol acetate, characterized in that it reaches the Δ 1-dehydrocortisol acetate (11 β, 17 α -dihydroxy-21-acetoxy Δ 1,4-preg-nadiene 3.20 -dione) by means of dibromidation in the dioxane medium of 11 β, 17 α -dihydroxy 21-acetoxy pregnane 3,20-dione followed by a double dehydromination of 2,4-dibromo 11 β, 17 α -dihydroxy 21-acetoxy pregnane 3,20-dione by known methods, obtaining 11 β 17 α -dihydroxy 21-acetoxy pregnane 3,20-dione starting by transformation of 17 α -hydroxy-21-acetoxy pregnane 3,11, 20-trione in its 3,20-disemicarbazone, being reduced therein by a mixed hydride with the simultaneous elimination of the acetyl group in 21, being reacted in 21 the 3,20-disemicarbazone of 11 beta, 17 α, 21-trihydroxy pregnane 3,20-dione and hydrolyzed by the hydrochloric acetone of the disemicarbazone of 11 β, 17 α -hydroxy 21-acetoxy pregnane 3,20-dione.
ES0230040A1955-07-291956-07-28A procedure for obtaining dehydrocortisol acetate (Machine-translation by Google Translate, not legally binding)
ExpiredES230040A1
(en)
A method for the production of 3-ceto-delta4,6-6-trifluorometilo steroids and 3-ceto-delta1,4,6-6-trifluoromethyl esteroids of the androstano series, of the 19-nor-androstano series and of the 19-nor-pregnano series (Machine-translation by Google Translate, not legally binding)